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Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation

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World Journal of Gastroenterology 2005年第38期11卷 5944-5950页

作者： Pierluigi Toniutto Carlo Fabris Claudio Avellini Rosalba Minisini Davide Bitetto elisabetta rossi Carlo Smirne Mario Pirisi Liver Transplantation Unit Pathology Department of Medical Sciences

AIM: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the ***: Ninety consecutive patients (63 males,median age 53 years; 55 with HCV-related liver disease),transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single,experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic *** SFP was quantified in fibrosis units/month (FU/mo).The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after ***: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point,a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value ＞26.0 kg/m2. At completion of the first post-transplant year, a BMI value ＞26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP ＞0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging ***: Among HCV positive recipients, excessweight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it.

关键词： Liver transplantation Hepatitis C infection Liver fibrosis Liver steatosis Body mass index

Seed-Specific Expression of Apolipoprotein A-IMilano Dimer in Engineered Rice Lines

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Rice science 2023年第6期30卷 587-597页

作者： Serena REGGI elisabetta ONELLI Alessandra MOSCATELLI Nadia STROPPA Matteo DELL’ANNO Kiril PERFANOV Luciana rossi Department of Veterinary Medicine and Animal Science University of MilanLodi 26900Italy Department of Biosciences University of MilanMilan 20133Italy Plantechno Srl Casalmaggiore 26040Italy

Apolipoprotein A-IMilano(ApoA-IM)has been shown to significantly reduce coronary atherosclerotic ***,the preparation of cost-effective pharmaceutical formulations of ApoA-IM is limited by the high cost and difficulty of purifying the protein and producing the highly effective dimeric *** aim of this study was to create an expression cassette that specifically drives the expression of dimeric ApoA-IM in the protein bodies of rice *** ApoA-IM protein under control of the 13 kDa prolamin promoter is expressed exclusively in its dimeric form within the seeds,and immunocytochemical and immunogold analyses confirmed its expression in different caryopsis tissue such as seed coat,aleurone cell and endosperm,particularly in amyloplast and storage vacuoles.A plant-based ApoA-IM production system offered numerous advantages over current production systems,including the direct production of the most therapeutically effective dimeric ApoA-IM forms,long-term protein storage in seeds,and ease of protein production by simply growing ***,seeds had the potential to serve as a costeffective source of therapeutic ApoA-IM.

关键词： apolipoprotein A-IMilano engineered plant immunofluorescence immunogold analysis rice seed-specific promoter

Inflammatory bowel disease in the dog:Differences and similarities with humans

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World Journal of Gastroenterology 2010年第9期16卷 1050-1056页

作者： Matteo Cerquetella Andrea Spaterna Fulvio Laus Beniamino Tesei Giacomo rossi elisabetta Antonelli Vincenzo Villanacci Gabrio Bassotti School of Medical Veterinary Sciences University of CamerinoVia Circonvallazione Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineSanta Maria della Misericordia Hospital 2nd Department of Pathology Spedali Civili of BresciaPiazza Spedali Civili

Inflammatory bowel diseases (IBD) represent important chronic conditions affecting the gastrointestinal tract in ***,similar disorders are found in several animal species and the IBD affecting dogs are particularly *** are encompassed by an umbrella of probably several different entities with common symptoms,some of which seem to share striking similarities with human *** review will focus on the actual knowledge of IBD in dogs,and attempt to identify differences and similarities with human IBD conditions.

关键词： Colitis Dog Inflammatory bowel diseases

Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies

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World Journal of Gastroenterology 2007年第30期13卷 4035-4041页

作者： Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas elisabetta Antonelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Italy 2nd Pathology Department Spedali Civili Brescia Italy Department of Surgery Liestal Hospital Switzerland Department of Pathology Liestal Hospital Switzerland

The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies.

关键词： Enteric glia Glial cells Gastrointestinal motility

Double tracer PET/CT:what is it and what does it mean?

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 321-328页

作者： Mattia Pellicciari Silvia Ortolani elisabetta Grego Giampaolo Tortora Sara Cingarlini Department of Clinical Oncology Comprehensive Cancer NetworkG.B.Rossi University HospitalUniversity of Verona37134 VeronaItaly

^(68)Ga-DOTA-peptide PET/CT is a recommended imaging modality in the workup of neuroendocrine neoplasms(NENs),which shows high diagnostic sensitivity and is a strong predictor of successful somatostatin receptor directed *** not routinely recommended,reliable evidences show that^(18)F-FDG PET/CT can provide complementary information in this setting with the ability to discriminate slow-proliferating tumors from aggressive,rapidly-proliferating ***,it has been proposed as an independent prognostic factor for the prediction of either overall survival or progression free *** this review,we provide insight into the biologic significance of ^(68)Ga-DOTA-peptides and ^(18)F-FDG uptake,and of the use of double tracer(^(68)Ga-DOTA-peptides plus ^(18)F-FDG)PET/CT in the clinical evaluation of patients affected by NENs.

关键词： 68Ga-DOTATOC PET/CT ^(18)F-FDG PET/CT neuroendocrine neoplasms

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression