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Lovastatin as a supplement to mitigate rumen methanogenesis:an overview

Journal of Animal Science and Biotechnology 2022年第2期13卷 353-364页

作者： Amaury Ábrego-Gacía Héctor M.Poggi-Varaldo Vania Robles-González Teresa Ponce-Noyola Graciano Calva-Calva elvira Ríos-Leal Daniel Estrada-Bárcenas Alfredo Mendoza-Vargas Department of Biotechnology and Bioengineering CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Environmental Biotechnology and Renewable Energies Group CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Instituto de Hidrología Universidad Tecnológica de la MixtecaOaxaca 69000 Huajuapan de LeónMexico National Collection of Microbial and Cellular Cultures CINVESTAV-IPNP.O.Box17-74007000 Mexico CityMexico Unidad de Secuenciación e Identificación de Polimorfismos Instituto Nacional de Medicina Genómica14610 Mexico CityMexico

Methane from enteric fermentation is the gas with the greatest environmental impact emitted by ***(Lv)addition to feedstocks could be a strategy to mitigate rumen methane emissions via decreasing the population of methanogenic archaea(MA).Thus,this paper provides the first overview of the effects of Lv supplementation,focusing on the inhibition of methane production,rumen microbiota,and ruminal *** indicated that Lv treatment had a strong anti-methanogenic effect on pure strains of ***,there are uncertainties from in vitro rumen fermentation trials with complex substrates and rumen ***-state fermentation(SSF)has emerged as a cost-effective option to produce *** this way,SSF of agricultural residues as an Lv-carrier supplement in sheep and goats demonstrated a consistent decrease in ruminal methane *** experimental evidence for in vitro conditions showed that Lv did not affect the volatile fatty acids(VFA).However,in vivo experiments demonstrated that the production of VFA was *** did not negatively affect the digestibility of dry matter during in vitro and in vivo methods,and there is even evidence that it can induce an increase in *** the rumen microbiota,populations of MA were reduced,and no differences were detected in alpha and beta diversity associated with Lv ***,some changes in the relative abundance of the microbiota were *** studies are recommended on:(i)Lv biodegradation products and stability,as well as its adsorption onto the solid matter in the rumen,to gain more insight on the“available”or effective Lv concentration;and(ii)to determine whether the effect of Lv on ruminal fermentation also depends on the feed composition and different ruminants.

关键词： Fermentation Lovastatin Methanogenesis Microbiota Rumen

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Current knowledge on the laboratory diagnosis of Clostridium difficile infection

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World Journal of Gastroenterology 2017年第9期23卷 1552-1567页

作者： Adrián Martínez-Meléndez Adrián Camacho-Ortiz Rayo Morfin-Otero Héctor Jesús Maldonado-Garza Licet Villarreal-Trevino elvira Garza-González Departamento de Microbiología e Inmunología Facultad de Ciencias BiológicasUniversidad Autónoma de Nuevo León.Pedro de Alba S/NCiudad UniversitariaSan Nicolás de los Garza Servicio de Infectología Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo León.Av.Francisco I.Madero Pte.S/NCol.Mitras Centro.Monterrey Hospital Civil de Guadalajara “Fray Antonio Alcalde”e Instituto de Patología Infecciosa y ExperimentalCentro Universitario de Ciencias de la SaludUniversidadde Guadalajara.Sierra Mojada 950Col.Independencia Servicio de Gastroenterología Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo León.Av.Francisco I.Madero Pte.S/NCol.Mitras Centro.Monterrey

Clostridium difficile (C. difficile) is a spore-forming, toxin-producing, gram-positive anaerobic bacterium that is the principal etiologic agent of antibiotic-associated diarrhea. Infection with C. difficile (CDI) is characterized by diarrhea in clinical syndromes that vary from selflimited to mild or severe. Since its initial recognition as the causative agent of pseudomembranous colitis, C. difficile has spread around the world. CDI is one of the most common healthcare-associated infections and a significant cause of morbidity and mortality among older adult hospitalized patients. Due to extensive antibiotic usage, the number of CDIs has increased. Diagnosis of CDI is often difficult and has a substantial impact on the management of patients with the disease, mainly with regards to antibiotic management. The diagnosis of CDI is primarily based on the clinical signs and symptoms and is only confirmed by laboratory testing. Despite the high burden of CDI and the increasing interest in the disease, episodes of CDI are often misdiagnosed. The reasons for misdiagnosis are the lack of clinical suspicion or the use of inappropriate tests. The proper diagnosis of CDI reduces transmission, prevents inadequate or unnecessary treatments, and assures best antibiotic treatment. We review the options for the laboratory diagnosis of CDI within the settings of the most accepted guidelines for CDI diagnosis, treatment, and prevention of CDI.

关键词： Clostridium difficile Toxigenic culture Nucleic acid amplification tests Enzyme immunoassay Diagnosis Glutamate dehydrogenase

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Drying Kinetics and Energy Consumption in Vacuum Drying Process with Microwave and Radiant Heating

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Chinese Journal of Chemical Engineering 2004年第6期12卷 809-813页

作者： M.Kamel J.I.Lombrana C.de elvira R.Rodríguez Department of Chemical Engineering Facultad de Ciencias Universidad del Pais Vasco. Apdo. 644 48080 Bilbao SpainDepartment of Chemical Engineering Facultad de Ciencias Universidad del Pais Vasco. Apdo. 644 48080 Bilbao SpainInstituto del Frio (CSIC) Ciudad Universitaria. 28040 Madrid SpainDepartment of Chemical Engineering Facultad de Ciencias Universidad del Pais Vasco. Apdo. 644 48080 Bilbao Spain

The general objective of this work is to analyze energy input in a vacuum process with the incorporation of microwave heating. Thus, necessary criteria for designing an efficient freeze-drying operation are considered through the analysis of strategies based on the combination of different intensities of radiant and microwave *** other aim of this research topic is to study the kinetics of drying in relation to mass transfer *** freeze-drying strategies using both heating systems were used. Consequently, energy input could be related to diffusivity coefficients, temperature and pressure profiles during dehydration of the product and analyzed in comparison to a conventional freeze-drying process.

关键词： vacuum microwave drying diffusivity constant energy

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Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-Broto Francisco Segura Ana Cavero elvira Orduna-Hospital Gema Insa-Sánchez Ana Isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

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守住创意，与时间赛跑16天

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影像视觉 2007年第3期8卷 36-42页

作者： elvira 麦肯光明广告SGM Works

在早些年的广告中,就数房地产广告的竞争最为激烈,而眼下,随着私车购买欲不断攀升的趋势越来越明显,我们已经能感觉到在当前,甚至未来十年,针对不同消费层面的汽车广告将会逐渐成为人们关注的焦点。""摄影工作者可能都会有相同的感受,车... 详细信息

在早些年的广告中,就数房地产广告的竞争最为激烈,而眼下,随着私车购买欲不断攀升的趋势越来越明显,我们已经能感觉到在当前,甚至未来十年,针对不同消费层面的汽车广告将会逐渐成为人们关注的焦点。""摄影工作者可能都会有相同的感受,车,是众多摄影类别中较难的工作之一,这是由于产品本身体积大,不易操控,所以拍摄时对场地、灯光、镜头的把握都有特别高的要求。这尤其考验一个专业摄影师的操作技能、丰富经验和艺术水准。""随着中国汽车产业的高速发展,由此广告业中应运而生了专门服务此行业的专业队伍。好像开辟荒地的生力军,我们感受到压力,也享受到乐趣。

关键词：创意广告业摄影师香水瓶玻璃碎片自信操控品牌焦点美术

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Sony Walkman广告制作大放送

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影像视觉 2007年第1期8卷 32-37页

作者： elvira 灵智精实广告阿米巴数码影像

　　当你流连于美轮美奂或者让人拍案叫绝的平面广告作品,对其创意和视觉折服时,你不一定知道广告的背后也许隐藏着更好的创意,在制作过程中更是充满了有意思的小插曲和不为人知的故事.下面,就跟随我们去一探Sony Walkman广告的诞生过程... 详细信息

　　当你流连于美轮美奂或者让人拍案叫绝的平面广告作品,对其创意和视觉折服时,你不一定知道广告的背后也许隐藏着更好的创意,在制作过程中更是充满了有意思的小插曲和不为人知的故事.下面,就跟随我们去一探Sony Walkman广告的诞生过程,听听创意人、摄影师和后期制作人对他们工作的一些想法吧!……

关键词：广告制作摄影师 Sony Walkman 创意团队平面广告后期制作

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遇见非凡艺术人物

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影像视觉 2007年第3期8卷 66-71页

作者： elvira

融会了法兰西优雅艺术气质与经典干邑文化的马爹利,自2004年创办至今始终与艺术世界紧密相连,欣赏与褒奖充满灵感与才华的艺术家们。"2007年度马爹利非凡艺术人物"名单已揭晓,其中有两位摄影师荣登榜单:意大利的保罗·罗维西和中国的缪... 详细信息

融会了法兰西优雅艺术气质与经典干邑文化的马爹利,自2004年创办至今始终与艺术世界紧密相连,欣赏与褒奖充满灵感与才华的艺术家们。"2007年度马爹利非凡艺术人物"名单已揭晓,其中有两位摄影师荣登榜单:意大利的保罗·罗维西和中国的缪晓春。保罗·罗维西的作品具有明快的幽默感而不显浮华,敏感而纯真的捕捉了光鲜时尚界人性中纯洁动人的美丽。观念摄影家缪晓春拥有惊人的创造力,把中国的文化遗产融入当代艺术的全新意境,其作品呈现出时间流逝及深邃的空间感。以下是本刊对他们的采访实录,带您走近平凡的大师们。

关键词：当代艺术作品艺术气质艺术世界维西保罗中国文化遗产法兰西创造力

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The contribution of proteoglycans to heterogeneity and temozolomide resistance of glioblastoma cells

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 431-444页

作者： Sofia A.Nikitina Dmitry K.Sokolov Alexandra Y.Tsidulko Anastasia V.Strokotova Elizaveta Fasler Kan elvira V.Grigorieva Institute of Molecular Biology and Biophysics FederalResearchCenter of Fundamental and Translational Medicine(FRC FTM)Novosibirsk 630117Russia Department of Pediatric Surgery Children’s Hospital InselspitalBernUniversity of BernBern 3010Switzerland

Aim:Heterogeneity of glioblastoma(GB)cells significantly contributes to tumor resistance against temozolomide(TMZ)and the development of disease *** molecular mechanisms are involved in this process,yet the contribution of proteoglycans(PGs)remains *** study aimed to investigate the potential involvement of PGs(both at core proteins and polysaccharide chains)in the heterogeneity and TMZ resistance of GB ***:Seven human GB cell lines were characterized for TMZ sensitivity,cell phenotypic traits,gene expression for glucocorticoid receptor(GR,NR3C1),PG core proteins-and heparan sulfate(HS)biosynthesis-related genes and content of their chondroitin sulfate(CS)and HS ***:Although the studied cell lines have similar proliferation rates,they significantly differ in their migration activity,clonogenicity,and TMZ resistance(IC508.51-369.59µM in the line of U343,LN215,HS683,U87,LN71,LN405,LN18),creating a specific phenotype for each cell *** PGs(NG2/CSPG4,CSPG5,and versican)contributed to the molecular heterogeneity of these cells being cell line-specifically expressed in all cell lines,which also differed in terms of the CS/HS *** activity of the HS metabolic system was low in these GB cell lines,expressing mainly EXT1/2 and NDST1/2,while expression levels of sulfotransferases and SULF2 were cell *** resistance of these cells was correlated with the expression of stem-cell marker CD44(+3.5-fold,r=0.73)and GR(-3-fold,r=-0.81).TMZ treatment of the resistant(LN405)and sensitive(LN215)cells resulted in complex changes in cell migration as well as NG2/CSPG4 expression and CS/HS ***:Differential expression of PGs and CS/HS content contribute to the heterogeneity of GB cells,and CD44 and NR3C1 might be informative biomarkers for TMZ resistance.

关键词： Glioblastoma temozolomide resistance extracellular matrix proteoglycan glycosaminoglycan heparan sulfate chondroitin sulfate glucocorticoid receptor

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安吉高校影像大展

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影像视觉 2007年第5期8卷 78-83页

作者： elvira

　　2007年10月21日～22日,"中国安吉高校影像大展"在浙江省安吉县揭幕,此次活动主要由摄影学院助学金单元(图片摄影、DV短片)、竹乡安吉主题创作单元(图片摄影、DV短片)、平面模特单元、明星摄影作品邀请展这五大板块组成.本次展览中,... 详细信息

　　2007年10月21日～22日,"中国安吉高校影像大展"在浙江省安吉县揭幕,此次活动主要由摄影学院助学金单元(图片摄影、DV短片)、竹乡安吉主题创作单元(图片摄影、DV短片)、平面模特单元、明星摄影作品邀请展这五大板块组成.本次展览中,全国共有178所高校的二千三百余幅照片、四百余部DV短片参展,美国、法国、韩国等一些大学也送来了一百多幅作品参展.以下我们请到了主办方、摄影院校的老师代表以及本次大赛的评委来谈谈展览活动的情况.……

关键词：艺术摄影 DV 图片摄影摄影专业北京电影学院

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科帕奇汽车广告诞生记

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影像视觉 2007年第5期8卷 36-42页

作者： elvira SGM WORKS

　　说起SGM WORKS,也许并没有很多人了解,但说起那些雪佛兰精彩的电视广告和平面广告相信很多人都记忆犹新.其实,所有这些雪佛兰汽车的优秀广告作品都出自SGM *** WORKS是麦肯旗下专为服务上海通用而成立的一个汽车广告作业机构.掌门... 详细信息

　　说起SGM WORKS,也许并没有很多人了解,但说起那些雪佛兰精彩的电视广告和平面广告相信很多人都记忆犹新.其实,所有这些雪佛兰汽车的优秀广告作品都出自SGM *** WORKS是麦肯旗下专为服务上海通用而成立的一个汽车广告作业机构.掌门人是莫康孙先生,而负责创意的则是具有丰富汽车广告经验的吴泰仪先生.……

关键词：汽车广告雪佛兰诞生记

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