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Gastrointestinal motility disorders in inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第1期20卷 37-44页

作者： Gabrio Bassotti elisabetta antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola Vito Annese Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineUniversity of Perugia06156 PerugiaItaly Second Pathology Section Spedali Civili of Brescia25100 BresciaItaly Gastroenterology Unit Careggi University Hospital50134 FlorenceItaly

The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic, environmental, immunological and microbial predisposing factors. In addition, significant symptom overlapping may occur, muddling the waters within the clinical context. Although on one hand this represents a challenge for the clinician for a potential under- or over-treatment and diagnostic delay, on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic (often low-grade) inflammation, motor disorders and deranged sensory function. The best example is probably represented by Crohn’s disease and ulcerative colitis. In fact, a number of gastrointestinal motor disorders have been described in association with these diseases, disorders which span from the esophagus to the anorectum, and which will be extensively covered in this review. It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes; however, given the high prevalence of functional gastrointestinal disorders in the general population, this overlap might also be serendipitous. However, it is worth noting that literature data on this topic are relatively scarce, sometimes quite outdated, and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease. Nevertheless, both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease, correlate with greater psychological comorbidity and poorer quality of life, and may negatively influence the therapeutic approaches.

关键词： Crohn’ s disease, Gastrointestinal motility disorders, Gut, Inflammatory bowel diseases, Perception, Ulcerative colitis

Histological healing in inflammatory bowel disease:A still unfulfilled promise

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World Journal of Gastroenterology 2013年第7期19卷 968-978页

作者： Vincenzo Villanacci elisabetta antonelli Karel Geboes Giovanni Casella Gabrio Bassotti Department of Pathology Spedali Civili of Brescia25100 BresciaItaly Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineUniversity of Perugia06156 PerugiaItaly Department of Pathology University Hospital KU Leuven and UZ Gent3000 LeuvenBelgium Division of Internal Medicine Desio General Hospital20033 DesioItaly

Treatment of inflammatory bowel disease(IBD) is traditionally based on several drugs,including salicylates,corticosteroids,and antibiotics;in addition,the therapeutic armamentarium has considerably evolved with the advent of newer,effective therapeutic measures(such as the biological agents) that are able to improve in a considerable manner both the clinical and endoscopic ***,mucosal healing,at least considered from an endoscopic point of view,is today regarded as the ultimate endpoint for treatment of these ***,it is also increasingly clear that endoscopic healing is not necessarily paralleled by histological healing;There are few doubts that the latter should be considered as a true,objective healing and the ultimate goal to reach when treating patients with ***,and surprisingly,only a few,incomplete,and somewhat conflicting data exist on this topic,especially because there is still the need to standardize both histological assessment and the severity grading of these disorders;Issues that have not been yet been resolved for clinical practice and therapeutic ***,with the help of an increased awareness on the clinical researchers' side,and the availability of dedicated pathologists on the other side,this matter will be effectively faced and resolved in the near future.

关键词： Crohn’s disease Healing Histology Inflammatory bowel diseases Ulcerative colitis

Inflammatory bowel disease in the dog:Differences and similarities with humans

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World Journal of Gastroenterology 2010年第9期16卷 1050-1056页

作者： Matteo Cerquetella Andrea Spaterna Fulvio Laus Beniamino Tesei Giacomo Rossi elisabetta antonelli Vincenzo Villanacci Gabrio Bassotti School of Medical Veterinary Sciences University of CamerinoVia Circonvallazione Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineSanta Maria della Misericordia Hospital 2nd Department of Pathology Spedali Civili of BresciaPiazza Spedali Civili

Inflammatory bowel diseases (IBD) represent important chronic conditions affecting the gastrointestinal tract in ***,similar disorders are found in several animal species and the IBD affecting dogs are particularly *** are encompassed by an umbrella of probably several different entities with common symptoms,some of which seem to share striking similarities with human *** review will focus on the actual knowledge of IBD in dogs,and attempt to identify differences and similarities with human IBD conditions.

关键词： Colitis Dog Inflammatory bowel diseases

Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies

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World Journal of Gastroenterology 2007年第30期13卷 4035-4041页

作者： Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas elisabetta antonelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Italy 2nd Pathology Department Spedali Civili Brescia Italy Department of Surgery Liestal Hospital Switzerland Department of Pathology Liestal Hospital Switzerland

The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies.

关键词： Enteric glia Glial cells Gastrointestinal motility