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C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data

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Cancer Communications 2023年第3期43卷 400-404页

作者： Haiping Song Hector Manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He eleanor lawrence Alison Gartland Jian Luo Ning Wang Department of Internal Medicine-Oncology Qingdao Tumor HospitalThe Second Affiliated Hospital of Medical College of Qingdao UniversityQingdaoShandong 266042P.R.China The Mellanby Centre for Musculoskeletal Research Department of Oncology and MetabolismThe University of SheffieldSheffieldSouth Yorkshire S102RXUK Yangzhi Rehabilitation Hospital(Sunshine Rehabilitation Centre) Tongji University School of MedicineShanghai 201619P.R.China

Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa *** adenosine triphosphate(ATP)was shown to be a major biochemical constituent of the tumor microenvironment and regulates the tumor and host interactions by acting at P2 purinergic *** the P2 receptors,the ion channel P2X purinergic receptor 7(P2X7R)has an unusually long C-terminus containing 200 amino acids,which forms the molecular basis for the unique bi-function of P2X7R promoting cancer cell proliferation or inducing membrane permeabilization and apoptosis,upon activation by a low or high concentration of ATP,respectively.

关键词： metastasis cancer clinical

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Potential annual daylighting performance of a high-efficiency daylight redirecting slat system

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Building Simulation 2021年第3期14卷 495-510页

作者： Luis L.Fernandes eleanor S.Lee Anothai Thanachareonkit Stephen E.Selkowitz lawrence Berkeley National Laboratory BerkeleyCaliforniaUSA

While the primary role of window attachments is often to moderate glare and solar heat gains,they are also able to provide additional daylight to interior *** this purpose,a variety of daylight-redirecting window systems have been developed over the past 150 *** reflective systems(slats/light shelves)or prismatic systems that rely on total internal reflection work well under specific solar conditions,but generally sacrifice performance over a much wider range of incident solar angles and sky *** systems-typically reflective slats-are more responsive to sun angles but have not been able to achieve optimal performance for glare and daylight redirection efficiency.A previous investigation into an adjustable,reflective blind concept first conceived of in the late 1970s showed promise but was not reduced to practice due to lack of adequate simulation and analysis *** this paper,this concept is further developed and its energy and visual comfort performance evaluated for four mid-latitude,temperate climates using ray-tracing simulation *** indicate significant potential lighting energy savings when compared with conventional automated reflective blinds(2.1-4.9 kWh/(m^(2)·a),or 14%-42%,depending on climate and orientation)or,especially,manually-operated matte white Venetian blinds(1.4-7.9 kWh/(m^(2)·a),or 9%-54%,depending on climate and orientation),while maintaining acceptable or better visual comfort conditions throughout the interior space.

关键词： daylighting windows light-redirecting systems dynamic fenestration

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Delayed peripheral treatment with neurotrophin-3 improves sensorimotor recovery after central nervous system injury

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Neural Regeneration Research 2019年第10期14卷 1703-1704页

作者： Sotiris G.Kakanos lawrence D.F.Moon Neurorestoration Group Wolfson Centre for Age-Related DiseasesKing’s College of London

Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the survival, correct connectivity and function of sensory (“proprioceptive”) afferents that innervate muscle spindles;these neurons express receptors for NT3 including tropomyocin receptor kinase C. These proprioceptive afferents are important for normal movement (Boyce and Mendell, 2014) and signals from muscle spindles are important for recovery of limb movement (e.g., after spinal cord lateral hemisection)(Takeoka et al., 2014). The level of NT3 declines in most tissues during postnatal development;its level is low in adult and elderly humans and other mammals (Murase et al., 1994). Elevation of NT3 has been shown to improve outcome in various animal models of neurological disease and injury. For example, many groups have shown that delivery of NT3 directly into the central nervous system promotes recovery after spinal cord injury but this often involved invasive routes or gene therapy (Boyce and Mendell, 2014;Petrosyan et al., 2015;Wang et al., 2018).

关键词： Neurotrophin-3(NT3) tissues including the heart Boyce and Mendell

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不同电池宽度半透明光伏窗天然采光分析

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太阳能学报 2022年第3期43卷 223-230页

作者：高静彭晋卿王韬宁薛鹏罗伊默 eleanor SLee 湖南大学土木工程学院长沙410082 劳伦斯伯克利国家实验室伯克利94720 北京工业大学绿色建筑环境与节能技术北京市重点实验室北京100124

为了模拟不同太阳电池宽度对半透明光伏窗采光性能的影响,提出将非透光电池和透光玻璃间隙分开模拟的新方法,并使用实验数据验证新方法和模型的准确性。通过与实验结果的差异分析,采用新方法模拟所得到的照度和眩光可能性(DGP)的准确性... 详细信息

为了模拟不同太阳电池宽度对半透明光伏窗采光性能的影响,提出将非透光电池和透光玻璃间隙分开模拟的新方法,并使用实验数据验证新方法和模型的准确性。通过与实验结果的差异分析,采用新方法模拟所得到的照度和眩光可能性(DGP)的准确性均明显优于传统方法。采用新方法对太阳电池覆盖率相同但电池宽度分别为2.5、5.0以及7.5 mm的3种半透明光伏窗的天然采光特性进行模拟研究,并采用全天然采光时间百分比(DA)、有效天然采光照度(UDI)、天然光眩光指数(DGI)、眩光可能性(DGP)等指标对不同电池宽度光伏窗的采光和眩光性能进行对比分析。结果表明,随着电池宽度增加,室内平均DA和UDI逐渐减小,产生眩光的可能性增加,室内视觉舒适度下降。该文提出的方法使得研究不同电池宽度条件下半透明光伏窗的采光和眩光性能变为可能,且利用该方法得出相同电池覆盖率下最佳的电池宽度。

关键词：太阳电池采光模拟眩光光伏窗视觉舒适度

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