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A typological,environmental and socio-cultural study of semi-open spaces in the Eastern Mediterranean vernacular architecture:The case of Cyprus

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Frontiers of Architectural Research 2021年第3期10卷 483-501页

作者： Maria Philokyprou Aimilios Michael eleni Malaktou Department of Architecture University of Cyprus1678 NicosiaCyprus

Semi-open spaces-largely incorporated in vernacular dwellings in Cyprus during the 19th and 20th centuries-formed diachronically significant socio-cultural, functional and environmental features of the vernacular architecture of the area. The climate of the Eastern Mediterranean region, i.e., hot summers and mild winters, encouraged the use of open weather protected spaces, thus leading to the widespread incorporation of such spaces in the vernacular architecture of the region. This paper focuses on the interconnections between architectural forms and human comfort, convenience or pleasure in relation to the semiopen spaces found in the vernacular architecture of Cyprus-an island in the Eastern Mediterranean region. For the purpose of this research, characteristic traditional settlements found in the coastal, lowland and mountainous areas-which represent three different climatic regions and topographies of the island-were selected for an in-depth investigation. The findings confirm a high frequency of semi-open spaces, as well as the existence of a remarkable richness of typologies. Although semi-open spaces constitute a fundamental part of the structure of these vernacular dwellings in all climatic regions examined, they dominate in the lowland regions due to the particularly hot climate, as well as the specific activities of the inhabitants of these areas. The prevailing architectural forms and constructions of these spaces in each climatic region under investigation was found to be closely adapted to the local resources, terrain and climate, while also being related to the social, household and agricultural needs of the inhabitants, thus underlining their sustainable and locus-specific conception. Research findings can contribute towards critically re-thinking semi-open spaces and their inherent value in rehabilitation projects, as well as in contemporary residential architecture.

关键词： Semi-open spaces Vernacular residential architecture Different climatic regions and topographies Typology Environmentally responsive design Socio-cultural aspects

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Neighborhood environment,physical activity,and quality of life in adults:Intermediary effects of personal and psychosocial factors

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Journal of Sport and Health Science 2017年第1期6卷 96-102页

作者： eleni Theodoropoulou Nektarios A.M.Stavrou Konstantinos Karteroliotis School of Physical Education and Sport Science National and Kapodistrian University of AthensAthens 17237Greece

Background: Studies have indicated that there is a positive and indirect relationship between physical activity(PA) and quality of life(QoL). The current study examined this relationship through a social cognitive model with consideration to the intermediary effects of exercise self-efficacy,and physical(PCS, physical component summary) and psychological(MCS, mental component summary) health. Additionally, this model was widened to include concepts from the ecological theory, and any causal associations among neighborhood environment, PA, and ***: Six hundred and eighty-four physically active adults(39.16 ± 13.52 years, mean ± SD), living in Athens, Greece, completed a series of questionnaires measuring PA, QoL, exercise self-efficacy, PCS, MCS, neighborhood environment, and family and friend support for PA. The examined models were analyzed using structural equation ***: The social cognitive and ecological models proved to be of appropriate fit. Within the social cognitive model, PA positively affected QoL through the mediating effects of exercise self-efficacy, PCS, and MCS. With regards to the ecological model, neighborhood environment positively influenced QoL through the intermediary effects of family support for PA, exercise self-efficacy, PA, PCS, and ***: Results indicated that the most important mediators in the examined models were exercise self-efficacy and health. Further, findings demonstrated the role of neighborhood environment in enhancing PA and QoL. Future studies should be carried out applying longitudinal data for a better understanding of these associations over time.

关键词： Cognitive Ecological Health Self-efficacy Structural equation modeling

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Effects of antidiabetic drugs on epicardial fat

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World Journal of Diabetes 2018年第9期9卷 141-148页

作者： eleni Xourgia Athanasia Papazafiropoulou Andreas Melidonis 1st Department of Internal Medicine and Diabetes Center Tzaneio General Hospital of Piraeus

Epicardial adipose tissue is defined as a deposit of adipocytes with pathophysiological properties similar to those of visceral fat, located in the space between the myocardial muscle and the pericardial sac. When compared with subcutaneous adipose tissue, visceral adipocytes show higher metabolic activity, lipolysis rates, increased insulin resistance along with more steroid hormone receptors. The epicardial adipose tissue interacts with numerous cardiovascular pathways via vasocrine and paracrine signalling comprised of pro-and anti-inflammatory cytokines excretion. Both the physiological differences be-tween the two tissue types, as well as the fact that fat distribution and phenotype, rather than quantity, affect cardiovascular function and metabolic processes, establish epicardial fat as a biomarker for cardiovascular and metabolic syndrome. Numerous studies have underlined an association of altered epicardial fat morphology, type 2 diabetes mellitus(T2 DM) and adverse cardiovascular events. In this review, we explore the prospect of using the epicardial adipose tissue as a therapeutic target in T2 DM and describe the underlying mechanisms by which the antidiabetic drugs affect the pathophysiological processes induced from adipose tissue accumulation and possibly allow for more favourable cardiovascular outcomes though epicardial fat manipulation.

关键词： Epicardial fat Adipose tissue Type 2 diabetes mellitus Antidiabetic drugs

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Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron

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World Journal of Diabetes 2019年第3期10卷 169-180页

作者： eleni Xourgia Athanasia Papazafiropoulou Andreas Melidonis 1~(st) Department of Internal Medicine and Diabetes Center Tzaneio General Hospital of Piraeus

The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (DE) are impaired synaptic adaptation and diminished spatial learning capacity. Chronic and progressive cognitive dysfunction, perpetuated by several positive feedback mechanisms in diabetic subjects, facilitates the development of early-onset dementia and Alzheimer’s disease. Despite the numerous clinical manifestations of DE having been described in detail and their pathophysiological substrate having been elucidated in both type 1 and type 2 diabetes mellitus, an effective therapeutic approach is yet to be proposed. Therefore, the aim of this review is to summarize the growing body of evidence concerning the effect of current antidiabetic treatment options on diabetic and non-DE.

关键词： Memory Spatial learning Cognitive Neural remodeling Type 2 diabetes mellitus Antidiabetic drugs

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Development of a Soft Actor Critic deep reinforcement learning approach for harnessing energy flexibility in a Large Office building

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Energy and AI 2021年第3期5卷 228-241页

作者： Anjukan Kathirgamanathan eleni Mangina Donal P.Finn School of Mechanical and Materials Engineering University College DublinIreland UCD Energy Institute O’Brien Centre for ScienceUniversity College DublinIreland School of Computer Science University College DublinIreland

This research is concerned with the novel application and investigation of‘Soft Actor Critic’based deep reinforcement learning to control the cooling setpoint(and hence cooling loads)of a large commercial building to harness energy *** research is motivated by the challenge associated with the development and application of conventional model-based control approaches at scale to the wider building *** Actor Critic is a model-free deep reinforcement learning technique that is able to handle continuous action spaces and which has seen limited application to real-life or high-fidelity simulation implementations in the context of automated and intelligent control of building energy *** control techniques are seen as one possible solution to supporting the operation of a smart,sustainable and future electrical *** research tests the suitability of the technique through training and deployment of the agent on an EnergyPlus based environment of the office *** agent was found to learn an optimal control policy that was able to minimise energy costs by 9.7%compared to the default rule-based control scheme and was able to improve or maintain thermal comfort limits over a test period of one *** algorithm was shown to be robust to the different hyperparameters and this optimal control policy was learnt through the use of a minimal state space consisting of readily available *** robustness of the algorithm was tested through investigation of the speed of learning and ability to deploy to different seasons and *** was found that the agent requires minimal training sample points and outperforms the baseline after three months of operation and also without disruption to thermal comfort during this *** agent is transferable to other climates and seasons although further retraining or hyperparameter tuning is recommended.

关键词： Deep Reinforcement Learning(DRL) Building energy flexibility Soft Actor Critic(SAC) Machine learning Smart grid

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VPOT:A Customizable Variant Prioritization Ordering Tool for Annotated Variants

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Genomics, Proteomics & Bioinformatics 2019年第5期17卷 540-545页

作者： Eddie Ip Gavin Chapman David Winlaw Sally LDunwoodie eleni Giannoulatou Victor Chang Cardiac Research Institute Sydney 2010Australia St Vincent’s Clinical School University of New South WalesSydney 2052Australia Heart Centre for Children The Children’s Hospital at WestmeadSydney 2145Australia Sydney Medical School University of SydneySydney 2050Australia School of Biotechnology and Biomolecular Sciences University of New South WalesSydney 2033Australia

Next-generation sequencing(NGS) technologies generate thousands to millions of genetic variants per *** of potential disease-causal variants is labor intensive as it relies on filtering using various annotation metrics and consideration of multiple pathogenicity prediction *** have developed VPOT(variant prioritization ordering tool),a python-based command line tool that allows researchers to create a single fully customizable pathogenicity ranking score from any number of annotation values,each with a user-defined *** use of VPOT can be informative when analyzing entire cohorts,as variants in a cohort can be *** also provides additional functions to allow variant filtering based on a candidate gene list or by affected status in a family *** outperforms similar tools in terms of efficacy,flexibility,scalability,and computational *** is freely available for public use at Git Hub(https://***/VCCRI/VPOT/).Documentation for installation along with a user tutorial,a default parameter file,and test data are provided.

关键词： Next-generation sequencing Pathogenicity predictions Variant prioritization Customizable ranking Genomic annotation

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Assessing the impacts of traffic calming at network level:A multimodal agent-based simulation

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 41-54页

作者： Eftychia Zargiannaki Panagiotis G.Tzouras eleni Antoniou Christos Karolemeas Konstantinos Kepaptsoglou School of Rural Surveying and Geoinformatics EngineeringNational Technical University of AthensZografou 15780Greece

The reduction of speed limits in urban roads through traffic calming schemes intends to ensure safer traffic conditions among road users by reducing the probability related to the occurrence of severe *** it from a different perspective,traffic calming measures can potentially resolve congestion problems at the same time by lowering the overall accessibility and attractiveness of private cars in urban *** study proposes a new methodological approach to explore and assess the direct impacts of traffic calming in the transport system efficiency of a metropolitan *** multi-agent transport simulation(MATSim)and Open-Berlin scenario are utilized to perform this simulation *** developing a new external tool,the free flow speed and road capacity of each network link is updated based on new speed limits and different compliance rates,which are defined per road hierarchy *** test scenarios that are formulated present radical conditions,where the speed limit in most urban roads of Berlin drops to 30 km/h or even 15 km/*** findings of this study show a considerably high increase in trips,passenger hours,and passenger kilometers using public transport modes,when traffic calming links are introduced,the reserve change is observed in private cars *** the speed limits are decreased in inner urban roads in most of the scenarios,the decrease of average travel speed of private cars is not so high as it was ***,private cars are used for longer distances in all test *** drivers seem to use already existed motorways and private road to *** simulations,driver compliance to the new speed limits seems to be a determinant factor that is strongly influenced by the design interventions applied in a traffic calming area.

关键词： Agent-based simulation Traffic calming Impact assessment Urban road network

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Testing optically stimulated luminescence dating on sand-sized quartz of deltaic deposits from the Sperchios delta plain, central Greece

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Journal of Palaeogeography 2018年第2期7卷 130-145页

作者： Evangelos Tsakalos Elias Dimitriou Maria Kazantzaki Christos Anagnostou John Christodoulakis eleni Filippaki Hellenic Centre for Marine Research Institute of Inland Waters Laboratory of Archaeometry Institute of Nanoscience and Nanotechnology National Centre for Scientific Research N.C.S.R. "Demokritos" Department of Geophysics Division of Earth and Planetary Sciences Graduate School of Science Kyoto University Hellenic Centre of Marine Research Institute of Oceanography Climate Research Group Division of Environmental Physics and Meteorology Faculty of Physics National and Kapodistrian University of Athens

This study reports on the first investigation into the potential of luminescence dating to establish a chronological framework for the depositional sequences of the Sperchios delta plain, central Greece. A series of three borehole cores(20 m deep) and two shallow cores(4 m deep), from across the delta plain, were extracted, and samples were collected for luminescence dating. The luminescence ages of sand-sized quartz grains were obtained from small aliquots of quartz, using the Single-Aliquot Regenerative-dose(SAR) *** equivalent dose determination included a series of tests and the selection of the Minimum Age Model(MAM) as the most appropriate statistical model. This made it possible to confirm the applicability of quartz Optically Stimulated Luminescence(OSL) dating to establish absolute chronology for deltaic sediments from the Sperchios delta *** age results of the five cores showed that the deltaic sediments were deposited during the Holocene.A relatively rapid deposition is implied for the top14 m possibly as a result of the deceleration in the rate of the sea-level rise and the transition to terrestrial conditions, while on the deeper parts, the reduced sedimentation rate may indicate a lagoonal or coastal environment.

关键词： Luminescence dating Holocene Sedimentation rates Deltaic deposits Sperchios delta plain Central Greece

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Yolk-sac larval development of the substrate-brooding cichlid Archocentrus nigrofasciatus in relation to temperature

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Integrative Zoology 2015年第5期10卷 497-504页

作者： Nikolaos VLAHOS Michael VASILOPOULOS eleni MENTE George HOTOS George KATSELIS Kosmas VIDALIS Department of Aquaculture and Fisheries Technological Educational Institution of Western GreeceMesollonghiGreece Department of Ichthyology and Aquatic Environment School of Agricultural SciencesUniversity of ThessalyVolosGreece

In order to conserve and culture the cichlid fish Archocentrus nigrofasciatus,more information about its reproductive biology and its larval behavior and morphogenesis is ***,temperatures ranging from 21 to 27°C are used in ornamental aquaculture *** temperatures are preferred to reduce the costs of water heating,and 23°C is usually the selected ***,there is limited information on culturing protocols for ornamental species and most of the information generated on this topic remains ***,the present study examines the morphological development of Archocentrus nigrofasciatus during the yolk-sac period up to the age of 100 h post-hatching in relation to 2 temperature regimes used in ornamental aquaculture:a temperature of 27°C(thermal optimum)and a decreased temperature of 23°C(thermal tolerance).The results of this study suggest that the 27°C temperature generates intense morphological changes in yolk-sac development in a shorter *** has advantages as it reduces the time of yolk-sac larval development,and,thus,minimizes the transition phase to exogenous feeding and maximizes the efficiency at which yolk is converted into body *** present paper provides necessary information to produce freshwater ornamental fish with better practices so as to increase larval survival and capitalize on time for growth.

关键词： Archocentrus nigrofasciatus convict cichlid growth yolk-sac development temperature

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Music as medicine for traumatic brain injury:a perspective on future research directions

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Neural Regeneration Research 2024年第10期19卷 2105-2106页

作者： Anthony E.Kline eleni H.Moschonas Corina O.Bondi Department of Physical Medicine&Rehabilitation University of PittsburghPittsburghPAUSA Safar Center for Resuscitation Research University of PittsburghPittsburghPAUSA Center for Neuroscience University of PittsburghPittsburghPAUSA Department of Critical Care Medicine University of PittsburghPittsburghPAUSA Center for the Neural Basis of Cognition University of PittsburghPittsburghPAUSA Department of Psychology University of PittsburghPittsburghPAUSA Department of Neurobiology University of PittsburghPittsburghPAUSA

Traumatic brain injury(TBI) impacts 69 million individuals globally each year and is a leading cause of death and disability(Dewan et al.,2019).The majority of moderate-to-severe TBI survivors endure long-lasting disturbances in motor,cognitive,and affect that negatively impacts their *** a plethora of research on pharmacological interventions for TBI has been conducted,none has translated to the clinic,thus advocating for the evaluation of nonpharmacological therapeutic approaches that may increase translational success.

关键词： injury traumatic

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