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A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo qin yu.n Lei Luo Bao You-jia Zhang Ke-Yin Liu yu.Hong Chen Department of Ophthalmology&Visual science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China Key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China state Key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(sIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(Ps were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,Psma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,Psma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,Pministering MnTMPyP to mouse eyes reversed the elevated IOP caused by sIN-1(PsION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional survey

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Biomedical and Environmental sciences 2024年第3期37卷 254-265页

作者： sHAN Xiao yu. ZOU Yan HUANG Li Chun jiaNG shan ZHOU Wei Wen qin Qiu Lan LIU Chang qing LUO Xiao Yan LU jia Xi MAO De Qian LI min YANG Zhen yu.YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TsH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TsH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,*** median TsH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TsH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TsHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TsH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TsH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A single-Institution study

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Biomedical and Environmental sciences 2024年第5期37卷 457-470页

作者： KONG Zi qing LIU Li Qun HUANG De qin WANG yu.Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di sHAO jia Kang ZHU Yi min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical school of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University school of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(Pstatus increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,Pson’s R=0.159,Psurvival analysis revealed a significantly longer overall survival(Os)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFs).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： yu.Cong Wang Xin-Yang Jin Zheng Lei Xiao-jiao Liu yu.Liu Bang-Guo Zhang jian Gong Lie-Tao Wang Lv-yu.n shi Ding-yu.n Wan Xin Fu Lu-Ping Wang Ai-jia Ma Yi-song Cheng Jing Yang min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina school of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCs score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence sunstroke Intensive care units Diarrhea

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Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports

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World Journal of Clinical Cases 2024年第22期12卷 5208-5216页

作者： qing-Mei Deng jian Zhang Yi-Yong Zhang min jia Du-shan Ding yu.qin Fang Hong-Zhi Wang Hong-Cang Gu science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230031Anhui ProvinceChina Institute of Health and Medical Technology Hefei Institutes of Physical ScienceChinese Academy of ScienceHefei 230031Anhui ProvinceChina Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefei 230031Anhui ProvinceChina

BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly *** culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only ***-generation nanopore sequencing technology provides new options for identifying *** sUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and *** sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural *** sodium sulbactam treatment was *** 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung *** treatment for streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was *** 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six *** antibacterial treatment,her symptoms *** nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus *** patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with *** Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases.

关键词： Nanopore sequencing technology Third-generation sequencing technology Infection Pathogen Case report

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Electrically conductive and highly compressible anisotropic MXene-wood sponges for multifunctional and integrated wearable devices

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Journal of Materials science & Technology 2023年第13期144卷 102-110页

作者： Dekui song Mei-jiao Zeng Peng min Xue-qin jia Fu-Lin Gao Zhong-Zhen yu.Xiaofeng Li state Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029China College of Chemistry Beijing Normal UniversityBeijing100875China

Although piezoresistive sensors have wide applications in human motion detection and wearable elec-tronics,it is still a challenge to produce multifunctional and integrated sensors with wide working ranges and linear sensing ***,electrically conductive,highly compressible,and structurally anisotropic MXene-wood(MW)sponges are fabricated by converting balsa wood blocks to compressible wood sponges with extremely low density and highly anisotropic porous structure,followed by deco-rating with conductive MXene *** MW sponge is utilized to assemble a piezoresistive sensor with a large working range of 0-25 kPa,wide linear sensing ranges of 5%-50%and 0-180°,and excellent long-term reliability under a bending angle of 30°for 5000 ***,the sensor is suitable for monitoring practical human physiological signals including pulse beating,and finger and wrist *** all-MW sponge-based multifunctional and integrated sensing system is constructed by integrating the MW sponge piezoresistive sensor,the MW sponge-based solid-state supercapacitor,and the MW sponge electrophysiological *** sensing system can concurrently detect surface electromyogram and tactile pressures,and hence realize real-time closed-loop *** multifunctional and integrated MW sponge sensing system would have great potentials in real-time pressure recognition and human-machine interfaces.

关键词： MXene sheets Wood sponges Piezoresistive sensors Compressibility

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Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2225-2236页

作者： min Lai Ya-Lu qin Qiong-yu.Jin Wen-Jing Chen jia Hu Department of Gastroenterology the Third Affiliated Hospital of Chengdu Medical College/Chengdu Pidu District People's HospitalChengdu 611730Sichuan ProvinceChina Department of Cardiology the Affiliated Third Hospital of Chengdu Traditional Chinese Medicine University/Chengdu Pidu District Hospital of Traditional Chinese MedicineChengdu 611730Sichuan ProvinceChina

BACKGROUND The MBOAT7 rs641738 single-nucleotide polymorphism(sNP)has been proven to influence various liver diseases,but its association with hepatocellular carcinoma(HCC)susceptibility has been *** address this discrepancy,we conducted the current systematic review and *** To perform a systematic review and meta-analysis on association of MBOAT7 sNP and HCC *** We performed a systematic review in PubMed,Web of science,scopus,and EMBAsE;applied specific inclusion and exclusion criteria;and extracted the ***-analysis was conducted with the meta package in *** and subgroup analyses were also *** meta-analysis was registered in PROsPERO(CRD42023458046).REsULTs Eight studies were included in the systematic review,and 12 cohorts from 6 studies were included in the *** meta-analysis revealed an association between the MBOAT7 sNP and HCC susceptibility in both the dominant[odds ratio(OR):1.14,95%confidence interval(95%CI):1.02-1.26,P=0.020]and recessive(OR:1.21,95%CI:1.05-1.39,P=0.008)*** analysis revealed that stratification of the included patients by geographical origin showed a significant association in Asia(OR:1.20,95%CI:1.03-1.39).CONCLUsION This meta-analysis underscores the contribution of the MBOAT7 rs641738 sNP to hepatocarcinogenesis,especially in Asian populations,which warrants further investigation.

关键词： MBOAT7 single-nucleotide polymorphisms Hepatocellular carcinoma systematic review Meta-analysis Asian populations

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Myotonic dystrophy type 1 presenting with dyspnea:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7060-7067页

作者： yu.Xi jia Chun-Ling Dong jia-Wei Xue Xiao-qin Duan ming-yu.Xu Xiao-min su Ping Li Department of Orthopedics The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Application Demonstration Center of Precision Medicine Molecular Diagnosis The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Rehabilitation Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Developmental Pediatrics The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Myotonic dystrophy type 1(DM1)is a genetic neuromuscular disease involving multiple systems,especially the cardiopulmonary *** clinical phenotype of DM1 patients is highly variable,which limits early diagnosis and *** the present study,we reported a 35-year-old female DM1 patient with dyspnea as the primary onset clinical manifestation,analyzed her family's medical history,and reviewed related *** sUMMARY A 35-year-old woman was admitted to the hospital with dyspnea of 1 mo duration,and sleep apnea for 3 *** respiratory pattern and effort were normal,but limb muscle tension was *** into the patient's medical history revealed that she might have hereditary neuromuscular *** showed that her myotonia potentials were visible in the resting state of the examined muscles,with decreased motor unit potential time limit and *** testing for DM1 revealed that the cytosine-thymine-guanine(CTG)repeat number of the DMPK gene exceeded 50,while cytosine-CTG expansion in intron 1 of ZNF9 gene wass diagnosed with *** DM1 is a genetic neuromuscular disease involving multiple systems,and the clinical phenotype in DM1 is extremely *** patients with DM1 may be presented at the respiratory department because of dyspnea,which should be cautioned by the *** may be no obvious or specific symptoms in the early stage of disease,and clinicians should improve their understanding of DM1 and make an early diagnosis,which will improve patients’quality of life.

关键词： Myotonic dystrophy type 1 DMPK gene Respiratory insufficiency sleep apnea Non-invasive ventilation

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Acquired double pylorus:A case report

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 503-504页

作者： qing-yu.Chen Yan Chen Liang Jing Wang qin Du jian-Ting Cai jia-min Chen Department of Gastroenterology Second Affiliated HospitalZhejiang University College of MedicineChina

Double pylorus is one of the rare anomalies of the gastrointestinal tract,it can be congenital or *** this case we report a case of double pylorus because of chronic peptic *** GI endoscopy revealed gastroduodenal fistula located on the lesser curve of the antrum,the patient’s symptoms were improved rapidly by intensive antiulcer treatment.

关键词： Acquired double pylorus Gastric endoscopy Gastroduodenal fistula

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Exogenous Hydrogen sulfide Enhanced Antioxidant Capacity, Amylase Activities and salt Tolerance of Cucumber Hypocotyls and Radicles

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Journal of Integrative Agriculture 2013年第3期12卷 445-456页

作者： yu.Li-xu ZHANG Cun-jia sHANG Hong-qin WANG Xiu-feng WEI min YANG Feng-juan sHI qing-hua state Key Laboratory of Crop Biology/College of Horticulture science and Engineering Shandong Agricultural University Department of Life sciences Heze University

In the present experiment, effects of sodium hydrosulfide （Naris）, a H2s donor, on the oxidative damage, antioxidant capacity and the growth of cucumber hypocotyls and radicles were studied under 100 mmol L^-1 NaCl stress. NaCl treatment significantly induced accumulation of H2O2 and thiobarbituric acid-reactive substances （TBARs） in cucumber hypocotyls and radicles, and application of Naris dramatically reduced the accumulation of H/O2 and lipid peroxidation. However, the alleviating effects greatly depended on the concentrations of Naris, and 400 ~tmol L-1 Naris treatment showed the most significant effects. Corresponding to the change of lipid peroxidation, higher activities of antioxidant enzymes as well as the antioxidant capacity indicated as DPPH scavenging ac＇tivity, chelating activity of ferrous ions and hydroxyl radical （.OH） scavenging activity were induced by Naris treatment under NaCI stress, especially by 400 Ixmol L-I Naris treatment. With the alleviating lipid peroxidation, the amylase activities in cotyledons were increased, and the length of cucumber hypocotyls and radicles were significantly promoted by Naris treatment under NaCI stress. Unlike the effects of Naris, pretreatment with other sodium salts including Na2s, NazsO4, NaHsO4, Na2sO3, NaHsO3 and NaAc did not show significant effects on the growth of cucumber hypocotyls and radicles. These salts do not release H2s. Based on above results, it can be concluded that the effects of Naris in the experiment depended on the H2s rather than other compounds derived from Naris, and the alleviating effects might related with its function in modulating antioxidant capacity and amylase activities.

关键词： cucumber tolerance salt stress seed priming hydrogen sulfide antioxidant capacity

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