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The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples

Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid Alexandra Ortega Ubbo Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie Kirsten Horne Crenshaw Ashleigh Beaulieu Brooke Bosworth Liz Gallardo Emory Neer Sofia Ramirez elizabeth A. Crocco Mike Georgiou Efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

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On the potential of iPhone significant location data to characterize individual mobility for air pollution health studies

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 109-113页

作者： Eastman elizabeth A.Stevens Kelly Ivey Cesunica Haofei Yu Department of Civil Environmentaland Construction EngineeringUniversity of Central FloridaOrlandoFL 32816USA School of Public Administration University of Central FloridaOrlandoFL 32801USA Department of Civil and Environmental Engineering University of California-BerkeleyBerkeleyCA 94720USA

In many air pollution health studies,the time-activity pattern of individuals is often ignored largely due to lack of ***,a better understanding of this location-based information is expected to decrease uncertainties in exposure ***,we showcase the potential of iPhone’s Significant Location(iSL)data in capturing the user’s historical time-activity patterns in order to estimate exposure to ambient air *** this study,one subject carried an iPhone in tandem with a reference GPS tracking device for one *** GPS device recorded locations in 10 second intervals while the iSL recorded the time spent in locations the subject visited *** GPS data as a reference,we then evaluated the accuracy of iSL data in capturing the subject’s time-activity patterns and time-weighted air pollution concentration within the study time *** found the iSL data accurately captured the time the subject spent in 16 microenvironments(*** the subject visited more than once),which was 93%of the time during the study *** average error of time-weighted aerosol optical depth value,a surrogate of particle pollution,is only 0.012%.To explore the availability of iSL data among iPhone users,an online survey was *** the 349 surveyed participants,72%of them have iSL data *** the popularity of iPhones,iSL data may be available for a significant portion of the general *** results suggest iSL data have great potential for characterizing historical time-activity patterns to improve air pollution exposure estimation.

关键词： Air pollution exposure Human mobility iPhone Significant Location Smartphone data

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疗愈花园类型的概念界定

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风景园林 2024年第5期31卷 75-90页

作者：伊丽莎白·R·M·黛尔姜博(译) 程宇(译) 佛罗里达大学环境园艺学院哈尔滨工业大学建筑与设计学院哈尔滨工业大学寒地城乡人居环境科学与技术工业和信息化部重点实验室

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项... 详细信息

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项目的开发。【方法】建立疗愈花园类型层次框架,并以现有花园为例,分析每种类型疗愈花园的设计目的、设计重点和潜在用户。【结果】将疗愈花园类型层次框架的基本结构分为主动型(使能型)和被动型(恢复型)的双轨结构,明确了不同类型疗愈花园的区别和联系。【结论】“疗愈花园”一词常被用于描述医疗机构中的花园,而不同类型的疗愈花园之间存在一些重要区别。这些区别为疗愈花园的设计提供了依据,有助于在花园空间中开展高质量的活动,同时兼顾使用者的需求。疗愈花园的设计必须满足使用人群的特定需求,包括居民/患者、员工和家庭成员。

关键词：疗愈花园恢复花园使能花园治疗花园感官花园

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Can a multistage approach improve individual tree mortality predictions across the complex mixed-species and managed forests of eastern North America?

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Forest Ecosystems 2023年第1期10卷 21-30页

作者： Cen Chen John Kershaw Jr Aaron Weiskittel elizabeth McGarrigle Center for Research on Sustainable Forests University of MaineOronoME04469USA Faculty of Forestry&Environmental Management University of New BrunswickFrederictonNBE3B 5A3Canada Nova Scotia Department of Natural Resources HalifaxNSB3J 3M8Canada

Tree mortality plays a fundamental role in the dynamics of forest ecosystems,yet it is one of the most difficult phenomena to accurately *** modeling strategies have been developed to improve individual tree mortality *** less explored strategy is the use of a multistage modeling *** improvements from this approach have remained largely *** this study,we developed a novel multistage approach and compared its performance in individual tree mortality predictions with a more conventional approach using an identical individual tree mortality model *** permanent plot data(n=9442)covering the Acadian Region of North America and over multiple decades(1965–2014)were used in this *** results indicated that the model behavior with the multistage approach better depicted the observed mortality and showed a notable improvement over the conventional *** difference between the observed and predicted numbers of dead trees using the multistage approach was much smaller when compared with the conventional *** addition,tree survival probabilities predicted by the multistage approach generally were not significantly different from the observations,whereas the conventional approach consistently underestimated mortality across species and overestimated tree survival probabilities over the large range of DBH in the *** new multistage approach also predictions of zero mortality in individual plots,a result not possible in conventional ***,the new approach was more tolerant of modeling errors because it based estimates on ranked tree mortality rather than error-prone predicted ***,this new multistage approach deserves to be considered and tested in future studies.

关键词： Tree mortality modeling Mortality disaggregation Mixed effect model Annualization Mixed forests

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Is early patent ductus arteriosus ligation helpful in premature neonates? A 10-year retrospective study

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World Journal of Pediatrics 2022年第5期18卷 350-357页

作者： Anip Garg Naveen Athiraman elizabeth Jenkins David Crossland Prakash Kannan Loganathan Neonatal Unit Royal Victoria InfirmaryNewcastleUK Paediatric Cardiology Freeman HospitalNewcastleUK Neonatal Unit James Cook University HospitalMarton RoadMiddlesbrough TS43BWUK

Background To compare short and long outcomes between early(≤28 days)(EL)and late ligation(LL)*** explore factors predicting early extubation(≤7 days)after patent ductus arteriosus(PDA)*** We conducted a single center,retrospective cohort study of preterm infants<32 weeks who underwent surgical ligation over a 10-year period(2009-2019).Results A total of 133 infants underwent PDA ligation,in the study *** groups had similar short-term outcome such as bronchopulmonary dysplasia(BPD)or death(96%vs.98%,P=0.64)and long-term clinical outcomes including Bayley's assessment at 2 years corrected *** infants in the EL group developed severe BPD(63%vs.81%,P=0.02).Age at ligation had adjusted odds ratio of 1.04 with over lapping confidence interval(95%CI 1.0-1.1,P=0.02)for severe BPD/*** was no difference in day of extubation between the EL and LL group(8 days vs.7 days,P=0.85).Left atrium/aortic root ratio of ≥1.75 would give sensitivity of 41% and 80% specificity for early extubation(area under the curve of 0.61).There was marginal reduction of hospital stay in the EL group[113(105-121)days vs.115(107-123)days;log rank P=0.026].Conclusion EL can be delivered safely with a clinically important lower incidenee of severe BPD and shorter duration of hospital stay compared to LL.

关键词： Bronchopulmonary dysplasia Extubation Patent ductus arteriosus ligation

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在发病前,拯教青少年抑郁

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环球科学 2024年第3期 50-57页

作者：伊丽莎白·斯沃博达张胜楠(译) 不详中国科学院心理研究所

当埃丝特·奥拉德乔(Esther Oladejo)连续好几天都想不起来吃饭时,她意识到自已已经越过了一条无形的边界。作为一名颇有天赋的橄榄球运动员,忙碌的学校日程也不曾停下她成长的脚步。

关键词：橄榄球运动员青少年抑郁发病前

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Cell adhesion in renal tubular epithelial cells:Biochemistry,biophysics or both

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BIOCELL 2022年第4期46卷 937-940页

作者： CLAIRE elizabeth HILLS ELEFTHERIOS SIAMANTOURAS PAUL EDWARD SQUIRES Diabetes Metabolism&Inflammation GroupSchool of Life SciencesJoseph Banks LaboratoriesUniversity of LincolnLincolnLN67DLUK

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and ***,these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix,as well as the biophysical and mechanical properties orchestrated by cytoskeletal,membrane and matrix *** fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function,it is important to consider both biochemical and biophysical attributes of the system being *** this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

关键词： Cell-adhesion Cadherin Cytoskeleton AFM Kidney Epithelium

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Thrombosis after SARS-CoV2 infection or COVID-19 vaccination:will a nonpathologic anti-PF4 antibody be a solution?—A narrative review

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Journal of Bio-X Research 2022年第3期5卷 97-103页

作者： elizabeth Rao Payal Grover Hongtao Zhang Department of Pathology and Laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

The coronavirus disease 2019(COVID-19)pandemic was triggered by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),a previously unknown strain of *** fully understand the consequences and complications of SARS-CoV-2 infections,we have reviewed current literature on coagulation dysfunctions that are related to the disease and *** COVID-19 is more commonly considered as a respiratory illness,studies indicate that,in addition to respiratory illness,a coagulation dysfunction may develop in individuals after the initial infection,placing them at the risk of developing thrombotic *** who died of COVID-19 had higher levels of D-dimer,a biomarker for blood clot formation and *** treatments for coagulation dysfunctions are critically needed to improve patient *** the other hand,antibodies against platelet factor 4(PF4)/heparin may be found in patients with rare instances of vaccine-induced immunological thrombotic thrombocytopenia(VITT)following vaccination with adenovirus-based *** is characterized by atypical thrombosis and thrombocytopenia,similar to immune-mediated heparin-induced thrombocytopenia(HIT),but with no need for heparin to trigger the immune *** both adenovirus-based and mRNA-based vaccines express the Spike protein of SARS-CoV-2,VITT is exclusively related to adenovirus-based *** to the resemblance with HIT,the use of heparin is highly discouraged against treating patients with thrombotic thrombocytopenia after SARS-CoV-2 infection or with VITT after *** immunoglobulin therapy coupled with anticoagulation is recommended *** well-studied anti-PF4 monoclonal antibody RTO,which does not induce pathologic immune complexes in the presence of heparin and has been humanized for a potential treatment modality for HIT,may provide a nonanticoagulant HIT-specific solution to the problem of increased blood coagulation after SARS-CoV-2 infecti

关键词： antibody coagulation dysfunctions COVID-19 PF4 vaccine-induced immunological thrombotic thrombocytopenia

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Telehealth interventions for alcohol use disorder:A systematic review

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Liver Research 2022年第3期6卷 146-154页

作者： Arpad Kelemen elizabeth Minarcik Christopher Steets Yulan Liang Department of Organizational Systems and Adult Health University of MarylandBaltimoreMDUSA Department of Family and Community Health University of MarylandBaltimoreMDUSA

Alcohol use disorder(AUD)is a worldwide problem for individuals of varying ages and backgrounds and is associated with the underlying cause of alcoholic liver disease,liver cirrhosis,liver cancer,or many other common diseases and health *** treatments such as cognitive behavioral therapy(CBT)have been demonstrated as an evidence-based treatment to aid individuals struggling with ***,these treatments have excessive costs and time demand with trained *** this paper,we examine the efficacy and long-term impacts of digitally delivered CBT and other online telehealth tools and apps for AUD *** show the effectiveness in the ability of digitally delivered CBT to decrease alcohol use in AUD *** additional use of online technologies and smartphone apps for post-CBT care demonstrates that such computer-aided apps could have long-term effects when it is continually employed,which opens the door for AUD patients who were not seeking treatment *** longitudinal examination research is needed to evaluate the lasting effects in liver health and other chronic diseases associated with digitally delivered alcohol reduction for AUD patients.

关键词： Alcohol use disorder(AUD) Liver disease Cognitive behavioral therapy(CBT) Telehealth Digitally delivered Systematic review

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Importance of Standardizing Analytical Characterization Methodology for Improved Reliability of the Nanomedicine Literature

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Nano-Micro Letters 2022年第11期14卷 18-32页

作者： Shahriar Sharifi Nouf N.Mahmoud elizabeth Voke Markita P.Landry Morteza Mahmoudi Department of Radiology and Precision Health Program Michigan State UniversityEast LansingMIUSA Faculty of Pharmacy Al-Zaytoonah University of JordanAmman 11733Jordan Department of Biomedical Sciences College of Health SciencesQU HealthQatar University2713 DohaQatar Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyBerkeleyCAUSA Innovative Genomics Institute BerkeleyCAUSA California Institute for Quantitative Biosciences University of CaliforniaBerkeleyCAUSA Chan Zuckerberg Biohub San FranciscoCAUSA

Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine *** lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine *** such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical ***,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as *** also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical ***,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.

关键词： Characterization Nanomedicine Standard protocols Reproducibility Nanomedicine devices

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