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Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi Laurenz Thomsen Sascha Flögel Nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon Sergio Stefanni Jordi Grinyó Emanuela Fanelli Cinzia Corinaldesi Joaquin Del Rio Fernandez Marcello Calisti Furu Mienis elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal Netherlands Institute for Sea Research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

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男性雄激素性脱发患者毛囊皮脂腺单位的转录组学分析显示其细胞间连接网络发生改变

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中华皮肤科杂志 2024年第10期57卷 967-967页

作者： elias Bou Samra Yann Franck Mahé Mickael Le Balch Nükhet Cavusoglu Pierre Bouhanna Khalid Bakkar L'Oréal Research and Innovation Aulnay-sous-Bois France Bouhanna Hair Transplant Clinic Paris France

随着研究的不断深入,越来越多的证据表明,脱发的发病机制涉及多种生理途径,包括引起直接损伤的炎症细胞因子和趋化因子、调节形态发生的以Wnt/β-联蛋白(catenin)为主的信号通路以及系统性炎症和脂质代谢相关通路。根据个体的遗传背景... 详细信息

随着研究的不断深入,越来越多的证据表明,脱发的发病机制涉及多种生理途径,包括引起直接损伤的炎症细胞因子和趋化因子、调节形态发生的以Wnt/β-联蛋白(catenin)为主的信号通路以及系统性炎症和脂质代谢相关通路。根据个体的遗传背景、生活方式、性别和年龄,上述效应因子和靶点先后被不同程度地激活。因此,深入解析脱发患者特异性的病理生理机制,对于制定精准的治疗方案尤为重要。

关键词：病理生理机制雄激素性脱发炎症细胞因子细胞间连接系统性炎症趋化因子脂质代谢形态发生

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Real-time calculation of fragment velocity for cylindrical warheads

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Defence Technology（防务技术） 2019年第3期15卷 264-271页

作者： David Felix Ian Colwill elias Stipidis Institution of Engineering and Technology Stevenage England Member of British Computer Society London Institute of Electrical and Electronics Engineers London

To simulate explosion fragments, it is necessary to predict many variables such as fragment velocity, size distribution and projection angle. For active protection systems these predictions need to be made very quickly, before the weapon hits the target. Fast predictions also need to be made in real time simulations when the impact of many different computer models need to be assessed. The research presented in this paper focuses on creating a fast and accurate estimate of one of these variables - the initial fragment velocity. The Gurney equation was the first equation to calculate initial fragment velocity. This equation, sometimes with modifications, is still used today where finite element analysis or complex mathematical approaches are considered too computationally expensive. This paper enhances and improves Breech’s two-dimensional Gurney equation using available empirical data and the principals of conservation of momentum and energy. The results are computationally quick, providing improved accuracy for estimating initial fragment velocity. This will allow the developed model to be available for real-time simulation and fast computation, with improved accuracy when compared to existing approaches.

关键词： Initial fragment velocity Real-time simulation Cylindrical explosion

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Young blood products:emerging treatment for Alzheimer's disease?

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Neural Regeneration Research 2018年第4期13卷 624-627页

作者： Rita Khoury elias Ghossoub Department of Psychiatry and Behavioral Neuroscience Saint Louis University

Alzheimer＇s disease is the most common neurodegenerative disorder and no disease-modifying treatment is currently *** has shown that while brain neurogenesis continues in adult life,it declines with *** parabiosis,plasma transfusions and direct administration of neural growth factors,animal studies have demonstrated the positive impact of exposure to young blood products on neurogenesis and synaptic plasticity in an aging *** hippocampus and the sub-ventricular zones were identified as the main regions *** findings have prompted researchers to experiment their effects in subjects with an established neurocognitive disorder,such as Alzheimer＇s *** argued that modification of brain vasculature,reactivation of adult neural stem cells,and remodeling of their synaptic activity/plasticity may lead to cognitive enhancement and increased *** pilot human study found that young donor plasma infusion protocols for adults with Alzheimer＇s disease were safe and feasible;however,no statistically significant improvements in cognition were *** is a need to conduct additional placebo-controlled human studies in larger *** studies should focus on identifying an “optimal age” at which an intervention in humans may yield significant cognitive enhancement,as well as determining the types of transfusions with the best efficacy and tolerability profiles.

关键词： young blood rejuvenation cognition Alzheimer's disease plasma transfusion aging neurogenesis

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Selective serotonin reuptake inhibitors and Alzheimer’s disease

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Neural Regeneration Research 2020年第1期15卷 41-46页

作者： Bernadette Mdawar elias Ghossoub Rita Khoury Department of Psychiatry American University of Beirut Medical CenterBeirutLebanon Department of Psychiatry and Behavioral Neuroscience Saint Louis University School of MedicineSt.LouisMOUSA

Given the failure to develop disease-modifying therapies for Alzheimer’s disease(AD),strategies aiming at preventing or delaying the onset of the disease are being *** the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on,a key determining factor may be the timing of depression onset in older *** is increasing evidence that untreated early-onset depression is a risk factor and that late-onset depression may be a catalyst of cognitive *** from animal studies have shown a beneficial impact of selective serotonin reuptake inhibitors on pathophysiological biomarkers of AD including amyloid burden,tau deposits and *** humans,studies focusing on subjects with a prior history of depression also showed a delay in the onset of AD in those treated with most selective serotonin reuptake ***,which has strong anticholinergic properties,was associated with increased mortality and mixed effects on amyloid and tau deposits in mice,as well as increased odds of developing AD in *** most of the data regarding selective serotonin reuptake inhibitors is promising,findings should be interpreted cautiously because of notable methodological heterogeneity between *** is thus a need to conduct large scale randomized controlled trials with long follow up periods to clarify the dose-effect relationship of specific serotonergic antidepressants on AD prevention.

关键词： Alzheimer’s disease amyloidogenesis animal models antidepressant depression onset delay prevention selective serotonin reuptake inhibitor SSRI

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Intestinal microbiota and its interaction to intestinal health in nursery pigs

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Animal Nutrition 2022年第1期8卷 169-184页

作者： Marcos elias Duarte Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC27695United States

The intestinal microbiota has gained increased attention from researchers within the swine industry due to its role in promoting intestinal maturation,immune system modulation,and consequently the enhancement of the health and growth performance of the *** review aimed to provide updated scientific information on the interaction among intestinal microbiota,dietary components,and intestinal health of *** small intestine is a key site to evaluate the interaction of the microbiota,diet,and host because it is the main site for digestion and absorption of nutrients and plays an important role within the immune *** diet and its associated components such as feed additives are the main factors affecting the microbial composition and is central in stimulating a beneficial population of *** microbiotaehost interaction modulates the immune system,and,concurrently,the immune system helps to modulate the microbiota *** direct interaction between the microbiota and the host is an indication that the mucosa-associated microbiota can be more effective in evaluating its effect on health *** was demonstrated that the mucosa-associated microbiota should be evaluated when analyzing the interaction among diets,microbiota,and *** addition,supplementation of feed additives aimed to promote the intestinal health of pigs should consider their roles in the modulation of mucosa-associated microbiota as biomarkers to predict the response of growth performance to dietary interventions.

关键词： Intestinal health Mucosa-associated microbiota Nursery pig

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Effect of TiO_2 nanoparticles on hydrogen evolution reaction activity of Ni coatings

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International Journal of Minerals,Metallurgy and Materials 2018年第4期25卷 472-479页

作者： Revanna Kullaiah Liju elias Ampar Chitharanjan Hegde Electrochemistry Research Lab Department of Chemistry National Institute of Technology Karnataka

The electrocatalytic activity of electrodeposited Ni and Ni–TiO2 coatings with regard to the alkaline hydrogen evolution reaction（HER） was investigated. The Ni coatings were electrodeposited from an acid chloride bath at different current densities, and their HER activities were examined in a 1.0-mol·L^-1 KOH medium. The variations in the HER activity of the Ni coatings with changes in surface morphology and composition were examined via the electrochemical dissolution and incorporation of nanoparticles. Electrochemical analysis methods were used to monitor the HER activity of the test electrodes; this activity was confirmed via the quantification of gases that evolved during the analysis. The obtained results demonstrated that the Ni–TiO2 nanocomposite test electrode exhibited maximum activity toward the alkaline HER. The surface appearance, composition, and the phase structure of all developed coatings were analyzed using scanning electron microscopy（SEM）, energy dispersive spectroscopy（EDS）, and X-ray diffraction（XRD）, respectively. The improvement in the electrocatalytic activity of Ni–TiO2 nanocomposite coating toward HER was attributed to the variation in surface morphology and increased number of active sites.

关键词： coatings electrodeposition nanocomposite electrocatalysis

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Pathogenesis of primary biliary cirrhosis: A unifying model

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World Journal of Gastroenterology 2006年第15期12卷 2320-2327页

作者： elias Kouroumalis George Notas Laboratory of Gastroenterology and Hepatology University of Crete Faculty of MedicineHeraklion 71003Greece

Primary biliary cirrhosis （PBC） is a disease of unknown etiology leading to progressive destruction of small intrahepatic bile ducts and eventually to liver cirrhosis and failure. It is characterised by female predominance and serum auto-antibodies to mitochondrial antigens targeting the E2 components of the 2-oxoacid dehydrogenase complex. Although they are associated with disease pathogenesis, no concrete evidence has been presented so far. Epidemiological data indicate that a geographical clustering of cases and possible environmental factors are implicated in pathogenesis. A number of genetic factors play a role in determining disease susceptibility or progression, although no definitive conclusion has been reached so far. A key factor to immune pathogenesis is considered to be the breakdown of immune tolerance, either through molecular mimicry or through the so called determinant density model. In this review, the available data regarding the pathogenesis of primary biliary cirrhosis are described and discussed. A new unifying hypothesis based on early endothelin overproduction in primary biliary cirrhosis （PBC） is presented and discussed.

关键词： Primary biliary cirrhosis Pathogenesis

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Effects of seed moisture content, stratification and sowing date on the germination of Corylus avellana seeds

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Journal of Forestry Research 2020年第3期31卷 743-749页

作者： elias Pipinis Athanasios Stampoulidis elias Milios Kyriaki Kitikidou Sofia Akritidou Stavroula Theodoridou Kalliopi Radoglou School of Forestry and Natural Environment Aristotle University of Thessaloniki54124 ThessalonikiGreece Department of Forestry and Management of the Environment and Natural Resources Democritus University of ThracePandazidou 19368200 OrestiadaGreece 67133 Dioikitirio XanthiPrefecture of XanthiGreece

For Corylus avellana, pericarp permeability,seed desiccation tolerance, and the effect of warm and cold moist stratification combinations on germination and of outdoor sowing date on dormancy breaking and seedling emergence were investigated. Seeds with(intact fruit nut)and without the pericarp were subjected to an imbibition test, and water uptake was measured. After nuts had been stored for 5 months at 3–5℃, seeds and desiccated seeds were cold-stratified at 3–5 ℃(for 0, 1, 2 or 3 months),then tested for germination. Nuts were warm-stratified at 20–25℃(for 0, 1 or 2 months), then cold-stratified(for 0,1, 2 or 3 months) and tested for seed germination. The nuts were sown outdoors on three dates in the same year of their collection: 15 September(immediately after collection), 2 November, and 17 December, and emerged seedlings were counted the following spring. The pericarp was not a barrier to water uptake by the seed;however, the seeds imbibed water faster and had more mass when the pericarp was removed. Seeds tolerated desiccation;germinationpercentage was not reduced when seed moisture content was reduced to 8.71%. Germination of seeds without the pericarp(regardless of the moisture content) was the highest when the seeds were cold-stratified for 2 *** seeds with the pericarp were tested for germination,2 months of warm stratification before a 2-month cold stratification maximized seed germination. For outdoor sowing of nuts, sowing date affected percentage of seedling emergence the following spring;early autumn sowing(immediately after collection) resulted in the best emergence.

关键词： Corylus avellana Desiccation tolerance Dormancy Pericarp Water uptake

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Experimental and finite element analysis on determining the fatigue life of pb-free solder joint(Sn-0.5Cu-3Bi-1Ag)used in electronic packages under harmonic loads

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第3期11卷 60-67页

作者： Jayesh S Jacob elias Department of Mechanical Engineering School of Engineering Cochin University of Science and Technology KochiKerala-682022India

Electronic packages that are used these days are exposed to different types of vibration loadings in their usage *** vibration exposure can be categorized as harmonic and random *** reliability assessment of modern electronic systems is considered,vibration loading has an important role to *** of the biggest challenges facing today is the accurate and rapid assessment of fatigue life under the vibration *** solder joints were made of lead-tin *** to many environment legislations and rules,lead is prohibited as an ingredient in the solder *** reason for the prohibition of the usage of the lead is that it poisons the *** this study,Sn-0.5Cu-3Bi-1Ag is used as the lead-free solder *** life prediction of electronic package containing SAC405 is conducted with the aid of vibration testing and Finite element analysis under harmonic vibration loading.A specially designed Plastic Ball Grid Array Package(PBGA)component is mounted on Printed Circuit Board(PCB).It is taken as a test vehicle for the vibration *** test vehicle is excited by a sinusoidal *** frequency of this excitation equals the fundamental frequency of the test vehicle and it is continued till the component *** the solder balls are very small for direct measurement,Finite Element analysis(FEA)is used for noting down the *** stress versus failures cycles(S-N)curve is made by relating both the stresses on the solder balls obtained and the number of failure cycles from vibration *** fatigue life of the component can be estimated from the generated S-N *** is analyzed that the methodology is effective in predicting the component’s ***,the reliability of electronic package can be improved.

关键词： PCB lead free solder joint FEA PBGA S-N curve

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