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Radioecology: Why Bother?

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Journal of Environmental Protection 2014年第3期5卷 181-192页

作者： Emily Amanda Caffrey Mary elizabeth Leonard Jonathan Bamberger Napier Delvan reed Neville Kathryn Ann Higley Department of Nuclear Engineering and Radiation Health Physics Oregon State University Corvallis USA.

The importance of radioecology to the discussion of radioactive contamination is discussed here. This paper discusses the history of radioecology, alongside the most recent developments in the science. It describes the need for more environmental data, and explains where the gaps in current knowledge lie. The calculation of radiation dose to wildlife along with the complications in performing such calculations is discussed. The paper also tackles the difficult question of the implications of radioecology on nuclear waste management and site decommissioning policies. From the beginnings of the science to today, radioecology is poised to be an important field of study as humans continue to rely on ionizing radiation to improve their lives.

关键词： Radioecology Wildlife Dose Calculations Nuclear Waste Disposal Environmental Protection

The role of long noncoding RNAs in cancer metastasis

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 237-259页

作者： Christine Parsons Alexis M.Tayoun Benjamin D.Benado Gabriel Ragusa Rose F.Dorvil elizabeth A.Rourke Kaitlyn O’Connor Irene G.reed Angela Alexander Lian Willetts Maryam Habibian Brian D.Adams School of Medicine UConn HealthFarmingtonCT 06030USA Department of RNA Sciences The Brain Institute of AmericaGrotonCT 06340USA Department of Biology and Environmental Sciences University of New HavenWest HavenCT 06516USA Department of Biology University of Saint JosephWest HartfordCT 06117USA Department of Breast Medical Oncology MD Anderson Cancer CenterHoustonTX 77030USA Cumming School of Medicine University of CalgaryCalgaryAB T2N 1N4Canada Department of Chemistry Stanford UniversityStanfordCA 94305USA Investigative Medicine Program Yale University Medical SchoolNew HavenCT 06520USA

Signaling pathways are tightly controlled systems that regulate the appropriate timing of gene expression required for the differentiation of cells down a particular lineage essential for proper tissue ***,apoptosis and metabolic pathways are just a few examples of the signaling pathways that require fine-tuning,so as to control the proper development of a particular tissue type or organ *** estimated 70%of the genome is actively transcribed,only 2%of which codes for known protein-coding *** noncoding RNAs(lncRNAs)in particular,are a large and diverse class of RNAs>200 nucleotides in length,and not translated into *** are essential transcriptional and post-transcriptional regulators that control the expression of genes in a spatial,temporal,and cell context-dependent *** aberrant expression of lncRNAs is therefore linked with a number of chronic diseases including cardiac dysfunction,diabetes,and *** this review,we highlight the specific role lncRNAs have in promoting the metastatic cascade across a number of epithelial cancer models.

关键词： Long noncoding RNA long intergenic noncoding RNA microRNA competitive endogenous RNA breast cancer brain cancer lung cancer prostate cancer metastasis therapeutics

Effects of maternal nutrition on the expression of genomic imprinted genes inovine fetuses

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Effects of maternal nutrition on the expression of genomic i...

第十四届中国实验动物科学年会

作者： Jingyue (Ellie) Duan 张名媛 Kaleigh Flock Sahar Al Seesi Ion Mandoiu Amanda Jones elizabeth Johnson Sambhu Pillai Maria Hoffman Katelyn McFadden Hesheng Jiang Sarah reed Kristen Govoni Steve Zinn Zongliang Jiang Xiuchun (Cindy) Tian Department of Animal Science University of Connecticut College of Animal Science and Technology Guangxi University Laboratory Animal Center Guangxi Medical University Department of Computer Science University of Connecticut School of Animal Science Louisiana StateUniversity Agricultural Center

Genomic imprinting is an epigenetic phenomenon of differential allelic expression based on parentalorigin. To date, 263 imprinted genes have been identified among all investigated mammalian ***, only 21 have been described in sheep, of which 11 are annotated in the current ovinegenome. Here, we aimtoi) use DNA/RNA high throughput sequencing to identify new monoallelicallyexpressed and imprinted genes in day 135 ovine fetuses and ii) determine whether maternal diet(100%, 60%, or 140% of National Research Council Total Digestible Nutrients) influences expression ofimprinted genes. We also reported strategies to solve technical challenges in the data analysispipeline. We identified 80 monoallelically expressed, 13 new putative imprinted genes, and fiveknown imprinted genes in sheep using the 263 genes stated above as a guide. Sanger sequencingconfirmed allelic expression of seven genes, CASD1, COPG2, DIRAS3, INPP5 F, PLAGL1, PPP1 R9 A, and SLC22 A18. Among the 13 putative imprinted genes, five were localized in the known sheep imprintingdomains of MEST on chromosome 4, DLK1/GTL2 on chromosome 18 and KCNQ1 on chromosome 21,and three were in a novel sheep imprinted cluster on chromosome 4, known in other species asPEG10/SGCE. The expression of DIRAS3, IGF2, PHLDA2, and SLC22 A18 was altered by maternal diet,albeit without allelic expression reversal. Together, our results expanded the list of sheep imprintedgenes to 34 and demonstrated that while the expression levels of four imprinted genes were changedby maternal diet, the allelic expression patterns were un-changed for all imprinted genes studied.

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严峻的英国经济形势考验下任首相

商业周刊（中文版） 2022年第18期 7-8页

作者： reed Landberg David Goodman Liza Tetley 简远(译) 不详

无论接替刚刚下台的伊丽莎白·特拉斯(elizabeth Truss)的人是谁。下一任英国首相都将接手一个近期会受到借贷成本上升、能源账单不堪重负、高税收以及没有复苏增长战略困扰的英国经济。

关键词：借贷成本英国首相账单伊丽莎白税收

An update on the influence of natural climate variability and anthropogenic climate change on tropical cyclones

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Tropical Cyclone Research and Review 2023年第3期12卷 216-239页

作者： Suzana J.Camargo Hiroyuki Murakami Nadia Bloemendaal Savin S.Chand Medha S.Deshpande Christian Dominguez-Sarmiento Juan Jesús Gonz´alez-Alem´an Thomas R.Knutson I.-I.Lin Il-Ju Moon Christina M.Patricola Kevin A.reed Malcolm J.Roberts Enrico Scoccimarro Chi Yung(Francis)Tam elizabeth J.Wallace Liguang Wu Yohei Yamada Wei Zhang Haikun Zhao Lamont-Doherty Earth Observatory Columbia UniversityPalisadesNYUSA National Oceanographic and Atmospheric Administration/Geophysical Fluid Dynamics Laboratory PrincetonNJUSA University Corporation for Atmospheric Research BoulderCOUSA Vrije University Amsterdam AmsterdamNetherlands Federation University Australia BallaratVictoriaAustralia Indian Institute of Tropical Meteorology Ministry of Earth SciencesPuneIndia Instituto de Ciencias de la Atmosfera y Cambio Clim´atico Universidad Nacional Autonoma de Mexico(UNAM)Mexico CityMexico Spanish State Meteorological Agency(AEMet) MadridSpain National Taiwan University TaiwanChina Jeju National University JejuRepublic of Korea Iowa State University AmesIAUSA Stony Brook University Stony BrookNYUSA Met Office ExeterUnited Kingdom Fondazione Centro Euro-Mediterraneo sui Cambiamenti Climatici BolognaItaly The Chinese University of Hong Kong Hong KongChina Old Dominion University NorfolkVAUSA Fudan University ShanghaiChina Japan Agency for Marine-Earth Science and Technology YokohamaJapan Utah State University LoganUTUSA Nanjing University of Information Science and Technology NanjingChina

A substantial number of studies have been published since the Ninth International Workshop on Tropical Cyclones(IWTC-9)in 2018,improving our understanding of the effect of climate change on tropical cyclones(TCs)and associated hazards and *** studies have reinforced the robustness of increases in TC intensity and associated TC hazards and risks due to anthropogenic climate *** modeling and observational studies suggested the potential influence of anthropogenic climate forcings,including greenhouse gases and aerosols,on global and regional TC activity at the decadal and century time ***,there are still substantial uncertainties owing to model uncertainty in simulating historical TC decadal variability in the Atlantic,and the limitations of observed TC *** projected future change in the global number of TCs has become more uncertain since IWTC-9 due to projected increases in TC frequency by a few climate models.A new paradigm,TC seeds,has been proposed,and there is currently a debate on whether seeds can help explain the physical mechanism behind the projected changes in global TC *** studies also highlighted the importance of large-scale environmental fields on TC activity,such as snow cover and air-sea *** projections on TC translation speed and medicanes are new additional focus topics in our *** and future research are proposed relevant to the remaining scientific questions and assisting policymakers.

关键词： tropical climate variability