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Tissue tropism and parasite burden of Toxoplasma gondii RH strain in experimentally infected mice

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 521-524页

作者： Yousef Dadimoghaddam Ahmad Daryani Mehdi Sharif ehsan ahmadpour Zahra Hossienikhah Toxoplasmosis Research Center Mazandaran University of Medical Sciences Parasitology and Mycology Department.Sari Medical School Mazandaran University of Medical Sciences Molecular and Cell Biology Research Center Mazandaran University of Medical Sciences

Objective:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time ***:In this survey 16 Balb/c mice were inoculated with 1×10~4 alive tachyzoites of Toxoplasma gondii RH *** 1,2,3 days post infection and the last day(before death),different tissues of mice including blood,brain,eye,liver,spleen,kidney,heart and muscle were *** tissues DNA extraction,the parasite burden was quantified using real time QPCR targeting the B1 gene(451 bp).Results:It showed that Toxoplasma after intraperitoneal injection was able to movement to various tissues in24 *** burden was high in all tissues but the most number of parasites were observed in kidney,heart and liver,***:These data provide significant baseline information about Toxoplasma pathogenesis,vaccine monitoring and drug efficiency.

关键词： Parasite burden Toxoplasma gondii Tissue tropism Quantitative PCR Murine model

Tuberculous meningitis and miliary tuberculosis in Iran:A review

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Asian Pacific Journal of Tropical Medicine 2022年第4期15卷 143-152页

作者： Sayyed Gholamreza Mortazavi-Moghaddam Abdol Sattar Pagheh ehsan ahmadpour Alacsandra Barac Azadeh Ebrahimzadeh Infectious Diseases Research Center Birjand University of Medical SciencesBirjandIran Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Clinic for Infectious and Tropical Diseases Clinical Centre of Serbia11000BelgradeSerbia

In recent years,the number of cases of extrapulmonary tuberculosis in Iran has *** goal of this study was to determine the epidemiological status,clinical symptoms,diagnostic methods,and treatment strategies of extrapulmonary tuberculosis in Iran,with a focus on tuberculosis meningitis and miliary *** January 1,2000 and June 1,2021,1651 cases of tuberculosis meningitis and miliary tuberculosis were discovered in *** prevalence of tuberculosis meningitis was higher in Sistan and Baluchestan,South Khorasan,and Mazandaran compared with other *** most prevalent symptoms of tuberculous meningitis were fever,anorexia,headache,neck stiffness,loss of consciousness,and *** most commonly used procedures for diagnosing tuberculous meningitis were polymerase chain reaction and cerebrospinal fluid *** most prevalent clinical symptoms of miliary tuberculosis were fever,lethargy,weariness,and *** 70%of chest radiographs,a miliary pattern was *** marrow biopsy was used to diagnose miliary tuberculosis in 80%of patients,while bronchoalveolar lavage was used in 20%of *** conventional 6-month treatment approach for tuberculous meningitis and miliary tuberculosis was used for all of the participants in the *** the high prevalence of extrapulmonary tuberculosis patients in Iran and the devastating consequences of the disease,the researchers recommend that further study be done to prevent extrapulmonary tuberculosis in the general population.

关键词： Extrapulmonary tuberculosis Tuberculous meningitis Miliary tuberculosis Iran

Global prevalence,mortality,and main risk factors for COVID-19 associated pneumocystosis:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 431-441页

作者： Hossein Khodadadi ehsan ahmadpour Sanam Nami Rasoul Mohammadi Hanieh Hosseini Mahsa Behravan Hamid Morovati Department of Parasitology and Mycology School of MedicineShiraz University of Medical SciencesShirazIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran Department of Medical Mycology and Parasitology School of MedicineTabriz University of Medical SciencesTabrizIran Department of Medical Parasitology and Mycology School of MedicineIsfahan University of Medical SciencesIsfahanIran Immunology Research Center Tabriz University of Medical SciencesTabrizIran Student Research Committee Shiraz University of Medical SciencesShirazIran

Objective:Pneumocystis pneumonia(PcP)is a life-threatening infection caused by the opportunistic fungi Pneumocystis *** emergence of the COVID-19 pandemic forced the focus of attention of health policymakers on these two infections due to their clinical and paraclinical similarities,which cause diagnostic *** study was undertaken to evaluate and estimate the global prevalence and main leading risk factors of coronavirus-associated pneumocystosis(CAP).Methods:We searched related databases between December 2019 and May 2022 for studies reporting ***-analysis was performed using StatsDirect software(version 2.7.9)according to the DerSimonian and Laird method applying the random-effects *** evaluated heterogeneity using theχ2-based Q statistic(significant for P75%indicative of“notable”heterogeneity).Moreover,an odds ratio(OR)analysis was performed for eligible ***:Our meta-analysis included eight studies with 923 patients hospitalized with COVID-19;among them,92 were PcP *** overall pooled prevalence of CAP was estimated at 11.5%.The mortality among CAP patients was lower than that of non-PcP patients(OR 1.93;95%CI 0.86-4.31).Long-term corticosteroid therapy(OR 28.22;95%CI 0.54-1480.84)was the most predisposing factor for PcP among COVID-19 patients,followed by pulmonary diseases(OR 1.46;95%CI 0.43-4.98),kidney diseases(OR 1.26;95%CI 0.21-7.49),and acute respiratory destruction syndrome(OR 1.22;95%CI 0.05-29.28).Conclusions:The prevalence of PcP among the COVID-19 population is almost similar to the pre-COVID ***,PcP-related mortality was decreased by the emergence of the COVID-19 *** with COVID-19 are more susceptible to PcP than *** respiratory distress syndrome,kidney diseases,pulmonary diseases,and long-term corticosteroid therapy increased the risk of PcP;however,transplantation and malignancy decreased the risk for PcP among COVID-19 *** retrospective,cas

关键词： Coronavirus disease 19 COVID-19 SARS-CoV-2 Pneumocystis pneumonia(PcP) COVID-associated infections Prevalence Odds ratio Risk factors

Cattle toxoplasmosis in Iran:a systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2015年第2期8卷 120-126页

作者： Shahabeddin Sarvi Ahmad Daryani Mohammad Taghi Rahimi Mohsen Aarabi Azar Shokri ehsan ahmadpour Azadeh Mizani Mahdi Sharif Toxoplasmosis Research Center Mazandaran University of Medical SciencesSariIranPostal Code:48168-95475 Department of Parasitology and Mycology Sari Medical SchoolMazandaran University of Medical SciencesSariIranPostal Code:48168-95475 Sari Medical School Mazandaran University of Medical SciencesSariIranPostal Code:48168-95475

Objective:To analyze and review the overall seroprevalence rate of Toxoplasma gondii(***) infection in cattle from ***:In the current study,data collection(published and unpublished papers,abstracts of national scientific congresses and dissertations) using particular terms was carried out systematically on the following electronic databases like PubMed,Google Scholar,Ebsco,Science Direct,Scopus,Magiran,Irandoc,IranMedex and SID(Scientific Information Database).Results:A total of 22 studies since 1983 to 2012 reporting the seroprevalence of toxoplasmosis in cattle from different regions of Iran met our eligibility *** pooled proportion of toxoplasmosis,using random effect model,among cattle in Iran from over the 30-year period was estimated 18.1%(95%CI:9.9%to 28.2%).Conclusions:This study firstly establishes a crude seroprevalence rate of Toxoplasma infection in cattle which can lead us to understand the condition of eattle toxoplasmosis,which have to take into accounted fur an appropriate and effective prevention and ***,it compares and discusses elaborately the role of risk factors including sex,age and breed in the epidemiology of the ***,it determines gaps and drawbacks in the prior studies which are greatly useful to design more accurate investigations in the future.

关键词： Toxoplasma gondii Prevalence Systematic review Meta-analysis Iran

Phylogeography,genetic variability and structure of Acanthamoeba metapopulations in Iran inferred by 18S ribosomal RNA sequences:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 855-863页

作者： Adel Spotin Hamid Reza Moslemzadeh Mahmoud Mahami-Oskouei ehsan ahmadpour Maryam Niyyati Seyed Hossein Hejazi Fatemeh Memari Jafar Noori Immunology Research Center Tabriz University of Medical SciencesTabrizIran Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Department of Medical Parasitology and Mycology School of MedicineShahid Beheshti University of Medical SciencesTehranIran Department of Parasitology and Mycology School of MedicineIsfahan University of Medical SciencesIsfahanIran

Objective: To verify phylogeography and genetic structure of Acanthamoeba populations among the Iranian clinical isolates and natural/artificial environments distributed in various regions of the ***: We searched electronic databases including Medline, Pub Med, Science Direct, Scopus and Google Scholar from 2005 to 2016. To explore the genetic variability of Acanthamoeba sp, 205 sequences were retrieved from keratitis patients, immunosuppressed cases and environmental sources as of various geographies of ***: T4 genotype was the predominant strain in Iran, and the rare genotypes belonged to T2, T3, T5(Acanthamoeba lenticulata), T6, T9, T11, T13 and T15(Acanthamoeba jacobsi).A total of 47 unique haplotypes of T4 were identified. A parsimonious network of the sequence haplotypes demonstrated star-like feature containing haplogroups IR6(34.1%) and IR7(31.2%) as the most common haplotypes. In accordance with the analysis of molecular variance, the high value of haplotype diversity(0.612–0.848) of Acanthamoeba T4 represented genetic variability within populations. Neutrality indices of the 18 S ribosomal RNA demonstrated negative values in all populations which represented a considerable divergence from neutrality. The majority of genetic diversity belonged to the infected contact lens and dust samples in immunodeficiency and ophthalmology wards, which indicated potential routes for exposure to a pathogenic Acanthamoeba sp. in at-risk individuals. A pairwise fixation index(FST) was from low to high values(0.024 33–0.418 92). The statistically FST points out that T4 is genetically differentiated between north-west, north-south and centralsouth metapopulations, but not differentiated between west-central, west-south, centralsouth, and north-central ***: An occurrence of IR6 and IR7 displays that possibly a gene flow of Acanthamoeba T4 occurred after the founder effect or bottleneck experience through ecological changes or host mobility

关键词： Acanthamoeba metapopulations Genetic variability Gene flow Molecular phylogeny Iran

Birds and poultries toxoplasmosis in Iran: A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 775-780页

作者： Azar Shokri Mehdi Sharif Saeed Hosseini Teshnizi Shahabeddin Sarvi Mohammad-TaghiRahimi Azadeh Mizani ehsan ahmadpour Mahboobeh Montazeri Ahmad Daryani Toxoplasmosis Research Center Mazandaran University of Medical Sciences Students Research Committee Department of Parasitology and MycologySchool of MedicineMazandaran University of Medical Sciences Infectious and Tropical Diseases Research Center Hormozgan University of Medical Sciences School of Medicine Shahrood University of Medical Sciences

Objective: To evaluate the overall prevalence of Toxoplasma gondii infection among birds and poultries in Iran. Methods: Data were systematically collected from 1983 to 2016 in Iran on the following electronic databases: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Magiran, Irandoc, Iran Medex, and Scientific Information Database. Additionally, the abstracts of national scientific congresses and dissertations were included. Results: A total of 20 articles in the field of birds and poultries toxoplasmosis, totally examining 4 563 cases with 754 positive results reporting the overall prevalence of infection from all parts of Iran could fulfill our eligibility criteria. The overall estimated prevalence included in chicken 20%(95% CI: 3% to 38%) in chicken, pigeons 8%(95% CI:-17% to 33%) and in sparrows 15%(95% CI:-25% to 54%). Conclusion: Although there is a lack in data about poultries and birds toxoplasmosis in Iran, our meta-analysis revealed that infection rate is high among birds and poultries in Iran. More studies are needed to manage controlling programs and prevention strategies among poultries in Iran.

关键词： Poultry Bird Toxoplasma gondii Iran Systematic review

Microsporidiosis in Iran:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 322-330页

作者： Roghayeh Ghoyounchi ehsan ahmadpour Adel Spotin Mahmoud Mahami-Oskouei Azim Rezamand Nayyereh Aminisani Morteza Ghojazadeh Reza Berahmat Tahereh Mikaeili-Galeh Pediatric Health Research Center Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical Sciences Immunology Research Center Tabriz University of Medical Sciences Department of Pediatrics Faculty of MedicineTabriz University of Medical Sciences Department of Statistics and Epidemiology Faculty of Health SciencesTabriz University of Medical Sciences Research Center of Evidence Based Medicine Tabriz University of Medical Sciences

Objective:To examine all evidences about Microspondia infection in vertebrate/invertebrate hosts and Iranian populations distributed in different regions of the ***:All published articles up to December 2015,including descriptive and cross-sectional studies related to the prevalence and genotyping of Microspondia infection in Iran,was considered in this systematic *** meta-analysis was done using the random-effects model and Stats Direct statistical *** 5.05 software and maximum likelihood algorithm with Kimura 2-parameter model were used for phylogenetic ***:Of the 1 152 investigated studies,33 eligible studies reported a prevalence of Microspondia infection in vertebrate and invertebrate *** to this systematic review,the overall prevalence rate of Microsporidia infection in immunocompromised patients in Iran was 8.18%.Furthermore,the overall prevalence rate of Microsporidia infection in immunocompromised patients with chronic diarrhoea,patients with non-diarrhoea,gastroenteritis,and patients with CD4(< 200 cells/μL) was 15.4%,4.1%,0.5%,and 12.9%*** highest prevalence rate of human and animal Microsporidia was estimated in Kerman(29%) and Khuzestan(26.5%).The overall prevalence rate of Microsporidia infection in honeybees using the random-effects model was 40%.Furthermore,the highest prevalence rate of nosemosis was described in East Azerbaijan(48.2%).The maximum number of Microsporidia isolates from immunocompromised patients and pigeons in Iran belonged to genotypes D(n=16;50%) and E(n=6;20.6%) of Enterocytozoon ***:This study may be the first systematic review and meta-analysis that provides a broad outlook on the prevalence of microsporidiosis in *** is necessary to investigate Microsporidia infection in vertebrate and invertebrate hosts and environmental resources in Iran.

关键词： Microsporidia Microsporidiosis Genotypes Iran Prevalence Epidemiology

Diagnosis of Toxoplasma gondii infection in pregnant women using automated chemiluminescence and quantitative real time PCR

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 26-31页

作者： ehsan ahmadpour Elmira Zargami Mahmoud Mahami-Oskouei Adel Spotin Abbas Shahbazi Hossein Samadi Kafil Saba Rajabi Paria Alizadeh Yagoob Azadi Reza Bahaj Firouz Shahrivar Aleksandra Barac Infectious and Tropical Disease Research Center Tabriz University of Medical Sciences Students Research Committee Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of Medicine Tabriz University of Medical Sciences Drug Applied Research Center Tabriz University of Medical Sciences Clinic for Infectious and Tropical Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade

Objective: To identify serodiagnosis and quantification of Toxoplasma gondii(T. gondii) infection among pregnant women in Salmas, northwest of Iran. Methods: In this crosssectional study, 276 blood samples were collected from pregnant women referred to the health care centers in Salmas city. The demographic variables were also recorded. Titers of antiToxoplasma IgM and IgG antibodies(Ab) were determined using the chemiluminescence immunoassay. Quantitative real-time PCR targeting the T. gondii repeated element gene was also performed on the blood sample. Results: Out of all, 19.92%(55/276) and 2.17%(6/276) patients were seropositive for anti-Toxoplasma IgG and IgM Ab, respectively. Moreover, the presence of T. gondii DNA was observed in 12.31%(34/276) blood samples. A significant relationship was observed between the IgG Ab seropositivity and contact with the cat as a risk factor(P=0.022). Conclusions: The seroprevalence rate of T. gondii infection in pregnant women is relatively low. Consequently, the seronegative pregnant women are at risk, and a considerable rate of positive blood samples for the presence of parasite's DNA should not be ignored. Besides, quantitative real-time PCR could be considered as an accurate method for diagnosis of acute toxoplasmosis especially when the precise results are of the most importance in pregnancy. Limiting contact with cats is also suggested for pregnant women.

关键词： Toxoplasmosis Toxoplasma gondii Chemiluminescence immunoassay Real time PCR Pregnancy

A New Extension of Chen Distribution with Applications to Lifetime Data

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Communications in Mathematics and Statistics 2021年第1期9卷 23-38页

作者： Bahman Tarvirdizade Mohammad ahmadpour Department of Mathematics Maku BranchIslamic Azad UniversityMakuIran

In this paper,we introduce a new lifetime distribution with increasing,decreasing and bathtub-shaped hazard rate function which is constructed by compounding of the Weibull and Chen distributions and is called Weibull–Chen(W–C)*** new distribution is more flexible to model the bathtub-shaped hazard rate data,and its hazard rate function is *** study its statistical properties including quantiles,moments,order statistics and Renyi *** estimation of parameters by maximum likelihood method is discussed,and a Monte Carlo simulation study is conducted to investigate the performance of the maximum likelihood ***,it is shown that the proposed distribution fits two real lifetime data better than other distributions.

关键词： Chen distribution Weibull distribution Maximum likelihood estimation Lifetime data analysis