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Optimizing perioperative crohn's disease management: Role of coordinated medical and surgical care

World Journal of Gastroenterology 2015年第4期21卷 1182-1188页

作者： Jennifer L Bennett christina Y Ha Jonathan E Efron Susan L Gearhart Mark G Lazarev elizabeth c wick Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Gastroenterology the Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Digestive Diseases the David Geffen School of Medicine at University of California Los AngelesLos AngelesCA 90095United States

AIM: To investigate rates of re-establishing gastroenterology care, colonoscopy, and/or initiating me-dical therapy after crohn's disease(cD) surgery at a tertiary care referral ***: cD patients having small bowel or ileocolonic resections with a primary anastomosis between 2009-2012 were identified from a tertiary academic referral center. cD-specific features, medications, and surgical outcomes were abstracted from the medical record. The primary outcome measure was compliance rates with medical follow-up within 4 wk of hospital discharge and surveillance colonoscopy within 12 mo of surgery. RESULTS: Eighty-eight patients met study inclusion criteria with 92%(n = 81) of patients returning for surgical follow-up compared to only 41%(n = 36) of patients with documented gastroenterology follow-up within four-weeks of hospital discharge, P ctors associated with more timely postoperative medical follow-up included younger age, longer length of hospitalization, postoperative biologic use and academic center patients. In the study cohort, 75.0% of patients resumed medical therapy within 12 mo, whereas only 53.4% of patients underwent a colonoscopy within 12 mo of ***: Our study highlights the need for coordinated cD multidisciplinary clinics and structured handoffs among providers to improve of quality of care in the postoperative setting.

关键词： coordinated care crohn’s disease Postoperative pro

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Lip rejuvenation and filler complications in the perioral region

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Plastic and Aesthetic Research 2022年第1期9卷 413-419页

作者： elizabeth H.wick Erin Ostby Lisa D.Grunebaum Department of Otolaryngology-Head and Neck Surgery University of MiamiMiamiFL 33136USA Department of Surgery Division of Otolaryngology-Head and Neck SurgeryUniversity of VermontBurlingtonVT 05401USA

Lip and perioral augmentation procedures have become increasingly popular over the last two decades due to cultural trends,emphasizing youth and *** understanding of lip anatomy and aesthetics has traditionally formed the basis for successful ***,as new technology becomes available,patient standards have increased,requiring an intricate understanding of filler properties and the advantages of different technical *** chapter touches on pertinent anatomy and aesthetics of perioral *** also provides an overview of the properties of the fillers currently available in the United States marketplace for perioral *** technique and materials currently favored by the senior author are described in greater ***,the chapter will overview potential complications and recommended management.

关键词： Hyaluronic acid filler lip augmentation perioral augmentation rheology

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Role of(～(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies

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World Journal of Gastroenterology 2011年第46期17卷 5059-5074页

作者： elizabeth c Smyth Manish A Shah Department of Gastrointestinal Oncology Weill Cornell Medical CollegeMemorial Sloan-Kettering Cancer Center Department of Gastrointestinal Oncology Weill Cornell Medical CollegeNew York-Presbyterian Hospital

The role of whole-body FDG [(～(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two ***-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging *** sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose *** metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall *** may offer a future paradigm ofpersonalized treatment based on the PET response to ***-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal *** to improve the accuracy of PET include the use of novel radiotrac-ers such as(～(18)F)FLT(3-deoxy-3-fluorothymidine)or 11c-choline,or fusion PET-cT with concurrent high-res-olution computed *** review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma.

关键词： Positron emission tomography Gastric cancer Esophageal cancer Pancreas cancer

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carbon Dioxide and Nitrous Oxide Emissions from Naturally Occurring Sulfate-Based Saline Soils at Different Moisture contents

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Pedosphere 2017年第5期27卷 868-876页

作者： Resham THAPA Amitava cHATTERJEE Abbey wick Kirsten BUTcHER Department of Soil Sciences School of Natural Resources Management North Dakota State University

Soil salinization may negatively affect microbial processes related to carbon dioxide （cO2） and nitrous oxide （N20） emissions. A short-term laboratory incubation experiment was conducted to investigate the effects of soil electrical conductivity （Ec） and moisture content on cO2 and N20 emissions from sulfate-based natural saline soils. Three separate 100-m long transects were established along the salinity gradient on a salt-affected agricultural field at Mooreton, North Dakota, USA. Surface soils were collected from four equally spaced sampling positions within each transect, at the depths of 0-15 and 15-30 cm. In the laboratory, artificial soil cores were formed combining soils from both the depths in each transect, and incubated at 60% and 90% water-filled pore space （WFPS） at 25 ~c. The measured depth-weighted Ec of the saturated paste extract （Ece） across the sampling positions ranged from 0.43 to 4.65 dS m-1. Potential nitrogen （N） mineralization rate and cO2 emissions decreased with increasing soil Ece, but the relative decline in soil cO2 emissions with increasing Ece was smaller at 60% WFPS than at 90% WFPS. At 60% WFPS, soil N20 emissions decreased from 133 g N20-N kg-1 soil at Ece （ 0.50 dS m-1 to 72 μg N20-N kg-1 soil at Ece = 4.65 dS m-1. In contrast, at 90% WFPS, soil N20 emissions increased from 262 g N20-N kg-1 soil at Ece ： 0.81 dS m-1 to 849 g N20-N kg-1 soil at Ece ： 4.65 dS m-1, suggesting that N20 emissions were linked to both soil Ece and moisture content. Therefore, spatial variability in soil Ece and pattern of rainfall over the season need to be considered when up-scaling N20 and cO2 emissions from field to landscape scales.

关键词： electric conductivity c and N mineralization salinity sulfate salts soil salinization soil water-filled pore space

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Male courtship signal modality and female mate preference in the wolf spider Schizocosa ocreata: results of digital multimodal playback studies

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current Zoology 2019年第6期65卷 705-711页

作者： elizabeth c.KOZAK George W.UETZ Department of Biological Sciences University of CincinnatiCincinnatiOHP.0.Box 260006USA45221-0006

Females must be able to perceive and assess male signals,especially when they occur simultaneously with those of other *** studies show female Schizocosa ocreata wolf spiders display receptivity to isolated visual or vibratory courtship signals,but increased receptivity to multimodal *** is unknown whether this is true when females are presented with a choice between simultaneous multimodal and isolated unimodal male *** used digital playback to present females with a choice simulating simultaneous male courtship in different sensory modes without variation in information content:1)isolated unimodal visual versus vibratory signals;2)multimodal versus vibratory signals;and 3)multimodal versus visual *** choosing between isolated unimodal signals(visual or vibratory),there were no significant differences in orientation latency and number of orientations,approaches or receptive displays directed to either *** given a choice between multimodal versus vibratory-only male courtship signals,females were more likely to orient to the multimodal stimulus,and directed significantly more orients,approaches and receptivity behaviors to the multimodal *** presented with a choice between multimodal and visual-only signals,there were significantly more orients and approaches to the multimodal signal,but no significant difference in female *** suggest that signal modes are redundant and equivalent in terms of qualitative responses,but when combined,multimodal signals quantitatively enhance detection and/or *** study confirms the value of testing preference behavior using a choice paradigm,as female preferences may depend on the context(e.g.,environmental context and social context)in which they are presented with male signals.

关键词： mate choice multimodal communication Schizocosa signaling wolf spider

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Operable gastro-oesophageal junctional adenocarcinoma: Where to next?

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World Journal of Gastrointestinal Oncology 2014年第6期6卷 145-155页

作者： elizabeth c Smyth David cunningham Department of Gastrointestinal Oncology Royal Marsden Hospital

Oesophageal junctional adenocarcinoma is a challeng-ing and increasingly common disease. Optimisation ofpre-operative staging and consolidation of surgery inlarge volume centres have improved outcomes, howev-er the preferred adjunctive treatment approach remainsa matter of debate. This review examines the benefitsof neoadjuvant, peri-operative, and post-operative che-motherapy and chemoradiotherapy in this setting in anattempt to reach an evidence based conclusion. Recentfindings relating to the molecular characterisation ofoesophagogastric cancer and their impact on therapeu-tics are explored, in addition to the potential benefitsof fluoro-deoxyglucose positron emission tomography(FDG-PET) directed therapy. Finally, efforts to decreasethe incidence of junctional adenocarcinoma using earlyintervention in Barrett's oesophagus are discussed,including the roles of screening, endoscopic mucosalresection, ablative therapies and chemoprevention.

关键词： Oesophageal adenocarcinoma Junctional adenocarcinoma Gastric adenocarcinoma Peri-operative chemotherapy Pre-operative chemoradiotherapy Molecular profiling Fluoro-deoxyglucose-positron emission tomography Barrett's oesophagus chemoprevention

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Emerging molecular targets and therapy for cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2017年第7期9卷 268-280页

作者： Hamzeh Kayhanian elizabeth c Smyth chiara Braconi Department of Gastrointestinal Oncology Royal Marsden Hospital London and Surrey SM2 5PT Institute of cancer Research London and Surrey SM2 5PT

cholangiocarcinoma(ccA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in ccA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of ccA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. challenges in ccA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for ccA patients.

关键词： cholangiocarcinoma Biliary tract cancer Targeted therapy immunotherapy Mutation Molecular Microenvironment Stroma MiRNA

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Landscape Genetics of Plants: challenges and Opportunities

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Plant communications 2020年第6期1卷 43-57页

作者： Mitchell B.cruzan elizabeth c.Hendrickson Department of Biology Portland State UniversityPO Box 751PortlandOR 97207USA

Dispersal is one of the most important but least understood processes in plant ecology and evolutionary *** of seeds maintains and establishes populations,and pollen and seed dispersal are responsible for gene flow within and among *** views of dispersal and gene flow assume models that are governed solely by geographic distance and do not account for variation in dispersal vector behavior in response to heterogenous *** genetics integrates population genetics with Geographic Information Systems(GIS)to evaluate the effects of landscape features on gene flow patterns(effective dispersal).Surprisingly,relatively few landscape genetic studies have been conducted on *** present advantages because their populations are stationary,allowing more reliable estimates of the effects of landscape features on effective dispersal *** the other hand,plant dispersal is intrinsically complex because it depends on the habitat preferences of the plant and its pollen and seed dispersal *** discuss strategies to assess the separate contributions of pollen and seed movement to effective dispersal and to delineate the effects of plant habitat quality from those of landscape features that affect vector *** analyses of seed dispersal for three species indicate that isolation by landscape resistance is a better predictor of the rates and patterns of dispersal than geographic *** of effective dispersal are lower in areas of high plant habitat quality,which may be due to the effects of the shape of the dispersal kernel or to movement behaviors of biotic *** genetic studies in plants have the potential to provide novel insights into the process of gene flow among populations and to improve our understanding of the behavior of biotic and abiotic dispersal vectors in response to heterogeneous landscapes.

关键词： effective dispersal cpDNA ResistanceGA circuitscape geographic information systems(GIS) ecological niche modeling(ENM)

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Delayed assessment and eager adoption of laparoscopic cholecystectomy:Implications for developing surgical technologies

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World Journal of Gastroenterology 2010年第33期16卷 4115-4122页

作者： Alexander c Allori I Michael Leitman elizabeth Heitman Department of Surgery Beth Israel Medical Center center for Biomedical Ethics and Society Vanderbilt University Medical Center

Despite the prevailing emphasis in the medical literature on establishing evidence,many changes in the practice of surgery have not been achieved using proper evidence-based *** paper examines the adoption of laparoscopic cholecystectomy(Lc)into regular use for the treatment of cholecystitis and the process of its acceptance,focusing on the limited role of technology assessment in its appraisal.A review of the published medical literature concerning Lc was *** 3000 studies of Lc have been conducted since 1985,and there have been nearly 8500 publications to *** Lc was adopted enthusiastically into practice,the results of outcome studies generally showed that it compared favorably with the traditional,open cholecystectomy with regard to mortality,complications,and length of hospital ***,despite the rapid general agreement on surgical technique,efficacy,and appropriateness,there remained lingering doubts about safety,outcomes,and cost of the procedure that suggested that essential research questions were ignored even as the procedure became *** Lc as a case study,there are important lessons to be learned about the need for important guidelines for surgical innovation and the adoption of minimally invasive surgical techniques into current clinical and surgical *** highlight one recent example,natural orifice transluminal endoscopic surgery and how necessary it is to properly evaluate this new technology before it is accepted as a safe and effective surgical option.

关键词： Laparoscopy Endoscopy Minimally invasive surgery cholecystectomy Natural orifice transluminal endoscopic surgery Evidence-based medicine Technol- ogy assessment comparative effectiveness research

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Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response

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Bioactive Materials 2024年第2期32卷 415-426页

作者： elizabeth E.Marr Brett c.Isenberg Joyce Y.Wong Boston University Division of Materials Science and EngineeringUnited States charles Stark Draper Laboratory Bioengineering DivisionUnited States Boston University Department of Biomedical EngineeringUnited States

In the United States,1 in 10 infants are born *** majority of neonatal deaths and nearly a third of infant deaths are linked to preterm *** birth is initiated when the quiescent state of the uterus ends prematurely,leading to contractions and parturition beginning as early as 32 weeks,though the origins are not well *** enable research and discovery of therapeutics with potential to better address preterm birth,the capability to study isolated cell processes of pregnant uterine tissue in vitro is *** development of an in vitro model of the myometrium utilizing human uterine smooth muscle cells(uSMcs)responsible for contractions provides a methodology to examine cellular mechanisms of late-stage pregnancy potentially involved in preterm *** discuss culture of uSMcs on a flexible polydimethylsiloxane(PDMS)substrate functionalized with cationic poly-L-lysine(PLL),followed by extracellular matrix(EcM)protein *** work exploring uSMc behavior on PDMS substrates have utilized collagen-I coatings,however,we demonstrated the first exploration of human uSMc response to strain on fibronectin-coated flexible membranes,importantly reflecting the significant increase of fibronectin content found in the myometrial EcM during late-stage *** the model we developed,we conducted proof-of-concept studies to investigate the impact of substrate strain on uSMc cell morphology and gene *** was found that PLL and varied EcM protein coatings(collagen I,collagen III,and fibronectin)altered cell nuclei morphology and density on PDMS ***,varied strain rates applied to uSMc substrates significantly impacted uSMc gene expression of IL-6,a cytokine associated with instances of preterm *** results suggest that both surface and mechanical properties of in vitro systems impact primary human uSMc phenotype and offer uSMc culture methodologies that can be utilized to further the understanding of cellu

关键词： Uterine Myometrium Bioengineered in vitro models Strain Pregnancy Nuclei Interleukin 6 Preterm labor

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