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Neuroendocrine carcinomas arising in ulcerative colitis:Coincidences or possible correlations?

World Journal of Gastroenterology 2009年第33期15卷 4193-4195页

作者： Roberto Grassia Paolo Bodini Paolo Dizioli Teresa Staiano elena iiritano Guglielmo Bianchi Federico Buffoli Digestive Endoscopy and Gastroenterology Unit A.O. "Istituti Ospitalieri di Cremona"

Patients with in· ammatory bowel disease (IBD) are at increased risk of colorectal malignancies. Adenocarcinoma is the commonest type of colorectal neoplasm associated with ulcerative colitis (UC) and Crohn's disease, but other types of epithelial and non-epithelial tumors have also been described in inflamed bowel. With regards to non-epithelial malignancies, lymphomas and sarcomas represent the largest group of tumors reported in association with IBD, especially in immunosuppressed patients. Carcinoids and in particular neuroendocrine neoplasms other than carcinoids (NENs) are rare tumors and are infrequently described in the setting of IBD. Thus, this association requires further investigation. We report two cases of neoplasms arising in mild left-sided UC with immuno-histochemical staining for neuroendocrine markers: a large cell and a small cell neuroendocrine carcinoma of the rectum. The two patients were different in age (35 years vs 77 years) and disease duration (11 years vs 27 years), and both had never received immuno-suppressant drugs. Although the patients underwent regular endoscopic and histological follow-up, the two neoplasms were locally advanced at diagnosis. One of the two patients developed multiple liver metastases and died 15 mo after diagnosis. These findings confirm the aggressiveness and the poor prognosis of NENs compared to colorectal adenocarcinoma. While carcinoids seem to be coincidentally associated with IBD, NENs may also arise in this setting. In fact, long-stand-ing in· ammation could be directly responsible for thedevelopment of pancellular dysplasia involving epithelial, goblet, Paneth and neuroendocrine cells. It has yet to be established which IBD patients have a higher risk of developing NENs.

关键词：溃疡性结肠炎神经内分泌癌

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Non-variceal upper gastrointestinal bleeding: Rescue treatment with a modified cyanoacrylate

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World Journal of Gastroenterology 2016年第48期22卷 10609-10616页

作者： Roberto Grassia Pietro Capone elena iiritano Katerina Vjero Fabrizio Cereatti Mario Martinotti Gabriele Rozzi Federico Buffoli Digestive Endoscopy and Gastroenterology Unit "ASST di Cremona" Department of Surgery "ASST di Cremona" Department of Radiology "ASST di Cremona"

AIM To evaluate the safety and efficacy of a modified cyanoacrylate [N-butyl-2-cyanoacrylate associated with methacryloxysulfolane(NBCA + MS)] to treat nonvariceal upper gastrointestinal bleeding(NV-UGIB).METHODS In our retrospective study we took into account 579 out of 1177 patients receiving endoscopic treatment for NV-UGIB admitted to our institution from 2008 to 2015; the remaining 598 patients were treated with other treatments. Initial hemostasis was not achieved in 45 of 579 patients; early rebleeding occurred in 12 of 579 patients. Thirty-three patients were treated with modified cyanoacrylate: 27 patients had duodenal, gastric or anastomotic ulcers, 3 had post-mucosectomy bleeding, 2 had Dieulafoy's lesions, and 1 had duodenal diverticular *** Of the 45 patients treated endoscopically without initialhemostasis or with early rebleeding, 33(76.7%) were treated with modified cyanoacrylate glue, 16(37.2%) underwent surgery, and 3(7.0%) were treated with selective transarterial embolization. The mean age of patients treated with NBCA + MS(23 males and 10 females) was 74.5 years. Modified cyanoacrylate was used in 24 patients during the first endoscopy and in 9 patients experiencing rebleeding. Overall, hemostasis was achieved in 26 of 33 patients(78.8%): 19 out of 24(79.2%) during the first endoscopy and in 7 out of 9(77.8%) among early rebleeders. Two patients(22.2%) not responding to cyanoacrylate treatment were treated with surgery or transarterial embolization. One patient had early rebleeding after treatment with cyanoacrylate. No late rebleeding during the follow-up or complications related to the glue injection were *** Modified cyanoacrylate solved definitively NV-UGIB after failure of conventional treatment. Some reported life-threatening adverse events with other formulations, advise to use it as last option.

关键词： Rescue treatment Glubran Non-variceal upper gastrointestinal bleeding Endoscopic treatment Cyanoacrylate

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Opinion Dynamics in Two-Layer Networks with Hypocrisy

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Journal of the Operations Research Society of China 2024年第1期12卷 109-132页

作者： Chi Zhao elena Parilina Saint Petersburg State University Saint Petersburg199034Russia Qingdao University School of Mathematics and StatisticsQingdao 266071ShandongChina

We propose a general concealed voter model(GCVM),in which individuals interact in two layers and can exchange their opinions in the internal *** interaction is not allowed in a *** exchanging opinions in the internal layer,we mean that individuals share their real or internal opinions with their close *** process of opinion formation in GCVM is presented in the *** make the series of numerical simulations of GCVM with different network structures(both external and internal)and get some counterintuitive *** instance,we find out that sometimes with a relatively simple network structure of an external layer the consensus within the individuals’opinions cannot be reached,and if individuals in the network are not good at expressing their opinions publicly(in an external layer),exchanging opinions with their close friends(in an internal layer)is almost useless.

关键词： Opinion dynamics Voter model Concealed voter model General concealed voter model

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Strong Subgame Consistency of the Core in Stochastic Network Formation Games

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Journal of the Operations Research Society of China 2024年第1期12卷 189-213页

作者： Ping Sun elena Parilina Faculty of Applied Mathematics and Control Processes Saint Petersburg State UniversitySaint Petersburg199034Russia

We consider a model of network formation as a stochastic game with random duration proposed initially in Sun and Parilina(Autom Remote Control 82(6):1065–1082,2021).In the model,the leader first suggests a joint project to other players,i.e.,the network connecting ***,the players are allowed to form fresh links with each other updating the initially proposed *** stage payoff of any player is defined depending on the network *** are two types of randomness in the network formation process:(i)links may fail to be formed with different probabilities although players intend to establish them,(ii)the game process may terminate at any stage or transit to the next stage with a certain probability ***,a network is formed as a result of players’decisions and realization of random *** cooperative version of the stochastic game is *** particular,we examine the properties of subgame consistency as well as strong subgame consistency of the *** provide a payment mechanism or regularization of the core elements to sustain its subgame consistency and avoid the player’s deviations from the cooperative *** addition,the distribution procedure of the core elements is regularized in case there are negative payments to achieve only nonnegative payments to the players at any *** sufficient condition of a strongly subgame consistent core is also *** illustrate our theoretical results with a numerical example.

关键词： Stochastic game Network formation Core Strong subgame consistency

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Applying the Shearlet-Based Complexity Measure for Analyzing Mass Transfer in Continuous-Flow Microchannels

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1743-1758页

作者： elena Mosheva Ivan Krasnyakov Institute of Continuous Media Mechanics UB RAS Perm614013Russia Department of Applied Physics Perm National Research Polytechnic UniversityPerm614990Russia

Continuous-flow microchannels are widely employed for synthesizing various materials,including nanoparticles,polymers,and metal-organic frameworks(MOFs),to name a *** technology allows precise control over reaction parameters,resulting in purer,more uniform,and structurally stable products due to more effective mass transfer ***,continuous-flow synthesis processes may be accompanied by the emergence of spatial convective structures initiating convective *** the one hand,convection can accelerate reactions by intensifying mass *** the other hand,it may lead to non-uniformity in the final product or defects,especially in MOF microcrystal *** ability to distinguish regions of convective and diffusive mass transfer may be the key to performing higher-quality reactions and obtaining purer *** this study,we investigate,for the first time,the possibility of using the information complexity measure as a criterion for assessing the intensity of mass transfer in microchannels,considering both spatial and temporal non-uniformities of liquid’s distributions resulting from convection *** calculate the complexity using shearlet transform based on a local *** contrast to existing methods for calculating complexity,the shearlet transform based approach provides a more detailed representation of local *** analysis involves experimental images illustrating the mixing process of two non-reactive liquids in a Y-type continuous-flow microchannel under conditions of double-diffusive convection *** obtained complexity fields characterize the mixing process and structure formation,revealing variations in mass transfer intensity along the *** compare the results with cases of liquid mixing via a pure diffusive *** analysis,it was revealed that the complexity measure exhibits sensitivity to variations in the type of mass transfer,establishing its feasibility as an ind

关键词： Shearlet analysis complexity measure entropy measure convection microchannels double-diffusive instability

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SIRT2 as a potential new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 124-131页

作者： Noemi Sola-Sevilla elena Puerta Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of NavarraNavarra Institute for Health Research(IdiSNA)PamplonaSpain

Alzheimer's disease is the most common cause of dementia globally with an increasing incidence over the years,bringing a heavy burden to individuals and society due to the lack of an effective *** this context,sirtuin 2,the sirtuin with the highest expression in the brain,has emerged as a potential therapeutic target for neurodegenerative *** review summarizes and discusses the complex roles of sirtuin 2 in different molecular mechanisms involved in Alzheimer's disease such as amyloid and tau pathology,microtubule stability,neuroinflammation,myelin formation,autophagy,and oxidative *** role of sirtuin 2 in all these processes highlights its potential implication in the etiology and development of Alzheimer's ***,its presence in different cell types and its enormous variety of substrates leads to apparently contra dictory conclusions when it comes to understanding its specific *** studies in sirtuin 2 research with selective sirtuin2 modulators targeting specific sirtuin 2 substrates are necessary to clarify its specific functions under different conditions and to validate it as a novel pharmacological *** will contribute to the development of new treatment strategies,not only for Alzheimer's disease but also for other neurodegenerative diseases.

关键词： Alzheimer's disease amyloid autophagy memory neurodegenerative diseases neuroinflammation sirtuin 2 tau

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Effect of the anionic composition of sulfolane based electrolytes on the performances of lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第8期95卷 231-240,I0005页

作者： elena V.Karaseva elena V.Kuzmina Bo-Quan Li Qiang Zhang Vladimir S.Kolosnitsyn Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science 71Prospect OktyabryaUfa 450054BashkortostanRussia Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

In lithium-sulfur batteries,cell design,specifically electrolyte design,has a key impact on the battery *** effect of lithium salt anion donor number(DN)(DN[PF_(6)]^(-)=2.5,DN[N(SO_(2)CF_(3))_(2)]^(-)=5.4,DN[ClO_(4)]^(-)=8.4,DN[SO_(3)CF_(3)]^(-)=16.9,and DN[NO_(3)]^(-)=21.1)on the patterns of lithium-sulfur batteries and lithium metal electrode performances with sulfola ne-based electrolytes is *** increase in DN of lithium salt anions leads to an increase in the depth and rate of electrochemical reduction of sulfur and long-chain lithium polysulfides and to a decrease in those for medium-and short-chain lithium *** of lithium salt anions has weak effect on the discharge capacity of lithium-sulfur batteries and the Coulomb efficiency during cycling,with the exception of LiSO_(3)CF_(3)and LiNO_(3).An increase in DN of lithium salt anions leads to an increase in the cycling duration of lithium metal anodes and to a decrease in the presence of lithium *** sulfolane solutions of LiNO_(3)and LiSO_(3)CF_(3),lithium polysulfides do not affect the cycling duration of lithium metal anodes.

关键词： Donor number Lithium salt Sulfolane Lithium polysulfide Electrolyte Lithium-sulfur battery Lithium metal electrode

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Combined Endoscopic Transanal Vacuum-Assisted Rectal Drainage:A Novel Therapy for Colorectal Anastomotic Leak after TME for Cancer

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Surgical Science 2014年第10期5卷 467-470页

作者： Mario Martinotti Valerio Ranieri elena iiritano Teresa Staiano Roberto Dusi Ernesto Laterza Federico Buffoli Departement of General Surgery IstitutiOspitalieri di CremonaCremonaItaly Endoscopy Unit IstitutiOspitalieri di CremonaCremonaItaly General Surgery Unit Ospedale Oglio PoCasalmaggioreItaly

Introduction: Low colorectal and colo-anal anastomosis leakage after anterior resection of rectum occurs in up to 24% of cases. Leak is the main cause of morbidity and mortality in postoperative period and can result in a permanent stoma in up to 25% of cases. Loop ileostomy or colostomy does not reduce the percentage of fistulas, but reduces flow rate. Conservative management imply long times to heal. Endosponge®system (B. Braun Aesculap AG, Germany) was recently acquired in clinical practice. This system accelerates healing process through vacuum creation, removal of fluids and edema, infection control, local increase of blood flow and stimulation of granulation tissue formation. The device consists of a cylindrical polyurethane sponge, with 400 to 600 micron pores, standard dimension of 7 cm, which can be cut to fit the estimated size of the abscess cavity. The drain tube is connected to a Redyrob Trans Plus®bottle which exerts a constant suction during the therapy. Materials and Methods: From November 2012 and March 2014 four patients were treated with Endosponge®system, all of them underwent operation of anterior resection of rectum for cancer and developed anastomotic leakage during postoperative course. All patients had loop ileostomy, none presented signs of sepsis. The Endosponge®system was then placed endoscopically. In all cases, after the first placing, the authors utilized sterile foam dressing from negative pressure wound therapy kit, tailored to better fill the abscess cavity and connected with Redyrob Trans Plus?bottle. Device changes were performed every 5 - 7 days, according to the size of the cavity and the amount of secretions produced. The treatment was started during hospitalization first and then continued as outpatient. Results: There was no mortality. The amount of secretions was related to the initial size and the degree of contamination of the abscess cavity. Antibiotic therapy was discontinued after an average of 21 days,

关键词： Endosponge^(█) Colorectal Anastomotic Leak Transanal Vacuum Therapy

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Outpatient management of obscure gastrointestinal bleeding:A new perspective in high-risk patients

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World Journal of Gastroenterology 2024年第19期30卷 2502-2504页

作者： Maria elena Riccioni Clelia Marmo Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy CEMAD Centro Malattie Dell’Apparato Digerente Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy

Mid-gastrointestinal bleeding accounts for approximately 5%-10%of all gastrointestinal bleeding cases,and vascular lesions represent the most frequent *** rebleeding rate for these lesions is quite high(about 42%).We hereby recommend that scheduled outpatient management of these patients could reduce the risk of rebleeding episodes.

关键词： Gastrointestinal bleeding Small bowel bleeding Recurrent bleeding Rebleeding risk Rebleeding Outpatient management

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Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

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Fluid Dynamics & Materials Processing 2024年第4期20卷 739-748页

作者： Andrei Vasiliev Andrei Sukhanovskii elena Popova Laboratory of Turbulence Institute of Continuous Media Mechanics UB RASPerm614013Russia

The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is *** is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the *** horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex *** mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential *** a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper *** baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity *** is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic *** increase in the inclination angle leads to a significant increase in the energy of the *** obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.

关键词： Laboratory modeling global atmospheric circulation baroclinic waves beta-effect

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