Variations in vascular endothelial growth factor levels during ovarian superovulation and reduction of ovarian hyperstimulation incidence in young women: A prospective study
Variations in vascular endothelial growth factor levels during ovarian superovulation and reduction of ovarian hyperstimulation incidence in young women: A prospective study作者机构：Department of Epidemiology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Department of Immunology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Fertility and IVF Unit Department of Obstetrics and Gynecology Soroka University Medical Center Beer-Sheva Israel
出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)
年 卷 期：2013年第3卷第2期
页 面：296-300页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Vascular Endothelial Growth Factor (VEGF) In Vitro Fertilization Gonadotropin Stimulation Follicle Size Prevention of Ovarian Hyperstimulation
摘 要：Variations in Vascular Endothelial Growth Factor (VEGF) levels were prospectively evaluated in 18 young women undergoing in vitro fertilization treatments according to the “Long Protocol and a typical pattern of VEGF levels was recorded. A significant increase in VEGF concentrations was observed only when the follicles reached a mean diameter of 15.3 mm in concurrence with mature oocyte retrieval. Since an increase in VEGF levels is related to follicular vascularity and oocyte developpment, our study supports the approach that oocyte retrieval may be performed when follicles 15 mm in diameter appear. Anticipating egg retrieval in young patients with an optimal ovarian reserve may decrease the incidence of severe ovarian hyperstimulation, without compromising the treatment results.
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