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Determination of the physical and interaction properties of sorghum grains:Application to computational fluid dynamics-discrete element method simulations of the fluid dynamics of a conical spouted bed

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Particuology 2021年第1期19卷 91-101页

作者： J.N.m.Batista D.A.santos R.Bettega Federal University of São Carlos Department of Chemical EngineeringSPBrazil Institute of Chemistry Federal University of GoiásGOBrazil

Computational simulation is an important tool for design and improvement of industrial *** fluid dynamics(CFD)coupled with the discrete element method(DEm)has been applied to simulate drying equipment that usually involves gas-solid *** reliable results of CFD-DEm simulations,the properties related to the interactions of the material within the industrial equipment,such as the restitution or friction coefficients,must be *** this study,CFD-DEm was applied to simulate the fluid dynamics inside a conical spouted bed operating with sorghum *** physical properties of the particulate phase and the particle-particle and particle-wall interaction parameters were determined by the direct measurement approach and applied to *** interaction parameters were experimentally determined,including the particle-particle interaction parameters ofη=0.46,μ^(S)=0.79,andμ_(R)=0.70,and the particle-wall interaction parameters ofη=0.56,μ_(S)=0.75,andμ_(R)=*** simulated minimum spouting velocity and characteristic curves were compared with the experimental *** was good agreement between the simulated and experimental results.

关键词： Restitution coefficient Static friction coefficient Rolling friction coefficient CFD DEm

Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer Vaccines

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 25-43页

作者： José Alexandre Ferreira marta Relvas-santos Andreia Peixoto Andrém.N.Silva Lúcio Lara santos Experimental Pathology and Therapeutics Group Portuguese Institute of OncologyPorto 4200-072Portugal Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal Porto Comprehensive Cancer Center(P.ccc) Porto 4200-072Portugal REQUImTE-LAQV Department of Chemistry and BiochemistryFaculty of Sciences of the University of PortoPorto 4169-007Portugal

molecular-assisted precision oncology gained tremendous ground with high-throughput next-generation sequencing(NGS),supported by robust *** quest for genomicsbased cancer medicine set the foundations for improved patient stratification,while unveiling a wide array of neoantigens for *** pre-clinical and clinical studies have successfully used tumor-specific peptides in vaccines with minimal off-target ***,the low mutational burden presented by many lesions challenges the generalization of these solutions,requiring the diversification of neoantigen *** utilizing customized databases for protein annotation by mass spectrometry(mS)is a powerful tool toward this *** the concept toward exploring proteoforms originated from post-translational modifications(PTms)will be decisive to improve molecular subtyping and provide potentially targetable functional nodes with increased cancer *** through the path of systems biology,we highlight that alterations in protein glycosylation at the cell surface not only have functional impact on cancer progression and dissemination but also originate unique molecular fingerprints for targeted ***,we discuss the outstanding challenges required to accommodate glycoproteomics in oncoproteogenomics *** envisage that such rationale may flag a rather neglected research field,generating novel paradigms for precision oncology and immunotherapy.

关键词： Glycoproteogenomics Oncoproteogenomics Cancer neoantigens Glycosylation Precision oncology

Skew Pairs of Idempotents in Transformation Semigroups

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Acta mathematica Sinica,English Series 2006年第6期22卷 1705-1714页

作者： T.S.BLYTH m.H.ALmEIDA santos mathematical Institute University of St Andrews Departamentode matemática F.C.T.Universidade Nova de Lisboa

An ordered pair （e, f） of idempotents of a regular semigroup is called a skew pair if ef is not idempotent whereas fe is idempotent. We have shown previously that there are four distinct types of skew pairs of idemp... 详细信息

关键词： full transformation semigroups idempotents skew pairs

Validation of kinetic modeling of progesterone release from polymeric membranes

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 54-62页

作者： Analia Irma Romero mercedes Villegas Alicia Graciela Cid mónica Liliana Parentis elio Emilio Gonzo José maría Bermúdez Instituto de Investigaciones para la Industria Química Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas Facultad de Ingeniería Universidad Nacional de Salta

mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone(Prg) controlled release from poly-3-hydroxybutyric acid(PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion(AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found,which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.

关键词： mathematical models model validation Drug delivery/release mass transfer coefficient Equilibrium distribution constant

Cataracting-centrifuging transition investigation using nonspherical and spherical particles in a rotary drum through CFD simulations

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Particuology 2022年第1期20卷 48-60页

作者： Wanessa m.Benedito Claudio R.Duarte marcos A.S.Barrozo Dyrney A.santos Institute of Chemistry Federal University of Goias-UFGCampus SamambaiaGoianiaGO74690-900Brazil School of Chemical Engineering Federal University of Uberlandia-UFUCampus Santa MonicaUberlandiaMG38408-144Brazil

This paper aims to systematically investigate the cataracting-centrifuging transition in a rotary drum involving spherical and nonspherical particles by using the multiphase Granular Eulerian model(mGEm).The effects of drum length and particle shape on the cataracting-centrifuging transition behavior were *** results showed that drum length plays an important role in the cataracting-centrifuging transition,although most related works in the literature do not consider *** particle shape also significantly affects the cataracting-centrifuging transition *** particles required lower rotation speeds than spherical particles to reach the centrifuging *** particle shape was shown to be related to the critical solid fraction(asc)from Schaeffer’s model,although further investigations are required to completely correlate particle spherecity with critical solid volume fractions.

关键词： Frictional viscosity mGEm model Particle shape Drum length Drum flow regimes

Paraneoplastic leukemoid reaction in pancreatic cancer: A case report

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 259-262页

作者： mélanie Dos santos Karine Bouhier manh-Thong Dao Department of Gastroenterology CHU de Caen

Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter(G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/L without identified infectious, iatrogenic or hematologic causes. His overall condition quickly degraded and he died three weeks after the discovery of the leukemoid reaction. This is the first case in French literature of leukemoid reaction in a patient with pancreatic carcinoma with poor prognostic value.

关键词： Leukemoid reaction Pancreatic neoplasms Paraneopla

Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

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Journal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： Joao Pedro A.santos manuel J.Pinzón érick A.santos Rafael Vicentini Cesar J.B.Pagan Leonardo m.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T mesoporous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) Raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

methanol oxidation in acidic and alkaline electrolytes using PtRuIn/C electrocatalysts prepared by borohydride reduction process

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燃料化学学报 2018年第12期46卷 1462-1471页

作者： santos m.C.L. Nandenha J. Ayoub J.m.S. Assumpao m.H.m.T. Neto A.O. Instituto de Pesquisas Energéticas e Nucleares IPEN/CNEN-SPAv.Prof.Lineu Prestes2242 Cidade UniversitáriaCEP 05508-000Sao PauloSPBrazil Universidade Federal de Sao Carlos UFSCar Campus Lagoa do Sino Rodovia Lauri Simoes de Barros Km 12 CEP 18290-000-Buri-Sao Paulo SP Brazil

PtRuIn/C electrocatalysts( 20% metal loading by weight) were prepared by sodium borohydride reduction process using H_2PtCl6·6H_2O,RuCl_3·xH_2O and InCl_3·xH_2O as metal sources,borohydride as reducing agent and Carbon Vulcan XC72 as support. The synthetized PtRuIn/C electrocatalysts were characterized by X-ray diffraction( XRD),energy dispersive analysis( EDX),transmission electron microscopy( TEm),cyclic voltammetry( CV),chronoamperommetry( CA) and polarization curves in alkaline and acidic electrolytes( single cell experiments). The XRD patterns showPtpeaks are attributed to the face-centered cubic( fcc) structure,and a shift of Pt( fcc) peaks indicates that Ru or In is incorporated into Ptlattice. TEmmicrographs showmetal nanoparticles with an average nanoparticle size between 2.7 and 3.5 nm. methanol oxidation in acidic and alkaline electrolytes was investigated at room temperature,by CV and CA. PtRu/C( 50 ∶ 50) shows the highest activity among all electrocatalysts in study considering methanol oxidation for acidic and alkaline electrolyte. Polarization curves at 80 ℃ showPtRuIn/C( 50 ∶ 25 ∶ 25)with superior performance for methanol oxidation,when compared to Pt/C,PtIn/C and PtRu/C for both electrolytes. The best performance obtained by PtRuIn/C( 50 ∶ 25 ∶ 25) in real conditions could be associated with the increased kinetics reaction and/or with the occurrence simultaneously of the bifunctional mechanism and electronic effect resulting from the presence of Ptalloy.

关键词： borohydride reduction process PtRuIn/C electrocatalysts methanol oxidation acidic and alkaline electrolytes polarization curves

The USLE soil erodibility nomograph revisited

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International Soil and Water Conservation Research 2023年第1期11卷 1-13页

作者： Eva Corral-Pazos-de-Provens ígor Rapp-Arraras Juan m.Domingo-santos School of Engineering University of HuelvaE-21007 HuelvaSpain

The nomograph by Wischmeier et al.(1971)for calculating the K-factor in the USLE was extremely useful when there was low access to ***,the generalised calculation of this factor requires the development of analytic *** paper presents a detailed analysis of the nomograph and its underlying equation,which is applicable only when the silt plus very find sand fraction does not exceed 70%.We also examined the quality of fit on the nomograph of the adaptations to the equation that have been proposed,as a means of dealing with those areas where the original equation is not *** models are shown to have areas where the fit is deficient or even ***,the family of curves on the nomograph for the various values taken by the organic matter are not coincident with the mathematical function from which they presumably *** study also identifies those areas of the textural triangle in which the soils originally used in developing the USLE are located,with a view to according a lower predictive value to the contrasting areas in which calculations of the K-factor will necessarily be ***,a new equation for calculating the K-factor is presented,which accurately reproduces the different sections of the nomograph,and allows the poorly functioning graph to be dispensed *** paper ends with a link to a tool in R for simplifying the procedure for calculating the K-factor,taking into account varying situations of data availability.

关键词： K-factor RUSLE Soil texture Organic matter Very find sand Soil loss prediction