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Journal of Environmental Protection 2017年第8期8卷 844-866页

作者： Larisa I. Privalova Boris A. Katsnelson Marina P. Sutunkova Ilzira A. Minigalieva vladimir B. Gurvich Oleg H. Makeyev vladimir Ya. Shur Irene E. valamina Svetlana v. Klinova ekaterina v. Shishkina Ilya v. Zubarev The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russia The Institute of Natural Sciences The Ural Federal University Yekaterinburg Russia The Ural State Medical University Ekaterinburg Russia The Ural State Medical University Ekaterinburg Russia

Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism’s resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs’ toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs’ oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research.

关键词： Nanoparticles Toxic metals Bioptotectors

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俄罗斯传统医学在皮肤科的应用

亚太传统医药 2018年第6期14卷 1-2页

作者： Olga Y Olisova Elena S Snarskaya victor v Gladko ekaterina P Burova 莫斯科第一州立西切诺夫医科大学

草药处方在临床中的应用越来越多,皮肤科也不例外。俄罗斯地大物博,药材资源丰富。综述俄罗斯传统医学中用以治疗白癜风、脓皮病、痤疮等常见皮肤疾病的传统草药方剂,以供参考。

关键词：俄罗斯传统医学皮肤疾病

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Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

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Journal of Environmental Protection 2014年第14期5卷 1435-1449页

作者： Boris A. Katsnelson Larisa I. Privalova vladimir B. Gurvich Sergey v. Kuzmin ekaterina P. Kireyeva Ilzira A. Minigalieva Marina P. Sutunkova Nadezhda v. Loginova Olga L. Malykh Sergey v. Yarushin Julia I. Soloboyeva Natalia I. Kochneva Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russian Federation Sverdlovsk Regional Office of the Federal Service on Supervision in Sphere of Protection of the Consumers’ Rights and Well-Being of a Person (Rospotrebnadzor) Ekaterinburg Russian Federation

Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low levels as possible, the “biological prophylaxis” aims at enhancing host’s protective mechanisms. During over 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called “bioprophylatic complexes” (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs proved protectively effective in animal experiments were then subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals.

关键词： Environmental Pollution Health Risks Bio-Protectors

The Effects of Nanodiamonds at the Action of Colored Metal Ions on the Skin of Guinea Pigs

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Journal of Biomaterials and Nanobiotechnology 2016年第4期7卷 214-224页

作者： ekaterina Yu. vasilyeva victor I. Prokhorenkov Alexey P. Puzyr vladimir S. Bondar Krasnoyarsk State Medical University Named Prof. v.F. voyno-Yasenetsky Krasnoyarsk Russia Institute of Biophysics SB RAS Krasnoyarsk Russia

The protective effect of modified nanodiamonds (MND) under the action of cobalt and nickel ions on the skin of Guinea pigs was shown. At the action of chromium ions on the skin of animals, the protective effect of MND was not found. The differences are related to different adsorption properties of MND to the investigated colored metal ions. It is shown in vitro that MND can adsorb ions of cobalt and nickel and don’t bind ions of chromium from aqueous medium. The perspectives using of MND as a new drug for the prevention allergic dermatitis caused by action of bivalent ions of metals are discussed.

关键词： Nanodiamonds Allergic Contact Dermatitis Colored Metal Ions Clinical-Morphological Study

The Rate of Aging of the <i>Dunaliella viridis</i>Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

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Advances in Aging Research 2014年第2期3卷 187-198页

作者： A. I. Bozhkov M. K. Kovaleva N. G. Menzyanova Y. A. kuznetsova Research Institute of Biology V.N. Karazin Kharkov National University 4 Svobody Sq. Kharkov Ukraine

Two sublines of microalgae Dunaliella viridis Teodor. were obtained: CuS—a subline sensitive to toxic concentration of copper ions and CuR—a subline resistant to toxic concentration of copper ions. The chronological aging of cultures was revealed in increase of DNA (polyploidization) and triacylglycerols (TAG) content in microalgae cells. The adaptation of D. viridis to toxic concentrations of copper ions resulted in formation of an adaptive epygenotype characterized by increased content of carbonylated proteins and decreased content of proline compared to the CuS-subline. The adaptation of D. viridis to toxic concentrations of copper ions resulted in the increase of the rate of chronological aging compared to the CuS-subline. Four subcultures with different rates of transplanting were obtained from each subline. The rate of replicative aging was shown to be dependent on the rate of chronological aging of subcultures (passage rate). The pre-adaptation of D. viridis to toxic concentrations of copper ions was accompanied by increase of accumulation rate of TAG and DNA in cells, which was interpreted as a sign of cellular aging during the progressive passages of the algae culture.

关键词： Microalgae Dunaliella viridis Adaptation to Copper Ions Chronological and Replicative Aging Epigenotype

Intimal pericytes as the second line of immune defence in atherosclerosis

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World Journal of Cardiology 2015年第10期7卷 583-593页

作者： ekaterina A Ivanova Yuri v Bobryshev Alexander N Orekhov Department of Development and Regeneration Biomedical Sciences Group KU LeuveLeuvenBelgium Faculty of Medicine School of Medical Sciences University of New South Wales School of Medicine University of Western Sydney Laboratory of Angiopathology Institute of General Pathology and Pathophysiology Russian Academy of Sciences Institute for Atherosclerosis Research Skolkovo Innovative Center Department of Biophysics Faculty of Biology Lomonosov Moscow State University

Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions.

关键词： Atherosclerosis Arteries Intima Immune-inflammator

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日轮果属,越南唇形科黄芩亚科一新属

热带亚热带植物学报 2023年第5期31卷 727-735页

作者：李波 Thanh Son HOANG Maxim S.NURALIEv vu Anh TAI Andrey N.KUZNETSOv Svetlana P.kuznetsova 向春雷中国科学院西双版纳热带植物园云南勐腊666303 Silviculture Research Institute Vietnamese Academy of Forest SciencesHanoi 10000Vietnam Joint Russian-vietnamese Tropical Scientific and Technological Center Hanoi 122000Vietnam Department of Higher Plants Biological FacultyM.V.Lomonosov Moscow State UniversityMoscow 119234Russia Institute of Geography Vietnam Academy of Science and TechnologyHanoi 10000Vietnam 中国科学院昆明植物研究所昆明650201

描述并绘制了越南唇形科一新属及新种:日轮果属(Heliacria Bo Li,***,***&Nuraliev)和日轮果(*** Bo Li,***,***&Nuraliev)。日轮果属因具攀援藤本习性,花大且花冠为纯白色,花萼近辐射对称、5深裂、裂片长且在果期增大并开展,果实顶端... 详细信息

描述并绘制了越南唇形科一新属及新种:日轮果属(Heliacria Bo Li,***,***&Nuraliev)和日轮果(*** Bo Li,***,***&Nuraliev)。日轮果属因具攀援藤本习性,花大且花冠为纯白色,花萼近辐射对称、5深裂、裂片长且在果期增大并开展,果实顶端具放射状的瘤状突起等特征而明显区别于黄芩亚科的其他5属。目前,该属仅发现于越南东南部沿海的平定省、富安省、庆和省和宁顺省,常生于海岸边干旱的低地矮林中。

关键词：新分类群特有属冬红属膜萼藤属唇形目

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Development of Contactless Method of the DUT Heating during Single-Event Effect Tests

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Journal of Physical Science and Application 2018年第2期8卷 22-27页

作者： vasily S.Anashin Eugeny v.Mitin Aleksandr E.Koziukov ekaterina N.Nekrasova Branch of Joint-Stock Company United Rocket and Space Corporation–Institute Of Space Device Engineering Moscow 111250Russia

This paper presents two approaches to perform the electronic device heating during radiation hardness assurance *** used conductive heating approach is compared with contactless laser-based approach,characteristics and limitations of these methods are *** results for temperature dependence of single-event latchup(SEL)cross-section during heavy ion irradiation along with some aspects of physics-based numerical simulation of heat transfer processes are presented.

关键词： Single-event effect(SEE)tests heavy ions radiation hardness heating methods SEL

左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究

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中华高血压杂志 2014年第10期22卷 934-934页

作者：刘莉叶鹏 Kloch-Badelek M Knez J Tikhonoff v Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA kuznetsova T

确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法：随机抽取316个家庭样本,包... 详细信息

确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法：随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁,

关键词：左心室舒张功能障碍家庭影响因素遗传性人口多普勒指数遗传因素一般人群

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補體結合反應作鼠疫疫鼠檢查的評價

微生物学报 1957年第4期 451-454页

作者：陸品璋蔡珠欽劉仁漢翁文淵福建省鼠疫防治所

補體結合反應在鼠疫免疫學研究的應用曾有Moses,Damperoff,Jaltrain,及Simard。諸氏用它來診斷人類鼠疫,但是陽性反應的顯現太遲緩(常在病愈二星期後),因而失去在臨床應用上的及時診斷的價值。kuznetsova和Dobrokhtova等氏用它來测驗鼠... 详细信息

補體結合反應在鼠疫免疫學研究的應用曾有Moses,Damperoff,Jaltrain,及Simard。諸氏用它來診斷人類鼠疫,但是陽性反應的顯現太遲緩(常在病愈二星期後),因而失去在臨床應用上的及時診斷的價值。kuznetsova和Dobrokhtova等氏用它來测驗鼠類血液有無鼠疫抗體存在,作為是否疫鼠的鑑定;但由於鼠類血液中有抗補體現象的發生,結果不一致而未能廣泛應用。陳氏等曾擴大實驗範圍,成效顯

关键词：鼠疫血清保存方法甘油浸出液巴氏杆菌感染多元醇阿斯乾乾