The pharmacological treatment of epilepsy:recent advances and future perspectives
作者机构：Department of Internal Medicine and TherapeuticsDivision of Clinical and Experimental PharmacologyUniversity of PaviaVia Ferrata 927100 PaviaItaly Department of NeuroscienceCentral Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia
出 版 物：《Acta Epileptologica》 (癫痫学报（英文）)
年 卷 期：2021年第3卷第1期
页 面：141-151页
主 题：Epilepsy Seizures Drug therapy Antiepileptic drugs Antiseizure medications Advances Review
摘 要：The pharmacological armamentarium against epilepsy has expanded considerably over the last three decades,and currently includes over 30 different antiseizure *** this large armamentarium,about one third of people with epilepsy fail to achieve sustained seizure freedom with currently available *** sobering fact,however,is mitigated by evidence that clinical outcomes for many people with epilepsy have improved over the *** particular,physicians now have unprecedented opportunities to tailor treatment choices to the characteristics of the individual,in order to maximize efficacy and *** present article discusses advances in the drug treatment of epilepsy in the last 5 years,focusing in particular on comparative effectiveness trials of second-generation drugs,the introduction of new pharmaceutical formulations for emergency use,and the results achieved with the newest *** article also includes a discussion of potential future developments,including those derived from advances in information technology,the development of novel precision treatments,the introduction of disease modifying agents,and the discovery of biomarkers to facilitate conduction of clinical trials as well as routine clinical management.
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