Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron
Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron作者机构：1~(st) Department of Internal Medicine and Diabetes Center Tzaneio General Hospital of Piraeus
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2019年第10卷第3期
页 面：169-180页
核心收录：
主 题：Memory Spatial learning Cognitive Neural remodeling Type 2 diabetes mellitus Antidiabetic drugs
摘 要：The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (DE) are impaired synaptic adaptation and diminished spatial learning capacity. Chronic and progressive cognitive dysfunction, perpetuated by several positive feedback mechanisms in diabetic subjects, facilitates the development of early-onset dementia and Alzheimer’s disease. Despite the numerous clinical manifestations of DE having been described in detail and their pathophysiological substrate having been elucidated in both type 1 and type 2 diabetes mellitus, an effective therapeutic approach is yet to be proposed. Therefore, the aim of this review is to summarize the growing body of evidence concerning the effect of current antidiabetic treatment options on diabetic and non-DE.
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