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Snapshot Survey of the presence of perfluoroalkyl Substances in products, Articles, and the Environment in Ecuador

Engineering 2024年第6期37卷 49-61页

作者： Heidelore Fiedler Luis Vega-Bustillos Jenny arias-pastrano Lander Vinicio pérez-Aldás Jose Castro-Díaz MTM Research Centre School of Science and TechnologyÖrebro UniversityÖrebro 70182Sweden Undersecretariat of Environmental Quality Ministry of EnvironmentWater and Ecological Transition of EcuadorQuito 170525Ecuador Department of Environmental Chemistry The Technical University of AmbatoHuachi CampusAmbato 180207Ecuador Alternativavision Ambiental Cia.Ltda. Mexico 03100Mexico

The Stockholm Convention on persistent Organic pollutants(pOps)is a legally binding instrument for 186 parties(status:April 2023).Accordingly,among other responsibilities,countries are obliged to report the production,import,or export of the pOps listed in Annexes A,B,or C;provide information to registers;maintain inventories;and monitor the presence of pOps in the *** the broader context of international chemicals and waste management,producer responsibilities,harmonized reporting,and compliance with national and international regulations,Ecuador has addressed the newly listed group of perfluorinated alkyl substances(pFAS)in its national implementation plan and sent selected products from its national market for pFAS *** products analyzed came from the initially listed fields of specific exemptions and acceptable purposes,including:fire-fighting foams;photographic aids;greasers/degreasers;various kinds of paper/packaging;textiles;and leather,coatings,cleaners,metal plating,and *** results showed that the three pFAS presently listed in the Stockholm Convention could be quantified in only a few samples;additional pFAS,not yet listed in the Convention also had low detection *** the number of samples was limited,the samples covered a large spectrum of sample matrices,making it possible to conclude that—once these products become waste and are regulated under the Basel Convention—they would not constitute a disposal ***,verification of the presence of pFAS in products on the market is expected to pose an analytical challenge for both,developed and developing countries.

关键词： Emerging or newly listed pOps Stockholm Convention products and articles pFAS analysis Developing countries

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parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen M.Labandeira Arturo Fraga-Bau David arias Ron elena Alvarez-Rodriguez pablo Vicente-Alba Javier Lago-Garma ana I.Rodriguez-perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and Molecular Neurobiology of parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing parkinson’s disease but can also determine the prognosis and progression of parkinsonian ***,there are no available curative or disease modifying treatments for parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against parkinson’s disease,both in diabetic and nondiabetic parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as parkinson’s ***,we review the present evidence on the connection between parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation parkinson’s disease repurposing

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prognostic implication of the coronary microvascular dysfunction in patients with isolated left bundle branch block

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World Journal of Cardiovascular Diseases 2014年第2期4卷 61-69页

作者： Francisco J. Rodríguez Rodrigo Juan Medina peralta Eddy Velásquez arias ana Alegría Barrero Teresa San Agustín Lascorz elena pérez pereira Adriana Rodríguez Chaverri Servicio Cardiología Hospital Universitario Madrid Montepríncipe Madrid Spain

The present study aims to determine the influence of microvascular dysfunction (MVD) in the prognosis of patients presenting isolated left bundle branch block (LBBB). Methods: We studied 30 patients (pts), 22 males, 8 females, mean age 57 ± 4 years, with isolated LBBB, with a mean follow up of 48 ± 6 months. The control group consisted of 20 healthy individuals, 12 males, mean age 52 ± 10 years. Both groups were screened for cardiovascular risk factors (RF);they also had an echocardiogram and Coronary CT Scan, ruling out both structural heart disease and obstructive lesions of the epicardial coronary arteries. A myocardial perfusion study was then performed, with two groups emerging according to these results: Group A, 8 pts (26%), with reversible perfusion defects, in which the diagnosis of MVD was suspected, and Group B, 22 pts (74%), with either normal perfusion or minor septal/apical reversible defects (related to LBBB). All Group A pts, and 9 of the Group B pts, underwent coronary arteriography, with intracoronary acetylcholine and nitroglycerine infusion, thus evaluating vasomotor response as endothelium dependent (acetylcholine) or endothelium independent (nitroglycerine). During follow up, we reviewed functional class, 12 lead ECG and echocardiogram on a yearly basis. Results: All Group A patients had an abnormal acetylcholine response;only three of them had abnormal response to nitroglycerine infusion, suggesting endothelium dependent MVD. Of those in Group B, only one patient had abnormal acetylcholine response. At the end of the follow up period, 3 pts (37%) in Group A, showed functional class decrease vs 5 pts (22%) of those in Group B. In Group A, a significant increase of End Diastolic Left Ventricle Diameter (EDLVD) was found (51.6 ± 3.6 vs 59.3 ± 6.8 mm;p p variation. In neither group major complications (death, heart failure admissions) were found. Conclusion: We confirm the associat

关键词： Microvascular Dysfunction Isolated Left Bundle Branch Block Left Ventricular Dysfunction

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The flowerpiercers interactions with a community of high Andean plants

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Avian Research 2021年第2期12卷 181-194页

作者： Jairo Andrés Cuta-pineda Luis Alejandro arias-Sosa Roxibell C.pelayo Research Group“Grupo Ecología de Organismos(GEO-UpTC)” TunjaColom-bia Maestría en Ciencia Biológicas Universidad Pedagógica y Tecnológica de ColombiaTunjaColombia Instituto de Ciencias Ambientales y Ecológicas(ICAE) Universidad de Los AndesMéridaVenezuela

Background:Flowerpiercers(Diglossa)are traditionally considered as“parasites”of the pollination processes,as they can access the nectar without entering in contact with the reproductive structures of the ***,the effect of flowerpiercers seems to vary according to their behavior and the flower’s ***,in this work,we aimed to explore the floral characteristics that may determine the susceptibility to robbing and pollen transport by ***,we identified the potential types of interactions and studied interaction network ***:We collected the information of 16 ornithophilic plants regarding their floral traits and robbing ***,we captured 4 species of flowerpiercers and evaluated pollen transport(frequency and loads).We tested the correlation between floral traits,robbing frequency,and pollen ***,we used these variables in a cluster and principal component analyses to identify the potential types of ***,we analyzed and com-pared the structure of the plants-flowerpiercers interaction ***:Nectar production significantly influenced both nectar robbing and pollen *** the corolla length was only correlated to the robbing ***,we found that particular flowerpiercers species trans-ported higher loads of some plant pollen,which can be related to the differences in behavior and morphometric *** proposed the classification of five different types of plant-flowerpiercer interactions,that showed differ-ent potential mutualist or antagonist relations based on the affectation of nectar robbing and the service of pollen *** interaction networks consisted of 49 links,with 2.4 links per species,and presented indicators of a medium to high resilience,stability,and resistance(nestedness,connectance,and robustness).Also,the network presented medium to low specialization and substantial niche ***:The ecological role of

关键词： Diglossa Flower traits Nectar robbing Nectivorous birds pollen transport pollination

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Binge eating and psychostimulant addiction

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World Journal of psychiatry 2021年第9期11卷 517-529页

作者： M Carmen Blanco-Gandia Sandra Montagud-Romero Marta Rodriguez-arias Department of psychology and Sociology University of ZaragozaTeruel 44003Spain Department of psychobiology Facultad de PsicologiaUniversitat de ValenciaValencia 46010Spain

Many of the various factors,characteristics,and variables involved in the addictive process can determine an individual’s vulnerability to develop drug *** eating,based on pleasure rather than energy needs,modulates the same reward circuits,as do drugs of *** to the last report of the World Health Organization,the worldwide obesity rate has more than doubled since 1980,reaching especially critical levels in children and young people,who are overexposed to high-fat,high-sugar,energy-dense *** the past few decades,there has been an increase in the number of studies focused on how eating disorders can lead to the development of drug addiction and on the comorbidity that exists between the two ***,we review the most recent research on the subject,focusing especially on animal models of binge eating disorders and drug *** complex profile of patients with substance use and binge eating disorders requires an integrated response to dually diagnosed *** patterns should be considered an important variable in the treatment of substance use disorders,and future studies need to focus on specific treatments and interventions in individuals who show a special vulnerability to shift from one addiction to the other.

关键词： Binge eating psychostimulant Dopamine Obesity Reward Addiction

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Investigation of temporal and spatial heterogeneities of the immune responses to Bordetella pertussis infection in the lung and spleen of mice via analysis and modeling of dynamic microarray gene expression data

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Infectious Disease Modelling 2019年第1期4卷 215-226页

作者： Nan Deng Juan C.Ramirez Michelle Carey Hongyu Miao Cesar A.arias Andrew p.Rice Hulin Wu Department of Biostatistics and Data Science School of Public HealthThe University of Texas Health Science Center at HoustonHoustonTXUSA Facultad de Ingeniería de Sistemas Universidad Antonio NariňoBogotáColombia School of Mathematics and Statistics University College DublinDublinIreland Center for Antimicrobial Resistance and Microbial Genomics(CARMiG) UTHealth McGovern Medical SchoolUSA Divicon of Infectious Diseases and Department of Microbiology and Molecular Genetics UTHealth McGovern Medical SchoolUSA Center for Infectious Diseases UTHealth School of Public HealthUSA Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics Universidad El BosqueBogotaColombia Department of Molecular Virology&Microbiology Baylor College of MedicineHoustonTXUSA

Bordetella pertussis(***)is the causative agent of pertussis,also referenced as whooping *** pertussis has been appropriately controlled by routine immunization of infants,it has experienced a resurgence since the beginning of the 21st *** that elucidating the immune response to pertussis is a crucial factor to improve therapeutic and preventive treatments,we re-analyzed a time course microarray dataset of *** infection by applying a newly developed dynamic data analysis *** results indicate that the immune response to *** is highly dynamic and heterologous across different organs during ***1 and Th17 cells,which are two critical types of T helper cell populations in the immune response to ***,and follicular T helper cells(TFHs),which are also essential for generating antibodies,might be generated at different time points and distinct locations after *** phenomenon may indicate that different lymphoid organs may have their unique functions during *** findings provide a better understanding of the basic immunology of bacterial infection,which may provide valuable insights for the improvement of pertussis vaccine design in the future.

关键词： pertussis organs microarray

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electrospun pLLA Membranes for Caffeine Delivery: Diffusional Approach

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Journal of Biomedical Science and Engineering 2017年第12期10卷 563-574页

作者： ana paula S. Immich José Antonio Tornero Francesc Cano Casas Manuel J. Lis arias Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa Universitat Politècnica de Catalunya Terrassa Spain Chemical Engineering Department Universitat Politècnica de Catalunya Terrassa Spain

One of the great advantages of electrospun fibers is the large tridimensional area produced, capable of storing any type of material. The aim of our investigation is to study the electrospinning technique to produce polymer membranes for drug delivery applications, given their large surface area and ability to transport a bioactive compound. A mathematical modeling of the delivery system kinetics was also studied to find the mechanism that controls the releasing process. Results showed that electrospinning could provide regular and smooth membranes suitable for drug delivery processes. The mathematical modeling also proved that thicker pLLA membranes exhibited a Fickian diffusion behavior during the drug transport, presenting better control in drug delivery processes.

关键词： Diffusion polymer Nano Escale Kinetics

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Morphometric and Biochemical Changes in Agave americana *** Induced By Ethyl Methanesulfonate

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phyton-International Journal of Experimental Botany 2019年第3期88卷 277-284页

作者： S.J.Reyes-Zambrano M.L.Ramírez-Merchant C.arias-Castro M.A.Rodríguez-Mendiola C.A.Lecona-Guzmán V.M.Ruíz-Valdiviezo D.González-Mendoza F.A.Gutiérrez-Miceli Laboratorio de Biotecnología Vegetal Instituto Tecnológico de Tuxtla GutiérrezTecnológico Nacional de México.Carretera Panamericana Km.1080TeránTuxtla GutiérrezChiapasC.P.29050México Laboratorios de Análisis Instrumental Bioquímico DEPI del Instituto Tecnológico de TlajomulcoTecnológico Nacional de México.Tlajomulco de ZuñigaC.P.45640México Instituto de Ciencias Agrícolas Universidad Autónoma de Baja California(ICA-UABC)Carretera a Delta s/n Ejido Nuevo LeónCP.21705Baja CaliforniaMéxico

*** *** a crop with very little genetic *** order to evaluate the effect of ethyl methanesulfonate(EMS)to induce variability in in vitro plantlets of ***,different explants(meristems,leaves and roots)were evaluated for the production of *** medium supplemented with ana(2.68μM)and BAp(2.68μM)was *** obtained from apical meristem were treated with 15 mM EMS for two hours after which shoot formation was induced using 2,4-D(0.11μM)and BAp(44μM).The EMS induced variations in the morphometric and morphological parameters of the plantlets obtained,with 60%of the plantlets presenting differences such as dwarfism and different leaf forms,without the presence of spines,as well as an increase in fructan content of 30%with respect to the control *** was increased and this activity is related with higher anthocyanins concentration in *** ***.

关键词： Fructans callus mutagenesis flavonoids anthocyanins phenylalanine ammonia lyase activity

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蓬勃发展的西班牙生物技术、生物经济与生物企业

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生物技术世界 2009年第1期6卷 5-13页

作者： ana arias Urones[西班牙] 封颖（译）西班牙政府所属机构“投资西班牙”之生命科学投资服务部主任中国科学技术信息研究所

一．西班牙生命科学的发展概况西班牙的生命科学研究和生物技术行业发展情况良好。通过大学、国家卓越中心和制药公司的工作，公共健康医疗体系很好地整合进了国家科学和技术体系之中。

关键词：生物技术西班牙生物企业生物经济生命科学发展概况科学研究制药公司

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Mixed reality head mounted displays for enhanced indoor point cloud segmentation with virtual seeds

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Resilient Cities and Structures 2024年第3期3卷 43-52页

作者： Juan C.Navares-Vázquez pedro arias Lucía Díaz-Vilarino Jesús Balado CINTECX Universidade de VigoGeoTECH group36310 VigoSpain

Mixed Reality(MR)Head Mounted Displays(HMDs)offer a hitherto underutilized set of advantages compared to conventional 3D *** benefits,inherent to MR-HMDs albeit not originally intended for such appli-cations,encompass the freedom of hand movement,hand tracking capabilities,and real-time mesh *** study leverages these attributes to enhance indoor scanning *** primary innovation lies in the con-ceptualization of manual-positioned MR virtual seeds for the purpose of indoor point cloud segmentation via a region-growing *** proposed methodology is effectively implemented using the HoloLens 2 *** application is designed to enable the remote placement of virtual tags based on the user’s visual focus on the MR-HMD *** non-intrusive interface is further enriched with expedited tag saving and deletion functionalities,as well as augmented tag visualization through overlaying them on real-world *** assess the practicality of the proposed method,a comprehensive real-world case study spanning an area of 330 s^(2) is ***,the survey demonstrates remarkable efficiency,with 20 virtual tags swiftly deployed,each requiring a mere 2 s for precise ***,these virtual tags are employed as seeds in a region-growing algorithm for point cloud *** accuracy of virtual tag positioning is found to be exceptional,with an average error of 2.4±1.8 ***,the user experience is significantly enhanced,leading to improved seed positioning and,consequently,more accurate final segmentation results.

关键词： Augmented reality eXtended Reality Handheld mobile laser scanning Region growing Semantic segmentation

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