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Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers

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World Journal of Gastroenterology 2016年第22期22卷 5165-5172页

作者： Maria emília L Monteiro Analucia R Xavier Felipe L Oliveira Porphirio JS Filho Vilma B Azeredo Department of Internal Medicine Medicine College Fluminense Federal University Niteroi RJ 24030-210 Brazil Department of Pathology Medicine College Fluminense Federal University Niteroi RJ 24030-210 Brazil Biomedical Science Institute Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-913 Brazil Department of Nutrition and Dietitian Nutrition College Fluminense Federal University Niteroi RJ 24030-210 Brazil

AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat ***: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93 M diet, and animals in the experimental group received an Atkins-based diet(59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies. We expressed the data as mean ± standard deviation(sd) assuming unpaired and parametric data; we analyzed differences using the student's t-test. statistical significance was set at P emistry for autophagy was negative in both groups. sinusoidal dilation around the central vein and small hepatocytes was only observed in the experimental diet group, and fibrosis was not identified by hematoxylin-eosin or Trichrome Masson staining in either ***: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions.

关键词： Apoptosis Liver injury High-protein diet High-fat diet Low-carbohydrate diet

Mechanism of frost heave by film water migration under temperature gradient

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Chinese Science Bulletin 1997年第15期42卷 1290-1294页

作者： Xu, XZ Wang, JC Zhang, LX Deng, YS Chuvilin, em Yershov, ED Ishizaki, T Fukuda, M State Key Laboratory of Frozen Soil Engineering Lanzhou Institute of Glaciology and Geocryology Chinese Academy of Sciences Lanzhou China Geological Faculty of Moscow University Russia Institute of Low Temperature Science Hokkaido University Japan

IT is well known that there exists unfrozen film water in frozen soils due to the action of sur-face energy among soil particles and frost heave occurs by water migration under the tempera-ture gradient. The problem is how to determine the amount of frost heave quantitatively. The amount of frost heave induced by ice segregation can be calculated by the following e-quations:

关键词： temperature gradient film water frost heave.

A first look at communication theory / em Griffin ; special consultant, Glen McClish. 5th ed.

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A first look at communication theory / Em Griffin ; special ...

楚地出土战国简册研究 . 1 :新出楚简研读

2003年

作者： em Griffin special consultant Glen McClish.

来源：畅想之星图书光盘版（南... 评论

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Autoimmune gastritis presenting as iron deficiency anem.a.in childhood

2010年

作者：陈伟 20100519d2010 em y0chiy50 ea

本书收集了作者近几年来对新颁布的楚地出土战国简册的研究心得，其内容十分丰富，其研究有的是纠正他人的误读，更多的则是作者独到的学术见解，具有较高的学术价值和史料价值。

ISBN: (纸本)9787307079991

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World Journal of Gastroenterology 2014年第42期20卷 15780-15786页

作者： Cristina Gon?alves Maria emília Oliveira Ana M Palha Anabela Ferr?o Anabela Morais Ana Isabel Lopes Gastroenterology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre Pathology Department University Hospital Santa Maria Lisbon Academic Medical Centre Hematology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre

AIM: To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anem.a.investigation.

关键词： Autoimmune gastritis Iron deficiency anemia Children

Recurrence of inflammatory pseudotumor in the distal bile duct: Lessons learned from a single case and reported cases

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World Journal of Gastroenterology 2006年第24期12卷 3938-3943页

作者： em López-Tomassetti Fernández H Díaz Luis A Martín Malagón I Arteaga González A Carrillo Pallarés Department of Gastrointestinal Surgery University Hospital of Canary Islands Ofra s/n. La Cuesta38320 La LagunaSanta Cruz de TenerifeSpain

Inflammatory myofibroblastic tumors （IMTs） or inflammatory pseudotumors （IPs） have been extensively discussed in the literature. They are usually found in the lung and upper respiratory tract. However, reporting of cases involving the biliopancreatic region has increased over recent years. Immunohistochemical study of these lesions limited to the pancreatic head or distal bile duct seems to be compatible with those observed in a new entity called autoimmune pancreatitis, but usually intense fibrotic reaction （zonation） predominates producing a mass. When this condition is limited to the pancreatic head, the common bile duct might be involved by the inflammatory process and jaundice may occur often resembling adenocarcinoma of the pancreas. We have previously reported a case of IMT arising from the bile duct associated with autoimmune pancreatitis which is an extremely rare entity. Four years after Kaush-Whipple resection, radiological examination on routine follow-up revealed a tumor mass, suggesting local recurrence. Ultrasound-guided FNA confirmed our suspicious diagnosis. This present case, as others, suggests that persistent follow-up is necessary in order to prevent irreversible liver damage at this specific location.

关键词： Inflammatory myofibroblastic tumor Inflammatory pseudotumor Local recurrence Pancreasresection Whipple procedure

Therapeutic interventions of acute and chronic liver disorders:A comprehensive review

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World Journal of Hepatology 2023年第1期15卷 19-40页

作者： Fares em.a.i Mostafa K Abd El-Aziz Elham I Sharab Adel G Bakr Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Faculty of Pharmacy Al-Azhar UniversityAssiut BranchAssiut 71524Egypt

Liver disorders are one of the most common pathological problems *** affects more than 1.5 billion *** types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases,including hepatocytes,Kupffer cells,sinusoidal endothelial cells,and hepatic stellate cells(HSCs).In addition,oxidative stress,cytokines,fibrogenic factors,microRNAs,and autophagy are also *** the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in ***,antioxidant,anti-inflammatory,anti-HSCs therapy,gene therapy,cell therapy,gut microbiota,and nanoparticles have great potential for preventing and treating liver ***,we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver ***,we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.

关键词： Liver disorders Autophagy Gene therapy Anti-hepatic stellate cells Cell therapy

Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 466-474页

作者： René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur em Berkel Joost M Klaase Paul J van Diest Department of Surgery Medisch Spectrum Twente Laboratory for Pathology East-Netherlands Netherlands Comprehensive Cancer Organization Location Enschede Department of Pathology University Medical Center Utrecht

AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal *** TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards *** Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases.

关键词： Rectal cancer Adenocarcinoma Prognosis Recurrence Pathology Tumor-stroma ratio

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官箴的智慧 : 最新经典珍藏第2版