Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review
Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review作者机构：Department of Gynecology Hassan II Teaching Hospital Fez Morocco Department of Oncology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco
出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)
年 卷 期：2012年第2卷第3期
页 面：279-282页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Genital Tract Malignant Melanoma Cervix Vagina Chemotherapy CD117
摘 要：Introduction: Malignant melanoma (MM) represents 1% of all cancers and has an incidence of 3% - 7% in the female genital tract, the majority of cases being reported in the vulva. The cervico-vaginal region is an unsual primary location of the malignant mela-noma. Case report: The clinical and morphologic findings of 3 MM patients with cervico-vaginal tumours mimicking cervical polyp in third case. Histologically, the neoplasia was formed by nodules of broad cytoplasmic cells with poorly defined borders with pleomorphic nuclei with prominent nucleolae. Tumor cells were positive for S-100 protein, Melan A, HMB 45 and CD117. The authors discuss three cases of cervico-vaginal melanoma and analyze clinical and prognostic aspects of this disease. Conclusion: Primary MM of the cervix should be considered in the differential diagnosis of cervical malignancies. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.
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