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NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

Journal of Materials science & Technology 2022年第19期114卷 120-130页

作者： M.M.Costa A.Miranda F.Bartolomeu O.Carvalho s.Matos G.Miranda F.s.silva Center for MicroElectroMechanical systems(CMEMs-UMinho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVs/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and Research in Oral sciences(CIROs) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for *** work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based *** performance was evaluated in vivo through implantation in sprague Dawley rats’femur,being then analyzed after 4 and 12 weeks of ***-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured *** showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had ***-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).Moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212%when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

关键词： NiTi Laser surface texturing In vivo studies Osseointegration Implants

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Mechanical stimulation devices formechanobiology studies:a market,literature,and patents review

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Bio-Design and Manufacturing 2023年第3期6卷 340-371页

作者： F.Melo-Fonseca O.Carvalho M.Gasik G.Miranda F.s.silva Center for MicroElectroMechanical systems University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELs–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal school of Chemical Engineering Aalto University Foundation00076 EspooFinland seqvera Ltd. HelsinkiFinland Department of Materials and Ceramic Engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

关键词： Biomaterials Polymers Actuators Mechanical stress Mechanotransduction

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Bactericidal activity of hydrogel beads based on N,N,N-trimethyl chitosan/alginate complexes loaded with silver nanoparticles

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Chinese Chemical Letters 2015年第9期26卷 1129-1132页

作者： Alessandro F.Martins Johny P.Monteiro Elton G.Bonaf Adriana P.Gerola Cleiser T.P.silva emerson M.Girotto Adley F.Rubira Edvani C.Muniz Departamento de Quimica Universidade Tecnologica Federal do Parana(UTFPR) Grupo de Materials Polimericos e Compositos Universidade Estadual de Maringa(UEM)

Polysaccharide-based composite materials（beads） containing silver nanoparticles（AgNPs） were successfully *** beads acted as an efficient vehicle for Ag＊ *** promoted the AgNPs protection and inhibited their *** assays showed that the beads/AgNPs concentration can be modulated to deliver an amount of Ag＊ necessary for kill Escherichia coli cells.

关键词： N N N-Trimethyl chitosan Alginate silver nanoparticles Antimicrobial activity Delivery

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Progress of Pb-sn Mixed Perovskites for Photovoltaics: A Review

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Energy & Environmental Materials 2022年第2期5卷 370-400页

作者： Rajapakshe Mudiyanselage Indrachapa Bandara shashini M.silva Cameron C.L.Underwood K.D.G.Imalka Jayawardena Radu A.sporea s.Ravi P.silva Advanced Technology Institute Faculty of Engineering and Physical SciencesUniversity of SurreyGuildford Surrey GU27XHUnited Kingdom

Pb-sn mixed perovskites are becoming increasingly popular as narrowbandgap(1.2–1.3 eV)light absorbers in single-junction perovskite solar cells(PsCs)and as bottom cells for all-perovskite tandem solar cells,for highefficiency,low-cost,lightweight,roll-to-roll printable photovoltaic(PV)*** the first report of planar Pb:sn mixed PsCs in 2014,the power conversion efficiencies(PCE)have increased from 10%to 21%by the end of 2020 with an exponential growth in research conducted in this *** much effort,the performance and stability of Pb-sn mixed PsCs are still limited,which constrains their long-term use in all-perovskite tandem *** review highlights the avenues explored in improving different aspects of Pb-sn mixed PsCs and provides a comprehensive discussion of the interdependent factors affecting the device *** includes compositional engineering of the perovskite crystal,absorber layer fabrication and crystallization methods,bandgap tuning,sn4+reduction,and surface passivation of the absorber layer,as well as the selection of interlayers and electrodes of the final PsC.

关键词： inorganic-organic hybrids lead-tin mixed perovskites perovskites photovoltaics solution-processed

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Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： CARLOs ALBERTO-silva BRENDA RUFINO DA silva Natural and Humanities sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic *** review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake *** also includes a brief evaluation of short peptides that are being considered as potential therapeutic ***-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial *** signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMDA)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

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Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

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Neural Regeneration Research 2022年第8期17卷 1640-1644页

作者： Tayana silva de Carvalho Herz-und Diabeteszentrum NRW(HDZ NRW) Bad OeynhausenGermany

Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative *** general,these patients develop strong metabolic alterations,resulting in lower treatment efficacy and higher mortality ***,there are still many open questions regarding the effectiveness of dietary interventions in *** studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such ***,it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories(hypocaloric diet)or a specific nutrient restriction(diet restriction).Therefore,here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

关键词： Alzheimer’s disease diet therapy dietary intervention epilepsy fasting glucose restriction hypocaloric diet multiple sclerosis Parkinson’s disease stroke

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Influence of age in estimating maximal oxygen uptake

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Journal of Geriatric Cardiology 2016年第2期13卷 126-131页

作者： Christina G de souza silva Barry A Franklin Daniel E Forman Claudio Gil s Araujo Heart Institute Edson saad and Medical school Federal University of Rio de Janeiro Rio de Janeiro R J Brazil Exercise Medicine Clinic CLINIMEX Rio de Janeiro R J Brazil Preventive Cardiology and Cardiac Rehabilitation William Beaumont Hospital Royal Oak MI United States section of Geriatric Cardiology University of Pittsburgh Medical Center Geriatrics Research Education and Clinical Center System University of Pittsburgh Pittsburgh PA USA

Objective To assess the influence of age on the error of estimate （EE） of maximal oxygen uptake （VO2max） using sex and population specific-equations in cycle ergometer exercise testing, since estimated VO2 max is associated with a substantial EE, often exceeding 20%, possibly due to intrinsic variability of mechanical efficiency. Methods 1850 adults （68% men）, aged 18 to 91 years, underwent maximal cycle ergometer cardiopulmonary exercise testing. Cardiorespiratory fitness （CRF） was assessed relative to sex and age [younger （18 to 35 years）, middle-aged （36 to 60 years） and older （〉 60 years）]. VO2max [mL.（***）-1] was directly measured by assessment of gas exchange and estimated using sex and population specific-equations. Measured and estimated values of VO2max and related EE were compared among the three age- and sex-specific groups. Results Directly measured VO2max of men and women were 29.5 ± 10.5 mL.（***）-1 and 24.2 ± 9.0 mL.（kg·min） -1 （P 〈 0.01）. EE [mL·（kg·min）-1] and percent errors （%E） for men and women had similar values, 0.5 ± 3.2 and 0.4 ± 2.9 mL·（kg·min）-1, and -0.8 ± 13.1% and -1.7 ± 15.4% （P 〉 0.05）, respectively. EE and %E for each age-group were, respectively, for men： younger = 1.9 ± 4.1 mL·（kg·min）-1 and 3.8 ± 10.5%, middle-aged = 0.6 ± 3.1 mL.（kg·min）-1 and 0.4 ± 10.3%, older = -0.2 ± 2.7 mL·（kg·min） -1 and -4.2 ± 16.6% （P 〈 0.01）; and for women： younger = 1.2 ± 3.1 mL.（***）-1 and 2.7 ±10.0%, middle-aged = 0.7 ± 2.8 mL·（kg·min）-1 and 0.5 ± 11.1%, older = -0.8 ± 2.3 mL-（kg·min）-1 and -9.5 ± 22.4% （P 〈 0.01）. Conclusion VO2max were underestimated in younger age-groups and were overestimated in older age groups. Age significantly influences the magnitude of the EE of VO2max in both men and women and should be considered when CRF is estimated using population specific equations, rather than directly measured.

关键词： Aging Cardiopulmonary exercise testing Error of measurement

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structural and photoluminescent properties of the MgGa_(2)O_(4):Co^(2+)ceramic compound revisited after two decades

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Journal of Advanced Ceramics 2015年第4期4卷 267-271页

作者： s.s.PEDRO M.A.F.M.DA silva A.LÓPEZ,L.P.sOsMAN Instituto de Física Universidade do Estado do Rio de JaneiroRJ 20550-900Brazil

In this work,we revisit and show how the structural and photoluminescent properties of the MgGa_(2)O_(4) ceramic compound have been kept unchanged for more than two *** obtained results confirm the high quality,radiative efficiency,and chemical stability of this ceramic,proving that the material is a strong candidate to be used in optical device applications with relatively long useful life.

关键词： ceramic compound cobalt solid-state reaction photoluminescence

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Bartter's syndrome:clinical findings,genetic causes and therapeutic approach

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World Journal of Pediatrics 2021年第1期17卷 31-39页

作者： Flavia Cristina Carvalho Mrad sílvia Bouissou Morais soares Luiz Alberto Wanderley de Menezes.silva Pedro Versiani dos Anjos Menezes Ana Cristina simoes-e-silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Backgound Bartter's syndrome(Bs)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's *** sources Literature reviews and original research articles were collected from database,including PubMed and *** According to the time of onset and symptoms,Bs can be classified into antenatal and classic *** studies have identified different subtypes of *** types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),***-of-function mutations of Barttin CLCNK type accessory beta subunit cause Bs type Ⅳ*** mutations of CLCNKB and CLCNKA cause Bs type Ⅳ*** type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGE family member *** gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of *** clinical and biochemical alterations in Bs include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to *** focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin E2 *** Early diagnosis and treatment of Bs may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease.

关键词： Bartter's syndrome Hypercalciuria Hypokalemia Metabolic alkalosis Nephrocalcinosis

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The corpus cavernosum after treatment with dutasteride or finasteride： a histomorphometric study in a benign prostatic hyperplasia rodent model

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Asian Journal of Andrology 2018年第5期20卷 505-510页

作者： Marcello H A Da silva Waldemar s Costa Francisco J B sampaio Diogo B De souza Urogenital Research Unit Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Erectile dysfunction is a common side effect of finasteride and dutasteride treatments. The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia （BPH） rodent model treated with dutasteride or finasteride. sixty male rats were divided into the following groups： C, untreated control rats; C ＋ D, control rats receiving dutasteride; C ＋ F, control rats receiving finasteride; H, untreated spontaneously hypertensive rats （sHRs）; H ＋ D, sHRs treated with dutasteride; and H ＋ F, sHRs treated with finasteride. Treatments were performed for 40 days, and penises were collected immediately thereafter. The organs were analyzed using histomorphometric methods to determine the cross-sectional penile area, as well as the surface density （sv） of smooth muscle fibers, connective tissue, elastic system fibers, and sinusoidal spaces of the corpus cavernosum. The results were compared using a one-way ANOVA with Bonferroni＇s posttest. Groups C ＋ D and C ＋ F had a significantly smaller penile cross-sectional area, but more elastic system fiber sv compared to Group C. Group C ＋ D showed less smooth muscle sv, and Group H showed more connective tissue but a smaller sinusoidal space sv in the corpus cavernosum compared to Group C. Groups H ＋ D and H ＋ F had less smooth muscle sv than Group H. Group H ＋ D also had more connective tissue and elastic system fiber sv than Group H. Both dutasteride and finasteride promoted penile modifications in the control rat penis, although this affect was ~reater in Group H animals. In this rodent model, dutasteride was the drug that most affected the corpus cavernosum.

关键词： animal models benign prostatic hyperplasia dutasteride erectile dysfunction finasteride penis

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