SIRT2 as a potential new therapeutic target for Alzheimer's disease

作     者：Noemi Sola-Sevilla Elena Puerta Noemi Sola-Sevilla;Elena Puerta

作者机构：Department of Pharmacology and ToxicologyFaculty of PharmacyUniversity of NavarraNavarra Institute for Health Research(IdiSNA)PamplonaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第1期

页      面：124-131页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：funded by FEDER/Ministerio de Ciencia Innovacion y Universidades Agencia Estatal de Investigacion(MCIN/AEI 10.13039/501100011033)Grant(SAF2017-87595-R and PID2020-119729G8-100)(to EP) "Amigos de Ia Universidad de Navarra"and the Spanish Ministry of Universities for a fellowship(FPU)to NSS 

主　　题：Alzheimer's disease amyloid autophagy memory neurodegenerative diseases neuroinflammation sirtuin 2 tau 

摘      要：Alzheimer s disease is the most common cause of dementia globally with an increasing incidence over the years,bringing a heavy burden to individuals and society due to the lack of an effective *** this context,sirtuin 2,the sirtuin with the highest expression in the brain,has emerged as a potential therapeutic target for neurodegenerative *** review summarizes and discusses the complex roles of sirtuin 2 in different molecular mechanisms involved in Alzheimer s disease such as amyloid and tau pathology,microtubule stability,neuroinflammation,myelin formation,autophagy,and oxidative *** role of sirtuin 2 in all these processes highlights its potential implication in the etiology and development of Alzheimer s ***,its presence in different cell types and its enormous variety of substrates leads to apparently contra dictory conclusions when it comes to understanding its specific *** studies in sirtuin 2 research with selective sirtuin2 modulators targeting specific sirtuin 2 substrates are necessary to clarify its specific functions under different conditions and to validate it as a novel pharmacological *** will contribute to the development of new treatment strategies,not only for Alzheimer s disease but also for other neurodegenerative diseases.