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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan cuccia Rachael coates Blake Nassar Ethan Littlefield elizabeth c.martin Adam T.Melvin cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on McF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on McF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the McF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOR,and p-STAT3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Output digitization of simple measure-preserving linear systems

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control Theory and Technology 2021年第4期19卷 430-443页

作者： A.DeStefano M.Thitsa c.martin Department of Mathematics and computer Science College of the Holy CrossWorcesterMA 01610USA Department of Electrical and computer Engineering Mercer UniversityMaconGA 31207USA Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79430USA

We examine three simple linear systems from the viewpoint of ergodic *** digitize the output and record only the sign of the output at integer *** show that even with this minimal output we can recover important information about the *** particular,for a two-dimensional system viewed as a fow on the circle,we can determine the rate of *** then use these results to determine the slope of the trajectories for constant irrational fow on the two-dimensional *** achieve this,we randomize the system by partitioning the state space and only recording which partition the state is in at each integer *** show directly that these systems have entropy ***,we examine two four-dimensional systems and reduce them to the study of linear fows on the two-dimensional torus.

关键词： Ergodic Linear system Observability cantor set

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Lipopolysaccharide immune stimulation but not β-mannanase supplementation affects maintenance energy requirements in young weaned pigs

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Journal of Animal Science and Biotechnology 2018年第4期9卷 901-916页

作者： Nichole F.Huntley c.martin Nyachoti John F.Patience Department of Animal Science Iowa State University Department of Animal Science University of Manitoba

Background: Pathogen or diet-induced immune activation can partition energy and nutrients away from growth,but clear relationships between immune responses and the direction and magnitude of energy partitioning responses have yet to be elucidated. The objectives were to determine how β-mannanase supplementation and lipopolysaccharide(LPS) immune stimulation affect maintenance energy requirements(MEm) and to characterize immune parameters, digestibility, growth performance, and energy ***: In a randomized complete block design, 30 young weaned pigs were assigned to either the control treatment(cON; basal corn, soybean meal and soybean hul s diet), the enzyme treatment(ENZ; basal diet + 0.056% β-mannanase),or the immune system stimulation treatment(ISS; basal diet + 0.056% β-mannanase, chal enged with repeated increasing doses of Escherichia coli LPS). The experiment consisted of a 10-d adaptation period, 5-d digestibility and nitrogen balance measurement, 22 h of heat production(HP) measurements, and 12 h of fasting HP measurements in indirect calorimetry chambers. The immune chal enge consisted of 4 injections of either LPS(ISS) or sterile saline(cON and ENZ), one every48 h beginning on d 10. Blood was collected pre-and post-challenge for complete blood counts with differential,haptoglobin and mannan binding lectin, 12 cytokines, and glucose and insulin ***: Beta-mannanase supplementation did not affect immune status, nutrient digestibility, growth performance,energy balance, or MEm. The ISS treatment induced fever, elevated proinflammatory cytokines and decreased leukocyte concentrations(P ct nitrogen balance or nutrient digestibility(P > 0.10),but increased total HP(21%) and MEm(23%), resulting in decreased lipid deposition(-30%) and average daily gain(-18%)(P conclusions: This experiment provides novel data on β-mannanase supplementation effects on immune parameters and energy balance i

关键词： Acute phase proteins β-Mannan cytokines Digestibility Feed induced immune response Heat production Inflammation Lipopolysaccharide Nitrogen balance Swine

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Functionalized EDOT and ProDOT Thiophene copolymers for Interfacing Electronic Biomedical Devices with Living Tissue

Functionalized EDOT and ProDOT Thiophene Copolymers for Inte...

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2013年全国高分子学术论文报告会

作者： David c.martin Materials Science and Engineering The University of Delaware

＜正＞We continue to be interested in the development of conjugated organic polymers and copolymers for interfacing a variety of hard, inorganic metallic and semiconductor, engineered electronic biomedical devices with ionically-conducting, soft, living neural and muscular tissue. current examples of these devices include cardiac pacemakers, cochlear implants, retinal implants, peripheral

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clean code（评注版）

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作者： (美)Robert c.martin

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新型导电高聚物对神经元修补元件的表面改性

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电子元件与材料 2003年第8期22卷 18-19,22页

作者：肖迎红 David c.martin 南京理工大学化工学院江苏南京210014 材料科学与工程系 The University of Michigan

利用一种新型的导电聚合物——聚3,4-二氧化乙烷噻吩(PEDOT)的衍生物PEDTM,成功地在用微加工技术制作的神经元修补元件的电极上制得了导电涂层。该导电聚合物既克服了聚吡咯由于α—β(β?键接而产生的缺陷, 又克服了EDOT在水中溶解度小... 详细信息

利用一种新型的导电聚合物——聚3,4-二氧化乙烷噻吩(PEDOT)的衍生物PEDTM,成功地在用微加工技术制作的神经元修补元件的电极上制得了导电涂层。该导电聚合物既克服了聚吡咯由于α—β(β?键接而产生的缺陷, 又克服了EDOT在水中溶解度小,无法在生物分子的掺杂下电化学合成PEDOT/生物分子导电涂层的缺陷。SEM和AFM照片表明PEDTM/PSS导电涂层具有粗糙的表面形貌,表面积增加,其阻抗也比未涂层前降低很多,在1 kHz处其阻抗值降低了两个数量级。研究结果表明,PEDTM/生物分子导电涂层的阻抗比聚吡咯/生物分子涂层降低得更多。

关键词：导电聚合物神经元修补元件表面改性

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Two in One-combining Mechanical and Thermal Solids/Liquids Separation Technology

Two in One-Combining Mechanical and Thermal Solids/Liquids S...

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第六届化学工程与生物技术展览暨会议

作者： c.martin Y.Lu Krauss-Maffei Process Technology AG Postfach 500332 80973 Munchen Process Technology AG Postfach 500332 80973 Munchen Process Technology AG Postfach 500332 80973 Munchen

＜正＞ When planning separation processes the thermal and mechanical separation step arefrequently evaluated individually. By looking at these unit operations together,substantialbenefits could be gained from the optimization of the process scheme to the minimization ofinterfaces, This is demonstrated by the following example of an application to dry a chemicalor pharmaceutical product.

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Role of(～(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies

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World Journal of Gastroenterology 2011年第46期17卷 5059-5074页

作者： elizabeth c Smyth Manish A Shah Department of Gastrointestinal Oncology Weill Cornell Medical CollegeMemorial Sloan-Kettering Cancer Center Department of Gastrointestinal Oncology Weill Cornell Medical CollegeNew York-Presbyterian Hospital

The role of whole-body FDG [(～(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two ***-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging *** sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose *** metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall *** may offer a future paradigm ofpersonalized treatment based on the PET response to ***-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal *** to improve the accuracy of PET include the use of novel radiotrac-ers such as(～(18)F)FLT(3-deoxy-3-fluorothymidine)or 11c-choline,or fusion PET-cT with concurrent high-res-olution computed *** review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma.

关键词： Positron emission tomography Gastric cancer Esophageal cancer Pancreas cancer

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Weedy Rice(Oryza sativa L.)Problem in Rice(Oryza sativa L.)Based cropping Systems in the Philippines

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American Journal of Plant Sciences 2013年第12期4卷 2359-2366页

作者： Irene R.Tanzo Edwin c.martin Bhagirath S.chauhan Philippines Rice Research Institute(PhilRice) MaligayaMunozNueva EcijaPhilippines International Rice Research Institute(IRRI) Los BañosPhilippines

A study was undertaken in February 2012 to understand the knowledge and practices of rice farmers about weedy rice in two municipalities of Iloilo, Philippines. The specific objectives of the study were to establish what rice farmers know about weedy rice, examine rice farmers’ practices in managing weedy rice, and recommend policies on weedy rice management based on the results of the study. Farmers’ knowledge of weedy rice did not differ much between two villages. Results showed that 41% from the second most affected village and 33% from the most affected village thought that weedy rice cannot reduce the market value of the harvested rice. Majority of the farmers (68%) responded that awns can be absent in some weedy rice and about 40% of the farmers did not know that seeds of weedy rice have dormancy. cutting the weedy rice panicles at harvest, as the best way of reducing weedy rice, was practiced by majority of the respondents (82%) from the most affected village. Our study suggests that there is a need to increase awareness about weedy rice among Asian farmers.

关键词： Knowledge Awareness Iloilo Weedy Rice

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纳米结构膜的制备及其在导电聚合物电化学聚合中的应用

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电子元件与材料 2003年第11期22卷 50-52页

作者：肖迎红杨俊颜 David c.martin 南京理工大学化工学院江苏南京210014 Department of Materials Science and Engineering The University of Michigan USA

导电聚合物涂层的表面粗糙度和表面积对神经元传感器电极的敏感性和生物相容性有着重要的影响,利用纳米多孔膜材料进行电化学模板聚合是获得高粗糙度和高表面积的导电聚合物涂层的理想途径。利用聚苯乙烯(PS)、聚甲醛丙烯酸甲酯(PMMA)... 详细信息

导电聚合物涂层的表面粗糙度和表面积对神经元传感器电极的敏感性和生物相容性有着重要的影响,利用纳米多孔膜材料进行电化学模板聚合是获得高粗糙度和高表面积的导电聚合物涂层的理想途径。利用聚苯乙烯(PS)、聚甲醛丙烯酸甲酯(PMMA)两者的紫外光辐照特性不同,研究了用紫外光辐照光刻法制备聚苯乙烯-甲基丙烯酸甲酯嵌段共聚物P(S-b-MMA)纳米结构膜的方法。同时基于P(S-b-MMA)共聚物纳米结构膜的电化学模板聚合研究表明,该法可在神经元传感器电极表面获得理想的发丝状高粗糙度和高表面积PPy/PSS导电高聚物涂层。

关键词：共聚物纳米膜材料电化学聚合导电聚合物

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