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Interleukin-12 supports in vitro self-renewal of long-term hema.opoietic stem cells

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Blood Science 2019年第1期1卷 92-101页

作者： Shanshan Zhang maiko Morita Zhao Wang Jun Ooehara Sen Zhang Miner Xie Haitao Bai Wenying Yu Xiaofang Wang Fang Dong Jinhong Wang Shihui ma Satoshi Yamazaki Hideo ema Institute of Hema.ology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina Project Division of Advanced Regenerative Medicine Institute of Medical ScienceUniversity of TokyoTokyoJapan Laboratory of Stem Cell Therapy Center for Experimental MedicineInstitute of Medical ScienceUniversity of TokyoTokyoJapan

Hema.opoietic stem cells(HSCs)self-renew or differentiate through *** are essential for inducing HSC division,but the optimal cytokine combination to control self-renewal of HSC in vitro rema.ns *** this study,we compared the effects of interleukin-12(IL-12)and thrombopoietin(TPO)in combination with stem cell factor(SCF)on in vitro self-renewal of ***-cell assays were used to overcome the heterogeneity issue of HSCs,and serum-free conditions were newly established to permit reproduction of *** single-cell cultures,CD150^(+)CD48^(-)CD41^(-)CD34^(-)c-Kit^(+)Sca-1^(+)lineage^(-)SCs divided significantly more slowly in the presence of SCF+IL-12 compared with cells in the presence of SCF+*** transplantation of cells from bulk and clonal cultures revealed that TPO was more effective than IL-12 at supporting in vitro self-renewal of short-term(mation,whereas IL-12 was more effective than TPO at supporting the in vitro selfrenewal of long-term(>6 months)HSCs,resulting in a biphasic reconstitution wave *** control of division rate in HSCs appeared to be crucial for preventing the loss of self-renewal potential from their in vitro culture.

关键词： Ex vivo expansion Hema.opoietic stem cells Interleukin-12 Self-renewal

Investigations on MBSE modelling and dynamic performance assessment of an electrical trimmable horizontal stabilizer actuator

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Chinese Journal of Aeronautics 2023年第11期36卷 417-433页

作者： Wensen ZHANG Jian FU Jean-Charles maRÉ Haolin ma Tianxiang XIA Yongling FU Jiangao ZHAO School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China INSA–Institut Clément Ader(CNRS UMR 5312) Toulouse 31400France Nanjing Engineer Institute of Aircraft System Jincheng AVICNanjing 211100China

With the development of power-by-wire technology for more electric aircraft,the electromechanical actuator(ema.has the advantages to replace the conventional hydraulic servo actuator in some aerospace flight *** hydraulically powered trimmable horizontal stabilizer actuation(THSA)system is nowadays developed to be electrically *** their safety-criticality,no-back mechanism and redundant load paths are utilized to meet the flight control ***,rare literatures have introduced these functions and addressed the virtual prototyping activities from system-level point of *** paper proposed such a model of a THSA system with dual electric power sources and fault-tolerant mechanical load *** nonlinear effects of components are considered with realism,and system-level simulation test is conducted to support the model-based system engineering(MBSE)*** models are developed with a power view instead of a pure signal *** on the friction effect and compliance effect with backlash or preload,some improved and novel approaches are adopted for these crucial components and validated via experimental ***,the implemented systemlevel model enables injection of crucial ***,the simulation of the proposed model shows that it is an efficient resource to investigate the actuator’s dynamic performance,to virtually prove that the actuator meets the fail/safe constraint,and to demonstrate the soundness of the fault monitoring functions.

关键词： Electro-mechanical actuator Flight control Mechanical load path Modelling No-back mechanism

Dependence of electromagnetic wave absorption properties on the topography of Ni anchoring on reduced graphene oxide

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Chinese Chemical Letters 2021年第2期32卷 870-874页

作者： Luyang Liang Zhaoyang Li Zhongyi Bai Yuezhan Feng Xiaoqin Guo Jianmin ma Chuntai Liu Key Laboratory of Advancedεmaterials Processing Mold Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China Henan Key Laboratory of Aeronautical materials and Application Technology School of Material Science and EngineeringZhengzhou University of AeronauticsZhengzhou 450046China Key Laboratory for Micro-/Nano-Optoelectronic Devices Ministry of EducationSchool of Physics and ElectronicsHunan UniversityChangsha 410022China

Specific topographic Ni anchoring on reduced graphene oxide(rGO) composites show an astronomical potential as effective wave absorbers due to the synergistic electromagnetic loss ***,Ni/rGO composites with different topography were successfully prepared via hydrothermal in-situ reduction *** structure and morphology characteristics revealed that particle-like,chain-like,coin-like and flower-like Ni were closely anchored onto rGO,*** electromagnetic wave absorption(ema. performance revealed that chain-like Ni/rGO exhibited the optimal reflection loss of-43.7 dB with a thickness of 1.8 mm as well as the EAB of 6.1 GHz at 2.0 mm among all samples due to the good impedance match and the synergistic dielectric and magnetic ***,one conclusion can be drawn that excellent magnetic coupling effect and impedance matching were the main reasons for significantly improving the ema.*** the systema.ic dependence of morphology on ema.this work provides a perspective for designing high-performance absorbing materials.

关键词： Ni/rGO Morphology structure magnetic coupling effect Synergistic effect Electromagnetic wave absorption

Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon

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Journal of Environmental Sciences 2018年第2期30卷 82-91页

作者： Runmiao Xue Ariel Donovan Haiting Zhang Yinfa ma Craig Adams John Yang Bin Hua Enos Inniss Todd Eichholz Honglan Shi Department of Chemistry and Environmental Research Center Missouri University of Science and Technology RoIIa MO 65409 USA Center for Single Nanoparticle Single Cell and Single Molecule Monitoring (CS3M) Missouri University of Science and Technology RollaMO 6S409 USA Department of Civil Engineering Saint Louis University St. Louis MO 63103 USA Department of Agriculture and Environmental Sciences Lincoln University of Missouri Jefferson City MO 65101 USA Department of Civil & Environmental Engineering University of Missouri-Columbia Columbia MO 65211 USA Missouri Department of Natural Resources Jefferson City MO 65102 USA

When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products（DBPs） may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine（NDma）, may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment *** test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon（PAC） sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than67% ammonia and 70%–100% N-nitrosamine precursors were removed by Mordenite zeolite（except 3-（dimethylaminomethyl）indole（DmaI） and 4-dimethylaminoantipyrine（DmaP））. PAC effectively removed DmaI and DmaP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors（dimethylamine（Dma）, ethylmethylamine（ema., diethylamine（DEA）, dipropylamine（DPA）, trimethylamine（Tma）, DmaP, and DmaI） during the alum coagulation process.

关键词： Disinfection by-products Drinking water treatment Ammonia removal by zeolite N-nitrosodimethylamine(NDma) N-nitrosamines N-nitrosamine precursor removal by zeolite and powdered activated carbon

sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/ema.as a supplementary diagnostic indicator

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Cancer Biology & Medicine 2021年第2期18卷 477-489页

作者： Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu Department of Breast Cancer Pathology and Research Laboratory Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationBreast Cancer Innovation Team of the Ministry of EducationState Key Laboratory of Breast Cancer ResearchTianjin 300060China

Objective: Mucin 1(MUC1/ema. and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/ema.and sLe^(x) and to assess their diagnostic and prognostic value in patients with ***: The expression of sLe^(x) and MUC1/ema.in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence ***: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/ema.in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/ema. indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/ema.expression patterns, and 8 patients had sLe^(x)-/ema. expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/ema.and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS ***: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/ema.as a complementary diagnostic indicator to avoid missed IMPC diagnosis.

关键词： Invasive micropapillary carcinoma polarity reversal diagnostic indicator ema sLe^(x)

A reappraisal of the relationship between metatarsus adductus and hallux valgus

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Chinese Medical Journal 2014年第11期127卷 2067-2072页

作者： Chen Li Wang Chen Wang Xu Huang Jiazhang Zhang Chao Zhang Yijun ma Xin Department of Orthopedics Huashan Hospital Fudan University Shanghai 200040 China

Background A causal link between the metatarsus adductus and hallux valgus is not *** aim of this study was to investigate the configurations of the metatarsus adductus deformity by radiological measurements and reappraise the relationship between hallux valgus and metatarsus *** The first step was evaluation of the relationship between metatarsus adductus and hallux valgus on 143 dorsoplantar weight-bearing radiographs diagnosed as hallux valgus which was also known as *** including the hallux valgus angle （HVA）,the intermetatarsal angle （Ima）,the Kilmartin angle （KA）,the tibial sesamoid position （TSP）,and metatarsus adductus angle were *** metatarsus adductus angle is defined by Sgarlato＇s angle （Sma） and Engel＇s angle （ema. *** The metatarsus adductus angle positively correlates with the HVA （r=0.590,P=0.000） and KA （r=0.601,P=0.000）,yet negatively correlates with the grade of TSP,（r=-0.348,P=0.000）.Contradiction of diagnosis existed in 22 （22/100） subjects diagnosed as metatarsus adductus by Sma yet normal by *** this group,the correlation between HVA and metatarsus adductus angle was negative （r=-0.472,P=0.027）.Conclusions ema.and Sma defined metatarsus adductus by different deformity *** adductus configurations in that the apex of the deformity lay in either the base of metatarsals or *** respectively correlate positively or negatively to the HVA.

关键词： metatarsus adductus hallux valgus sesamoid bones radiological measurements

6-22 Mechanical Design and Processing Progress of LEAF-RFQ

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IMP & HIRFL Annual Report 2016年第1期 273-274页

作者： Jin Xiaofeng Zhang Bin Lu Liang ma Wei 不详

The working frequency of LEAF-RFQ is 81.25 MHz,and the voltage is 70 *** RFQ is used to accelerate uranium beam with 2 ema.current from 14 keV/u to 0.5 MeV/u and the basic structure parameters are listed in Table *** RFQ cavity is an oxygen-free copper cavity composed of six modules of the same structure and the same *** mechanical structure of cavity module is shown in *** outer stainless-steel casing is connected between each segment by *** both ends of the cavity,the inlet and outlet end plates and other connected parts are assembled,as shown in Fig.2 for the RFQ assembly.

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飞机全电刹车机电作动系统上电自检测

航空学报 2016年第12期37卷 3832-3842页

作者：相里康马瑞卿西北工业大学自动化学院西安710072

提出了一种飞机全电刹车机电作动(ema.系统的上电自检测(POST)方法,以保证系统在运行前处于安全工作区域。通过检测,可及时准确地定位和更换故障部件,提高飞机出勤率。在系统运行之前,尽可能在有限的检测次数内全面准确地检测敏感元件,... 详细信息

提出了一种飞机全电刹车机电作动(ema.系统的上电自检测(POST)方法,以保证系统在运行前处于安全工作区域。通过检测,可及时准确地定位和更换故障部件,提高飞机出勤率。在系统运行之前,尽可能在有限的检测次数内全面准确地检测敏感元件,定位故障部件,避免造成刹车系统的二次伤害。针对逆变器和电机三相绕组组成的驱动回路,利用母线电容放电产生电流,完成检测。检测过程利用电容电压而非电源为逆变器供电,可防止过高的短路电流对电源的冲击,且电容上存储的能量有限,可有效避免短路故障对系统的二次伤害。检测方法在原有电路的基础上并未增加传感器和检测电路,但实现了逆变器功率管以及电机绕组,短路和开路故障的全面检测,且可定位出故障部件和故障原因。该机电作动系统上电自检测方法能够保证在一秒内完成系统全面自检测,经过1 000次正常及带故障试验,故障的误报率和漏报率保持在1‰以下。在现场试验中,系统可抵御飞机复杂的电磁环境(EME),工作性能稳定。通过软件设置不同故障阈值,可方便移植到其他机电作动系统中。

关键词：机电作动系统全电刹车无刷直流电机自检测逆变器定子绕组短路开路

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遗传毒性杂质的警示结构

中国新药杂志 2014年第18期23卷 2106-2111页

作者：马磊马玉楠陈震蒋煜国家食品药品监督管理总局药品审评中心北京100038

遗传毒性杂质在很低的浓度下即可诱导基因突变以及染色体的断裂和重排,因而具有潜在的致癌性。在缺乏杂质安全性数据支持的情况下,在ema.FDA以及ICH发布的指导原则中均将警示结构作为区分普通杂质和潜在遗传毒性杂质的主要标志。本文就... 详细信息

遗传毒性杂质在很低的浓度下即可诱导基因突变以及染色体的断裂和重排,因而具有潜在的致癌性。在缺乏杂质安全性数据支持的情况下,在ema.FDA以及ICH发布的指导原则中均将警示结构作为区分普通杂质和潜在遗传毒性杂质的主要标志。本文就警示结构的起源、发展和识别进行简要论述。

关键词：遗传毒性杂质致癌性杂质警示结构