Investigation of temporal and spatial heterogeneities of the immune responses to Bordetella pertussis infection in the lung and spleen of mice via analysis and modeling of dynamic microarray gene expression data
作者机构：Department of Biostatistics and Data ScienceSchool of Public HealthThe University of Texas Health Science Center at HoustonHoustonTXUSA Facultad de Ingeniería de SistemasUniversidad Antonio NariňoBogotáColombia School of Mathematics and StatisticsUniversity College DublinDublinIreland Center for Antimicrobial Resistance and Microbial Genomics(CARMiG)UTHealth McGovern Medical SchoolUSA Divicon of Infectious Diseases and Department of Microbiology and Molecular GeneticsUTHealth McGovern Medical SchoolUSA Center for Infectious DiseasesUTHealth School of Public HealthUSA Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial GenomicsUniversidad El BosqueBogotaColombia Department of Molecular Virology&MicrobiologyBaylor College of MedicineHoustonTXUSA
出 版 物：《Infectious Disease Modelling》 (传染病建模（英文）)
年 卷 期：2019年第4卷第1期
页 面：215-226页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work is partially supported by NIH/NIAID grant RO1 AI087135 CAA is supported by NIH/NIAID grant K24 AI114818
主 题：pertussis organs microarray
摘 要：Bordetella pertussis(***)is the causative agent of pertussis,also referenced as whooping *** pertussis has been appropriately controlled by routine immunization of infants,it has experienced a resurgence since the beginning of the 21st *** that elucidating the immune response to pertussis is a crucial factor to improve therapeutic and preventive treatments,we re-analyzed a time course microarray dataset of *** infection by applying a newly developed dynamic data analysis *** results indicate that the immune response to *** is highly dynamic and heterologous across different organs during ***1 and Th17 cells,which are two critical types of T helper cell populations in the immune response to ***,and follicular T helper cells(TFHs),which are also essential for generating antibodies,might be generated at different time points and distinct locations after *** phenomenon may indicate that different lymphoid organs may have their unique functions during *** findings provide a better understanding of the basic immunology of bacterial infection,which may provide valuable insights for the improvement of pertussis vaccine design in the future.
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