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World Journal of Gastroenterology 2006年第24期12卷 3938-3943页

作者： em..ópez-Tomassetti Fernández H Díaz Luis A Martín Malagón I Arteaga González A Carrillo Pallarés Department of Gastrointestinal Surgery University Hospital of Canary Islands Ofra s/n. La Cuesta38320 La LagunaSanta Cruz de TenerifeSpain

Inflammatory myofibroblastic tumors （IMTs） or inflammatory pseudotumors （IPs） have been extensively discussed in the literature. They are usually found in the lung and upper respiratory tract. However, reporting of cases involving the biliopancreatic region has increased over recent years. Immunohistochem..al study of these lesions limited to the pancreatic head or distal bile duct seem..to be compatible with those observed in a new entity called autoimmune pancreatitis, but usually intense fibrotic reaction （zonation） predominates producing a mass. When this condition is limited to the pancreatic head, the common bile duct might be involved by the inflammatory process and jaundice may occur often resem..ing adenocarcinoma of the pancreas. We have previously reported a case of IMT arising from the bile duct associated with autoimmune pancreatitis which is an extrem..y rare entity. Four years after Kaush-Whipple resection, radiological examination on routine follow-up revealed a tumor mass, suggesting local recurrence. Ultrasound-guided FNA confirmed our suspicious diagnosis. This present case, as others, suggests that persistent follow-up is necessary in order to prevent irreversible liver damage at this specific location.

关键词： Inflammatory myofibroblastic tumor Inflammatory pseudotumor Local recurrence Pancreasresection Whipple procedure

Therapeutic interventions of acute and chronic liver disorders:A comprehensive review

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World Journal of Hepatology 2023年第1期15卷 19-40页

作者： Fares em..li Mostafa K Abd El-Aziz Elham I Sharab Adel G Bakr Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Faculty of Pharmacy Al-Azhar UniversityAssiut BranchAssiut 71524Egypt

Liver disorders are one of the most common pathological problem..*** affects more than 1.5 billion *** types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases,including hepatocytes,Kupffer cells,sinusoidal endothelial cells,and hepatic stellate cells(HSCs).In addition,oxidative stress,cytokines,fibrogenic factors,microRNAs,and autophagy are also *** the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in ***,antioxidant,anti-inflammatory,anti-HSCs therapy,gene therapy,cell therapy,gut microbiota,and nanoparticles have great potential for preventing and treating liver ***,we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver ***,we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.

关键词： Liver disorders Autophagy Gene therapy Anti-hepatic stellate cells Cell therapy

Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 466-474页

作者： René Scheer alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur em..erkel Joost M Klaase Paul J van Diest Department of Surgery Medisch Spectrum Twente Laboratory for Pathology East-Netherlands Netherlands Comprehensive Cancer Organization Location Enschede Department of Pathology University Medical Center Utrecht

AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal *** TSR was determined on hem..oxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards *** Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreem..t(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases.

关键词： Rectal cancer Adenocarcinoma Prognosis Recurrence Pathology Tumor-stroma ratio

Colonic duplication in an adult mimicking a tumor of pancreas

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World Journal of Gastroenterology 2008年第6期14卷 966-968页

作者： Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana em..ia B de Azevedo Andréa Pedrosa Ribeiro alves Karina Martins Campos Department of Pathology University of Brasília DF Brazil Department of Surgery University of Brasília DF Brazil

Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a fem..e adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass.

关键词： Intestinal duplication Ectopic gastric mucosa Pancreatic tumor Congenital malformations Abdominal mass

Conceptual Design and Aerodynamic Study of Joined-Wing Business Jet Aircraft

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Journal of Mechanics Engineering and Automation 2013年第5期3卷 263-278页

作者： Harijono Djojodihardjo Kim em..oong Department of Aerospace Engineering Faculty of Engineering Universiti Putra Malaysia Serdang 43400 Selangor Malaysia

The concept of joined-wing aircraft with nonplanar wings as conceived and patented by Wolkovitch is attractive due to various advantages such as light weight, high stiffness, low induced drag, high trimmed CLmax, reduced wetted area and parasite drag and good stability and control, which have been supported by independent analyses, design studies and wind tunnel tests. With such foreseen advantages, the present work is carried out to design joined-wing business-jet aircraft and study and investigate its advantages and benefits as compared to the current available conventional business jet of similar size, passenger and payload capacity. In particular, the work searches for a conceptual design of joined-wing configured business-jet aircraft that possesses more superior characteristics and better aerodynamic performance in terms of increased lift and reduced drag, and lighter than the conventional business jet of similar size. Another significant objective of this work is to prove that the added rigidity possessed by the joined wing configuration can contribute to weight reduction.

关键词： Aircraft conceptual design aerodynamic design joined wing box wing.

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乳癌：有成效的早期诊断和升高的死亡率

放射学实践 1996年第1期11卷 7-13页

作者： Pate,em..林同济医科大学附属同济医院

早期乳癌的诊断可借助于乳房Ｘ线摄影术、超声和磁共振成像。有关乳癌的年龄特异性及年龄划分的死亡率自１９７７年以来明显升高。为了阻止死亡率再升高，在诊断及治疗方面的紧迫感是必不可少的。

关键词：乳房肿瘤早期诊断死亡率治疗

Socio-cultural factors influencing insecticide treated bed net utilization in a malaria endem.. city in north-central Nigeria

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 402-406页

作者： Jombo GTA Mbaawuaga em..yuse AN Enenebeaku MNO Okwori EE Peters EJ Akpan S Odey F Etukumana EA Akosu JT Department of Medical Microbiology and Parasitology College of Health SciencesBenue State UniversityPMB 102119 MakurdiNigeria Department of Biological Sciences Faculty of ScienceBenue State UniversityPMB 102119 MakurdiNigeria Department of Family Medicine College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Medical Microbiology College of Medical SciencesUniversity of Jos Department of Internal Medicine College of Medical SciencesUniversity of Calabar PMB 1115 CalabarNigeria Department of Medical Microbiology and Parasitology College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Paediatrics College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Family Medicine University of Uyo Teaching Hospital Department of Community Medicine College of Medical SciencesUniversity of Jos

Objective:To ascertain the socio-cultural factors influencing the rate of utilization of insecticide treated bed nets(ITNs) in a malaria endem.. city of Makurdi,north central Nigeria. Methods:The study was cross-sectional in nature using system..ic sampling method to identify *** quantitative and qualitative data was generated from adult women using structured and sem..structured questionnaires,and focused group discussions(FGDs) to obtain information on rate and patterns of utilization of *** such as age,educational level, marital status,awareness or otherwise of the existence of malaria,and factors influencing rate of ownership and utilization of ITNs were *** were used to obtain qualitative information on rate of utilization of ITNs not captured in the *** obtained was analysed using Epi Info 6 statistical ***:Among the respondents interviewed,97.0% (2 013/2 075) were aware of existence of malaria and 87.0% of these(1 751/2 013) would associate it with *** rate of ownership of any bed net,ITNs and untreated bed nets(UTNs) was 25.1% ,17.0% and 8.3% ,*** of ITNs among children was 30.0% (112/373) and UTNs 12.9% (48/373).Positive contributors to ITNs utilization were literacy,enhanced economy, experience of marriage,and being gainfully em..oyed(Pal beliefs and ***:A more synchronized advocacy should be carried out on the potential benefits of ITNs utilization and *** ITNs should be made available to the people of the community at minimal or no cost.

关键词： Insecticide treated bed nets Utilization Households Malaria endem.. city

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《并行处理与情报检索》专刊导言

国外情报科学 1993年第3期11卷 52-56,62页

作者： Rasm.,em..同兴

目前,情报检索并行处理的资料甚多。这篇专刊导言对并行情报撞索的趋向帮研究工作做了评述。包括情报检索并行算法前开发并行结构设计和数据库在多种处理机上的分布。文章还介绍了这些研究工作的进展。[第一段]

关键词：并行处理情报检索数据库

Chem..al Compositions and Antioxidant Activity of Northern Thai Woods Aging Wine

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Journal of Food Science and Engineering 2013年第10期3卷 550-556页

作者： Pasu Pramokchon em..n Chairote Griangsak Chairote Department of Chem..try Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Department of Science and Agricultural Technology Rajamangala University of Technology Lanna Chiang Mai 50300 Thailand

Wine aging for 120 days was prepared by using luna nut （Lepisanthesfruticosa Leenh.）, Longan （Dimocarpus longan Lour.）, black poum （Cleistocalyx nervosum var. paniala）, neem..Azadirachta indica）, drumstick （Moringa oleifera Lam.） and oak （Quercus sp.）. The taste examination was done by 50 sensory examiners in order to evaluate the organoleptic quality of wine samples. The results showed that the highest score of organoliptic quality of wine aging with Longan woods relating to oak wood. Therefore, Longan wood is the most acceptable can used for wine aging process. The qualitative analysis for some volatile aroma of the two highest score wood aging wine was carried out by gas chromtography-mass spectrometer （GC-SPME） technique, equipped with a Flame lonisation Detector （FID） detector and a DB-WAX capillary column with helium as a carrier gas. The oven tem..rature was kept at 40 ℃ for 7 min followed by increasing to 230 ℃ with the rate of 3 ℃/min. The result showed the present β-caryophillene, humulene and eugenol in Longan wood wine while eugenol and ethyl octanoate were found in case of drumstick wood wine. The antioxidant activity of all wood aging wine was determined by DPPH scavenging technique. Wine aging with Longan used showed the test result with 1.62% v/v for EC50.

关键词：抗氧化活性葡萄酒化学成分 DPPH自由基老化过程衰老泰国感官质量

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疟原虫抗原的免疫识别

国外医学（寄生虫病分册） 1992年第1期19卷 17-19页

作者： Riley em..斌

为了阐明机体对疟原虫抗原的免疫反应性,作者分析了主要组织相容性复合物(MHC)对疟原虫抗原的免疫调节作用。由于人体MHC结构的多态性,对疟原虫抗原的免疫反应不完全由MHC所限制,同时也受MHC外的基因所调节。反复感染疟疾常引起机体的... 详细信息

为了阐明机体对疟原虫抗原的免疫反应性,作者分析了主要组织相容性复合物(MHC)对疟原虫抗原的免疫调节作用。由于人体MHC结构的多态性,对疟原虫抗原的免疫反应不完全由MHC所限制,同时也受MHC外的基因所调节。反复感染疟疾常引起机体的免疫抑制现象,作者分析了免疫抑制的机制。

关键词：疟原虫抗原免疫学识别