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SARS-CoV-2 in inflammatory bowel disease population:Antibodies,disease and correlation with therapy

World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 153-162页

作者： Clara Benedetta Conti elsa mainardi Sara Soro Sophie Testa Annalisa De Silvestri Andrea Drago Fabrizio Cereatti Roberto Grassia Department of Gastroenterology and Digestive Endoscopy ASST CremonaCremona 26100Italy Department of Laboratory Medicine Haemostasis and Thrombosis CenterASST CremonaCremona 26100Italy Department of Clinic Epidemiology and Biometric Scientific DirectionFondazione IRCCS Policlinico San MatteoPavia 27100Italy

BACKGROUND Guidelines recommend to cease inflammatory bowel disease(IBD)biologic therapy during coronavirus disease 2019(COVID-19).AIM To investigate severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibody positivity in an IBD cohort,COVID-19 disease severity and to evaluate the correlation with clinical/therapeutic *** Prospective observational cohort *** patients were tested for SARS-CoV-2 *** on COVID-19 disease,demographics/therapeutics and clinical features of the IBD population were ***≥7 was set for SARS-CoV-2 antibody *** swab was performed in cases of IgG *** between antibody positivity or COVID-19 symptoms and therapeutic/clinical data were *** In total,103 IBD patients were *** them,18.4%had IgG≥*** analysis of antibody positivity correlated only with IBD *** IgG≥7,the odds ratio was 1.44 and 0.16 for azathioprine and mesalazine,respectively,vs biologic drugs(P=0.0157 between them).COVID-19 related symptoms were reported in 63%of patients with IgG *** but one patient with COVID-19 symptoms did not require ceasing IBD treatment or hospitalization. IBDtreatment and body mass index correlated with COVID-19 disease development with *** IBD population does not have a higher risk of severe COVID-19. The relative risk of havingSARS-CoV-2 antibodies and symptoms was higher for patients taking azathioprine, then biologictherapy and lastly mesalazine. None of the patients under biologic therapy developed severeCOVID-19.

关键词： Inflammatory bowel disease SARS-CoV-2 COVID-19 Biologic treatment SARS-CoV-2 antibody Inflammatory bowel disease therapy

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Two-dimensional atomically thin Pt layers on MXenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane

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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias K.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao Ma Jeffrey T.Miller Daniela S.mainardi Collin D.Wick Zhenhua Zeng Yang Xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for Materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts.

关键词： MXene catalysis alkane dehydrogenation nanolayers

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How physical and motor training affect cognitive performance: lessons from an inflammatory molecule

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Neural Regeneration Research 2022年第12期17卷 2689-2690页

作者： Margherita Maffei Marco mainardi Institute of Clinical Physiology National Research Council(IFC-CNR)and Obesity/Lipodystrophies CenterPisa University HospitalPisaItaly Neuroscience Institute National Research Council(IN-CNR)PisaItaly

Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and *** fact,a good fraction of last decades’biomedical efforts were dedicated to understanding how different elements(e.g.,genetic polymorphisms,lifestyle components)participate in this interplay,ultimately contributing to affect a given phenotype up to the point of steering it towards *** and epigenetic elements are relatively easy to analyze individually using a reductionist approach,for instance via loss-or gain-of-function studies in cellular and animal models;the effects of nutrients,drugs,pollutants can be similarly tested as single specific stimuli.

关键词： instance drugs lesson

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Modeling uncertainties of reservoir flushing simulations

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International Journal of Sediment Research 2023年第5期38卷 698-710页

作者： Camila Bergmann Goulart Tobias Bleninger Hugo de Oliveira Fagundes Fernando mainardi Fan Department of Environmental Engineering Federal University of Parana Institute of Hydraulic Research Federal University of Rio Grande do Sul

Every dam or barrage construction affects the watercourse and the retention of sediment that previously was carried by the river, which can lead to siltation of the reservoir and obstruction of water intakes over time, reducing their capacities. However, the information available regarding the effect of sediment and drawdown parameters, sediment management at reservoirs, as well as different equational approaches,is scarce. The current research aims to evaluate the effect of parameters associated with numerical modeling of sediment management in reservoirs considering scenarios with different drawdowns,transport equations, sediment size distributions, and thickness of the initial sediment layer. The case study of the Aimore s Hydropower Plant(HPP) is used, applying the Delft3D-FLOW model for twodimensional modeling. All parameters influenced the volume of mobilized sediment, among which the initial layer thickness was the parameter that resulted in the greatest changes in simulated results. In general, the results show that the uncertainties in the input parameters outweigh the uncertainties between the techniques, which found large variations in results when evaluating the use of different transport equations. These results indicate the importance of proper estimation of model parameters for predicting effects with accuracy and the need for such studies before planning and management operations are evaluated to avoid environmental harm and energy waste.

关键词： Reservoir sedimentation Sediment transport modeling Flushing Sediment management

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Precipitating factors leading to decompensation of chronic heart failure in the elderly patient in South-American community hospital

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Journal of Geriatric Cardiology 2011年第1期8卷 12-14页

作者： Alejandro Diaz Cleto Ciocchini Mariano Esperatti Alberto Becerra Sabrina mainardi Alejandro Farah Department of Cardiology Hospital Privado de Comunidad Cordoba 4545 Mar del Plata 7600 Argentina Department of Internal Medicine Hospital Privado de Comunidad Cordoba 4545 Mar del Plata 7600 Argentina

Background Exacerbations of heart failure appear frequently associated with precipitating factors not directly related to the evolution of cardiac disease. There still a paucity of data on the proportional distribution of precipitating factors specifically in elderly patients. The aim of this study was to examine prospectively the precipitating factors leading to hospitalization in elderly patients with heart failure in our community hospital. Methods We evaluate elderly patients who need admissions for decompensate heart failure. All patients were reviewed daily by the study investigators at the first 24 h and closely followed-up. Decompensation was defined as the worsening in clinical NYHA class associated with the need for an increase in medical treatment （at minimum intravenously diuretics）. Results We included 102 patients （mean age 79 ± 12 years）. Precipitating factors were identified in 88.5%. The decompensation was sudden in 35% of the cases. Noncompliance with diet was identified in 52% of the patients, lack of adherence to the prescribed medications amounted to 30%. Others precipitating factors were infections （29%）, arrhythmias （25%）, acute coronary ischemia （22%）, and uncontrolled hypertension （15%）, miscellaneous causes were detected in 18% of the cases （progression of renal disease 60%, anemia 30% and iatrogenic factors 10%）. Concomitant cause was not recognizable in 11.5%. Conclusions Large proportion heart failure hospitalizations are associated with preventable precipitating factors. Knowledge of potential precipitating factors may help to optimize treatment and provide guidance for patients with heart failure. The presence of potential precipitating factors should be routinely evaluated in patients presenting chronic heart failure.

关键词： heart failure exacerbation elderly patient

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特斯克适应不断变化的形势

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生活用纸 2013年第6期13卷 42-44页

作者： Davide mainardi

在过去的10年里，生活用纸的造纸技术已经比较成熟，那么。如何才能在该领域脱颖而出呢？特斯克公司的销售和客户服务总监Davide mainardi介绍了该公司是运用怎样的工艺来应对这种挑战的。

关键词：造纸技术生活用纸客户服务

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耗散系统中的能量传播

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邵阳高等专科学校学报 1990年第3期7卷 211-218页

作者： E.Van Groesen F.mainardi 叶文宁陈光前

本文根据能量密度平衡方程,通过由于耗散存在而导之的损失流项推出了与通常能流速度相异的中心速度表达式.在这一部分中,我们研究了线性波方程特别是一阶双曲系统的中心速度表达式.

关键词：能量传播能流速度耗散系统失流算符密度D 线性波能量密度能量速度衰减因子

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让战略落地

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作者： (美)林文德(Paul Leinwand) (美)马赛斯(Cesare mainardi) (美)亚瑟·克莱纳(Art Kleiner)

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应用分数阶微分对地震波稳恒Q值的时间域模拟

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世界地震译丛 2005年第1期36卷 51-58页

作者： J．M．Carcione F．Cavallini F．mainardi A．Hanyga 张志中安镇文丁志峰不详中国地震局地球物理研究所

根据分数阶微分,在时间域应用新的模拟算法求解了Kjartansson的稳恒Q 值模型。在应力扩容公式中,代替2阶时间微分,Kjartansson的模型要求2γ阶的微分,这里γ为0<γ<1/2。应用Grunwald-Letnikov和中心差分近似计算了分数阶微分。对整阶微... 详细信息

根据分数阶微分,在时间域应用新的模拟算法求解了Kjartansson的稳恒Q 值模型。在应力扩容公式中,代替2阶时间微分,Kjartansson的模型要求2γ阶的微分,这里γ为0<γ<1/2。应用Grunwald-Letnikov和中心差分近似计算了分数阶微分。对整阶微分,上述方法是标准算子的有限差分的拓广。模拟中应用了傅里叶方法计算空间微分,因此,可以处理复杂的几何问题。合成井间地震实验展示了这种新颖模拟算法的能力。

关键词：分数阶微分地震波稳恒Q值时间域模拟应力扩容公式

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