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Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi ellen CS De Oliveira Luiz C Di Stasi Ligia Y sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Comparative study of three types of controllers for DFIG in wind energy conversion system

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Protection and Control of Modern Power Systems 2018年第1期3卷 223-234页

作者： saïd Boubzizi Hafedh Abid Ahmed el hajjaji Mohamed Chaabane lab-STa.la.oratory National Engineering School of SfaxRoute de la Soukra3029 SfaxTunisia MIS laboratory University of Picardie Jules Verne33Rue Saint-Leu80039 AmiensFrance

This paper presents an enhanced control strategy for Wind Energy Conversion System(WECS)using Doubly-Fed Induction Generator(DFIG).A robust Super-Twisting(STW)sliding mode control for variable speed wind turbine is developed to produce the optimal aerodynamic torque and improve the dynamic performance of the *** electromagnetic torque of the DFIG is directly tracked using the proposed control to achieve maximum power *** performance and the effectiveness of the STW control strategy are compared to conventional Sliding Mode(SM)and Proportional-Integral(PI)*** proposed STW algorithm shows interesting features in terms of chattering reduction,finite convergence time and robustness against parameters variations and system disturbances.

关键词： Wind turbine(WT) Doubly-fed induction generator(DFIG) Power generation STW(super-twisting) Second order sliding mode control(SOSMC) PI controller

The Role of the Solar Cycle in the Relationship Between the North a.la.tic Oscillation and Northern Hemisphere Surface Temperatures

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Advances in Atmospheric Sciences 2007年第2期24卷 191-198页

作者： laura DE la TORRE Luis GIMENO Juan Antonio Ael Raquel NIETO Universidad de Vigo Facultad de Ciencias de Ourense 32004OurenseSpain

The North a.la.tic Oscillation （NAO） is one of the leading modes of climate variability in the Northern Hemisphere. It has been shown that it clearly relates to changes in meteorological variables, such as surface temperature, at hemispherical scales. However, recent studies have revealed that the NAO spatial pattern also depends upon solar forcing. Therefore, its effects on meteorological variables must vary depending upon this factor. Moreover, it could be that the Sun affects climate through variability patterns, a hypothesis that is the focus of this study. We find that the relationship between the NAO/AO and hemispheric temperature varies depending upon solar activity. The results show a positive significant correlation only when solar activity is high. Also, the results support the idea that solar activity influences tropospheric climate fluctuations in the Northern Hemisphere via the fluctuations of the stratospheric polar vortex .

关键词： solar activity North a.la.tic Oscillation Arctic Oscillation Northern Hemisphere surface temperature

Optical and magnetic properties of perovskite materials:Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3)

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Journal of Rare Earths 2022年第4期40卷 652-659,I0005页

作者： Fatima el Bachraoui Zakaria Chchiyai Youssef Tamraoui Hassan el Moussaoui Jones Alami Bouchaib Manoun Materials Science Energy and Nano-engineering Department(MSN)University Mohammed VI Polytechnic43150BenguerirMorocco Hassan First University of Settat FSTRayonnement-Matière et InstrumentationS3M26000SettatMorocco Materials and Nanomaterials Center Moroccan Foundation for Advanced ScienceInnovation and Research10100RabatMorocco

Structural,optical and magnetic properties are reported for new synthesized perovskite ***_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite *** refinement method was used to confirm the phase formation and investigate the structure and space *** study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm ***–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 *** measurements were carried out for the compositions Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic *** temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.

关键词： Perovskites Co-substitution effect Phase transition Band gap Ferromagnetic Visible light absorption

Malignancy and mortality in a population-based cohort of patients with coeliac disease or ‘gluten sensitivity’

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World Journal of Gastroenterology 2007年第1期13卷 146-151页

作者： la Anderson sa McMillan RGP Watson P Monaghan AT Gavin C Fox LJ Murray Queen's University Belfast Centre for Clinical and Population Sciences Belfast United Kingdom Royal Group of Hospitals Regional Immunology Service Belfast United Kingdom Royal Group of Hospitals Institute of Clinical Science Belfast United Kingdom. Queen's University Belfast Northern Ireland Cancer Registry Belfast United Kingdom

AIM: To determine the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin an- tibody test in Northern Ireland. METHODS: A population-based retrospective cohort study design was used. laboratory test results used in the diagnosis of coeliac disease were obtained from the Regional Immunology laboratory, cancer statistics from the Northern Ireland Cancer Registry and mortal- ity statistics from the General Registrar Office, Northern Ireland. Age standardized incidence ratios of malignant neoplasms and standardized mortality ratios of all-cause and cause-specific mortality were calculated. RESULTS: A total of 13 338 people had an endomysial antibody and/or an anti-gliadin antibody test in Northern Ireland between 1993 and 1996. There were 490 pa- tients who tested positive for endomysial antibodies and they were assumed to have coeliac disease. There were 1133 patients who tested positive for anti-gliadin anti- bodies and they were defined as gluten sensitive. Ma- lignant neoplasms were not significantly associated with coeliac disease; however, all-cause mortality was signifi- cantly increased following diagnosis. The standardized incidence and mortality ratios for non-Hodgkin’s lym- phoma were increased in coeliac disease patients but did not reach statistical significance. Lung and breast cancer incidence were significantly lower and all-cause mortal-ity, mortality from malignant neoplasms, non-Hodgkin’s lymphoma and digestive system disorders were signifi- cantly higher in gluten sensitive patients compared to the Northern Ireland population. CONCLUSION: Patients with coeliac disease or gluten sensitivity had higher mortality rates than the Northern Ireland population. This association persists more than one year after diagnosis in patients testing positive for anti-gliadin antibodies. Breast cancer is significantly re- duced in the cohort of patients with gluten sensitivity.

关键词： Coeliac disease Cancer Mortality Gluten sensitivity

Magnetoresistive properties of Ni-doped la_(0.7)Sr_(0.3)MnO_3 manganites

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Rare Metals 2016年第7期35卷 551-558页

作者： Ahmed Mohamed Ahmed Abd el-Moez Ahmed Mohamed Medhat Abdelrady Abdellateef Hassan Ahmed Abd el-Ghanny Physics Department Faculty of ScienceSohag University

lao.7Sr0.3Mnl_xNixO3 （x = 0, 0.025, 0.050 and 0.075） ceramics were prepared by the conventional solid-state reaction method. The partial substitution of Mn by Ni2＋ leads to a decrease in cell volume as well as a structural transition from the rhombohedral to the orthorhombic structure. Ni2＋ doping increases the electrical resistivity, decreases the semiconductor-metal transition temperature （Tms） and relatively enhances the room temperature magnetoresistance （MR）, especially in x = 0.025 and around Tins. With respect to conduction mechanism, the small polaron hopping （SPH） and the variable range hopping （VRH） models were used to ex- amine conduction in the semiconducting region.

关键词： Manganites X-ray diffraction Structure electrical resistivity Magnetoresistance

Evaluating new biomarkers for diabetic nephropathy:Role ofα2-macroglobulin,podocalyxin,α-L-fucosidase,retinol-binding protein-4,and cystatin C

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World Journal of Diabetes 2024年第6期15卷 1212-1225页

作者： Jing-Jing Li Ru-la sa Yu Zhang Zhao-Li Yan Department of Infectious Diseases Inner Mongolia Medical UniversityHohhot First HospitalHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010000Inner Mongolia Autonomous RegionChina Department of Dermatology Inner Mongolia Autonomous Region People’s HospitalHohhot 010000Inner Mongolia Autonomous RegionChina

BACKGROUND The intricate relationship between type 2 diabetes mellitus(T2DM)and diabetic nephropathy(DN)presents a challenge in understanding the significance of various biomarkers in *** To elucidate the roles and diagnostic values ofα2-macroglobulin(α2-MG),podocalyxin(PCX),α-L-fucosidase(AFU),retinol-binding protein-4(RBP-4),and cystatin C(CysC)in *** From December 2018 to December 2020,203 T2DM patients were enrolled in the *** these,115 were diagnosed with DN(115 patients),while the remaining 88 patients were classified as *** urinary levels ofα2-MG,PCX,and AFU and the serum concentrations RBP-4 and CysC were measured in conjunction with other relevant clinical indicators to evaluate their potential correlations and diagnostic *** After adjustments for age and gender,significant positive correlations were observed between the biomarkers CysC,RBP-4,α2-MG/urinary creatinine(UCr),PCX/UCr,and AFU/UCr,and clinical indicators such as urinary albumin-to-creatinine ratio(UACR),serum creatinine,urea,24-h total urine protein,and neutrophil-to-lymphocyte ratio(NLR).Conversely,these biomarkers exhibited negative correlations with the estimated glomerular filtration rate(Ped the diagnostic performance of these biomarkers,with UACR showcasing the highest area under the ROC curve(AUC^(ROC))at *** This study underscores the diagnostic significance ofα2-MG,PCX,and AFU in the development of *** biomarkers RBP-4,CysC,PCX,AFU,andα2-MG provide promising diagnostic insights,while UACR is the most potent diagnostic biomarker in assessing DN.

关键词： α2-macroglobulin Podocalysin α-L-fucosidase Retinol binding protein-4 Cystatin C Diabetic nephropathy

Effect of Alkali Stress on Soluble Sugar, Antioxidant Enzymes and Yield of Oat

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Journal of Integrative Agriculture 2013年第8期12卷 1441-1449页

作者： BAI Jian-hui LIU Jing-hui ZHANG Na YANG Jun-heng sa Ru-la WU lan Science Innovation Team of Oat Inner Mongolia Agricultural University College of Foreign languages Inner Mongolia Agricultural University

Alkali stress can cause severe crop damage and reduce production. However, physiological processes involved in alkali stress in oat seedlings are not well understood. In this study, physiological responses and yield of oat to alkali stress were studied using the alkali-tolerant oat genotype Vao-9 and the alkali-sensitive oat genotype Baiyan 5. The results were：（i） low concentrations of alkali stress （25 and 50 mmol L^-1） significantly reduced the yield and grain weight while increased the oat grain number per spike. A negative correlation between yield and malondialdehyde （MDA） content at the jointing and grain filling stages and positive correlations between yield on one hand and superoxide dismutase （SOD）, and peroxidase （POD） activities on the other at the jointing stage were observed. There was a positive correlation between MDA and soluble sugar at the grain filling stage; （ii） soluble sugar content was increased at the jointing and grain filling stages and decreased at the heading stage by alkali stress; （iii） alkali stress increased the SOD activity during the heading and grain filling stages, and increased the POD activity at the heading stage. As compared to the control, the increase of MDA contents in alkali-treated oat was observed, during the jointing, heading and grain filling stages; （iv） under alkali stress, the oat genotype Vao-9 showed higher antioxidant enzyme activity and lower soluble sugar contents during the heading stage, and lower MDA contents than those in the oat genotype Baiyan 5 under alkali stress. The result suggested that the high ROS scavenging capacity and soluble sugar levels might play roles in oat response to alkali stress,

关键词： oat alkali stress MDA soluble sugar antioxidant enzyme yield

Magnetic properties of la2CuMnO6 double perovskite ceramic investigated by Monte Carlo simulations

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Chinese Physics B 2020年第5期29卷 387-391页

作者： S Mtougui I el Housni N el Mekkaoui S Ziti S Idrissi H labrim R Kha.la.i L Bahmad laboratoire de la Matière Condensée et des Sciences Interdisciplinaires (laMCScI) Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco Intelligent Processing and Security Systems Mohammed V University of RabatFaculty of SciencesB.P.1014 RabatMorocco USM/DERS/Centre National de l’Energie des Sciences et des Techniques Nucl´eaires(CNESTEN)RabatMorocco

We present a theoretical study of the magnetic properties of the lanthanum copper manganate double perovskite la2CuMnO6 ceramic,using Monte Carlo *** analyze and discuss the ground state phase diagrams in different planes to show the effect of every physical *** on the Monte Carlo simulations,which combine Metropolis algorithm and Ising model,we explore the thermal behavior of the total magnetization and *** also present and discuss the influence of physical parameters such as the external magnetic field,the exchange coupling interactions between magnetic atoms,and the exchange magnetic field on the magnetization of the ***,the critical temperature of the system is about Tc=70 K,in agreement with the experimental ***,the hysteresis loops of la2CuMnO6 are discussed.

关键词： double perovskite la2CuMnO6 Monte Carlo simulations Ising model hysteresis loops Metropolis algorithm critical temperature