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Misleading New Entity in Tumors of Kidney: A Case Report and Literature Review

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Open Journal of Urology 2012年第4期2卷 219-222页

作者： el fatemi hinde Hammas Nawal Hafid Imane Tazi Fadl elfassi Jamal Amarti Afaf Department of Pathology Hassan II Teaching Hospital Fez Morocco Department of Urology Hassan II Teaching Hospital Fez Morocco

Introduction: Mucinous tubular and spindle cell carcinomas (MTSCC's) are recently described rare type of renal cell carcinoma (RCC). They may have morphological similarities to papillary RCC (papRCC) and in our case to carcinoma collecting ducts of Bellini. Case report: We report a rare case of renal tumor, mucinous tubular and spindle cell carcinoma in a 56-year-old woman. The tumor, located in the left kidney, was well circumscribed. MTSCC's are characterized by small, elongated tubules lined by cuboidal cells and/or cords of spindled cells separated by pale mucinous stroma. Discussion: MTSCC is a rare type of renal cell carcinoma. Pathologists should be aware of the histological spectrum of MTSCCs to ensure an accurate diagnosis. Careful attention to the presence of a spindle cell population may be helpful in the differential diagnosis in tumors with predominant compact tubular growth.

关键词： Renal Carcinoma Mucinous Tubular and Spindle Cell Carcinoma CD10 Immunohistochemistry

Tumor Misdiagnosed As Cancer of the Sphenoid Sinus: Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第2期1卷 48-50页

作者： el fatemi hinde Bennani Amal Souaf Ihsane Zaki Zouhir Alami Noureddine Amarti Afaf Department of Oto-Rhino-Laryngology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract first described by Wenig and Heffner in 1995 as prominent glandular proliferations lined by ciliated respiratory epithelium originating from the surface epithelium. Case Report: We report a case of 48-year-old women with nasal polyposis history, which consults for nasal obstruction, with suspicion of malignancy on CT. Surgical resection showed a respiratory epithelial adenomatoid hamartoma (REAH) of the nasal cavity. Conclusion: REAH is a recently described pathologic entity that can present rhinorrhea, epistaxis, hyposmia, and headaches. It is a rare lesion of nasal and paranasal sinuses, but should be considered in the differential diagnosis because it is a benign lesion and complete surgical resection is curative.

关键词： Nasal Cavity REAH Nasal Polyposis Hamartoma Nasal Obstruction

Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 279-282页

作者： el fatemi hinde Bennani Amal Saadi Hannane Bouchikhi Cherhazade Bannani Abdelaziz Mellas Nawfel Mesbahi Omar Department of Gynecology Hassan II Teaching Hospital Fez Morocco Department of Oncology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Introduction: Malignant melanoma (MM) represents 1% of all cancers and has an incidence of 3% - 7% in the female genital tract, the majority of cases being reported in the vulva. The cervico-vaginal region is an unsual primary location of the malignant mela-noma. Case report: The clinical and morphologic findings of 3 MM patients with cervico-vaginal tumours mimicking cervical polyp in third case. Histologically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with pleomorphic nuclei with prominent nucleolae. Tumor cells were positive for S-100 protein, Melan A, HMB 45 and CD117. The authors discuss three cases of cervico-vaginal melanoma and analyze clinical and prognostic aspects of this disease. Conclusion: Primary MM of the cervix should be considered in the differential diagnosis of cervical malignancies. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

关键词： Genital Tract Malignant Melanoma Cervix Vagina Chemotherapy CD117

Rare Tumors of Ovary: Case Report and Literature Review

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Open Journal of Pathology 2012年第3期2卷 81-84页

作者： el fatemi hinde Hammas Nawal Saadi Hannane Brahmi Sami Amarti Afaf Bannani Abdelaziz Mesbahi Omar Department of Gynecology Hassan II Teaching Hospital Fez Morocco Department of Oncology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Introduction: Large cell neuroendocrine carcinoma (LCNEC) or non small cell neuroendocrine carcinoma the ovary is a rare entity and is frequently associated with ovarian surface epithelial tumors. However, its association with serous carcinoma is rarer, in our knowledge tree cases has been described in international literature and the first case in Moroccan literature. Case Report: A 54-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Immunohistochemistry stain confirmed the diagnosis of large cell neuroendocrine carcinoma with serous carcinoma. The patient received three courses of carboplatin and paclitaxel and she's still alivewith a decline of 6 months. Its clinicopathologic association is discussed and the literature is reviewed. Conclusion: In summary, ovarian LCNEC is an aggressive tumor with a tendency to present at advanced stage and cause death within a mean of 17 months after diagnosis;however, some patients, particularly those with stage I disease and/or those who have received platinum-based therapy, may have a more favorable prognosis.

关键词： Ovary Neuroendocrine Carcinoma Non-Small Cell Type Serous Carcinoma Immunohistochemistry

Aggressive angiomyxoma pelvis presenting as an ovarian tumor

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Open Journal of Obstetrics and Gynecology 2013年第8期3卷 621-624页

作者： Errarhay Sanaa Lamquami Safae Mahmoud Samia el fatemi hinde Saadi Hanane Squalli Nadia Bouchikhi Chahrazed Amarti Afaf Banani Abdelaziz Department of Pathology University Hospital of Fez Fez Morocco Department of Qynecology and Obstetrics University Hospital of Fez Fez Morocco Department of Radiology University Hospital of Fez Fez Morocco

Aggressive angiomyxoma is rare mesenchymal tumor that most commonly arises in the vulvo-vaginal region, perineum, and pelvis of women. The term aggressively emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Preoperative diagnosis and treatment may be difficult. We report a 55-year-old patient who presented with a pelvic mass with no significant medical history. The radiological assessment showed a pelvic cystic tumor retro and lateral bladder. A surgical excision was performed with a diagnosis of aggressive angiomyxoma pelvis that misdiagnosed as ovarian tumor. The patient received adjuvant radiotherapy after surgery and remains well with no signs of local recurrence at 12 months follow-up. As surgery is the main treatment, preoperative diagnosis and assessment of extent of the tumor for planning surgery can not be overemphasized. The authors discuss this finding through the diagnostic difficulties and the evolution of this entity.

关键词： Aggressive Angiomyxoma Pelvic Neoplasm Immunohistochemistry

Misleading New Entity in Tumors of Kidney: A Case Report and Literature Review

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Tumor Misdiagnosed as Cancer of the Sphenoid Sinus: Case Report and Literature Review

Open Journal of Urology（泌尿学期刊） 2012年第4期

作者： el fatemi hinde Hammas Nawal Hafid Imane Tazi Fadl elfassi Jamal Amarti Afaf

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Rare Tumors of Ovary: Case Report and Literature Review

International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2012年第2期

作者： el fatemi hinde Bennani Amal Souaf Ihsane Zaki Zouhir Alami Noureddine Amarti Afaf

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Quality assessment of intraoperative frozen sections: An analysis of 261 consecutive cases in a resource limited area: Morocco

Open Journal of Pathology（病理学期刊） 2012年第3期

作者： el fatemi hinde Hammas Nawal Saadi Hannane Brahmi Sami Amarti Afaf Bannani Abdelaziz Mesbahi Omar

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Health 2012年第7期4卷 433-435页

作者： Laila Chbani Sekal Mohamed Tawfik Harmouch hinde el fatemi Afaf Amarti Department of Pathology Hassan II Teaching Hospital Fez Morocco

Purpose: To evaluate the accuracy and limits of a frozen section analysis in our department in order to develop a quality control. Materials and methods: all frozen sections reported at our department between 1st January 2010 and 31st December 2010, have been retrospectively evaluated. The frozen section results were compared to permanent paraffin section results. Results: Frozen sections and final diagnosis agreed in 95% and disagreed in 5% (13 cases), 6.6% of the cases were deferred (17 cases). The most common pathological processes encountered were presence/typing of neoplasm (85.4%) and assessment of surgical margins (7.3%). Conclusion: The accuracy of frozen sections diagnosis at our department can be interpreted as comparable with the most international quality control series and is valuable to assist surgeons in their decision.

关键词： Frozen Sections Quality Control Discrepancies Accuracy