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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz elisa lopez-dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2013年第1期19卷 17-25页

作者： Elena Garrido elisa Carrera Rebeca Manzano Antonio lopez-Sanroman Inflammatory Bowel Disease Clinic Department of GastroenterologyUniversity Hospital Ramón y Cajal28034 MadridSpain Department of Gastroenterology University Hospital of Guadalajara19002 GuadalajaraSpain Department of Gastroenterology Hospital Sureste28500 MadridSpain

Cytomegalovirus(CMV) infection is common in *** virus then enters a "latency phase" and can reactivate to different stimuli such as *** clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of ***,CMV reactivation is frequent in severe or steroid-resistant *** is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe *** methods are used to diagnose CMV *** is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being *** chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic *** endoscopic features have not been described in active UC and CMV *** colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive *** antiviral drugs may be *** controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment.

关键词： Cytomegalovirus Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hematoxylin and eosin Immunohistochemical Polymerase chain reaction Ganciclovir Infectious colitis

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Assessing stakeholders'perceptions and values towards social-ecological systems using participatory methods

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Ecological Processes 2014年第1期3卷 31-42页

作者： Grace B Villamor Ignacio Palomo Cesar A lopez Santiago elisa Oteros-Rozas Joe Hill Department of Ecology and Natural Resources Management Center for Development Research(ZEF)University of Bonn53113BonnGermany World Agroforestry Centre(ICRAF) Jl.Situ Gede16115 BogorIndonesia Basque Centre for Climate Change(BC3) Alameda Urquijo 448008 BilbaoSpain Department of Ecology Social-Ecological Systems LaboratoryUniversidad Autónoma de MadridMadrid 28049Spain Department of Political and Cultural Change Center for Development Research(ZEF)University of Bonn53113 BonnGermany

Introduction:Many conservation initiatives for managing social-ecological landscapes factor in the best available biophysical ***,insufficient consideration of social aspects can render such initiatives *** incorporating stakeholders'perceptions and values,and by involving stakeholders(transparently)in decision-making processes,conservation plans and efforts can better achieve desired goals and ***:In this paper,we present and analyze three case studies within different ecological and land use *** case study uses different participatory approaches to elicit stakeholders'perceptions and values,while seeking to involve stakeholders in the decision-making *** case studies are the following:(1)participatory scenario planning for a protected area in Doñana coastal wetland in Southwestern Spain;(2)assessment of ecosystem services trade-offs and social responses on rewards for agro-biodiversity in the rubber agroforest landscape in Jambi,Indonesia;and(3)socio-cultural evaluation,through visual stimuli,of ecosystem services provided by transhumance cultural landscapes in Central *** discuss how stakeholders perceive and value their environments and to what extent participatory approaches are useful for capturing information relating to land use and ecological ***:Social-ecological systems are inherently complex,having a variety of interacting actors with different types of ecological knowledge,interests,and *** participatory tools or approaches are appropriate for various and specific contexts and *** and integrating the various types of knowledge and values of different actors can contribute to a more comprehensive understanding of social-ecological systems.

关键词： Actors Ecosystem services Ecological knowledge Social processes Socio-cultural valuation Values

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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio Ilaria Venezia Licia Pensabene elisa Blasi Donato Rigante Paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

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Fractions of a chloroform extract of ajenjo leaves (Artemisiamendozana DC. var. mendozana) inhibit the proliferation,viability and clonogenicity of B16-F0 melanoma cells

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BIOCELL 2020年第3期44卷 293-299页

作者： MARÍA elisa MILLÁN MARÍA FERNANDA MARRA LEONARDO ANDRÉS SALVARREDI EMILIO FERNANDO LIZARRAGA LUIS ALBERTO lopez Universidad Nacional de Cuyo MendozaArgentina Comisión Nacional de Energía Atómica Buenos AiresArgentina Fundación Escuela de Medicina Nuclear MendozaArgentina Fundación Miguel Lillo y Universidad Nacional de Tucumán San Miguel de TucumánArgentina

The ajenjo,Artemisia mendozana ***(Asteraceae),grows in the Andean foothills of Mendoza and San Juan,Argentina,and is used as a medicinal plant for its antispasmodic and antifungal *** aim of this work was to obtain fractions of a chloroform extract of ajenjo leaves and to evaluate the in vitro effects on proliferation,viability and clonogenicity of B16-F0 melanoma *** a silica gel chromatography column,120 fractions were collected and grouped according to the chromatographic profile in 9 main fractions(F1–F9).Their major compounds identified were:terpenes(F1),terpenes and sesquiterpene lactones(F2–F3),sesquiterpenes(F4–F6)and phenols and sesquiterpenes(F7-9).B16-F0 cells were incubated for 72 h with DMSO(vehicle)or 0.1 mg/ml F1–*** 72 h of culture,F1 decreased both the growing index(GI)and cell viability.F2 and F3 both decreased GI and only F3 decreased clonogenic activity.F4 and F5 both decreased *** F5 decreased cell viability and F4 decreased ***,fractions F6–F8 did not affect any of the cell parameters assayed,while F9 decreased cell viability and inhibited clonogenicity.

关键词： Terpenes Sesquiterpene lactones Sesquiterpenes Phenols

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Multi-family therapy for veteran and refugee families: a Delphi study

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Military Medical Research 2019年第1期6卷 39-44页

作者： elisa van Ee Psychotraumacentrum Zuid Nederland Behavioural Science Institute Radboud University

Background: Research indicates that Posttraumatic stress disorder(PTSD) has an extensive impact on family relationships. Nevertheless, there is a dearth of empirically supported interventions addressing family functioning and PTSD. In the Netherlands, it is considered good clinical practice to offer multi-family therapy(MFT) to veteran and refugee families. MFT for traumatized families aims to address the dysfunctional family patterns that have evolved to address the consequences with ***: The aim of this study is to generate a common framework for the practical impact and active ingredients of MFT in families confronted with trauma. The Delphi method was used to study the expert opinion of 11 therapists in Dutch expert trauma ***: The results indicate that MFT is a promising treatment for families dealing with the consequences of trauma. According to experts, positive outcomes include an increased understanding between family members,particularly visible in the de-escalation of conflicts within the family, and improved parenting. One explanation for the effectiveness of MFT with these target groups is its defining feature of therapy with several ***: The findings support the importance of considering family relationships and the family context in interventions for traumatized individuals.

关键词： PTSD Veteran Refugee Multi-family therapy Parenting Expert opinion

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Over-specialization versus synergy in neuroscience:professionals’integration is more than the sum of its parts

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Neural Regeneration Research 2021年第11期16卷 2232-2233页

作者： elisa Cainelli Luca Vedovelli Department of General Psychology University of PadovaPadovaItaly Unit of Biostatistics Epidemiology and Public HealthDepartment of CardiacThoracicVascular Sciencesand Public HealthUniversity of PadovaPadovaItaly

Health care systems in industrialized countries are built around acute health problems(Etzwiler,1997).This approach is successful when the goal is to improve or overcome pathologies that result in severe health issues or *** the recent tremendous improvement of the treatments of life-threatening conditions,the clinical focus has moved from short term results to the overall expected quality of life and longterm ***,the new objectives imply to consider a multitude of interacting processes and *** fact,a complex interplay of biological systems(nervous,immune,and endocrine)works together in an integrated and synergistic way to deal with a constantly evolving environment,determining our physical,behavioral,and psychological/subjective *** interplay is the mechanism that allows us to adapt promptly and appropriately to circumstances,the key feature for successful living.

关键词： overcome synergistic determining

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How do stream processes affect hazard exposure on alluvial fans? Insights from an experimental study

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Journal of Mountain Science 2020年第4期17卷 753-772页

作者： Bruno MAZZORANA elisa GHIANDONI Lorenzo PICCO Universidad Austral de Chile Faculty of SciencesInstituto de Ciencias de la Tierra5090000 ValdiviaChile Universidad Austral de Chile RINA–Natural and Anthropogenic Risks Research Center5090000 ValdiviaChile Universidad Austral de Chile Laboratory of HydromorphologyFaculty of Forest Sciences and Natural Resources5090000 ValdiviaChile University of Padova Department of LandEnvironmentAgriculture and Forestry35020 LegnaroItaly

Alluvial fans are among the most privileged settlement areas in many mountain regions. These landforms are particularly dynamic being episodically affected by distributary processes generated by extreme flood events. Addressing risk assessment entails determining hazard exposure and unravelling how it might be related to process loading and to process dynamics once the flow becomes unconfined on the surface of alluvial fans. By following a ‘similarity of process concept’, rather than by attempting to scale a real-world prototype, we performed a set of 72 experimental runs on an alluvial fan model. Thereby, we considered two model layouts, one without a guiding channel and featuring a convex shape and the other one with a guiding channel, a bridge, and inclined but planar overland flow areas as to mirror an anthropic environment. Process magnitude and intensity parameters were systematically varied, and the associated biphasic distributary processes video recorded. For each experiment, the exposure was detected by mapping the exposed area in a GIS, thereby discerning between areas exposed to biphasic flows and the associated depositional phenomena or to the liquid flow phase only. Our results reveal that total event volume, sediment availability and stream power in the feeding channel, as well as depositional effects, avulsion, and channelization on the alluvial fan concur to determine the overall exposure. Stream process loading alone, even when rigorously defined in terms of its characterizing parameters, is not sufficient to exhaustively determine exposure. Hence, further developing reliable biphasic simulation models for hazard assessment on settled alluvial fans is pivotal.

关键词： Alluvial fan Hazard Exposure Flood risk Experimental model Process similarity

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Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods

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World Journal of Gastroenterology 2014年第37期20卷 13325-13342页

作者： Emilio Marengo elisa Robotti Department of Sciences and Technological Innovation University of Piemonte Orientale

Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this f

关键词： Pancreatic cancer Biomarker identification Multivariate analysis Principal component analysis Ranking principal component analysis

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Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells

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World Journal of Stem Cells 2021年第8期13卷 1094-1111页

作者： Victoria Dupuis elisa Oltra Facultédes Sciences et d’Ingénierie Sorbonne UniversitéParis 75252France Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

Mesenchymal stem cells(MSCs)have received significant attention in recent years due to their large potential for cell ***,they secrete a wide variety of immunomodulatory factors of interest for the treatment of immune-related disorders and inflammatory *** can be extracted from multiple tissues of the human ***,several factors may restrict their use for clinical applications:the requirement of invasive procedures for their isolation,their limited numbers,and their heterogeneity according to the tissue of origin or *** addition,MSCs often present early signs of replicative senescence limiting their expansion in vitro,and their therapeutic capacity in *** to the clinical potential of MSCs,a considerable number of methods to differentiate induced pluripotent stem cells(iPSCs)into MSCs have *** represent a new reliable,unlimited source to generate MSCs(MSCs derived from iPSC,iMSCs)from homogeneous and well-characterized cell lines,which would relieve many of the above mentioned technical and biological ***,the use of iPSCs prevents some of the ethical concerns surrounding the use of human embryonic stem *** this review,we analyze the main current protocols used to differentiate human iPSCs into MSCs,which we classify into five different categories:MSC Switch,Embryoid Body Formation,Specific Differentiation,Pathway Inhibitor,and Platelet *** also evaluate common and method-specific culture components and provide a list of positive and negative markers for MSC *** guidance on material requirements to produce iMSCs with these methods and on the phenotypic features of the iMSCs obtained is *** information may help researchers identify protocol options to design and/or refine standardized procedures for large-scale production of iMSCs fitting clinical demands.

关键词： Mesenchymal stem cells Induced pluripotent stem cells Mesenchymal stem cells derived from induced pluripotent stem cells Differentiation methods Culture components Mesenchymal stem cell markers

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