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Involvement of Autoimmune Diseases in the Pathogenesis of Chronic Immune Thrombocytopenic Purpura

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Journal of Biomedical Science and Engineering 2015年第3期8卷 142-148页

作者： Madalina Mocanu Magda Badescu Manuela Ciocoiu codruta Badescu Cristina elena Iancu Oana Badulescu Department of Pathophysiology “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Deparment of Pharmaceutical Science Ⅱ “Grigore T.Popa”University of Medicine and PharmacyIasiRomania

Chronic immune thrombocytopenic purpura (ITP) is a condition based on an immune-mediated mechanism that determines the premature hyperdestruction of the thrombocytes in peripheral blood, as well as their deficient synthesis at the level of the bone marrow. The chronic immune purpura could be of primary, idiopathic cause, as well as of secondary cause, occurring in the context of other pathologies. The characteristic of the primary form of the disease is the presence of isolated thrombocytopenia, defined by a platelet count under 100,000/mm3 in peripheral blood, in the absence of supporting causes for thrombocytopenia. In the secondary form of the disease, the decreased platelet count is due to associated pathologies involving an immune mechanism, responsible for the occurrence of thrombocytopenia. This study aims to emphasize the involvement of autoimmune diseases, such as systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid polyarthritis or antiphospholipid syndrome in the pathogenesis of secondary thrombocytopenia. Furthermore, the study was conducted on a sample of 40 patients, divided into two groups: The first group comprising asymptomatic patients diagnosed with thrombocytopenia following routine tests, and the second group comprising patients with hemorrhagiparous symptomatology (petechiae, ecchymoses, epistaxis, gingivorrhagia), who went to the doctor in order to determine the etiology of the hemorrhagiparous syndrome. The average value of the thrombocytopenia of the patients included in the study was of 60.20 ± 19.75 × 103/μL. Laboratory investigations performed in order to establish the etiology of thrombocytopenia showed that 80% of patients presented positive antiplatelet antibodies. Moreover, 20% of the patients in the study showed positive anti-double-stranded DNA, 20% were identified with IgG anticardiolipin antibodies, while antinuclear antibodies were present in 10% of the patients.

关键词： Thrombocytopenic Purpura Antiplatelet Antibodies Systemic Lupus Erythematosus Antiphospholipid Syndrome

Alice Walker＇ s Colors of Identity

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Journal of Literature and Art Studies 2016年第9期6卷 989-995页

作者： codruta Mirela Stanisoara The Faculty of Letters Dr. Tr. Severin University of Craiova Craiova Romania

The paper traces back women like Celie, Shug, Sofia or Nettie engaged in journeys of self-discovery and development, ones that follow predicted feminist patterns, who try to get free from any dominance, either be it male, social or cultural. The colour purple signifies a metaphysical, social and personal rebirth reflected into different shades by their inner self. The social oppression for black women in their quest for freedom is the main theme of Walker＇s novel The Color Purple, written in the epistolary technique of Samuel Richardson＇s in the XVIllth century English novel. In our attempt to analyse the theme and the female characters of the novel we are also trying to cross a bridge from the slave woman of the past belonging to a completely different culture and race to the contemporary paradigm of the liberated woman. The movement in time encompasses possible similitudes and differences.

关键词： black women identity quest letters cultures

Mitral Valve Surgery for Functional Regurgitation: Insights into Heart Failure and Readmission

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World Journal of Cardiovascular Surgery 2022年第6期12卷 135-152页

作者： Joseph A. Gancayco Alexander P. Kossar codruta Chiuzan Isaac George Division of Cardiothoracic Surgery New York Presbyterian Hospital College of Physicians and Surgeons of Columbia University New York USA Department of Biostatistics Mailman School of Public Health Columbia University New York USA

Background: Functional mitral regurgitation (FMR) is an increasing burden as population ages. Mitral valve repair (MVr) is the preferred surgical treatment of FMR despite limited evidence supporting its efficacy. Mitral valve replacement (MVR) is the alternative procedure typically reserved for patients who are at higher risk or refractory to MVr. The present study aims to determine which of the two procedures is more effective in the surgical treatment of FMR. Methods: 344 charts of FMR patients who received either MVr (n = 263) or MVR (n = 81) from 2004-2016 at our institution were reviewed. Treatment efficacy was assessed based on heart failure (HF)-readmission and survival rates within 5 years from discharge. Propensity score approach with inverse probability weighting and Cox regression models were employed to evaluate procedural impact on survival and rehospitalizations, respectively. Follow-up echocardiographic data from the original cohort was assessed for differences in metrics between procedural groups at >6 months (MVr: n = 75;MVR: n = 23) and 1 year (MVr: n = 75;MVR: n = 18) post-op. Results: MVR patients had a lower risk of being readmitted for HF within 5 years compared to the MVr group (HR-adj (95% CI): 0.60 (0.41 - 0.88), p = 0.008). MVR patients also had a higher overall risk of death (HR-adj (95% CI): 1.82 (1.05 - 3.16), p = 0.034) but this was borderline significantly different at 5 years cut-off (p = 0.057). Conclusions: Higher HF readmission in MVr patients than in sicker, higher surgical-risk MVR patients reflects the inadequacy of MVr to treat FMR. Novel approaches to MVR may be necessary to adequately manage FMR.

关键词： Mitral Regurgitation Mitral Valve Repair Mitral Valve Replacement Heart Failure

Arava Treatment,between Beneficial Action on Joint Inflammation and Side Effects on Liver,Myocardium and Kidney in Experimental Murine Arthritis

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Journal of Biomedical Science and Engineering 2014年第9期7卷 712-720页

作者： Mihaela Manole codruta Badescu Manuela Ciocoiu Magda Badescu Mihaiela Chicu Pathophysiology Department University of Medicine and Pharmacy“Grigore T.Popa”IasiRomania Internal Medicine Clinic St.Spiridon HospitalIasiRomania

The purpose of the experiment was the follow-up in time of the course of joint inflammation phenomena in laboratory animals (white female adult Wistar rats) by determining particular biological, hematological, radiological, osteodensitometric, immunological and anatomic-pathological parameters and by assessing the effects of Leflunomide (Arava) on the course of the disease. ARAVA®(Leflunomide) is a pyrimidine synthesis inhibitor. The experimental study was conducted for 8 weeks. We have also assessed the side effects of the therapy on their liver, myocardium and kidney. Leflunomide therapy improved the course of the clinical and paraclinical parameters, but it did not cure the condition. The positive results in the joints were accompanied by many histological alterations. The experiment revealed the toxic visceral effects of Leflunomide on the liver, heart and kidney.

关键词： ARAVA^(█)(Leflunomide) Rheumatoid Arthritis Side Effects

Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense

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Journal of Biomedical Science and Engineering 2015年第4期8卷 237-245页

作者： Manuela Ciocoiu Magda Badescu Oana Badulescu Madalina Mocanu codruta Badescu Department of Pathophysiology Faculty of Medicine University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Internal Medicine Clinic St. Spiridon Hospital University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of?administration?of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.

关键词： Senescence Zinc Aspartate Aronia melanocarpa Oxidative Stress