Commanding the Commander:structure of a key protein machinery in endosomal trafficking

作     者：Xin Yong Chunzhuang Zhou Daniel D.Billadeau Da Jia Xin Yong;Chunzhuang Zhou;Daniel D.Billadeau;Da Jia

作者机构：Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenDepartment of PaediatricsWest China Second University HospitalState Key Laboratory of BiotherapySichuan UniversityChengdu 610041China Division of Oncology Research and Schulze Center for Novel TherapeuticsMayo ClinicRochesterMN 55905USA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第9期

页      面：3877-3879页

核心收录：

学科分类：081203[工学-计算机应用技术] 08[工学] 0835[工学-软件工程] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This work was supported by Natural Science Foundation of China(NSFC#32200559,#92254302) National Key Research and Development Program of China(2022YFA1105200) National Science Fund for Distinguished Young Scholars(#32125012) National Institutes of Health grant DK107733 to D.D.B 

主　　题：Commander Command sorting 

摘      要：In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microscopy(Cryo-EM),Alphafold predictions and extensive site-directed mutagenesis(Fig.1a),which sheds lights on the molecular characteristics of this evolutionarily-conserved protein machinery,and enables the mapping of mutations causing X-linked intellectual disability(XILD)and Ritscher-Schinzel syndrome(RSS).When proteins enter the endosomal network,they are either transported to lysosome for degradation,or recycled to the plasma membrane or the trans-Golgi network for *** protein machineries are essential for the process,including Retromer,Commander,and several members of the sorting nexin(SNX)*** genes are highly conserved in metazoa and can be found in almost all tissues and cells.