Antibiotics,gut microbiota,and irritable bowel syndrome:What are the relations?

作     者：Zarina Mamieva Elena Poluektova Valery Svistushkin Vasily Sobolev Oleg Shifrin Francisco Guarner Vladimir Ivashkin 

作者机构：Department of Internal Disease PropaedeuticsN.V.Sklifosovsky Institute of Clinical MedicineI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of EarThroat and Nose DiseasesN.V.Sklifosovsky Institute of Clinical MedicineI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Digestive System Research UnitVall d’Hebron Research InstituteBarcelona 08035Spain 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第12期

页      面：1204-1219页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gut microbiota Irritable bowel syndrome Antibiotics Intestinal barrier Gut motility Gut sensitivity 

摘      要：Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits(constipation,diarrhea,or both),and it is often accompanied by symptoms of abdominal bloating and *** is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care *** extensive research,the etiology and underlying pathophysiology of IBS remain incompletely *** mechanisms involved in its pathogenesis include increased intestinal permeability,changes in the immune system,visceral hypersensitivity,impaired gut motility,and emotional ***,accumulating evidence has highlighted the important role of the gut microbiota in the development of *** dysbiosis within the gut is thought to contribute to all aspects of its multifactorial *** last few decades have also seen an increasing interest in the impact of antibiotics on the gut ***,antibiotics have been suggested to play a role in the development of *** research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in *** suggestion is further supported by data from cohort and case-control studies,indicating that antibiotic treatment is associated with an increased risk of *** paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS.