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Vitamin D therapy in pediatric patients with inflammatory bowel disease:a systematic review and meta-analysis

World Journal of Pediatrics 2023年第1期19卷 48-57页

作者： Mohammad Hassan Sohouli Fatemeh Farahmand Hosein Alimadadi Parisa Rahmani Farzaneh Motamed elma izze da silva magalhaes Pejman Rohani Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of ExcellenceChildren's Medical CenterTehran University of Medical SciencesTehranIran Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyShahid Beheshti University of Medical SciencesTehranIran Postgraduate Programme in Collective Health Federal University of MaranhaoRua Barao de Itapary155CentroSao LuísMABrazil Pediatrics Gastroenterology Department of PediatricsSchool of MedicineChildren's Medical CenterTehran University of Medical SciencesTehranIran

Background There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease(IBD)in the pediatric ***,the results are ***,we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with *** We carried out a systematic search in databases from inception until 20 January *** included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity,inflammatory factors,and vitamin D and calcium levels in pediatric patients with *** effects models were used to combine the *** main outcomes were then analyzed using weight mean difference(WMD)and respective 95%confidence interval(CI).Results Fifteen treatment arms met the eligibility criteria and were *** estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxy vitamin D3[25(OH)D3](pooled WMD of 17.662 ng/mL;CI 9.77-25.46;P<0.001),calcium(pooled WMD of 0.17 mg/dL;CI 0.04-0.30;P=0.009),and inflammatory factors including C-reactive protein(CRP)(pooled WMD of-6.57 mg/L;CI-11.47 to-1.67;P=0.009)and erythrocyte sedimentation rate(ESR)(pooled WMD of-7.94 mm/h;CI-12.65 to-3.22;P=0.001)*** addition,this effect was greater for vitamin D levels at doses greater than 2000 IU,and when follow-up duration was more than 12 *** This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH)D3,calcium,and inflammatory factors in children and adolescents with IBD.

关键词： Disease activity index Inflammation Meta-analysis IBD Pediatric Vitamin D

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