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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG Dong-lei SUN Chen-yang LI yu-xin LUO Qian LIU yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

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Orbital angular momentum conversion of acoustic vortex beams via planar lattice coupling

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CHINESE PHYSICS B 2024年第9期33卷 413-420页

作者： Han, Qingbang Liu, Zhipeng Yin, Cheng Wu, Simeng Luo, Yinlong Yang, Zixin Pan, Xiuyang Wang, Yiqiu Kan, Xuefen Zhang, yuqiu yu, Qiang Wu, Jian Hohai Univ Coll Informat Sci & Engn Changzhou 213200 Peoples R China Natl Univ Def Technol Coll Adv Interdisciplinary Studies Nanhu Laser Lab Changsha 410073 Peoples R China Chinese Acad Sci Suzhou Inst Nanotech & Nanob i Lab Suzhou 215123 Peoples R China Jiangsu Shipping Coll Sch Transportat Engn Nantong 226010 Peoples R China

Orbital angular momentum (OAM) conversion is critical in understanding interactions between a structural sound field and a planar lattice. Herein, we explore the evolution of a monochromatic acoustic vortex beam (AVB) that is scattered by a phononic crystal (PnC) or a correlated random lattice. The phenomenon is ascribed to the enhanced orbit-orbit angular momentum coupling induced by the band structure. By modifying the coupling condition, accurate and continuous micro-manipulation of AVBs can be achieved, including the transverse/lateral gravity shift, the dynamics of the phase singularities, and the spatial distribution of acoustic pressure, etc. This research provides insight to the inhomogeneous coupling of AVBs with both propagating Bloch waves and localized Anderson modes, and may facilitate development of novel OAM-based acoustic devices for active sound field manipulation.

关键词： acoustic vortex beam phononic crystal Anderson localization Imbert-Fedorov effect 43.40.+s 43.20.+g 46.40.-f 46.40.Cd

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理解生成式AI:融通机器智能与人类智能的算法媒介

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新闻大学 2024年第6期 50-61,120页

作者：刘彧晗喻国明北京师范大学新闻传播学院北京100091

以媒介视角考察生成式AI是本文探讨的核心问题。研究尝试从媒介形态与特性、媒介化机制与路径方面为这一媒介技术提供较全面的价值阐释。研究认为,生成式AI具有独特的“微调”可供性,并赋予了“居”于机器智能与人类智能之“间”、连接... 详细信息

以媒介视角考察生成式AI是本文探讨的核心问题。研究尝试从媒介形态与特性、媒介化机制与路径方面为这一媒介技术提供较全面的价值阐释。研究认为,生成式AI具有独特的“微调”可供性,并赋予了“居”于机器智能与人类智能之“间”、连接机器智能要素与人类智能要素的媒介特性。生成式AI的媒介化力量,是借助机器的参数解构力和人类的标注牵引力实现的社会强媒介化过程,机器智能发挥解构社会秩序和执行生产过程的功能,人类智能则担任牵引社会方向和“赋魂”智力创新的角色。展望未来发展,生成式AI短期需解决数据契合度问题,完善模型;中期需解决使用契合度问题,培训提示工程;长期需解决社会契合度问题,适应政策市场。由此,生成式AI方可发挥最大的媒介化效应,迈向人机协同新文明。

关键词：生成式AI 媒介特性媒介化复杂性范式社会系统论

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Color center-rich γ-AlOpromotes propane dehydrogenation

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Science China Chemistry 2024年

作者： yu Wang Xiang Wang Mengfei Qiao Qingyuan Wu Kunlong Liu Xiaodong Yi Ruixuan Qin Gang Fu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Material SciencesZhejiang Normal University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM)

The PtSn/Al2O3catalyst is commonly used in commercial propane dehydrogenation （PDH） processes,but it faces challenges in the deactivation and periodic regeneration due to metal aggregation and coke deposition at high *** Al3+pentahas been proven to be beneficial for enhancing catalytic stability,bottom-up synthesis protocols usually restrict their ***,a facile post-treatment approach using acetic acid was applied to create color centers （electrons trapped within oxygen vacancies） on γ-Al3+***,the content of Alpentawas enriched to 18.3%.Then,the pre-established PtSn clusters were *** electrons facilitated the formation of ultrafine PtSn nanoparticles （～2 nm）,and the Al3+pentasites prevented the sintering of PtSn by constructing the strong Al3+penta–O–Sn ***,the catalytic durability of the catalyst prepared by conventional impregnation methods was remarkably extended from 186 h for the color center-free sample to 1,000 h using the HAc–*** facile post-modification was further successfully extended to commercial Al2O3pellets without altering their mechanical properties,highlighting its potential in industrial applications.

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Alkali-extracted polysaccharides from mung bean skin possess protective effect on HO-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

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Food Science and Human Wellness 2024年

作者： Shuai Chen Liuming Xie Pingwei Wen Qiang yu Yi Chen Hanyu Lu Ting Chen Xin Tao Jianhua Xie International Institute of Food Innovation Co.， Ltd.， Nanchang University State Key Laboratory of Food Science and Resources， Nanchang University

Intestinal oxidation-reduction balance is essential to protect host health. Research on the underlying mechanisms of oxidation homeostasis can provide conditions to the treatment or protection of intestinal oxidative stress. Therefore， the mechanism of polysaccharide (MBP) with alkali-extracted from mung bean skin in alleviating oxidative damage induced by H2O2-induced in Intestinal epithelial cells (IEC)-6 cells was explored. Results indicated that MBP effectively mitigated the H2O2-induced decrease in IEC-6 cell viability， restored superoxide dismutase (SOD) activity， lowered malondialdehyde (MDA) content， and decreased reactive oxygen species (ROS) level. Western blotting showed that MBP may mitigate oxidative damage through NF-κB， MAPK and Nrf2 signaling pathway， and RNA sequencing (RNA-seq) analysis confirmed that MBP can protect cells by regulating MAPK and NF-κB signaling pathways. Moreover， the results of the inhibitor experiment also support the above hypothesis. These results verified that MBP has the capacity to mitigate oxidative damage induced by H2O2in IEC-6 cells through MAPK and NF-κB signaling pathway. The study showed that MBP can assist preventing intestinal diseases relating to oxidative stress， which could facilitate the development of functional foods.

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting COphotoreduction

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Science China Chemistry 2024年

作者： Hui-Feng Wang Wen-Jie Shi yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of CoZn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of CoCo-In,ZnZn-In,Co-In,and Zn-In,***,the catalytic activities of CoNi-In and NiZn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Interface and mechanical degradation mechanisms of the silicon anode in sulfide-based solid-state batteries at high temperatures

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Chinese Physics B 2024年第8期33卷 117-126页

作者：王秋辰黄昱力许晶禹习谦李泓陈立泉 Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Huairou Division Institute of PhysicsChinese Academy of SciencesBeijing 101408China

Silicon(Si)is a competitive anode material owing to its high theoretical capacity and low electrochemical ***,the prospect of Si anodes in solid-state batteries(SSBs)has been proposed due to less solid electrolyte interphase(SEI)formation and particle ***,major challenges arise for Si anodes in SSBs at elevated *** this work,the failure mechanisms of Si-Li_(6)PS_(5)Cl(LPSC)composite anodes above 80℃are thoroughly investigated from the perspectives of interface stability and(electro)chemo-mechanical *** chemistry and growth kinetics of Lix Si|LPSC interphase are demonstrated by combining electrochemical,chemical and computational *** and/or Si–P compound formed at Lix Si|LPSC interface prove to be detrimental to interface stability at high *** the other hand,excessive volume expansion and local stress caused by Si lithiation at high temperatures damage the mechanical structure of Si-LPSC composite *** work elucidates the behavior and failure mechanisms of Si-based anodes in SSBs at high temperatures and provides insights into upgrading Si-based anodes for application in SSBs.

关键词： sulfide electrolytes silicon anodes interface stability degradation kinetics all-solid-state batteries

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Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma

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Chinese Journal of Natural Medicines 2024年第07期 632-642页

作者： CHENG Xinran FENG Mengyuan ZHANG Anjie GUO Jian GONG yunlai HU Xiaohui HAN Quanbin LI Shengbao yu Xianjun Department of Gastroenterology Taihe HospitalHubei University of Medicine Laboratory of Inflammation and Molecular Pharmacology School of Basic Medical Sciences & Biomedical Research InstituteHubei Key Laboratory of Wudang Local Chinese Medicine ResearchSchool of PharmacyHubei University of Medicine Inflammation-Cancer Transformation and Wudang Chinese Medicine Research Hubei Talent Introduction and Innovation Demonstration BaseHubei University of Medicine School of Chinese Medicine Hong Kong Baptist University

Gambogenic acid(GNA), a bioactive compound derived from the resin of Garcinia hanburyi, has demonstrated significant antitumor properties. However, its mechanisms of action in oral squamous cell carcinoma(OSCC) remain largely unclear. This study aimed to elucidate the apoptotic effects of GNA on OSCC cell lines CAL-27 and SCC-15. Our results indicated that GNA induced apoptosis by upregulating the pro-apoptotic protein Noxa. Mechanistic investigations revealed that GNA treatment led to the generation of reactive oxygen species(ROS), which activated endoplasmic reticulum(ER) stress, culminating in cell apoptosis. Inhibition of ROS production and ER stress pathways significantly mitigated GNA-induced Noxa upregulation and subsequent ***, in vivo studies using a murine xenograft model demonstrated that GNA administration effectively inhibited the growth of CAL-27 tumors. Collectively, these findings underscore GNA's potential as a therapeutic agent for the treatment of OSCC.

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Integration of gut microbiota and metabolomics analysis to unravel the neuroprotective effects of Hydroxy-α-sanshool on Alzheimer's Disease

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Food Science and Human Wellness 2024年

作者： Ruo-Lan Li Wen-Wen Chen Hong Zhang Qi Liang Ling-yu Wang Wei Peng Chun-Jie Wu State Key Laboratory of Southwestern Chinese Medicine Resources， School of Pharmacy， Chengdu University of Traditional Chinese Medicine Institute of Innovation， Chengdu University of Traditional Chinese Medicine Sichuan Cancer Hospital and Institute， School of Medicine， University of Electronic Science and Technology of China Chengdu Women's and Children's Central Hospital， School of Medicine， University of Electronic Science and Technology of China Meishan Hospital of TCM， Meishan Hospital Affiliated to Chengdu University of Traditional Chinese Medicine

Alzheimer's disease （AD） is a common neurodegenerative disease， and oxidative stress induced by Aβ deposition is the key cause of neuronal apoptosis in AD patient. Hydroxy-α-sanshool （HAS） is the predominant flavour substances in the pericarp of Zanthoxylum bungeanum Maxim. （Rutaceae family）， which is a known condiment food and herbal medicine in China. We attempt to comprehensively elucidate the pathway and related mechanisms of HAS therapy on AD through in vivo and in vitro experiments. The results showed that HAS could inhibit cell apoptosis， suppress the reactive oxygen species （ROS）， and increase the antioxidative enzymes in Aβ1-42induced HT22 cells. In vivo， HAS attenuated the learning and memory impairment in senescence-accelerated mouse prone 8 （SAMP8） mice， and protected neuronal cells in hippocampus. Interestingly， the 16S rRNA gene sequencing results showed HAS could restore the richness and diversity of the intestinal microbiota， reduce the abundance of Lactobacillus， and increase the abundance of Bateroides and Parabacteroides. Moreover， the contents of 10 metabolites were significantly changed after HAS treatment， which was beneficial to treat AD. In conclusion， HAS could inhibit apoptosis in nerve cells by attenuating Aβ induced oxidative stress level， while it can also influence the metabolic pathways and affect the gut microbiota composition of AD mice.

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聚乙烯对小白菜生长的潜在影响:内生效应

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中国环境科学 2024年第8期44卷 4621-4631页

作者：于方明高雨陈玉橼符明月唐炽健莫翠菊李艺广西师范大学环境与资源学院广西桂林541004 广西生态脆弱区环境过程与修复重点实验室广西桂林541004

以小白菜作为研究对象,通过盆栽实验,分析了不同粒径和不同添加水平的聚乙烯微塑料(PE-MPs)对小白菜生长及其生理生化特性的潜在影响.研究结果表明,PE添加显著降低了小白菜的株高和株重(P<0.05),在PE粒径为0.5μm,投加量为0.5%(w/w)的... 详细信息

以小白菜作为研究对象,通过盆栽实验,分析了不同粒径和不同添加水平的聚乙烯微塑料(PE-MPs)对小白菜生长及其生理生化特性的潜在影响.研究结果表明,PE添加显著降低了小白菜的株高和株重(P<0.05),在PE粒径为0.5μm,投加量为0.5%(w/w)的处理下,分别下降了86.8%和60.3%.并且,PE添加导致小白菜叶片中光合色素的含量显著降低(P<0.05).二元方差分析结果表明,PE粒径变化对小白菜生长和光合色素含量变化的影响更大.PE添加显著降低了内生细菌群落的Shannon指数和ACE指数(P<0.05),显著提高了内生细菌群落的Simpson指数(P<0.05).在各水平PE的添加下,小白菜根系内生细菌变形菌门和内生真菌子囊菌门的相对丰度升高,而内生细菌放线菌门的相对丰度降低.SEM观测结果表明PE-MPs颗粒主要出现在小白菜的木质部和根皮层组织的细胞壁上.二元方差分析结果表明,PE粒径变化对小白菜根系和地上部分的氧化应激指标的影响更大.PE的富集对小白菜造成了严重的结构、功能损伤和膜脂过氧化损伤,最终导致小白菜的生物量下降.

关键词：小白菜聚乙烯微塑料内生菌活性氧物质

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