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Risk factors for neoplastic progression in Barrett's esophagus

World Journal of Gastroenterology 2011年第32期17卷 3672-3683页

作者： elizabeth f wiseman Yeng S Ang Department of Gastroenterology Royal Albert Edward Infirmary Wigan Lane Wigan Greater Manchester WN1 2NN United Kingdom faculty of Medical and Human Sciences School of Translational Medicine The University of Manchester Oxford Road Manchester M13 9PL United Kingdom

Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.

关键词： Barrett’s esophagus Esophageal adeno-carcinoma Metaplasia-dysplasia-carcinoma Neoplastic progression Risk factors

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Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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The Journal of Biomedical Research 2010年第2期24卷 87-99页

作者： Aarti Ruparelia frances wiseman Olivia Sheppard Victor L.J.Tybulewicz elizabeth M.C.fisher Department of Neurodegenerative Disease UCL Institute of Neurology MRC National Institute for Medical Research

elizabeth fisher and Victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. elizabeth fisher＇s background is in molecular genetics and mouse models, with an interest in anueploidy. Victor Tybulewicz is an immunologist whose primary interest is in signal transduction from the antigen receptors of B and T cells.

关键词： Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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