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Advances in spray products for skin regeneration

Bioactive Materials 2022年第10期7卷 187-203页

作者： Paula Pleguezuelos-Beltran Patricia Galvez-Martín Daniel Nieto-Garcí Juan Antonio Marchal elena lopez-ruiz Biopathology and Regenerative Medicine Institute(IBIMER) Centre for Biomedical Research(CIBM)University of GranadaGranadaSpain Department of Human Anatomy and Embryology Faculty of MedicineUniversity of GranadaGranadaSpain BioFab i3D Lab-Biofabrication and 3D(bio)printing Laboratory GranadaSpain Excellence Research Unit“Modeling Nature”(MNat) University of GranadaGranadaSpain Biosanitary Research Institute of Granada(ibs.GRANADA) University Hospitals of Granada-University of GranadaGranadaSpain R&D Human Health Bioib´erica S.A.UBarcelonaSpain Department of Pharmacy and Pharmaceutical Technology Faculty of PharmacyUniversity of GranadaGranadaSpain Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineUniversiteitssingel 406229ER Maastrichtthe Netherlands Department of Health Sciences University of Ja´enJa´enSpain

To date,skin wounds are still an issue for healthcare professionals.Although numerous approaches have been developed over the years for skin regeneration,recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes,including 3D bioprinting,electrospinning or spraying,among others.In particular,skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic wounds.Skin sprays present significant advantages compared to conventional treatments for wound healing,such as the facility of application,the possibility to treat large wound areas,or the homogeneous distribution of the sprayed material.In this article,we review the latest advances in this technology,giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products,used for a variety of diseases and applying different experimental materials.Moreover,as skin sprays products are subjected to different classifications,we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment conditions.Finally,we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.

关键词： Skin Spray Tissue engineering Fibrin Hydrogel

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Opinion Dynamics in Two-Layer Networks with Hypocrisy

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Journal of the Operations Research Society of China 2024年第1期12卷 109-132页

作者： Chi Zhao elena Parilina Saint Petersburg State University Saint Petersburg199034Russia Qingdao University School of Mathematics and StatisticsQingdao 266071ShandongChina

We propose a general concealed voter model(GCVM),in which individuals interact in two layers and can exchange their opinions in the internal layer.This interaction is not allowed in a CVM.By exchanging opinions in the internal layer,we mean that individuals share their real or internal opinions with their close friends.The process of opinion formation in GCVM is presented in the paper.We make the series of numerical simulations of GCVM with different network structures(both external and internal)and get some counterintuitive conclusions.For instance,we find out that sometimes with a relatively simple network structure of an external layer the consensus within the individuals’opinions cannot be reached,and if individuals in the network are not good at expressing their opinions publicly(in an external layer),exchanging opinions with their close friends(in an internal layer)is almost useless.

关键词： Opinion dynamics Voter model Concealed voter model General concealed voter model

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Strong Subgame Consistency of the Core in Stochastic Network Formation Games

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Journal of the Operations Research Society of China 2024年第1期12卷 189-213页

作者： Ping Sun elena Parilina Faculty of Applied Mathematics and Control Processes Saint Petersburg State UniversitySaint Petersburg199034Russia

We consider a model of network formation as a stochastic game with random duration proposed initially in Sun and Parilina(Autom Remote Control 82(6):1065–1082,2021).In the model,the leader first suggests a joint project to other players,i.e.,the network connecting them.Second,the players are allowed to form fresh links with each other updating the initially proposed network.The stage payoff of any player is defined depending on the network structure.There are two types of randomness in the network formation process:(i)links may fail to be formed with different probabilities although players intend to establish them,(ii)the game process may terminate at any stage or transit to the next stage with a certain probability distribution.Finally,a network is formed as a result of players’decisions and realization of random variables.The cooperative version of the stochastic game is investigated.In particular,we examine the properties of subgame consistency as well as strong subgame consistency of the core.We provide a payment mechanism or regularization of the core elements to sustain its subgame consistency and avoid the player’s deviations from the cooperative trajectory.In addition,the distribution procedure of the core elements is regularized in case there are negative payments to achieve only nonnegative payments to the players at any stage.The sufficient condition of a strongly subgame consistent core is also obtained.We illustrate our theoretical results with a numerical example.

关键词： Stochastic game Network formation Core Strong subgame consistency

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SIRT2 as a potential new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 124-131页

作者： Noemi Sola-Sevilla elena Puerta Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of NavarraNavarra Institute for Health Research(IdiSNA)PamplonaSpain

Alzheimer's disease is the most common cause of dementia globally with an increasing incidence over the years,bringing a heavy burden to individuals and society due to the lack of an effective treatment.In this context,sirtuin 2,the sirtuin with the highest expression in the brain,has emerged as a potential therapeutic target for neurodegenerative diseases.This review summarizes and discusses the complex roles of sirtuin 2 in different molecular mechanisms involved in Alzheimer's disease such as amyloid and tau pathology,microtubule stability,neuroinflammation,myelin formation,autophagy,and oxidative stress.The role of sirtuin 2 in all these processes highlights its potential implication in the etiology and development of Alzheimer's disease.However,its presence in different cell types and its enormous variety of substrates leads to apparently contra dictory conclusions when it comes to understanding its specific functions.Further studies in sirtuin 2 research with selective sirtuin2 modulators targeting specific sirtuin 2 substrates are necessary to clarify its specific functions under different conditions and to validate it as a novel pharmacological target.This will contribute to the development of new treatment strategies,not only for Alzheimer's disease but also for other neurodegenerative diseases.

关键词： Alzheimer's disease amyloid autophagy memory neurodegenerative diseases neuroinflammation sirtuin 2 tau

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Outpatient management of obscure gastrointestinal bleeding:A new perspective in high-risk patients

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World Journal of Gastroenterology 2024年第19期30卷 2502-2504页

作者： Maria elena Riccioni Clelia Marmo Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy CEMAD Centro Malattie Dell’Apparato Digerente Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy

Mid-gastrointestinal bleeding accounts for approximately 5%-10%of all gastrointestinal bleeding cases,and vascular lesions represent the most frequent cause.The rebleeding rate for these lesions is quite high(about 42%).We hereby recommend that scheduled outpatient management of these patients could reduce the risk of rebleeding episodes.

关键词： Gastrointestinal bleeding Small bowel bleeding Recurrent bleeding Rebleeding risk Rebleeding Outpatient management

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Opto-fluidically multiplexed assembly and micro-robotics

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Light(Science & Applications) 2024年第3期13卷 544-554页

作者： elena Erben Weida Liao Antonio Minopoli Nicola Maghelli Eric Lauga Moritz Kreysing Max Planck Institute of Molecular Cell Biology and Genetics Dresden 01307Germany Center for Systems Biology Dresden 01307Germany Institute of Biological and Chemical Systems–Biological Information Processing.Karlsruhe Institute of Technology(KIT) Eggenstein-Leopoldshafen 76344Germany Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB30WAUK

Techniques for high-definition micromanipulations,such as optical tweezers,hold substantial interest across a wide range of disciplines.However,their applicability remains constrained by material properties and laser exposure.And while microfluidic manipulations have been suggested as an alternative,their inherent capabilities are limited and further hindered by practical challenges of implementation and control.Here we show that the iterative application of laser-induced,localized flow fields can be used for the relative positioning of multiple micro-particles,irrespectively of their material properties.Compared to the standing theoretical proposal,our method keeps particles mobile,and we show that their precision manipulation is non-linearly accelerated via the multiplexing of temperature stimuli below the heat diffusion limit.The resulting flow fields are topologically rich and mathematically predictable.They represent unprecedented microfluidic control capabilities that are illustrated by the actuation of humanoid micro-robots with up to 30 degrees of freedom,whose motions are sufficiently well-defined to reliably communicate personal characteristics such as gender,happiness and nervousness.Our results constitute high-definition micro-fluidic manipulations with transformative potential for assembly,micro-manufacturing,the life sciences,robotics and optohydraulically actuated micro-factories.

关键词： manipulation fluid assembly

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Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

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Current Zoology 2024年第2期70卷 233-243页

作者： Ivan Norscia Edoardo Collarini Carlo Robino elena Chierto Giada Cordoni Department of Life Sciences and Systems Biology University of TorinoVia Accademia Albertina 1310123 TorinoItaly Department of Public Health Sciences and Pediatric s University of TorinoC.So Galileo Galilei 2210126 TorinoItaly

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict studies.We investi-gated quadratic affliation in semi-free ranging pigs Sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was known.We collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video analyses.Affiliative and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)conditions.Quadratic affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting bystanders.Thus,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is involved.Quadratic affiliation was lowest after reconciliation and spontaneous triadic contacts.This suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic affiliation.Hence,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social factors.Such non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

关键词： anxiety reduction emotional regulation reconciliation social appraisal triadic contacts.

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Effect of the anionic composition of sulfolane based electrolytes on the performances of lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第8期95卷 231-240页

作者： elena V.Karaseva elena V.Kuzmina Bo-Quan Li Qiang Zhang Vladimir S.Kolosnitsyn Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University

In lithium-sulfur batteries,cell design,specifically electrolyte design,has a key impact on the battery performance.The effect of lithium salt anion donor number（DN）(DN[PF6]-=2.5,DN[N（SO2CF3）2]-=5.4,DN[ClO4]-=8.4,DN[SO3CF3]-=16.9,and DN[NO3]-=21.1) on the patterns of lithium-sulfur batteries and lithium metal electrode performances with sulfola ne-based electrolytes is investigated.An increase in DN of lithium salt anions leads to an increase in the depth and rate of electrochemical reduction of sulfur and long-chain lithium polysulfides and to a decrease in those for medium-and short-chain lithium polysulfides.DN of lithium salt anions has weak effect on the discharge capacity of lithium-sulfur batteries and the Coulomb efficiency during cycling,with the exception of LiSO3CF3and LiNO3.An increase in DN of lithium salt anions leads to an increase in the cycling duration of lithium metal anodes and to a decrease in the presence of lithium polysulfides.In sulfolane solutions of LiNO3and LiSO3CF3,lithium polysulfides do not affect the cycling duration of lithium metal anodes.

关键词： Donor number Electrolyte Lithium metal electrode Lithium polysulfide Lithium salt Lithium-sulfur battery Sulfolane

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Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

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Fluid Dynamics & Materials Processing 2024年第4期20卷 739-748页

作者： Andrei Vasiliev Andrei Sukhanovskii elena Popova Laboratory of Turbulence Institute of Continuous Media Mechanics UB RASPerm614013Russia

The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied.Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall.The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure.The mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential rotation.As a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper layer.The baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity fluctuations.It is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic waves.The increase in the inclination angle leads to a significant increase in the energy of the waves.The obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.

关键词： Laboratory modeling global atmospheric circulation baroclinic waves beta-effect

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HIFs in hypoxic regulation of the extracellular matrix:focus on little-known player HIF-3

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BIOCELL 2024年第5期48卷 677-692页

作者： ALEKSANDRA GORNOSTAEVA LUDMILA BURAVKOVA MARGARITA LOBANOVA elena ANDREEVA Institute of Biomedical Problems of the Russian Academy of Sciences Khoroshevskoye Shosse 76AMoscow123007Russia

The structural and associated molecules of the extracellular matrix(ECM)complex is an important component of the local milieu of cells,both for maintaining their functions and homeostasis.It is a dynamic structure that is finely tuned to changes in the microenvironment.One of these factors is hypoxia,which can arise in tissues due to physiological or pathological effects.As a result of the hypoxic effect,the properties of the ECM are significantly modified,stiffness increases,the balance between degradation and synthesis of structural proteins shifts,and the deposition of biologically active mediators’changes.Hypoxia-inducible factors(HIFs)contribute significantly to the modification of the properties of the ECM under hypoxia.Among the three HIF isoforms,HIF-1 is the most studied,with numerous identified target genes encoding proteins that participate in all matrisome compartments.Much less is known about HIF-2 and HIF-3.In the context of the effects of hypoxia on the matrisome,HIF-3 isoform is of particular interest.Unlike the first two isoforms,transiently expressed during the first hours of hypoxia,HIF-3 is activated after around 24 h of exposure to hypoxia and persists for a longer period.In addition,its transcription is more pronounced under hypoxia than are HIFs 1 and 2.HIF-3,rather than the first two isoforms,is possibly responsible for the changes that occur in matrisome during prolonged hypoxic conditions.This review attempts to summarize the available data on the involvement of HIF-3 in the matrisome modification under hypoxia.

关键词： Hypoxia Hypoxia-inducible factors Matrisome

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