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First Trimester Pregnancy Loss May Temporary Reduce the Ovarian Response during the Subsequent IVF Cycle

Open Journal of Obstetrics and Gynecology 2018年第4期8卷 344-353页

作者： Dina levitas Avi Harlev Michael Friger Iris Har-Vardi Atif Zeadna eliahu levitas Fertility and IVF Unit Department Of Obstetrics and Gynecology Faculty of Health Sciences Soroka Medical Center Beer-Sheva Israel Department of Epidemiology Ben-Gurion University of the Negev Beer-Sheva Israel

The aim of this study was to compare the in vitro fertilization (IVF) cycles ended by miscarriage with subsequent IVF cycles in relation to various IVF cycle parameters and pregnancy termination modalities. Comparison of pre-miscarriage to post-miscarriage IVF cycles parameters demonstrated that lower peak E2 levels (1087 ± 593 versus 1237 ± 676 pg/ml, respectively;p p p p p p < 0.05), and an increase in the conception rate (34.7% versus 42.2%, respectively) at the second post-miscarriage IVF cycle.

关键词： IVF Miscarriage First Trimester Pregnancy Loss Superovulation Ovarian Response Endometrial Thickness Conception Rates

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Is It Possible to Predict the Outcome of IVF Treatment in Poor Response Patients?

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Open Journal of Obstetrics and Gynecology 2014年第12期4卷 703-709页

作者： Adi Uretzky Avraham Harlev Limor Man Eitan Lunenfeld Iris Har-Vardi Michael Friger eliahu levitas Department of Epidemiology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Fertility and IVF Unit Department of Obstetrics and Gynecology Soroka University Medical Center Beer-Sheva Israel

Poor ovarian response (POR)—retrieval of 3 or fewer eggs, is a challenging issue in IVF. A retrospective study included POR women who underwent 386 IVF cycles. The data were classified in four groups according to women’s age (years) during the treatment cycle: 1) 20 - 34 (n = 133), 2) 35 - 39 (n = 133), 3) 40 - 42 (n = 78), 4) 43 - 47 y (n = 42), and correlated with the characteristics of the population. The clinical pregnancy rates for groups 1, 2, 3, and 4 were: 23.3%, 12%, 2.6%, 4.8%, respectively. It was found to be significantly higher (p < 0.001) comparing group 1 with group 3 patients. The “take home baby” rate was much lower (p < 0.001) in group 3;there were no deliveries in group 4. Delivery rates for groups 1, 2, 3, and 4 were: 19.5%, 10.5%, 1.3% and 0%, respectively. Intraabdominal adhesions were more common (p = 0.005) as the cause of infertility in group 3 women compared to groups 2 and 1: 24.4% compared with 9% and 9.8%, respectively. According to multivariate regression analysis, the parameters that negatively reflect on the pregnancy rate in POR women are intraabdominal adhesions, POR in the past, and increased age. We suggest encouraging young POR patients to pursue IVF treatments since the “take home baby” rates are reasonably good.

关键词： IVF Poor Ovarian Response Failed IVF Treatments

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Variations in vascular endothelial growth factor levels during ovarian superovulation and reduction of ovarian hyperstimulation incidence in young women: A prospective study

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 296-300页

作者： eliahu levitas M. Huleihal E. Lunenfeld R. Gakman M. Friger G. Potashnik Department of Epidemiology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Department of Immunology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Fertility and IVF Unit Department of Obstetrics and Gynecology Soroka University Medical Center Beer-Sheva Israel

Variations in Vascular Endothelial Growth Factor (VEGF) levels were prospectively evaluated in 18 young women undergoing in vitro fertilization treatments according to the “Long Protocol” and a typical pattern of VEGF levels was recorded. A significant increase in VEGF concentrations was observed only when the follicles reached a mean diameter of 15.3 mm in concurrence with mature oocyte retrieval. Since an increase in VEGF levels is related to follicular vascularity and oocyte developpment, our study supports the approach that oocyte retrieval may be performed when follicles > 15 mm in diameter appear. Anticipating egg retrieval in young patients with an optimal ovarian reserve may decrease the incidence of severe ovarian hyperstimulation, without compromising the treatment results.

关键词： Vascular Endothelial Growth Factor (VEGF) In Vitro Fertilization Gonadotropin Stimulation Follicle Size Prevention of Ovarian Hyperstimulation

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