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习近平新时代治国理政的历史观

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2019年

作者：卜宪群

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Commanding the Commander:structure of a key protein machinery in endosomal trafficking

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3877-3879页

作者： Xin Yong Chunzhuang Zhou daniel d.Billadeau da Jia Key Laboratory of Birth defects and Related diseases of Women and Children Department of PaediatricsWest China Second University HospitalState Key Laboratory of BiotherapySichuan UniversityChengdu 610041China division of Oncology Research and Schulze Center for Novel Therapeutics Mayo ClinicRochesterMN 55905USA

In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microscopy(Cryo-em),Alphafold predictions and extensive site-directed mutagenesis(Fig.1a),which sheds lights on the molecular characteristics of this evolutionarily-conserved protein machinery,and enables the mapping of mutations causing X-linked intellectual disability(XILd)and Ritscher-Schinzel syndrome(RSS).When proteins enter the endosomal network,they are either transported to lysosome for degradation,or recycled to the plasma membrane or the trans-Golgi network for *** protein machineries are essential for the process,including Retromer,Commander,and several members of the sorting nexin(SNX)*** genes are highly conserved in metazoa and can be found in almost all tissues and cells.

关键词： Commander Command sorting

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Radiotherapy-customized head immobilization masks:from modeling and analysis to 3d printing

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Nuclear Science and Techniques 2019年第9期30卷 103-118页

作者： m.A.R.Loja d.S.Craveiro L.Vieira E.Sousa J.A.Rodrigues R.J.F.Portal CImOSm Centro de Investigacao em Modelacao e Optimizacao de Sistemas Multifuncionais ISEL IPL Instituto Superior de Engenharia de Lisboa Av. Conselheiro Emidio Navarro 1 1959-007 Lisbon Portugal LAETA IDMEC Instituto Superior Teccnico Universidade de Lisboa Av. Rovisco Pais 1 1049-001 Lisbon Portugal department of mechanical and Industrial Engineering Faculty of Science and Technology NOVA UNIDEMI Universidade Nova de Lisboa Caparica Portugal H&TRC -Health &Technology Research Center ESTeSL - Escola Superior de Tecnologia da Saude de Lisboa Av. D. Joao II Lote 4.69.01 1990-096 Lisbon Portugal Instituto de Biofisica e Engenharia Biomedica Faculdade de Ciencias da Universidade de Lisboa Lisbon Portugal

Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in other situations, specifically when the superposition of various medical images is required for fine identification and characterization of some pathologies. Because of their structural characteristics, existing head immobilization systems may be claustrophobic and very uncomfortable for patients, during both the modeling and usage stages. Because of this, it is important to minimize all the discomforts related to the mask to alleviate patients’ distress and to simultaneously guarantee and maximize the restraint effectiveness of the mask. In the present work, various head immobilization mask models are proposed based on geometrical information extracted from computerized tomography images and from 3d laser scanning point clouds. These models also consider the corresponding connection to a radiotherapy table, as this connection is easily altered to accommodate various manufacturers’ solutions. A set of materials used in the radiotherapy field is considered to allow the assessment of the stiffness and strength of the masks when submitted to typical loadings.

关键词： Computed tomography 3d laser scanning Geometric modeling Head immobilization devices Stiffness and strength analyses 3d printing

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汉奸大审判

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2017年

作者：王晓华

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中国当代文学经典必读

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2016年

作者：吴义勤

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A new heparin fragment decreases liver ischemia-reperfusion injury

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Hepatobiliary & Pancreatic diseases International 2022年第2期21卷 190-192页

作者： Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol marcelo A Lima Tiago Rodrigues Joséem Cunha Eleazar Chaib Luiz AC d’Albuquerque Flávio HF Galvão Laboratorio de Investigaçao medica 37 Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246-903Brazil departamento de Gastroenterologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil disciplina de Anestesiologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil departamento de Bioquimica Universidade Federal de São PauloSão PauloBrazil Universidade Federal do ABC Santo AndreSão PauloBrazil Serviço de Transplante de Figado e Orgaos do Aparelho digestivo Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil

To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan *** calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (Td),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca^(2+),showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1].

关键词： irreversible heparin injury

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