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The effect of α-blocker therapy on erectile functions in patients with lower urinary tract symptoms due to benign prostate hyperplasia

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Asian Journal of Andrology 2009年第6期11卷 716-722页

作者： omer Demir Ismail Ozdemir Ozan Bozkurt Guven Asian Ahmet Adil Esen Dokuz Eylul University Medical School Department of Urology Inciralti Izmir 35340 Turkey

In this study we aimed to evaluate the impact of doxazosin treatment on erectile functions in patients with lower urinary tract symptoms （LUTS） and having erectile dysfunction （ed） at baseline. Fifty-three patients with LUTS （IPSS score 〉 7） whose maximum flow rate （Qmax）〈 15 mL s-1 and PSA 〈 4 ng dL^-1 were enrolled in the study. Patients received doxazosin 4 nag once daily for 6 weeks. Subjective efficacy was assessed by IPSS, IPSS- Quality of Life （IPSS-QoL） for LUTS and efficacy was assessed by International Index of Erectile Function （IIEF） for erectile functions at baseline and sixth weeks. The objective efficacy was assessed by Q The patients were classified according to their self reported erectile status： group I had ed and group II did not have ed. At the endpoint, doxazosin significantly improved the total IPSS score （-7.7 ±6.1, P = 0.006）, IPSS-QoL score （-1.5 ± 1.5, P = 0.024） and Qmax （3.2 ± 4.6 mL s^-1, P = 0.002） over baseline. Mean decrease in IPSS and IPSS-QoL scores after the treatment period were 6.9 ＋ 6.4 （P 〈 0.001） and 0.95 4- 1.80 （P 〈 0.05） in group I, whereas 8.2 4- 5.8 （P 〈 0.001） and 1.9 4- 1.1 in group IX （P 〈 0.001）, respectively. Mean changes of Qmax values were 2.3 4- 3.3 mL s^-1 in group I （P 〈 0.05） and 3.7 4- 5.3 mL s-1 in group II （P 〈 0.001）. The improvement of IIEF-EF scores after the treatment period was only significant for group I. The efficacy of a-blocker therapy for LUTS was better by means of symptomatic relief for patients who did not have ed when compared with patients who had ed at baseline. However, slight improvement in erectile functions with a-blocker therapy was only seen in LUTS patients with ed.

关键词： benign prostate hyperplasia doxazosinlerectile dysfunction lower urinary tract symptoms treatment outcome

Erectile function and late-onset hypogonadism symptoms related to lower urinary tract symptom severity in elderly men

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Asian Journal of Andrology 2013年第6期15卷 785-789,I0008页

作者： Ozan Bozkurt Deniz Bolat omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx Department of Urology Dokuz Eylul University Faculty of Medicine Izmir 35340 Turkey Division of Urology Doc. Dr. Yasar Eryilmaz Dogubayazit State Hospital Agri 04900 Turkey Department of Urology Celal Bayar University Manisa 45040 Turkey Department of Urology Sifa University Izmir 35230 Turkey Clinic of Urology Ataturk Training and Research Hospital Izmir 35965 Turkey Division of Urology Adiyaman 82. Yll State Hospital Adiyaman 02040 Turkey Department of Urology Pamukkale University Faculty of Medicine Denizli 20020 Turkey Clinic of Urology Tepecik Training and Research Hospital Izmir 35120 Turkey Department of Urology Adnan Menderes University Faculty of Medicine Aydin 09100 Turkey

The aim of this study was to evaluate the relationship between lower urinary tract symptoms （LUTSs）, erectile dysfunction （ed） and symptomatic late-onset hypogonadism （SLOH） in ageing men in the Aegean region of Turkey. Five hundred consecutive patients 〉40 years old who had been in a steady sexual relationship for the past 6 months and were admitted to one of six urology clinics were included in the study. Serum prostate-specific antigen and testosterone levels and urinary flow rates were measured. All patients filled out the International Prostate Symptom Score and Quality of Life （IPSS-QoL）, International Index of Erectile Function （IIEF） and Aging Males＇ Symptoms （AMS） scale forms. Of the patients, 23.9% had mild LUTSs, 53.3% had moderate LUTSs and 22.8% had severe LUTSs. The total testosterone level did not differ between groups. Additionally, 69.6% had ed. The presence of impotence increased with increasing LUTS severity. Symptomatic late-onset hypogonadism （AMS 〉27） was observed in 71.2% of the patients. The prevalence of severe hypogonadism symptoms increased with the IPSS scores. A correlation analysis revealed that all three questionnaire scores were significantly correlated. In conclusion, LUTS severity is an age-independent risk factor for ed and SLOH. LUTS severity and SLOH symptoms appear to have a strong link that requires etiological and biological clarification in future studies.

关键词： ageing male erectile dysfunction lower urinary tract symptoms symptomatic late-onset hypogonadism symptom scores testosterone

父母拒绝学龄期儿童接种疫苗相关因素的病例对照研究

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 43-44页

作者： Salmon D.A. Moulton L.H. omer S.B. 平智广 Institute for Vacc ine Safety J. Hopkins Bloomberg Sch. Pub. Hlth. 615 N Wolfe St. Baltimore MD 21205 United States Dr.

Background: The rate of nonmedical exemptions to school immunization requireme nts has been increasing, and children with exemptions have contributed to outbre aks of vaccine-preventable diseases. Objectives: To determine why parents claim nonmedical exemptions and to explore differences in percep- tions of vaccines and vaccine information sources between parents of exempt and fully vaccinated children. Design: Casecontrol study. Setting: Colorado, Massach usetts, Missouri, and Washington. Participants: Surveys were mailed to the paren ts of 815 exempt children (cases) and 1630 fully vaccinated children (controls r andomly selected from the same grade and school) recruited from 112 private and public elementary schools. Surveys were completed by 2435 parents (56.1%). Main Outcome Measures: Parental reports. Results: Most children (209 [75.5%] of 277 ) with non-medical exemptions received at least some vaccines. The most common vaccine not received was varicella (147 [53.1%] of 277 exempt children). The mo st commo nreason stated for requesting exemptions (190 [69%] of 277) was concer n that the vaccines might cause harm. Parents of exempt children were significan tly more likely than parents of vaccinated children to report low perceived vacc ine safety and efficacy, a low level of trust in the government, and low perceiv ed susceptibility to and severity of vaccine-preventable diseases. Parents of e xempt children were significantly less likely to report confidence in medical, p ublic health, and government sources for vaccine information and were more likel y to report confidence in alternative medicine professionals than parents of vac cinated children. Conclusion: Continued efforts must be made to educate parents about the utility and safety of vaccines, especially parents requesting nonmedic al exemptions to school immunization requirements.

关键词：学龄期儿童疫苗接种病例对照研究免疫接种马萨诸塞州公立小学科罗拉多州密苏里州信任程度政府资源

Equivalence of String Classical and Quantum Energy beside Equivalence of Wave Packet and Relativistic Velocity in Eucleadian and Curved Space

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Natural Science 2020年第7期12卷 520-525页

作者： Mashair Ahmed Mohammed Yousif Abeer Mohammed Khairy Ahmed Zainab Mustapha Kurawa.omer A. M. Elnor Mubarak Dirar Abd-Alla Yagoub Ibrahim Mohammed Elfaki El-Tahir Mohammed Idriss Ahmed Zoalnoon Ahmed Abeid Allah Saad Department of Physics Faculty of Science and Education at Alkurma Taif University Alkhurma Kingdom of Saudi Arabia Department of Physics Faculty of Art and Science at Al Muznab Al Qassim University Al Muznab Kingdom of Saudi Arabia Department of Physics School of Science Education Saadatu Rimi College of Education Kumbotso Nigeria Department of Physics Faculty of Science University of Bakhtalruda Ed Dueim Sudan Department of Physics Faculty of Science Sudan University of Science and Technology Khartoum Sudan Department of Natural and Applied Sciences College of Science and Humanities at Afif Sharga University Afif Kingdom of Saudi Arabia College of Arts and Sciences King Khalid University Dhahran Saudi Arabia

Plank quantum and classical string energy relations seem to be uncorrelated. This work correlated them. The relativistic energy-momentum relation has been used together with plank and de Brogglie hypothesis to prove that the wave group velocity is equal to the particle velocity in both ordinary and curved space. The plank energy relation is shown also to be related to the classical energy relation of an oscillating string. Starting from plank energy relation for n photons and performing integration, the expression of classical string energy was obtained. This means that one can treat electromagnetic waves as a collection of continuous photons having frequencies ranging from zero to w. Conversely, starting from classical string energy relation by differentiating it with respect to angular frequency, the plank quantum energy for n photons has been found. This means that the quanta results from separation of electromagnetic waves to single isolated waves. Each wave consists of n photons or quanta.

关键词： Plank Energy Classical Energy String Quanta Photons Electromagnetic Waves Curved Space Group Velocity Wave Packet