检索结果-南通市图书馆

Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study

引用

World Journal of Gastroenterology 2018年第41期24卷 4652-4662页

作者： Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra emilio di giulio Gianfranco Delle Fave Department of digestive and Liver disease School of Medicine and PsychologyS.Andrea HospitalSapienza University

AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at "regular", double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of

关键词： Lactobacillus rhamnosus GG Ulcerative colitis Probiotic Adhesion Cytokines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of Prucalopride in bowel cleansing before colonoscopy:Results of a pilot study

引用

World Journal of Gastrointestinal Endoscopy 2017年第11期9卷 558-560页

作者： Vito Domenico Corleto giulio Antonelli Chiara Coluccio Lucia D'Alba emilio di giulio Department of digestive Endoscopy School of Medicine and Psychology 'Sapienza' University of Rome Sant’ Andrea Hospital Gastroenterology and digestive Endoscopy San Giovanni-Addolorata Hospital

Colonoscopy is a crucial diagnostic instrument for colorectal cancer screening and an adequate bowel preparation is definitely decisive for the success of the procedure. Especially in elderly patients, bowel cleansing is considered a big issue, because it is often poorly tolerated for many reasons(like inability to swallow large volume of liquids or unlikable taste); this can cause a suboptimal preparation that may lead to miss a neoplastic lesion. There is relatively little data about how to improve preparation tolerability. The purpose of our pilot study was to analyze the effect of prucalopride(Resolor~?), a highly selective serotonin 5HT4 receptor agonist used for chronic constipation for its ability to stimulate gastrointestinal peristalsis, undertaken the day before colonoscopy, followed by half volume of polyethylene glycol solution. We found that this can be a good and safe method to achieve an adequate and better-tolerated colon cleansing.

关键词：清洁的肠 Colonoscopy Prucalopride 屏蔽 Colorectal 癌症

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tertiary stent-in-stent for obstructing colorectal cancer: A case report and literature review

引用

World Journal of Gastrointestinal Endoscopy 2019年第1期11卷 61-67页

作者： Giuseppe Vanella Chiara Coluccio emilio di giulio Daniela Assisi Rocco Lapenta Department of digestive Endoscopy Sant'Andrea Hospital Sapienza University of Rome Department of digestive Endoscopy Regina Elena National Cancer Institute

BACKGROUND Self-expandable metal stents(SEMSs) are frequently used in the setting of palliation for occluding, inoperable colorectal cancer(CRC). Among possible complications of SEMS positioning, re-obstruction is the most frequent. Its management is controversial, potentially involving secondary stent-in-stent placement, which has been poorly investigated. Moreover, the issue of secondary stent-in-stent re-obstruction and of more-than-two colonic stenting has never been assessed. We describe a case of tertiary SEMS-in-SEMS placement, and also discuss our practice based on available literature.CASE SUMMARY A 66-year-old male with occluding and metastatic CRC was initially treated by positioning of a SEMS, which had to be revised 6 mo later when a symptomatic intra-stent tumor ingrowth was treated by a SEMS-in-SEMS. We hereby describe an additional episode of intestinal occlusion due to recurrence of intra-stent tumor ingrowth. This patient, despite several negative prognostic factors(splenic flexure location of the tumor, carcinomatosis with ascites, subsequent chemotherapy that included bevacizumab and two previously positioned stents(1 SEMS and 1 SEMS-in-SEMS)) underwent successful management through the placement of a tertiary SEMS-in-SEMS, with immediate clinical benefit and no procedure-related adverse events after 150 d of post-procedural follow-up. This endoscopic management has permitted 27 mo of partial control of a metastatic disease without the need for chemotherapy discontinuation and, ultimately, a good quality of life until death.CONCLUSION Tertiary SEMS-in-SEMS is technically feasible, and appears to be a safe and effective option in the case of recurrent SEMS obstruction.

关键词： Bevacizumab Colorectal neoplasms Intestinal obstruction Palliative care Self-expandable metallic stents Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is proliferative colonic disease presentation changing?

引用

World Journal of Gastroenterology 2012年第45期18卷 6614-6619页

作者： Vito D Corleto Cristiano Pagnini Maria Sofia Cattaruzza Ermira Zykaj emilio di giulio Giovanna Margagnoni Emanuela Pilozzi Giancarlo D'Ambra Antonietta Lamazza Enrico Fiori Mario Ferri Luigi Masoni Vincenzo Ziparo Bruno Annibale Gianfranco Delle Fave Department of Medical and Surgical Sciences and Translational Medicine Faculty of Medicine and PsychologySant'Andrea Hospital"Sapienza" University00189 RomeItaly Department of Public Health and Inf.diseases Faculty of MedicinePoliclinico Umberto I"Sapienza" University00189 RomeItaly Department of Pathology Faculty of Medicine and PsychologySant'Andrea Hospital"Sapienza" University00189 RomeItaly Department of Surgery Faculty of MedicinePoliclinico Umberto I"Sapienza" University00189 RomeItaly

AIM:To compare the site,age and gender of cases of colorectal cancer(CRC) and polyps in a single referral center in Rome,Italy,during two periods.METHODS:CRC data were collected from surgery/pathology registers,and polyp data from colonoscopy reports.Patients who met the criteria for familial adenomatous polyposis,hereditary non-polyposis colorectal cancer syndrome or inflammatory bowel disease were excluded from the study.Overlap of patients between the two groups(cancers and polyps) was carefully avoided.Theχ 2 statistical test and a regression analysis were performed.RESULTS:Data from a total of 768 patients(352 and 416 patients,respectively,in periods A and B) who underwent surgery for cancer were collected.During the same time periods,a total of 1693 polyps were analyzed from 978 patients with complete colonoscopies(428 polyps from 273 patients during period A and 1265 polyps from 705 patients during period B).A proximal shift in cancer occurred during the latter years for both sexes,but particularly in males.Proximal cancer increased > 3-fold in period B compared to period A in males [odds ratio(OR) 3.31,95%CI:2.00-5.47;P < 0.0001).A similar proximal shift was observed for polyps,particularly in males(OR 1.87,95%CI:1.23-2.87;P < 0.0038),but also in females(OR 1.62,95%CI:0.96-2.73;P < 0.07).CONCLUSION:The prevalence of proximal proliferative colonic lesions seems to have increased over the last decade,particularly in males.

关键词：结肠疾病增生性癌症患者结直肠癌数据收集肠道疾病统计检验回归分析

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients?

引用

World Journal of Gastroenterology 2005年第47期11卷 7541-7544页

作者： Vito D Corleto Ermira Zykaj Paolo Mercantini Emanuela Pilozzi Michele Rossi Antonella Carnuccio emilio di giulio Vincenzo Ziparo Gianfranco Delle Fave Department of digestive and Liver diseases Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of digestive and Liver diseases Ⅱ School of MedicineUniversity "La Sapienza"Centro Ricerche S.Pietro FBFRomeItaly Department of Surgery Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of Pathology Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of Radiology Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly

有有在 hMSH2 的一个变化的结肠癌衬里的世袭 non-polyposis 的 34 岁的男性被报导。尽管有常规 colonoscopic 后续，他得了包含额外的钠区域的盲肠的癌症。由于亚 occlusive 症状，病人被提交推进结肠镜检查，然而没有瘤形成的清楚的... 详细信息

有有在 hMSH2 的一个变化的结肠癌衬里的世袭 non-polyposis 的 34 岁的男性被报导。尽管有常规 colonoscopic 后续，他得了包含额外的钠区域的盲肠的癌症。由于亚 occlusive 症状，病人被提交推进结肠镜检查，然而没有瘤形成的清楚的证据。计算断层摄影术 CT 扫描此后执行了的多平面的重建揭示了的薄片透壁集中在在盲肠的阀门附近局部性的尺寸的 2.5 厘米。讨论在右边的结肠癌的很高的风险在病人的后续象对进一步的调查的需要一样在 colonoscopic 考试的可靠性上被做，例如世袭 non-polyposis 结肠癌影响的男 hMSH2 搬运人。

关键词：结肠癌直肠癌结肠镜息肉

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy

引用

World Journal of Gastrointestinal Oncology 2012年第2期4卷 22-25页

作者： Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti emilio di giulio Vincenzo Ziparo Gianfranco Delle Fave digestive and Liver disease Unit Second Medical School"La Sapienza" UniversityS. An-drea Hospital00189 RomeItaly Nursery Science Second Medical School "La Sapienza" University00189 RomeItaly Radiology Unit "La Sapienza" University00189 RomeItaly Oncology Unit "La Sapienza" University00189 RomeItaly General Surgery Unit "La Sapienza" University00189 RomeItaly digestive Endoscopy Unit Catholic University000192 RomeItaly Radiotheraphy Unit "La Sapienza" Uni-versity00189 RomeItaly

Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery.

关键词： Intraductal papillary neoplasm Bile duct Simultaneous Pancreatic intraductal papillary mucinous neoplasm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intraparenchymal hepatic hematoma following endoscopic retrograde cholangiopancreatography: Risk factors and conservative approach in acute management

引用

Hepatobiliary & Pancreatic diseases International 2021年第3期20卷 293-295页

作者： Valeria D’Ovidio Giovanni Bruno giulio Sodani Cristina Lucidi Marco emilio Bazuro GI Endoscopy Unit S.Eugenio HospitalRome 00100Italy Unit of Radiology S.Eugenio HospitalRome 00100Italy

Endoscopic retrograde cholangiopancreatography(ERCP) is an invasive procedure with a complication rate ranging from 4% to 10% [1]. While post-procedure pancreatitis is the most common risk, bleeding also deserves attention. The most common symptoms of post-procedure bleeding were abdominal pain(91.7%), anemia(43.8%), hypotension(29.2%) and fever(20.8%) [2,3].

关键词： retrograde bleeding anemia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Measures of empathy in children and adolescents:A systematic review of questionnaires

引用

World Journal of Psychiatry 2021年第10期11卷 876-896页

作者： Gianluca Sesso giulio emilio Brancati Pamela Fantozzi Emanuela Inguaggiato Annarita Milone Gabriele Masi Department of Clinical and Experimental Medicine University of PisaPisa 56100Italy IRCCS Fondazione Stella Maris Scientific Institute of Child Neurology and PsychiatryCalambrone 56128Italy

BACKGROUND Empathy has long been considered a multidimensional construct,encompassing cognitive,affective and behavioral domains.Deficits in empathic competences in early childhood contribute to psychopathology,and have been variably implicated in several clinical conditions,such as autism spectrum disorders(ASD)and conduct disorders.AIM To identify and describe empirically validated questionnaires assessing empathy in children and adolescents and to provide a summary of related theoretical perspectives on empathy definitional issues.METHODS A systematic review of the literature was conducted.Three bibliographic databases were searched.A total of 47 studies were selected for final analysis and 16 distinct measures were identified and described.RESULTS Questionable to excellent levels of internal consistency were observed,while few studies assessed test-retest reliability.Although construct definitions only partially overlapped,affective and cognitive domains of empathy were the commonest internal factors that were often separately evaluated.New facets of the construct(i.e.,somatic empathy and sympathy)and specific clinical populations(i.e.,ASD)could be specifically addressed through more recent instruments.CONCLUSION The combination of different assessment methods is recommended in order to foresee further improvements in this field and try to overcome the problem of limited convergence with more objective measures.

关键词： Empathy Assessment Child Adolescent Autistic disorder Conduct disorder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

引用

World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio di Giacomo Rosanna De Marco Giorgio De Stefano giulio De Stefano Sebastiano di Salvo Raffaele di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of Medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal Medicine Unit Second University of Naples VI division of Infectious diseases Cotugno Hospital AORN "Ospedali dei Colli" division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS division of Infectious diseases Belcolle Hospital IX division of Infectious diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious disease University of Sassari Infectious disease IRCCS San Matteo division of Infectious diseases and Liver Unit "G. Iazzolino" Hospital division of Infectious diseases "Annunziata" Hospital Depart-ment of Internal Medicine Umberto I Hospital Internal Medicine Ospedale Evangelico Villa Betania division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal Medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of Medical Day Hospital "Rummo" Hospital Internal Medicine Regina Margherita Hospital division of Gastroenterology "Annunziata" Hospital Infectious disease Matera Hospital First division of Infectious diseases Cotugno Hospital AORN "Ospedali dei Colli" division of Infectious diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical disease Policlinico Umberto I division of Infectious disease Maria SS Addolorata Hospital division of Infectious diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver diseases "Loreto Crispi" Hospital V division of Infectious diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of Medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino Medicine and Health Unit for Prisoners Belcolle Hospital Internal Medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII division of Infectious diseases

AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：