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Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds

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Journal of Animal Science and Biotechnology 2023年第3期14卷 887-907页

作者： Michael N.Romanov Alexandra S.Abdelmanova vladimir I.Fisinin elena A.Gladyr Natalia A.volkova Olga A.Koshkina Andrey N.Rodionov Anastasia N.vetokh Igor v.Gusev Dmitry v.Anshakov Olga I.Stanishevskaya Arsen v.Dotsev Darren K.Griffin Natalia A.Zinovieva L.K.Ernst Federal Research Centre for Animal Husbandry DubrovitsyPodolskMoscow RegionRussia School of Biosciences University of KentCanterburyUK Federal State Budget Scientific Institution Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Breeding and Genetic Centre“Zagorsk Experimental Breeding Farm”–Branch of the Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Russian Research Institute of Farm Animal Genetics and Breeding–Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry St.PetersburgRussia

Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture *** to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed *** Using the Chicken 50K_CobbCons SNP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White *** of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation *** regions of true selection signatures were identified by two or more methods or in two or more *** these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other *** them,SOX5,ME3,ZNF536,WWP1,RIPK2,OSGIN2,DECR1,TPO,PPARGC1A,BDNF,MSTN,and beta-keratin genes can be especially mentioned as candidates for cold *** factors may be involved in regulating some of these important genes(e.g.,TPO and BDNF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken *** include genes representing the sine qua non for adaptation to harsh *** tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.

关键词： Acclimation Adaptation Chicken breeds Cold tolerance Divergent selection Genetic diversity Genomewide scan Phenotypic traits Selective sweeps

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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova Maria v.Zhukova elena v.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Contribution of the Earth's gravitational potential to variations in orbital motion of short-period comets

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Research in Astronomy and Astrophysics 2016年第4期16卷 1-6页

作者： valentina M.Chepurova Nelli v.Kulikova elena N.Petrovskaya Sternberg Astronomical Institute Lomonosov Moscow State University Department of Computer Systems Networks and Technologies National Research Nuclear University Moscow Engineering Physics Institute Institute for Nuclear Power Engineering

We present simulation results on evolution development of orbital motion of short-period comets with the revolution period not exceeding 6-7 years, namely comets 21P/Giacobini-Zinner, 26P/Grigg- Skjellerup and 7P/Pons-Winnecke. The calculations cover the range from the date of the object＇s discovery to 2100. variations in the objects＇ orbital elements under the action of gravity disturbances, taking Earth＇s gravitational potential into account when the small body approaches, are analyzed. Corrected dates of peri- helion passages can be used for scheduling observations.

关键词： comets: individual (21P/Giacobini-Zinner 26P/Grigg-Skjellerup 7P/Pons-Winnecke)-- me-teorites meteors meteoroids

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Evaluation of DNA Damage in the Marine Mussel Crenomytilus grayanus as a Genotoxic Biomarker of Pollution

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Journal of Ocean University of China 2019年第1期18卷 159-164页

作者： SLOBODSKOvA valentina v. ZHURAvEL elena v. KUKLA Sergey P. CHELOMIN victor P. Laboratory of Marine Ecotoxicology V.I.Ilichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences School of Natural Sciences Far Eastern Federal University

Marine pollution affects all life processes in aquatic organisms. The genotoxic effect of pollution on the mussel Crenomytilus grayanus was assessed. Bivalves were collected from the ‘clean'(vostochnaya Cove) and polluted(Nakhodka Bay) areas in the Peter the Great Bay. The degree of DNA damage in C. grayanus was determined by alkaline comet assay as mean percentage of DNA in tail, and the genetic damage index was calculated. Our results indicate that almost one-third of DNA in cells of gills and digestive gland of C. grayanus inhabiting the Nakhodka Bay had destructive changes compared to the individuals of this species from the vostochnaya Cove. This study has shown that chronic pollution of the aquatic environment causes destructive changes to DNA in gill and digestive gland cells of C. grayanus.

关键词： genotoxicity DNA comet assay Crenomytilus grayanus pollution

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Pharmacokinetic Study and Toxicity of Leukovir: A New Combined Drug for the Treatment of Multiple Sclerosis

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Advances in Biological Chemistry 2022年第1期12卷 1-15页

作者： elena N. Kalinichenko Irina v. Ponteleeva Marina B. Golubeva State Scientific Institution “Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus” Minsk Belarus

Leukovir, an enteric-coated tablet, is the original drug product for internal use. The well-known nucleosides cladribine and ribavirin are the active ingredients of the drug product leukovir. Pharmacokinetic parameters of the drug product for the internal use of leukovir active ingredients have been established. The cladribine half-absorption period was t1/2a = 49.5 h, C0 = 276.4 μg/ml, Cmax = 6.0 μg/ml. Distribution and accumulation parameters (vd, vss and AUC) have indicated that the drug distribution between the blood cells and blood plasma takes place in the same way, irrespective of the dosage form. Cladribine half-life period is t1/2e = 0.62 hours. The molecule total clearance and average lifetime in the body in the case of subcutaneous drug administration are approximately the same. Ribavirin is characterized by a half-absorption period of t1/2a = 0.71 h, C0 = 115.6 μg/ml and Cmax = 75.5 μg/ml. Ribavirin total volume of distribution (vd = 1.3 l/kg) and stationary volume of distribution (vss = 1.64 l/kg) were practically similar to leukovir when administered subcutaneously. The AUC value = 504.2 μg h/ml, which is 2.5 times less than that in the case of drug form administration. Leukovir was regarded as slightly toxic in an acute toxicity study. The risk of cumulation for this drug product is low.

关键词： Leukovir Cladribine Ribavirin Multiple Sclerosis Pharmacokinetics Toxicity

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Periodicities in Solar Activity, Solar Radiation and Their Links with Terrestrial Environment

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Natural Science 2023年第3期15卷 111-147页

作者： valentina v. Zharkova Irina vasilieva Simon J. Shepherd elena Popova Department of MPEE University of Northumbria Newcastle upon Tyne UK ZvS Research Enterprise Ltd. London UK Department of Solar Physics Main Astronomical Observatory Kyiv Ukraine PRIMAL Research Group Sorbonne Universite Paris France Centro de Investigación en Astronomía Universidad Bernardo O’Higgins Santiago Chile

Solar magnetic activity is expressed via variations of sunspots and active regions varying on different timescales. The most accepted is an 11-year period supposedly induced by the electromagnetic solar dynamo mechanism. There are also some shorter or longer timescales detected: the biennial cycle (2 - 2.7 years), Gleisberg cycle (80 - 100 years), and Hallstatt’s cycle (2100 - 2300 years). Recently, using Principal Component Analysis (PCA) of the observed solar background magnetic field (SBMF), another period of 330 - 380 years, or Grand Solar Cycle (GSC), was derived from the summary curve of two eigenvectors of SBMF. In this paper, a spectral analysis of the averaged sunspot numbers, solar irradiance, and the summary curve of eigenvectors of SBMF was carried out using Morlet wavelet and Fourier transforms. We detect a 10.7-year cycle from the sunspots and modulus summary curve of eigenvectors as well a 22-year-cycle and the grand solar cycle of 342 - 350-years from the summary curve of eigenvectors. The Gleissberg centennial cycle is only detected on the full set of averaged sunspot numbers for 400 years or by adding a quadruple component to the summary curve of eigenvectors. Another period of 2200 - 2300 years is detected in the Holocene data of solar irradiance measured from the abundance of 14C isotope. This period was also confirmed with the period of about 2000 - 2100 years derived from a baseline of the solar background magnetic field, supposedly, caused by the solar inertial motion (SIM) induced by the gravitation of large planets. The implication of these findings for different deposition of solar radiation into the northern and southern hemispheres of the Earth caused by the combined effects of the solar activity and solar inertial motion on the terrestrial atmosphere is also discussed.

关键词： Sun: Magnetic Field Sun: Solar Activity Sun: Sunspots Sun: Solar Dynamo

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Antibiotics,gut microbiota,and irritable bowel syndrome:What are the relations?

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World Journal of Gastroenterology 2022年第12期28卷 1204-1219页

作者： Zarina Mamieva elena Poluektova valery Svistushkin vasily Sobolev Oleg Shifrin Francisco Guarner vladimir Ivashkin Department of Internal Disease Propaedeutics N.V.Sklifosovsky Institute of Clinical MedicineI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of Ear Throat and Nose DiseasesN.V.Sklifosovsky Institute of Clinical MedicineI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Digestive System Research Unit Vall d’Hebron Research InstituteBarcelona 08035Spain

Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits(constipation,diarrhea,or both),and it is often accompanied by symptoms of abdominal bloating and *** is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care *** extensive research,the etiology and underlying pathophysiology of IBS remain incompletely *** mechanisms involved in its pathogenesis include increased intestinal permeability,changes in the immune system,visceral hypersensitivity,impaired gut motility,and emotional ***,accumulating evidence has highlighted the important role of the gut microbiota in the development of *** dysbiosis within the gut is thought to contribute to all aspects of its multifactorial *** last few decades have also seen an increasing interest in the impact of antibiotics on the gut ***,antibiotics have been suggested to play a role in the development of *** research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in *** suggestion is further supported by data from cohort and case-control studies,indicating that antibiotic treatment is associated with an increased risk of *** paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS.

关键词： Gut microbiota Irritable bowel syndrome Antibiotics Intestinal barrier Gut motility Gut sensitivity

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远震数据显示贝加尔裂谷带北穆伊斯克(Severomuysk)段地壳和上地幔的精细结构

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地学前缘 2022年第2期29卷 378-392页

作者： valentina v.MORDvINOvA Maria A.KHRITOvA elena A.KOBELEvA Mikhail M.KOBELEv Evgeniy Kh.TURUTANOv victor S.KANAYKIN Institute of the Earth’s Crust Siberian Branch of the Russian Academy of Science Irkutsk 664033Russia Baikal Branch of the Geophysical Service of the Russian Academy of Science Irkutsk 664033Russia Irkutsk National Research Technical University Irkutsk 664074Russia

通过贝加尔裂谷系统北穆伊斯克(Severomuysk)段的密集地震台站线性网络获得的远距离强震记录,并利用P波接收函数技术,揭示了地壳和上地幔顶部的复杂分层块状结构。横波速度的分布表明构成北穆伊斯克地壳的地块具有不同性质。这些地块的... 详细信息

通过贝加尔裂谷系统北穆伊斯克(Severomuysk)段的密集地震台站线性网络获得的远距离强震记录,并利用P波接收函数技术,揭示了地壳和上地幔顶部的复杂分层块状结构。横波速度的分布表明构成北穆伊斯克地壳的地块具有不同性质。这些地块的西部聚散和地壳下部的分层证实了该地区隆起的堆积-碰撞起源。位于西伯利亚克拉通变薄的倾斜边缘上的北穆伊斯克段解释了该地区地壳碰撞效应的强度。2015年地震的震中深度与Muyakan凹陷地壳上部的明显速度差异存在令人信服的相关性。

关键词：地球物理学 P-波接收函数地震速度剖面西伯利亚克拉通贝加尔裂谷带

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3D model of Svecofennian Accretionary Orogen and Karelia Craton based on geology,reflection seismics,magnetotellurics and density modelling:Geodynamic speculations

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Geoscience Frontiers 2020年第3期11卷 999-1023页

作者： Michael v.Mints victor N.Glaznev Olga M.Muravina elena Yu Sokolova Geological Institute RASMoscowRussia voronezh State University VoronezhRussia Schmidt Institute of Physics of the Earth RASMoscowRussia All-Russian Research Geological Oil Institute MoscowRussia

A 3D model of deep crustal structure of the Archaean Karelia Craton and late Palaeoproterozoic Svecofennian Accretionary Orogen including the boundary zone is *** model is based on the combination of data from geological mapping and reflection seismic studies,along profiles 1-EU,4 B,FIRE-1-2 a-2 and FIRE-3-3 a,and uses results of magnetotelluric soundings in southern Finland and northern Karelia.A seismogeological model of the crust and crust-mantle boundary is compared with a model of subhorizontal velocity-density layering of the *** TTG-type crust of the Palaeoarchaean and Mesoarchaean microcontinents within the Karelia Craton and the Belomorian Province are separated by gently dipping greenstone belts,at least some of which are *** structure of the crust was determined mainly by Palaeoproterozoic tectonism in the intracontinental settings modified by a strong collisional compression at the end of the *** insights into structure,origin and evolution of the Svecofennian Orogen are *** accretionary complex is characterized by inclined tectonic layering:the tectonic sheets,~15 km thick,are composed of volcanic-sedimentary rocks,including electro-conductive graphite-bearing sedimentary rocks,and electro-resistive granitoids,which plunge monotonously and consecutively *** reaching the level of the lower crust,the tectonic sheets of the accretionary complex lose their distinct *** the seismic reflection pattern they are replaced by a uniform acoustically translucent medium,where separate sheets can only be traced *** crust-mantle boundary bears a diffuse character:the transition from crust to mantle is recorded by the disappearance of the vaguely drawn boundaries of the tectonic sheets and in the gradual transition of acoustically homogeneous and translucent lower crust into transparent *** the effect of endogenic heat flow,the accretionary complex underwent high-temperatu

关键词： Reflection seismics Magnetotellurics Svecofennian accretionary Orogen Svecofennian Ocean 3D crustal model velocity-density layering

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Morphometric variability of Arctodiaptomus salinus （Copepoda） in the Mediterranean-Black Sea region

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Zoological Research 2015年第6期36卷 328-336页

作者： elena v.ANUFRIIEvA Nickolai v.SHADRIN The AO Kovalevsky Institute of Marine Biological Research Russian Academy of Sciences

Inter-species variability in morphological traits creates a need to know the range of variability of characteristics in the species for taxonomic and ecological tasks. Copepoda Arctodiaptomus salinus, which inhabits water bodies across Eurasia and North Africa, plays a dominant role in plankton of different water bodies-from fresh to hypersaline. This work assesses the intra- and inter-population morphometric variability of A. sa/inus in the Mediterranean-Black Sea region and discusses some observed regularities. The variability of linear body parameters and proportions was studied. The impacts of salinity, temperature, and population density on morphological characteristics and their variability can manifest themselves in different ways at the intra- and inter-population levels. A significant effect of salinity, pH and temperature on the body proportions was not found. Their intra-population variability is dependent on temperature and salinity. Sexual dimorphism of A. salinus manifests in different linear parameters, proportions, and their variability. There were no effects of temperature, pH and salinity on the female/male parameter ratio. There were significant differences in the body proportions of males and females in different populations. The influence of temperature, salinity, and population density can be attributed to 80%-90% of intra-population variability of A. salinus. However, these factors can explain less than 40% of inter-population differences. Significant differences in the body proportions of males and females from different populations may suggest that some local populations ofA. salinus in the Mediterranean-Black Sea region are in the initial stages of differentiation.

关键词： Crustacea Differentiation Morphology Sex differences Environmental factors

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