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Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis

Medicinal Plant Biology 2022年第1期1卷 8-23页

作者： Matthew L.Tomlinson Man Zhao elaine j.barclay jie Li Haixiu Li juri Felix Lionel Hill Gerhard Saalbach Martin Rejzek Dongfeng Yang Qing Zhao Paul Kroon Wei Wang Yongping Bao Melanie-jayne R.Howes Evangelos C.Tatsis Cathie Martin The john Innes Centre NorwichNR47UHUnited Kingdom College of Bioengineering and Biotechnology Zhejiang University of TechnologyHangzhou 310058China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Royal Botanic Gardens Kew RichmondSurreyLondon TW93ABUnited Kingdom College of Life Sciences Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602China Quadram Institute Bioscience Norwich Research ParkNorwichNR47UAUnited Kingdom Norwich Medical School University of East AngliaNorwichNorfolkNR47TJUnited Kingdom CEPAMS:CAS-jIC Centre of Excellence in Plant and Microbial Sciences

Medicinal plants are an excellent source of structurally diverse,bio-active compounds with potential in the fight against *** of the most promising is Scutellaria barbata,prescribed traditionally for the treatment of *** A is the major diterpenoid,produced in specialized large,peltate trichomes on leaves of *** induces dose-dependent apoptosis,specifically in cancer *** major class of proteins down-regulated are pro-survival proteins,the Inhibitors of Apoptosis(IAPs),and IAP regulating *** propose that scutebarbatine A works by releasing the molecular brakes(the IAPs)on apoptosis in cell death-evading cancer *** between the cytotoxicity of methanolic extracts of *** leaves and decoctions(Ban Zhi Lian)prepared traditionally,showed substantially different chemical compositions and differential induction of *** suggest polyvalency between the constituents in both extracts,and ways to produce enhanced chemopreventive preparations for the treatment of cancer.

关键词： prescribed methanol structurally

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Online machine learning for stream wastewater influent flow rate prediction under unprecedented emergencies

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Frontiers of Environmental Science & Engineering 2023年第12期17卷 137-147页

作者： Pengxiao Zhou Zhong Li Yimei Zhang Spencer Snowling jacob barclay Department of Civil Engineering McMaster UniversityHamiltonOntario L8S 4L8Canada MOE Key Laboratory of Resources and Environmental System Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Laboratory of Environmental Remediation and Functional Material Suzhou Research Academy of North China Electric Power UniversitySuzhou 215213China Hatch Ltd. Sheridan Science&Technology ParkMississaugaOntario L5K 2R7Canada

Accurate influent flow rate prediction is important for operators and managers at wastewater treatment plants(WWTPs),as it is closely related to wastewater characteristics such as biochemical oxygen demand(BOD),total suspend solids(TSS),and *** studies have been conducted to predict influent flow rate,and it was proved that data-driven models are effective ***,most of these studies have focused on batch learning,which is inadequate for wastewater prediction in the era of COVID-19 as the influent pattern changed *** learning,which has distinct advantages of dealing with stream data,large data set,and changing data pattern,has a potential to address this *** this study,the performance of conventional batch learning models Random Forest(RF),K-Nearest Neighbors(KNN),and Multi-Layer Perceptron(MLP),and their respective online learning models Adaptive Random Forest(aRF),Adaptive K-Nearest Neighbors(aKNN),and Adaptive Multi-Layer Perceptron(aMLP),were compared for predicting influent flow rate at two Canadian *** learning models achieved the highest R2,the lowest MAPE,and the lowest RMSE compared to conventional batch learning models in all *** R2 values on testing data set for 24-h ahead prediction of the aRF,aKNN,and aMLP at Plant A were 0.90,0.73,and 0.87,respectively;these values at Plant B were 0.75,0.78,and 0.56,*** proposed online learning models are effective in making reliable predictions under changing data patterns,and they are efficient in dealing with continuous and large influent data *** can be used to provide robust decision support for wastewater treatment and management in the changing era of COVID-19 and also under other unprecedented emergencies that could change influent patterns.

关键词： Wastewater prediction Data stream Online learning Batch learning Influent flow rates

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原镁生产中的能耗

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轻金属 1978年第3期 45-47页

作者： j.barclay 郑宏

尽管镁是地壳中第三种最丰富的元素,而且海水中的镁取之不尽,此外,还有菱镁矿、白云石这些矿物和含MgCl的盐水以及大盐湖水等镁资沅,但至今镁仍未达到作为结构材料

关键词：海水制取非金属矿物氯化镁溶液能量消耗电解法电化学分析原产品白云石镁肥金属金属材料

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Remembering,Forgetting,and Absencing Disasters in the Post-disaster Recovery Process

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International journal of Disaster Risk Science 2020年第3期11卷 287-299页

作者： Charlotte Monteil jenni barclay Anna Hicks Lancaster Environment Center Lancaster UniversityBailrigg LAI 4YWUK School of Environmental Sciences University of East AngliaNorwich NR47TJUK Edinburgh Office British Geological SurveyEdinburgh EH 144BAUK

Sustainable post-disaster recovery implies learning from past experience in order to prevent recreating forms of *** construction supports both the healing process and redevelopment ***,memory of disaster results from the balance between remembering,forgetting,and absencing elements of the disaster,and can be both a tool and an obstacle to sustainable *** explore here how collective memory is built in a post-disaster context to respond to the needs of this critical period,and how it shapes *** ethnographic study,conducted between 2015 and 2017,explores the recovery processes in Montserrat,a small Caribbean island affected by an extended volcanic crisis from 1995 to *** this study does not give tangible solutions for disaster risk reduction in a post-disaster context,it highlights potential obstacles for learning from a disaster and how they may be *** argue that it is crucial to acknowledge evolving collective memory in order to implement effective measures for preserving and sharing a shared understanding of disaster across generations and social groups in a way that supports disaster risk *** also maintain that acknowledging the dilemma faced by authorities and disaster management agencies during a period of conflicting needs may encourage the reconsideration of risk framing,and hence reveal how to improve implementation of disaster risk reduction measures.

关键词： Absencing risk information Disaster remembering Forgetting processes Montserrat Post-disaster recovery

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The complexity of providing humanitarian surgical care in armed conflict: a framework to help categorize needs

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Emergency and Critical Care Medicine 2022年第2期2卷 41-44页

作者： Kevin Gianaris barclay T.Stewart Sherry M.Wren Adam L.Kushner Indiana University School of Medicine IndianapolisINUSA Department of Surgery University of WashingtonSeattleWAUSA Harborview Injury Prevention and Research Center University of WashingtonSeattleWAUSA Department of Surgery Stanford UniversityPalo AltoCAUSA Surgeons OverSeas New York CityNYUSA Department of International Health Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMDUSA

Armed conflicts are increasing globally due to political unrest and the broader effects of climate *** resources to provide quality surgical care,it becomes nearly impossible to provide quality emergency surgery and trauma care similar to that in high-income *** understand and help aid organizations provide resources and address the surgical needs of populations facing armed conflict,a matrix to identify variables and help with interventions was *** published global surgery matrix based on the PIPES(Personnel,Infrastructure,Procedures,Equipment and Supplies)surgical capacity tool was adapted to this *** novel matrix incorporates 108 *** variables are grossly divided into local and international agency components to address the issue of who is providing *** a time continuum of pre-conflict,conflict,and post-conflict allows organizations to concentrate on when during the conflict to target their *** addition to the previously used personnel,infrastructure,procedures,equipment,and supplies categories,a sixth category called standards was included that addresses the issues such as information technology,data systems,quality improvement programs,and patient *** testing of this matrix to obtain feedback from end users is the next step in ***,peri-conflict preparedness should increase and improve surgical outcomes and reduce in death and disabilities around the world.

关键词： Armed conflict Emergency care Global surgery Humanitarian assistance Trauma care

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Esophagogastroduodenoscopy-assisted bowel preparation for colonoscopy

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World journal of Gastrointestinal Endoscopy 2013年第3期5卷 95-101页

作者： Robert L barclay Rockford Gastroenterology Associates RockfordIL 61107-5078United States

AIM:To compare the quality and tolerance of esophag ogastroduodenoscopy(EGD)-assisted and conventional split-dose polyethylene glycol electrolyte solution for inpatient ***:The study was a randomized controlled trial in hospitalized *** patients undergoing colonoscopy the day following EGD for evaluation of gastrointestinal(GI) bleeding or other *** randomized to either EGD-assisted bowel prep [2 L polyethylene glycol(PEG) administered endoscopically into distal duodenum at time of EGD,plus 1 L PEG orally the following day] or conventional-PEG(2 L PEG orally the evening prior and 1 L PEG orally the following day).The main outcome measurements are bowel preparation quality and patient tolerance of bowel ***:Forty-two patients randomized to EGD-assisted bowel prep and 40 patients to *** mean ± SD preparation quality was superior for EGD-PEG(4.1 ± 2.8) vs conventional-PEG(6.5 ± 3.1;P = 0.0005).Seventy-four percent of patients rated EGDPEG as easy or slightly difficult to tolerate compared to 46% for standard-PEG(P = 0.0133).Mean EGD-procedural time was greater for EGD-assisted subject(24 ± 10 min) compared to conventional-PEG prep subjects(15 ± 7 min;P jority of PEG solution improves patient tolerance and quality of bowel preparation for colonoscopy.

关键词： Colonoscopy Bowel preparation Tolerability Esophagogastroduodenoscopy-assisted

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SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status

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World journal of Gastroenterology 2010年第45期16卷 5727-5731页

作者： Lucy C Stewart Andrew S Day john Pearson Murray L barclay Richard B Gearry Rebecca L Roberts Robert W Bentley Department of Paediatrics University of OtagoChristchurch 8140New Zealand Department of Paediatrics Christchurch HospitalChristchurch 8140New Zealand Department of Pathology University of OtagoChristchurch 8140New Zealand Department of Medicine University of OtagoChristchurch 8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

AIM: To test for association of SLC11A1 with inflammatory bowel disease (IBD) and Mycobacterium avium subspecies paratuberculosis (MAP) status in a Caucasian cohort. METHODS: Five hundred and seven Crohn's disease (CD) patients, 474 ulcerative colitis (UC) patients, and 569 healthy controls were genotyped for SLC11A1 1730G>A and SLC11A1 469+14G>C using pre-designed TaqMan  SNP assays. χ 2 tests were applied to test for association of single nucleotide polymorphisms (SNPs) with disease, and the presence of MAP ***:SLC11A1 1730G>A and SLC11A 1469+14G>C were not associated with CD, UC, or IBD. The SLC11A1 1730A minor allele was over-represented in patients who did not require immunomodulator therapy (P = 0.002, OR: 0.29, 95% CI: 0.13-0.66). The frequency of the SLC11A1 469+14C allele was higher in the subset of study participants who tested positive for MAP DNA (P = 0.02, OR: 1.56, 95% CI: 1.06-2.29). No association of SLC11A1 1730G>A with MAP was ***: Although SLC11A1 was not associated with IBD, association with MAP suggests that SLC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD.

关键词： NRAMP1 Crohn’s disease Ulcerative colitis IS900 polymerase chain reaction

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NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease

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World journal of Gastroenterology 2011年第23期17卷 2829-2837页

作者： Dylan M Glubb Richard B Gearry Murray L barclay Rebecca L Roberts john Pearson jacqui I Keenan judy McKenzie Robert W Bentley Department of Medicine University of ChicagoIL 60637-1470United States Department of Medicine University of OtagoChristchurch8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch8140New Zealand Department of Biochemistry University of OtagoDunedin9054New Zealand Department of Pathology University of OtagoChristchurch8140New Zealand Department of Surgery University of OtagoChristchurch8140New Zealand Department of Haematology University of OtagoChristchurch8140New Zealand Department of Paediatrics University of OtagoChristchurch8140New Zealand

AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) ***:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and *** were challenged with MAP and bacterial persistence assessed at subsequent *** responses were assayed using a Milliplex multi-analyte profiling assay for 13 ***:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those *** was no effect of NOD2 genotype on subsequent cytokine *** T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.

关键词：单核苷酸多态性单核细胞反应细胞因子结核分枝杆菌白细胞介素基因多态性 MAP

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Strengthening the emergency health response to children wounded by explosive weapons in conflict

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World journal of Pediatric Surgery 2022年第4期5卷 196-203页

作者： Hannah Wild Paul Reavley Emily Mayhew Emmanuel A Ameh Mehmet Emin Celikkaya barclay Stewart Department of Surgery University of WashingtonSeattleWAUSA Bristol Royal Hospital for Children University Hospitals BristolBristolUK Department of Bioengineering Imperial College LondonLondonUK Division of Pediatric Surgery Department of SurgeryNational HospitalAbujaNigeria Department of Pediatric Surgery Mustafa Kemal UniversityHatayTurkey Global Injury Control Section Harborview Injury Prevention and Research CenterSeattleWAUSA

The 2022 war in Ukraine has highlighted the unacceptable consequences wrought on civilians and health infrastructure by *** are among the most vulnerable of those affected and constitute an increasing percentage of non-combatants injured in conflicts globally.A disproportionate number of these injuries are caused by blast mechanisms from munitions including‘conventional’landmines and indiscriminate explosive weapons such as barrel bombs and improvised explosive *** 21st century conflict,children are no longer only accidental casualties of war,but are increasingly targeted by parties through acts such as bombing of school buses and playgrounds,conscription as child soldiers,and use as human *** the present viewpoint article,we review the state of pediatric blast injury studies,synthesizing current understandings of injury epidemiology and identifying gaps in research to advance the field towards a concrete agenda to improve care for this vulnerable population.

关键词： consequences injuries globally

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Climate shapes the spatiotemporal variation in color morph diversity and composition across the distribution range of Chrysomela lapponica leaf beetle

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Insect Science 2022年第3期29卷 942-955页

作者： Mikhail V.Kozlov Zowi Oudendijk Anders Forsman Vojtech Lanta Maxwell V.L.barclay Vladimir I.Gusarov Bert Gustafsson Zheng-Zhong Huang Oksana Y.Kruglova Yuri M.Marusik Yuri E.Mikhailov Marko Mutanen Alexander Schneider Lukas Sekerka Maksim E.Sergeev Vitali Zverev Elena L.Zvereva Department of Biology University of TurkuTurkuFinland Department of Animal Ecology and Physiology Radboud UniversityNijmegenThe Netherlands Department of Biology and Environmental Science Linnaeus UniversityKalmarSweden Institute of Botany The Czech Academy of SciencesDukelskaTrebohCzech Republic Department of Life Sciences Natural History MuseumLondonUnited Kingdom Natural History Museum University of OsloOsloNorway Departmant of Zoology Swedish Museum of Natural HistoryStockholmSweden elnsititute of Zoology Chinese Academy of SciencesBeijingChina Faculty of Biology Belarusian State UniversityMinskBelarus Department of Biocenology Institute for Biological Problems of the NorthFar East Branch of the Russian Academy of SciencesMagadanRussia Department of Zoology&Entomology University of the Free StateBloemfonteinSouth Africa Department of Ecology&Nature Management Ural State Forest Engineering UniversityYekaterinburgRussia Ecology and Genetics Research Unit University of OuluOuluFinland Department of Terrestrial Zoology Senckenberg Research Institute and Natural History MuseumFrankfurt am MainGermany Department of Entomology National MuseumPrague 9CirkusovaCzech Republic Federal Scientific Center of the East Asia Terrestrial Biodiversity Far East Branch of the Russian Academy of SciencesVladivostokRussia

Color polymorphism offers rich opportunities for studying the eco-evolutionary mechanisms that drive the adaptations of local populations to heterogeneous and changing *** explored the color morph diversity and composition in a Chrysomela lapponica leaf beetle across its entire distribution range to test the hypothesis that environmental and climatic variables shape spatiotemporal variation in the phenotypic structure of a polymorphic *** obtained information on 13617 specimens of this beetle from museums,private collections,and *** specimens(collected from 1830-2020)originated from 959 localities spanning 33°latitude,178°longitude,and 4200 m *** classified the beetles into five color morphs and searched for environmental factors that could explain the variation in the level of polymorphism(quantified by the Shannon diversity index)and in the relative frequencies of individual color *** highest level of polymorphism was found at high latitudes and *** color morphs differed in their climatic requirements;composition of colour morphs was independent of the geographic distance that separated populations but changed with collection year,longitude,mean july temperature and betweenyear temperature *** proportion of melanic beetles,in line with the thermal melanism hypothesis,increased with increasing latitude and altitude and decreased with increasing climate *** morph frequencies also declined during the past century,but only at high latitudes and altitudes where recent climate warming was especially *** observed patterns suggest that color polymorphism is especially advantageous for populations inhabiting unpredictable environments,presumably due to the different climatic requirements of coexisting color morphs.

关键词： adaptive polymorphism color morphs evolutionary dynamics geographic variation phenotypic diversity thermal melanism

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