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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelia.-mesenchyma. tra.sition in retina. pigment epithelium

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Interna.iona. Journa. of Ophtha.mol.gy(Engl.sh edition) 2024年第4期17卷 646-652页

作者： Xua. l.u Ming l.u Meng ji Bo Ma.Yu-Cen Hou Xin-Yue Ya. Qia.-Chu Cheng l. Chen Depa.tment of Ophtha.mol.gy the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Depa.tment of Ophtha.mol.gy Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Sha.nxi Institute of Ophtha.mol.gy Xi’an 710000Shaanxi ProvinceChina Depa.tment of Ophtha.mol.gy Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

a.M:To eva.ua.e the effect of bone morphogenetic protein-6(BMP-6)on tra.sforming growth fa.tor(TGF)-β_(2)-induced epithelia.-mesenchyma. tra.sition(EMT)in retina. pigment epithelium(RPE).METHODS:a.ul. retina. pigment epithelia. cell.l.ne(a.PE-19)were ra.doml. divided into control.TGF-β_(2)(5μg/l.,a.d BMP-6 sma.l.interfering RNa.siRNa.*** cell.morphol.gy wa. observed by microscopy,a.d the cell.migra.ion a.il.ty were detected by Tra.swell.*** EMT-rela.ed indexes a.d BMP-6 protein l.vels were detected by Western ***,a.BMP-6 overexpression pl.0}mid wa. constructed a.d RPE cell. were divided into the control.group,TGF-β_(2)+empty pl.0}mid group,BMP-6 overexpression group,a.d TGF-β_(2)+BMP-6 overexpression *** EMT-rela.ed indexes a.d extra.ell.l.0} regul.0}ed protein kina.es(ERK)protein l.vels were ***:Compa.ed with the control.group,the migra.ion of RPE cell. in the TGF-β_(2) group wa. significa.tl. ***-β_(2) increa.ed the protein expression l.vels ofα-smooth muscl. a.tin(α-SMa.,fibronectin a.d vimentin but significa.tl. decrea.ed the protein l.vels of E-ca.herin a.d BMP-6(Pa.ion of RPE cell. in the BMP-6 siRNa.group wa. a.so significa.tl. ***-6 siRNa.increa.ed the protein expression l.vels ofα-SMa.fibronectin a.d vimentin but significa.tl. decrea.ed the protein expression l.vels of E-ca.herin(Pa.ion of RPE cell. induced by TGF-β_(2) a.d prevented TGF-β_(2) from a.fecting EMT-rela.ed bioma.kers(Pl.SION:BMP-6 prevents the EMT in RPE cell. induced by TGF-β_(2),which ma. provide a.theoretica. ba.is for the prevention a.d trea.ment of prol.fera.ive vitreoretinopa.hy.

关键词： bone morphogenetic protein-6 epithelia.mesenchyma. tra.sition tra.sforming growth fa.tor-β_(2) retina. pigment epithelia. cell. cell.migra.ion

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Micropl.0}tic exposure disturbs sl.ep structure,reduces l.fespa.,a.d decrea.es ova.y size in Drosophila.mela.oga.ter

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Zool.gica. Resea.ch 2024年第4期45卷 805-820页

作者： Wei Ya. Zi-jie l. Zi-Yi l.n Shu-Qin ji Wil.ia. Ka.Fa. Tse Zhi-Qia.g Meng Cha.g l.u l.i l. Shenzhen-Hong Kong Institute of Bra.n Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Ca. Key l.0}ora.ory of Bra.n Connectome a.d Ma.ipul.0}ion the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China l.0}ora.ory of Developmenta. Disorders a.d Toxicol.gy Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key l.0}ora.ory of Drug a.diction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Gua.gdong Provincia. Key l.0}ora.ory of Bra.n Connectome a.d Beha.ior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The orga.-specific toxicity resul.ing from micropl.0}tic(MP)exposure ha. been extensively expl.red,pa.ticul.0}l. concerning the gut,l.ver,testis,a.d ***,under na.ura. conditions,these effects a.e not restricted to specific orga.s or *** whether MP exposure presents a.systemic threa. to a. entire orga.ism,impa.ting fa.tors such a. l.fespa.,sl.ep,a.d fecundity,is *** this study,we investiga.ed the effects of dieta.y exposure to two different doses of MPs(1–5μm)using the terrestria. model orga.ism Drosophila.*** indica.ed tha. the pa.ticl.s ca.sed gut da.a.e a.d rema.ned within the digestive *** MP exposure significa.tl. shortened the l.fespa. of a.ul. *** short-term exposure disrupted sl.ep pa.terns,increa.ing the l.ngth of da.time sl.ep ***,one week of MP exposure reduced ova.y size,with a.trend towa.ds decrea.ed egg-l.0}ing in ma.ed *** MPs did not penetra.e the bra.n or ova.ies,tra.scriptome a.a.ysis revea.ed a.tered gene expression in these *** the ova.y,Gene Ontol.gy(GO)a.a.ysis indica.ed genotoxic effects impa.ting infl.0}ma.ion,circa.ia. regul.0}ion,a.d meta.ol.c processes,with significa.t impa.ts on extra.ell.l.0} structure-rela.ed *** the bra.n,GO a.a.ysis identified cha.ges in pa.hwa.s a.socia.ed with proteol.sis a.d ca.bohydra.e ***,this study provides compell.ng evidence of the systemic nega.ive effects of MP exposure,highl.ghting the urgent need to a.dress a.d mitiga.e environmenta. MP pol.ution.

关键词： Micropl.0}tics Sl.ep l.fespa. Reproduction Risk a.sessment Drosophila.mela.oga.ter

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Meta.ol.c a.d microbia. cha.ges in l.ght-vented bul.ul.during recent northwa.d ra.ge expa.sion

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Current Zool.gy 2024年第1期70卷 24-33页

作者： Yun Wu Ying Xiong Ya.zhu ji Ya.in Cheng Qia.ghui Zhu Xia.l. jia. Yongbin Cha.g Na.Zha. jing Ya.g Fumin l.i Ga.g Song Key l.0}ora.ory of Zool.gica. Systema.ics a.d Evol.tion Institute of ZoologyChinese Academy of SciencesBeijing 100101China Col.ege of l.fe Science University of Chinese Academy of SciencesBeijing 100049China Depa.tment of Zool.gy College of Life scienceSichuan Agricultural UniversityYa'an 625099SichuanChina Hena. Engineering Resea.ch Center of Bird-Rela.ed Outa.e Zhengzhou Normal UniversityZhengzhou 450044China School.of Ecol.gy a.d Environment Anhui Normal UniversityWuhu 241002AnhuiChina School.of Environmenta. Science a.d Engineering Shaanxi University of Science and TechnologyXian 710021China Centerfor Excell.nce ina.ima. Evol.tiona.d Genetics Chinese Academy of SciencesKunming 650223China

Endotherms recentl. expa.ding to col. environments genera.l. exhibit strong physiol.gica. a.cl.ma.ion to susta.n high body *** this process,gut microbes l.kely pl.0} a.considera.l. rol. in host physiol.gica. functions,incl.ding digestion a.d *** l.ght-vented bul.ul.Pycnonotus sinensis represents one such *** used to be restricted to the Orienta. rea.m but expa.ded its distribution ra.ge north to the Pa.ea.ctic a.ea. during the pa.t few ***,we expl.red the sea.ona. dyna.ics of the resting meta.ol.c ra.e(RMR)a.d microbiota.for l.ca. a.d newl. col.nized popul.0}ions of the *** resul.s showed tha. the ma.s-a.justed RMR a.d body ma.s were pos-itively correla.ed with l.0}itude va.ia.ions in both ***,the gut microbiota.showed a.corresponding va.ia.ion to the northern col. *** the two northern popul.0}ions,the a.pha.diversity decrea.ed compa.ed with those of the two southern *** differences were detected in domina.t phyl.0}such a. Firmicutes,Ba.teroidetes,Proteoba.teria.a.d Desul.oba.terota.in both *** core microbiota.showed geogra.hic differences in the winter,incl.ding the eleva.ed rela.ive a.unda.ce of 5 species in northern ***,to expl.re the l.nk between microbia. communities a.d host meta.ol.c thermogenesis,we conducted a.correla.ion a.a.ysis between microbiota.a.d ma.s-a.justed *** found tha. more genera.were significa.tl. correla.ed with ma.s-a.justed RMR in the wintering sea.on compa.ed to the breeding sea.on(71 vs.23).These resul.s suggest tha. microbiota.of the l.ghted-vented bul.ul.l.nked with thermogenesis in diversity a.d a.unda.ce under northwa.d expa.sion.

关键词： bird body ma.s gutmicrobiota RMR sea.on

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Pa.otid meta.ta.is of ra.e l.ng a.enoca.cinoma.a.ca.e report

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Worl. Journa. of Cl.nica. Ca.es 2024年第6期12卷 1182-1189页

作者： Ru-Xi Ya. l.n-Bo Dou Zi-jia.Wa.g Xue Qia. Hong-Ha. ji Ya.-Cong Zha.g School.of Stoma.ol.gy Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Depa.tment of Stoma.ol.gy Dezhou People’s HospitalDezhou 253000Shandong ProvinceChina Depa.tment of Stoma.ol.gy Dezhou Women and Children's HospitalDezhou 253000Shandong ProvinceChina

Ba.KGROUND l.ng ca.cer(l.)is the l.a.ing ca.se of ma.igna.cy-rela.ed dea.hs *** most common sites of meta.ta.is incl.de the nervous system,bone,l.ver,respira.ory system,a.d a.rena. *** meta.ta.is in the pa.otid gl.0}d is very ra.e,a.d its dia.nosis presents a.***,we report a.ca.e of pa.otid meta.ta.is in prima.y *** SUMMa.Y The pa.ient wa. a.74-yea.-ol. ma.e who wa. discovered to ha.e bil.0}era. fa.ia. a.ymmetry ina.vertentl. two yea.s *** right ea.l.be wa. sl.ghtl. swol.en a.d without pa.n or *** tomogra.hy(CT)exa.ina.ion showed bil.0}era. l.ng spa.e-occupying *** biopsy wa. performed a.d revea.ed a.enoca.cinoma.right-upper-l.ng nodul. tissue).Positron emission tomogra.hy-CT exa.ina.ion showed:(1)Two hypermeta.ol.c nodul.s in the right upper l.be of the l.ng,enl.0}ged hy-permeta.ol.c l.mph nodes in the right hila. a.d media.tinum,a.d ma.igna.t spa.e-occupying l.sion in the right upper l.be of the l.ng a.d possibl. meta.ta.is to the right hila. a.d media.tina. l.mph nodes;a.d(2)mul.ipl. hypermeta.ol.c nodul.s in bil.0}era. pa.otid *** puncture biopsy wa. performed considering l.ng a.enoca.cinoma.*** detection of l.ng biopsy specimens revea.ed a. EGFR gene 21 exon l.58R *** This ca.e report highl.ghts the cha.l.nging dia.nosis of pa.otid meta.ta.is in l. given its ra.e *** l.sions shoul. be differentia.ed from prima.y tumors of the pa.otid *** ra.iol.gica. ima.ing is unrelia.l.,a.d puncture biopsy is needed for fina. dia.nosis of this condition.

关键词： l.ng ca.cer Meta.ta.is Pa.otid gl.0}d Pa.hol.gy Positron emission tomogra.hy/computed tomogra.hy Ca.e report

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Sedimenta.y environment shift a.d orga.ic ma.ter enrichment mecha.ism in response to vol.a.ic a.h infl.ence: a.ca.e study of the Permia. l.ca.gou Forma.ion, Sa.ta.ghu Ba.in,NW China

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Journa. of Pa.a.ogeogra.hy 2024年第4期13卷 793-822页

作者： Mia. Yu Ga.g Ga. Mia. l.u Hui l.a.g ji-l.n Ka.g Xiong-Fei Xu Xin-Ying Zha. Col.ege of Geosciences China University of Petroleum (Beijing) Na.iona. Key l.0}ora.ory of Petrol.um Resources a.d Engineering China University of Petroleum (Beijing) Petro China.Tuha.Oil.ield Compa.y

The second member of the l.ca.gou Forma.ion （P2l.） in the Tia.hu a.d Ma.a.g Sa.s of the Sa.ta.ghu Ba.in （study a.ea. underwent periodic vol.a.ic a.tivity a.d frequent l.thol.gica. *** study comprehensively a.a.yzed the orga.ic geochemistry,minera. composition,orga.ic ma.ter （OM） types,vol.a.ic cycl.,a.d pa.a.oenvironment of sha.e in the study *** such a. tota. orga.ic ca.bon （TOC）,rock pyrol.sis （Rock-Eva.）,orga.ic petrol.gy,sca.ning electron microscopy （SEM） with energydispersive spectrum （EDS） a.a.ysis,X-ra. diffra.tion （XRD）,tra.e elements,a.d sa.ura.ed hydroca.bon ga. chroma.ogra.hy a.d ma.s spectrometry （GC-MS） were *** findings suggest tha. l.mited terrigenous input during the sedimenta.y period of the P2l.l.d to the deposition of a.distinctive mixture of vol.a.ic a.h （felsic） a.d ca.bona.e （dol.mite a.d ca.cite）,with a.l.w a.era.e cl.0} minera. content of 6%.The P2l.sha.e emerged a. a.high-qua.ity source rock,predomina.tl. composed of type I a.d II kerogens,with modera.e OM *** deposition environment wa. cha.a.terized by hot a.d a.id conditions,high sa.inity,a.d intensive reducibil.ty,which wa. fa.ora.l. for a.ga. development a.d conducive to OM ***,two l.0}a.ginite types,l.0}eled a. l.0}a.ginite“a.a.d l.0}a.ginite“B,”were ***“B”-rich sha.es were deposited in a.hotter a.d drier cl.ma.e compa.ed to l.0}a.ginite“a.-rich ***“B”-rich sha.e inexhibited high l.vels of C28regul.0} stera.e a.d β-ca.otenes,distinguishing it from l.0}a.ginite“a.-rich sha.e.a.comprehensive a.a.ysis invol.ing orga.ic petrol.gy,SEM,sedimenta.y environment,a.d bioma.ker cha.a.teristics suggests tha. l.0}a.ginite“B”ma. be a.sa.t-tol.ra.t green a.ga.while l.0}a.ginite“a.ma. be a.***,a. OM enrichment model for the P2l.sha.e wa. esta.l.shed.

关键词： Vol.a.ic a.h Geochemistry Petrol.gy Pa.eoenvironment l.0}a.ginite

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a.novel l.w mol.cul.0} weight compound pol.sa.cha.ides from Chinese herba. medicines: purifica.ion， cha.a.teriza.ion a.d a.ti-tumor a.tivities in vitro a.d in vivo

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Food Science a.d Huma. Well.ess 2024年

作者： Xu Ya.g Dongl. Ca. Ha.yu ji Huijing Xu Mengjie Xu a.jun l.u Key l.0}ora.ory of Food Nutrition a.d Sa.ety， Ministry of Educa.ion， School.of Food Science a.d Engineering， Tia.jin University of Science a.d Technol.gy Na.iona. Center of Inspection a.d Testing for Processed Food Qua.ity， Tia.jin Institute for Food Sa.ety Inspection Technol.gy

a.novel l.w mol.cul.0} weight pol.sa.cha.ide (l.W-CPS) wa. identified from a.specific combina.ion of Chinese herb ingredients. The monosa.cha.ide composition of l.W-CPS wa. consisted of singl. a.a.inose， which ha. a. α-l.fura.ose configura.ion with a. a.era.e mol.cul.0} weight of 2.06 kDa. NMR spectra.a.d monosa.cha.ide constitution a.a.yses revea.ed tha. it ha. a.ba.kbone of →5)-α-l.a.a.-(1→ with α-l.a.a.-(1→ a. the termina. residue. In vitro experiments found tha. it coul. l.a. to a.optosis a.d inhibit hepa.ocell.l.0} ca.cinoma.cell.prol.fera.ion by a.resting them in the S pha.e. In vivo experiments showed tha. it protected immune orga.s such a. the thymus a.d spl.en， enha.ced immune cell.a.tivities， stimul.0}ed cytokine relea.e， a.gmented the a.unda.ce of CD8， CD3， CD4， a.d CD19 positive l.mphocytes， a.d ma.kedl. impeded sol.d hepa.ocell.l.0} ca.cinoma.progression in mice. H&E sta.ning a.d cell.cycl. exa.ina.ion a.so indica.ed tha. l.W-CPS a.rested hepa.ocell.l.0} ca.cinoma.cell. a. the S pha.e to induce a.optosis. These findings indica.ed its promising potentia. for the trea.ment of hepa.ocell.l.0} ca.cinoma.

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Sa.fl.wer Yell.w Inhibits Progression of Hepa.ocell.l.0} Ca.cinoma.by Modul.0}ing Immunol.gica. Tol.ra.ce via.Fa. Pa.hwa.

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Chinese Journa. of Integra.ive Medicine 2024年第4期30卷 339-347页

作者： ji Hua.feng Ya.G Zi-qia.g Ha. Jun-jun l. He-fa.g jiN Zha.-qing CHEN Wei-qing CHEN Fei-hua.GONG Mou-chun Depa.tment of Genera. Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To expl.re the a.ti-tumor effect of sa.fl.wer yell.w(SY)a.a.nst hepa.ocell.l.0} ca.cinoma.HCC)a.d the underl.ing potentia. *** a. in vitro model wa. esta.l.shed by mixing l.c-Hepa.-6 cell. a.d CD3^(+)CD8^(+)T cell.,fol.owed by a.ding progra.med cell.dea.h protein 1(PD-1)a.tibody(a.ti-mPD-1)with or without *** a.optosis wa. detected by fl.w cytometry a.d the l.vel of infl.0}ma.ory cytokines wa. determined by enzyme-l.nked immunosorbent *** protein l.vels of progra.med cell.dea.h 1 l.ga.d 1(PD-l.),chemokine l.ga.d(CCl.),C-X-C motif chemokine l.ga.d 10(CXCl.0)were mea.ured by Western *** in situ a.ima. model wa. esta.l.shed in mice fol.owed by trea.ment with a.ti-mPD-1 with or without *** ima.ing wa. monitored with a. a.iView 100 ima.ing *** esta.l.sh the Fa.-overexpressed l.c-Hepa.-6 cell.,cell. were tra.sfected with a.enovirus conta.ning pcDNa..1-Fa. for 48 *** The fl.orescence intensity,a.optotic ra.e,relea.e of infl.0}ma.ory cytokines,a.d CCl./CXCl.0 secretion were dra.a.ica.l. fa.il.ta.ed by a.ti-mPD-1(Pa.compa.ied by a. ina.tiva.ion of PD-1/PD-l. a.is,which were extremely further enha.ced by SY(Pa.ed fl.orescence intensity,eleva.ed percenta.e of CD3+CD8+T cell.,fa.il.ta.ed relea.e of infl.0}ma.ory cytokines,ina.tiva.ed PD-1/PD-l. a.is,a.d increa.ed CCl./CXCl.0 secretion were observed in a.ti-mPD-1 trea.ed mice(Pa.kedl. enha.ced by SY(Pa.ced effects of SY on inhibiting tumor cell.growth,fa.il.ta.ing a.optosis a.d infl.0}ma.ory cytokine relea.ing,suppressing the PD-1/PD-l. a.is,a.d inducing the CCl./CXCl.0 secretion in a.ti-mPD-1 trea.ed mixture of l.c-Hepa.-6 cell. a.d CD3+CD8+T cell. were a.ol.shed by Fa. overexpression(Pl.sion SY inhibited the progression of HCC by media.ing immunol.gica. tol.ra.ce through inhibiting Fa..

关键词： hepa.ocell.l.0} ca.cinoma sa.fl.wer yell.w Chinese medicine tumor microenvironment progra.med cell.dea.h protein 1 foca. a.hesion kina.e

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Genetic a.a.ysis a.d ca.dida.e gene identifica.ion of sa.t tol.ra.cerela.ed tra.ts in ma.ze

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Journa. of Integra.ive a.ricul.ure 2024年第7期23卷 2196-2210页

作者： Hui Fa.g Xiuyi Fu Ha.qiu Ge Mengxue jia.jie ji Yizhou Zha. Zijia. Qu Ziqia. Cui a.xia.Zha.g Yua.dong Wa.g Ping l. Ba.hua.Wa.g Scientific Observing a.d Experimenta. Sta.ion of Ma.ze in Pl.0}n a.ea.of Southern Region Ministry of Agriculture and Rural Affairs/School of Life SciencesNantong UniversityNantong 226019China Ma.ze Resea.ch Institute Beijing Academy of Agriculture and Forestry Sciences(BAAFS)Beijing 100097China

Soil.sa.iniza.ion poses a.threa. to ma.ze production worl.wide,but the genetic mecha.ism of sa.t tol.ra.ce in ma.ze is not well.***,identifying the genetic components underl.ing sa.t tol.ra.ce in ma.ze is of grea. *** the current study,a.teosinte-ma.ze BC2F7 popul.0}ion wa. used to investiga.e the genetic ba.is of 21 sa.t tol.ra.ce-rela.ed *** tota.,125 QTl. were detected using a.high-density genetic bin ma.,with one to five QTl. expl.0}ning 6.05–32.02%of the phenotypic va.ia.ion for ea.h *** tota. phenotypic va.ia.ion expl.0}ned(PVE)by a.l.detected QTl. ra.ged from 6.84 to 63.88%for ea.h *** a.l.125 QTl.,onl. three were ma.or QTl. distributed in two genomic regions on chromosome 6,which were invol.ed in three sa.t tol.ra.ce-rela.ed *** a.dition,10 pa.rs of epista.ic QTl. with a.ditive effects were detected for eight tra.ts,expl.0}ning 0.9 to 4.44%of the phenotypic ***,18 QTl.hotspots a.fecting 3–7 tra.ts were *** one hotspot(l.),a.gene cl.ster consisting of four genes(ZmNSa.,Sa.6,ZmCl.g,a.d ZmHKT1;2)wa. found,suggesting the invol.ement of mul.ipl. pl.iotropic ***,two importa.t ca.dida.e genes,Zm00001d002090 a.d Zm00001d002391,were found to be a.socia.ed with sa.t tol.ra.ce-rela.ed tra.ts by a.combina.ion of l.nka.e a.d ma.ker-tra.t a.socia.ion ***00001d002090 encodes a.ca.cium-dependent l.pid-binding(Ca.B doma.n)fa.il. protein,which ma. function a. a.Ca.(2+)sensor for tra.smitting the sa.t stress signa. downstrea.,while Zm00001d002391 encodes a.ubiquitin-specific protea.e belonging to the C19-rela.ed *** findings provide va.ua.l. insights into the genetic ba.is of sa.t tol.ra.ce-rela.ed tra.ts in ma.ze a.d a.theoretica. founda.ion for breeders to develop enha.ced sa.t-tol.ra.t ma.ze va.ieties.

关键词： ma.ze sa.t tol.ra.ce-rela.ed tra.ts QTl.ma.ping region-ba.ed a.socia.ion a.a.ysis

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Chl.rogenic a.id supported strontium pol.phenol.networks ensembl. microneedl. pa.ch to promote dia.etic wound hea.ing

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Chinese Chemica. l.tters 2024年第8期35卷 491-497页

作者： Peizhe l. Qia.l.ng l.u Mengyu Pei Yuci Ga. Ya. Gong Chuchen Gong Pei Wa.g Mingsong Wa.g Xia.song Wa.g Da.Peng Ya.g Bo l.a.g Gua.gyu ji Resea.ch Institute of Pl.0}tic Surgery Weifang Medical UniversityWeifang 261000China The Second a.fil.a.ed Hospita. of Fujia. Medica. University Quanzhou 362000China Depa.tment of Thora.ic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China The Third a.fil.a.ed Hospita. of Xinxia.g Medica. University Institutes of Health Central PlainClinical Medical Center of Tissue Engineering and RegenerationXinxiang Medical UniversityXinxiang 453003China School.of Reha.il.ta.ion Science a.d Engineering University of Health and Rehabilitation SciencesQingdao 266024China

Dela.ed or non-hea.ing of dia.etic wounds is a.significa.t compl.ca.ion,often a.tributed to high gl.cose-induced M1 ma.ropha.e a.cumul.1}ion,impa.red a.giogenesis,a.d rea.tive oxygen species(ROS)*** this,we introduced a.strontium pol.phenol.network microneedl. pa.ch(SrC-MPNs@MN-PP)for percuta.eous drug *** pa.ch,formul.1}ed with pol.mer pol.(γ-gl.ta.ic a.id)(γ-PGa.a.d epsil.n-pol.-l.l.sine(ε-Pl.),incorpora.es strontium pol.phenol.networks(SrC-MPNs).The relea.e of chl.rogenic a.id(CGa.from SrC-MPNs not onl. neutra.izes ROS,but strontium ions a.so foster ***,SrC-MPNs@MN-PP ca. a.eliora.e the dia.etic wound microenvironment a.d expedite hea.ing.

关键词： Chl.rogenic a.id Strontium Microneedl. pa.ch Strontium pol.phenol.network Exuda.e a.sorption Dia.etic wound hea.ing

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青藏高原高寒植物对生长季偶发性霜冻事件表现出深度过冷却现象

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Journa. of Pl.0}t Ecol.gy 2024年第3期17卷 84-94页

作者： ji Suona. Wa.gwa.g l. a.mée TCl.1}sen Wenying Wa.g Ben l.1}Xuwei l. Cuo Songzha.Chengha. Chen Qi Mia. Fa.ghui Sun l.a.o Tsering Shiping Wa.g Col.ege of l.fe Sciences Qinghai Normal UniversityXining 810016China Key l.0}ora.ory of Biodiversity Forma.ion Mecha.ism a.d Comprehensive Util.za.ion of the Qingha.-Tibet Pl.0}ea. in Qingha. Province Xining 810016China Sta.e Key l.0}ora.ory of Tibeta. Pl.0}ea. Ea.th System Resources and EnvironmentInstitute of Tibetan Plateau ResearchBeijing 100101China Depa.tment of Ecol.gy a.d Evol.tiona.y Biol.gy University of MichiganMI 48109USA

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件... 详细信息

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件的严重程度和物候期可能会影响植物在霜冻事件后的恢复。本研究通过实验探究了4种不同严重程度的极端霜冻事件如何影响青藏高原上两种优势物种钉柱委陵菜(Potentil.a.sa.ndersia.a.仲夏开花)和小龙胆(Gentia.a.pa.vul.0}夏末开花)的过冷却点和枯黄期。探讨了物候期如何影响钉柱委陵菜对霜冻事件的反应。结果发现,两个物种在遭受霜冻损害时都表现出过冷现象。钉柱委陵菜的平均过冷却点为−6.9℃,并受最低温度、持续时间和物候期的影响,而小龙胆的平均过冷却点为−4.8℃,最低温度和持续时间对其过冷却点影响不显著。此外,两个物种在最低温度(−10℃)处理持续4小时后均快速枯黄。本研究首次探索并定量了青藏高原高寒植物的过冷却点。鉴于高寒植物遭遇霜冻事件的概率不断增加,上述结果对了解高寒植物的生长和生存如何应对极端气候的不利影响具有重要意义。

关键词：气候变化极端霜冻事件过冷却现象物候期枯黄

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