Histological healing in inflammatory bowel disease:A still unfulfilled promise

作     者：Vincenzo Villanacci Elisabetta Antonelli Karel Geboes Giovanni Casella Gabrio Bassotti 

作者机构：Department of PathologySpedali Civili of Brescia25100 BresciaItaly Gastroenterology and Hepatology SectionDepartment of Clinical and Experimental MedicineUniversity of Perugia06156 PerugiaItaly Department of PathologyUniversity Hospital KU Leuven and UZ Gent3000 LeuvenBelgium Division of Internal MedicineDesio General Hospital20033 DesioItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第7期

页      面：968-978页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Crohn’s disease Healing Histology Inflammatory bowel diseases Ulcerative colitis 

摘      要：Treatment of inflammatory bowel disease(IBD) is traditionally based on several drugs,including salicylates,corticosteroids,and antibiotics;in addition,the therapeutic armamentarium has considerably evolved with the advent of newer,effective therapeutic measures(such as the biological agents) that are able to improve in a considerable manner both the clinical and endoscopic ***,mucosal healing,at least considered from an endoscopic point of view,is today regarded as the ultimate endpoint for treatment of these ***,it is also increasingly clear that endoscopic healing is not necessarily paralleled by histological healing;There are few doubts that the latter should be considered as a true,objective healing and the ultimate goal to reach when treating patients with ***,and surprisingly,only a few,incomplete,and somewhat conflicting data exist on this topic,especially because there is still the need to standardize both histological assessment and the severity grading of these disorders;Issues that have not been yet been resolved for clinical practice and therapeutic ***,with the help of an increased awareness on the clinical researchers side,and the availability of dedicated pathologists on the other side,this matter will be effectively faced and resolved in the near future.