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Induced pluripotent stem cells as an innovative model to study drug induced pancreatitis

World Journal of Gastroenterology 2021年第35期27卷 5796-5802页

作者： elena genova Gabriele Stocco Giuliana Decorti Institute for Maternal and Child Health IRCCS Burlo GarofoloTrieste 34137Italy Department of Life Sciences University of TriesteTrieste 34127Italy Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34127Italy

Drug-induced pancreatitis is a gastrointestinal adverse effect concerning about 2%of *** majority of cases are mild to moderate but severe episodes can also occur,leading to hospitalization or even ***,the mechanisms of this adverse reaction are still not clear,hindering its prevention,and the majority of data available of this potentially life-threatening adverse effect are limited to case reports leading to a probable underestimation of this *** particular,in this editorial,special attention is given to thiopurine-induced pancreatitis(TIP),an idiosyncratic adverse reaction affecting around 5%of inflammatory bowel disease(IBD)patients taking thiopurines as immunosuppressants,with a higher incidence in the pediatric *** biomarkers are not available to assist clinicians in the prevention of TIP,also because of the inaccessibility of the pancreatic tissue,which limits the possibility to perform dedicated cellular and molecular *** this regard,induced pluripotent stem cells(iPSCs)and the exocrine pancreatic differentiated counterpart could be a great tool to investigate the cellular and molecular mechanisms underlying the development of this undesirable *** particular type of stem cells is obtained by reprogramming adult cells,including fibroblasts and leukocytes,with a set of transcription factors known as the Yamanaka’s *** unaltered the donors’genetic heritage,iPSCs represent an innovative model to study the mechanisms of adverse drug reactions in individual patients’tissues not easily obtainable from human ***,iPSCs can differentiate under adequate stimuli into almost any somatic lineage,opening a new world of opportunities for *** works are already available in the literature studying liver,central nervous system and cardiac cells derived from iPSCs and adverse drug ***,to our knowledge no studies have been performed on exocrine pancreas differentiated

关键词： Induced pluripotent stem cells Therapy personalization Patient-specific cells Drug-induced pancreatitis Thiopurines Inflammatory bowel disease

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Induced pluripotent stem cells for therapy personalization in pediatric patients:Focus on drug-induced adverse events

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World Journal of Stem Cells 2019年第12期11卷 1020-1044页

作者： elena genova Federica Cavion Marianna Lucafò Luigina De Leo Marco Pelin Gabriele Stocco Giuliana Decorti PhD School in Reproduction and Development Sciences University of TriesteTrieste 34127Italy Department of Life Sciences University of TriesteTrieste 34127Italy Institute for Maternal and Child Health IRCCS Burlo GarofoloTrieste 34137Italy Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34127Italy

Adverse drug reactions(ADRs)are major clinical problems,particularly in special populations such as pediatric ***,ADRs may be caused by a plethora of different drugs leading,in some cases,to hospitalization,disability or even *** addition,pediatric patients may respond differently to drugs with respect to adults and may be prone to developing different kinds of ADRs,leading,in some cases,to more severe *** improve the comprehension,and thus the prevention,of ADRs,the set-up of sensitive and personalized assays is urgently *** progress is represented by the possibility of setting up groundbreaking patient-specific *** goal has been powerfully achieved using induced pluripotent stem cells(iPSCs).Due to their genetic and physiological species-specific differences and their ability to be differentiated ideally into all tissues of the human body,this model may be accurate in predicting drug toxicity,especially when this toxicity is related to individual genetic *** review is an up-to-date summary of the employment of iPSCs as a model to study ADRs,with particular attention to drugs used in the pediatric *** especially focused on the intestinal,hepatic,pancreatic,renal,cardiac,and neuronal levels,also discussing progress in organoids *** latter are three-dimensional in vitro culture systems derived from pluripotent or adult stem cells simulating the architecture and functionality of native organs such as the intestine,liver,pancreas,kidney,heart,and *** on the existing knowledge,these models are powerful and promising tools in multiple clinical applications including toxicity screening,disease modeling,personalized and regenerative medicine.

关键词： Induced pluripotent stem cells Organoids Adverse drug reactions Intestinal toxicity Hepatic toxicity Pancreatic toxicity Nephrotoxicity Cardiotoxicity Neurotoxicity

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Opinion Dynamics in Two-Layer Networks with Hypocrisy

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Journal of the Operations Research Society of China 2024年第1期12卷 109-132页

作者： Chi Zhao elena Parilina Saint Petersburg State University Saint Petersburg199034Russia Qingdao University School of Mathematics and StatisticsQingdao 266071ShandongChina

We propose a general concealed voter model(GCVM),in which individuals interact in two layers and can exchange their opinions in the internal *** interaction is not allowed in a *** exchanging opinions in the internal layer,we mean that individuals share their real or internal opinions with their close *** process of opinion formation in GCVM is presented in the *** make the series of numerical simulations of GCVM with different network structures(both external and internal)and get some counterintuitive *** instance,we find out that sometimes with a relatively simple network structure of an external layer the consensus within the individuals’opinions cannot be reached,and if individuals in the network are not good at expressing their opinions publicly(in an external layer),exchanging opinions with their close friends(in an internal layer)is almost useless.

关键词： Opinion dynamics Voter model Concealed voter model General concealed voter model

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Strong Subgame Consistency of the Core in Stochastic Network Formation Games

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Journal of the Operations Research Society of China 2024年第1期12卷 189-213页

作者： Ping Sun elena Parilina Faculty of Applied Mathematics and Control Processes Saint Petersburg State UniversitySaint Petersburg199034Russia

We consider a model of network formation as a stochastic game with random duration proposed initially in Sun and Parilina(Autom Remote Control 82(6):1065–1082,2021).In the model,the leader first suggests a joint project to other players,i.e.,the network connecting ***,the players are allowed to form fresh links with each other updating the initially proposed *** stage payoff of any player is defined depending on the network *** are two types of randomness in the network formation process:(i)links may fail to be formed with different probabilities although players intend to establish them,(ii)the game process may terminate at any stage or transit to the next stage with a certain probability ***,a network is formed as a result of players’decisions and realization of random *** cooperative version of the stochastic game is *** particular,we examine the properties of subgame consistency as well as strong subgame consistency of the *** provide a payment mechanism or regularization of the core elements to sustain its subgame consistency and avoid the player’s deviations from the cooperative *** addition,the distribution procedure of the core elements is regularized in case there are negative payments to achieve only nonnegative payments to the players at any *** sufficient condition of a strongly subgame consistent core is also *** illustrate our theoretical results with a numerical example.

关键词： Stochastic game Network formation Core Strong subgame consistency

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Applying the Shearlet-Based Complexity Measure for Analyzing Mass Transfer in Continuous-Flow Microchannels

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1743-1758页

作者： elena Mosheva Ivan Krasnyakov Institute of Continuous Media Mechanics UB RAS Perm614013Russia Department of Applied Physics Perm National Research Polytechnic UniversityPerm614990Russia

Continuous-flow microchannels are widely employed for synthesizing various materials,including nanoparticles,polymers,and metal-organic frameworks(MOFs),to name a *** technology allows precise control over reaction parameters,resulting in purer,more uniform,and structurally stable products due to more effective mass transfer ***,continuous-flow synthesis processes may be accompanied by the emergence of spatial convective structures initiating convective *** the one hand,convection can accelerate reactions by intensifying mass *** the other hand,it may lead to non-uniformity in the final product or defects,especially in MOF microcrystal *** ability to distinguish regions of convective and diffusive mass transfer may be the key to performing higher-quality reactions and obtaining purer *** this study,we investigate,for the first time,the possibility of using the information complexity measure as a criterion for assessing the intensity of mass transfer in microchannels,considering both spatial and temporal non-uniformities of liquid’s distributions resulting from convection *** calculate the complexity using shearlet transform based on a local *** contrast to existing methods for calculating complexity,the shearlet transform based approach provides a more detailed representation of local *** analysis involves experimental images illustrating the mixing process of two non-reactive liquids in a Y-type continuous-flow microchannel under conditions of double-diffusive convection *** obtained complexity fields characterize the mixing process and structure formation,revealing variations in mass transfer intensity along the *** compare the results with cases of liquid mixing via a pure diffusive *** analysis,it was revealed that the complexity measure exhibits sensitivity to variations in the type of mass transfer,establishing its feasibility as an ind

关键词： Shearlet analysis complexity measure entropy measure convection microchannels double-diffusive instability

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Effect of the anionic composition of sulfolane based electrolytes on the performances of lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第8期95卷 231-240,I0005页

作者： elena V.Karaseva elena V.Kuzmina Bo-Quan Li Qiang Zhang Vladimir S.Kolosnitsyn Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science 71Prospect OktyabryaUfa 450054BashkortostanRussia Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

In lithium-sulfur batteries,cell design,specifically electrolyte design,has a key impact on the battery *** effect of lithium salt anion donor number(DN)(DN[PF_(6)]^(-)=2.5,DN[N(SO_(2)CF_(3))_(2)]^(-)=5.4,DN[ClO_(4)]^(-)=8.4,DN[SO_(3)CF_(3)]^(-)=16.9,and DN[NO_(3)]^(-)=21.1)on the patterns of lithium-sulfur batteries and lithium metal electrode performances with sulfola ne-based electrolytes is *** increase in DN of lithium salt anions leads to an increase in the depth and rate of electrochemical reduction of sulfur and long-chain lithium polysulfides and to a decrease in those for medium-and short-chain lithium *** of lithium salt anions has weak effect on the discharge capacity of lithium-sulfur batteries and the Coulomb efficiency during cycling,with the exception of LiSO_(3)CF_(3)and LiNO_(3).An increase in DN of lithium salt anions leads to an increase in the cycling duration of lithium metal anodes and to a decrease in the presence of lithium *** sulfolane solutions of LiNO_(3)and LiSO_(3)CF_(3),lithium polysulfides do not affect the cycling duration of lithium metal anodes.

关键词： Donor number Lithium salt Sulfolane Lithium polysulfide Electrolyte Lithium-sulfur battery Lithium metal electrode

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SIRT2 as a potential new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 124-131页

作者： Noemi Sola-Sevilla elena Puerta Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of NavarraNavarra Institute for Health Research(IdiSNA)PamplonaSpain

Alzheimer's disease is the most common cause of dementia globally with an increasing incidence over the years,bringing a heavy burden to individuals and society due to the lack of an effective *** this context,sirtuin 2,the sirtuin with the highest expression in the brain,has emerged as a potential therapeutic target for neurodegenerative *** review summarizes and discusses the complex roles of sirtuin 2 in different molecular mechanisms involved in Alzheimer's disease such as amyloid and tau pathology,microtubule stability,neuroinflammation,myelin formation,autophagy,and oxidative *** role of sirtuin 2 in all these processes highlights its potential implication in the etiology and development of Alzheimer's ***,its presence in different cell types and its enormous variety of substrates leads to apparently contra dictory conclusions when it comes to understanding its specific *** studies in sirtuin 2 research with selective sirtuin2 modulators targeting specific sirtuin 2 substrates are necessary to clarify its specific functions under different conditions and to validate it as a novel pharmacological *** will contribute to the development of new treatment strategies,not only for Alzheimer's disease but also for other neurodegenerative diseases.

关键词： Alzheimer's disease amyloid autophagy memory neurodegenerative diseases neuroinflammation sirtuin 2 tau

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How we look:European wild moufon and feral domestic sheep hybrids

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Current Zoology 2024年第3期70卷 298-303页

作者： Nikica Šprem elena Buzan Toni Safner Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebSvetošimunska cesta 2510000 ZagrebCroatia Faculty of Mathematics Natural Sciences and Information TechnologiesUniversity of PrimorskaGlagoljaška 86000 KoperSlovenia Faculty of Environmental Protection Trg mladosti 73320 VelenjeSlovenia Faculty of Agriculture Department of Plant BreedingGenetics and BiometricsUniversity of ZagrebSvetošimunska cesta 2510000 ZagrebCroatia Centre of Excellence for Biodiversity and Molecular Plant Breeding(CroP-BioDiv) Svetošimunska cesta 2510000 ZagrebCroatia

Hybridization between wild animals and feral individuals from closely related domestic species can occur when they share the same *** events are generally regarded as a threat to the genetic integrity and survival of established wild *** aim of this study is to confrm a hybridization between European moufon and feral sheep on the Adriatic island Dugi Otok,where a group of individuals phenotypically indicative of a possible introgression was *** an ovine medium-density SNP array genotypes,we provided genetic evidence of recent gene admixture between the two *** ADMIXTURE analysis suggests that two hybrid individuals had 82.2%and 94.1%of their ancestry attributable to feral sheep,respectively,with the rest of the moufon in *** analysis estimated the combined probabilities for the putative hybrid individuals belonging to one of the hybrid classes at 87.0%and 90.1%,*** main phenotypic differences in the hybrids were observed in the shape of the horns,a stronger horn circumference than in the moufon and weaker than for the sheep,pronounced horn rings,a shorter tail,and intermediate *** therefore recommend constant monitoring of the purity of the moufon population to maintain its genetic *** addition,all feral sheep should be removed from the wild,and released sheep raised in semi-wild conditions should be better controlled.

关键词： crossbreeding gene introgression livestock Ovis gmelinimusimon SNPs

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Outpatient management of obscure gastrointestinal bleeding:A new perspective in high-risk patients

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World Journal of Gastroenterology 2024年第19期30卷 2502-2504页

作者： Maria elena Riccioni Clelia Marmo Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy CEMAD Centro Malattie Dell’Apparato Digerente Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy

Mid-gastrointestinal bleeding accounts for approximately 5%-10%of all gastrointestinal bleeding cases,and vascular lesions represent the most frequent *** rebleeding rate for these lesions is quite high(about 42%).We hereby recommend that scheduled outpatient management of these patients could reduce the risk of rebleeding episodes.

关键词： Gastrointestinal bleeding Small bowel bleeding Recurrent bleeding Rebleeding risk Rebleeding Outpatient management

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Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

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Fluid Dynamics & Materials Processing 2024年第4期20卷 739-748页

作者： Andrei Vasiliev Andrei Sukhanovskii elena Popova Laboratory of Turbulence Institute of Continuous Media Mechanics UB RASPerm614013Russia

The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is *** is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the *** horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex *** mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential *** a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper *** baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity *** is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic *** increase in the inclination angle leads to a significant increase in the energy of the *** obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.

关键词： Laboratory modeling global atmospheric circulation baroclinic waves beta-effect

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