检索结果-南通市图书馆

Effect of long-acting testosterone undecanoate treatment on quality of life in men with testosterone deficiency syndrome： a double blind randomized controlled trial

引用

Asian Journal of Andrology 2012年第4期14卷 604-611页

作者： Seng-Fah Tong Chirk-Jenn Ng Boon-Cheok Lee Verna-KM Lee ee-ming khoo Eng-Giap Lee Hui-Meng Tan Universiti Kebangsaan Malaysia Kuala Lumpur 56000Malaysia University of Malaya Lumpur 56000Malaysia Sime Darby Medical Centre Selangor 47500Malaysia International Medical University Kuala Lumpur 57000Malaysia

This study aimed to investigate the effect of intramuscular injection of testosterone undecanoate on overall quality of life （QoL） in men with testosterone deficiency syndrome （TDS）. A randomized controlled trial over a 12-month period was carried out in 2009. One hundred and twenty men aged 40 years and above with a diagnosis of TDS （serum total testosterone 〈12 nmol 1-1 and total Aging Male Symptom （AMS） scores ≥ 27） were invited to participate. Interventions comprised intramuscular injection of either placebo or 1000 mg testosterone undecanoate, given at weeks O, 6, 18, 30 and 42. This paper presents the secondary analysis of QoL changes measured in the scores of Short-Form-12 （SF-12） scale at baseline, weeks 30 and 48 after the first injection. A total of 56/60 and 58/60 men from the active treatment and placebo group, respectively, completed the study. At week 48, before adjusting for baseline differences, the QoL of men in the treatment group improved significantly in five out of the eight domains on SF-12. The physical health composite scores improved 4.0 points from a baseline of 41.9±7.0 in the treatment group compared to 0.8 point from a baseline of 43.7--7.1 in the placebo group （F=3.652, P=0.027）. The mental health composite scores improved 4.4 points from a baseline of 37.1±9.0 in the treatment group compared to 1.0 points from a baseline of 37.6±7.9 in the placebo group （F=4.514, P=-0.018）. After adjusting for baseline differences, significant improvement was observed in mental health composite scores, but not in physical health composite scores. LQng-acting testosterone undecanoate significanUy improved the mental health component of QoL in men with TDS.

关键词： hypogonadism randomized controlled trial quality of life testosterone deficiency syndrome (TDS) testosterone therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tetraphenylethylene dicycle helicates: circularly polarized luminescence and chiral recognition based on emission wavelength change

引用

Science China Chemistry 2024年第11期67卷 3817-3824页

作者： Zhi-Rong Xu Miao-Li Gao ming Hu Wei Yu Yan-Song Zheng Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Chiral tetraphenylethylene(TPE) dicycle tetraaldehyde and TPE dicycle tetraacids bearing optically pure groups on the cycles were designed and synthesized. Due to the propeller-like conformation immobilization of TPE unit, this new class of TPE dicycle was resolved into M-and P-enantiomers, which could emit strong circular polarized luminescence(CPL). Interestingly,these TPE helicates displayed exceptional ability of molecule recognition. While the TPE dicycle tetraaldehyde could detect the microscale water in anhydrous tetrahydrofuran, the chiral TPE dicycle tetraacid could display different fluorescent color after interacting with two enantiomers of a wide variety of chiral amines including monoamines, diamines, and aminols, which could be applied to chiral recognition of these chiral amines. Furthermore, the emission wavelength of TPE dicycle tetraacid was found to change linearly with the enantiomer purity of chiral amine from enantiomer excess(ee) percent-100% to +100%, for the first time showing the potential for quantitative chiral analysis of chiral amines based on emission wavelength change. The emission wavelength was affected less by environmental factors than fluorescence intensity, which would enable the chiral analysis based on wavelength change with higher accuracy and repeatability.

关键词： TPE dicycle helicate CPL chiral recognition enantiomer excess analysis emission wavelength change

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

智慧医院应急管理信息系统的构建与应用

引用

中国卫生标准管理 2024年第9期15卷 1-4页

作者：高明郭扬帆广州康大职业技术学院护理学系广东广州510170 南方医科大学顺德医院信息科广东佛山528300

当前我国医疗领域飞速发展,通过先进医疗设备的应用明显提升了医疗水平,与此同时医院也在积极加强信息化建设,并通过应急管理信息系统应对突发公共卫生事件。医院信息化建设也能够为病理分析以及诊疗工作开展提供参考,因此必须加强安全... 详细信息

当前我国医疗领域飞速发展,通过先进医疗设备的应用明显提升了医疗水平,与此同时医院也在积极加强信息化建设,并通过应急管理信息系统应对突发公共卫生事件。医院信息化建设也能够为病理分析以及诊疗工作开展提供参考,因此必须加强安全管理系统建设,全力保证医疗信息安全。现阶段诸多医疗机构为保护医疗信息,加强信息安全建设,根据员工岗位和级别的差异赋予不同权限,这一管理方式使得医院信息系统访问环境更加安全,不过依旧缺乏应对突发事件的手段。为解决这些问题,文章从医院信息系统的应急管理和医院信息系统的总体结构出发,之后基于J2ee(Java 2 platform,enterprise edition)架构和可扩展标记语言(extensible markup language,XML)技术,分别分析系统框架设计、系统功能模块设计、系统数据库设计,最终证实该系统可在不同情境下准确识别故障问题,满足自动应急处理,可以作为医院信息管理工具,以供参考。

关键词：智慧医院应急突发事件应急管理信息系统构建应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Novel Bisoxazoline Ligands for the Enantioselective Diels-Alder Reaction

引用

Chinese Chemical Letters 2006年第8期17卷 1033-1036页

作者： Qing Hua BIAN Jun LIU ming ming YIN Min WANG College of Science China Agricultural University Beijing 100094

Four novel bisoxazoline ligands 8a-d were synthesized from （S）-amino alcohols and could be formed effective catalysts （up to 77% ee for endo isomer） with Cu（OTf）2 for enantioselective Diels-Alder addition. The f... 详细信息

关键词： Asymmetry catalytic bisoxazoline Diels-Alder reaction ligand.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

有机催化4-羟基香豆素与靛红、丙二腈的不对称Michael加成/环化串联反应

引用

化学研究与应用 2024年第9期36卷 2073-2079页

作者：孙玉虹顾盈盈王黎明金瑛吉林医药学院药学院吉林吉林132013 延边大学药学院吉林延吉133000

含有杂环的光学活性螺环羟吲哚衍生物因其多种多样的生物活性而备受关注。靛红衍生物的不对称Michael/环化串联反应是构建手性螺环羟吲哚化合物的重要方法。本文将11种有机催化剂用于靛红、4-羟基香豆素与丙二腈的不对称Michael加成/环... 详细信息

含有杂环的光学活性螺环羟吲哚衍生物因其多种多样的生物活性而备受关注。靛红衍生物的不对称Michael/环化串联反应是构建手性螺环羟吲哚化合物的重要方法。本文将11种有机催化剂用于靛红、4-羟基香豆素与丙二腈的不对称Michael加成/环化串联反应。筛选出最佳的催化剂体系为:10 mol%金鸡纳碱衍生物催化剂1f,二氯甲烷(1 m L)为溶剂,室温反应。将最佳条件用于不同取代靛红的反应,以80~88%的产率和最高达96%的对映选择性获得了螺[羟吲哚-3,4′-吡喃色烯]化合物。本研究拓宽了该反应的催化剂类型和底物范围。

关键词：金鸡纳碱衍生物有机催化不对称Michael加成/环化串联反应 4-羟基香豆素靛红

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emergency repair of blunt traumatic bronchus injury presenting with massive air leak

引用

Chinese Journal of Traumatology 2022年第6期25卷 392-394页

作者： Jun Sen Chuah Zhun ming Raymond Lim ee Peng Lee Jih Huei Tan Yuzaidi Mohamad Rizal Imran Alwi Trauma Surgery Unit Department of General SurgeryHospital Sultanah AminahMinistry of Health MalaysiaJohor BahruMalaysia

Blunt traumatic tracheobronchial injury is rare,but can be potentially *** accounts for only 0.5%-2%of all trauma *** may present with non-specific signs and symptoms,requiring a high index of suspicion with accurate diagnosis and prompt treatment.A 26-year-old female was brought into the emergency department after sustained a blunt trauma to the chest from a high impact motor vehicle *** presented with signs of respiratory distress and extensive subcutaneous emphysema from the chest up to the *** airway was secured and chest drain was inserted for right sided *** of the neck and thorax revealed a collapsed right middle lung lobe with a massive pneumothorax,raising the suspicion of a right middle lobe bronchus *** was confirmed by *** view of the difficulty in maintaining her ventilation and persistent pneumothorax with a massive air leak,immediate right thoracotomy via posterolateral approach was *** right middle lobar bronchus tear was *** were no intra-or post-operative *** made an uneventful *** was asymptomatic at her first month follow-up.A repeated chest X-ray showed expanded *** of the case including clinical presentation,imaging and management were discussed with an emphasis on the early uses of bronchoscopy in case of suspected blunt traumatic tracheobronchial injury.A review of the current literature of tracheobronchial injury management was presented.

关键词： Blunt chest trauma Bronchus injury Bronchoscopy Thoracotomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asynchronism of the spreading dynamics underlying the bursty pattern

引用

Chinese Physics B 2020年第5期29卷 586-592页

作者： Tong Wang ming-Yang Zhou Zhong-Qian Fu Department of Electronic Science and Technology University of Science and Technology of ChinaHefei 230027China Guangdong Province Key Laboratory of Popular High Performance Computers College of Computer Science and Software EngineeringShenzhen UniversityShenzhen 518060China Department of Physics University of FribourgChemin du Mus´ee 3FribourgCH-1700Switzerland

The potential mechanisms of the spreading phenomena uncover the organizations and functions of various ***,due to the lack of valid data,most of early works are limited to the simulated process on model *** this paper,we track and analyze the propagation paths of real spreading events on two social networks:Twitter and *** empirical analysis reveals that the spreading probability and the spreading velocity present the explosive growth within a short period,where the spreading probability measures the transferring likelihood between two neighboring nodes,and the spreading velocity is the growth rate of the information in the whole ***,we observe the asynchronism between the spreading probability and the spreading *** explain the interesting and abnormal issue,we introduce the time-varying spreading probability into the susceptible-infected(SI)and linear threshold(LT)*** the analytic and experimental results reproduce the spreading phenomenon in real networks,which deepens our understandings of spreading problems.

关键词： social network information diffusion spreading probability asynchronism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enantioselective Organocatalytic Aza-Michael Additions of Phthalimide Derivatives to α,β-Unsaturated Aldehydes

引用

Chinese Journal of Chemistry 2013年第6期31卷 726-730页

作者： Shijun Ma ming Liu Yaodong Huang Yongmei Wang Department of Chemistry The Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Department of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Phthalimide derivatives as nitrogen nucleophiles with α,β-unsaturated aldehydes for asymmetric aza-Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in goo... 详细信息

关键词： phthalimide derivatives α,β-unsaturated aldehydes aza-Michael addition enantioselectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal design of a linkage-cam mechanism-based redundantly actuated parallel manipulator

引用

Frontiers of Mechanical Engineering 2021年第3期16卷 451-467页

作者： Haiying WEN Zhisheng ZHANG Min DAI ming CONG Weiliang XU School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Dalian University of TechnologyDalian 116024China Department of Mechanical Engineering The University of AucklandAuckland 1142New Zealand

A redundantly actuated parallel manipulator(RAPM)with mixed translational and rotational degrees of freedom(DOFs)is challenged for its dimensionally homogeneous Jacobian modeling and optimal design of *** this paper,a means to achieve redundant actuation by adding kinematic constraints is introduced,which reduces the DOFs of the end-effector(ee).A generic dimensionally homogeneous Jacobian is developed for this type of RAPMs,which maps the generalized velocities of three points on the ee to the joint velocities.A new optimization algorithm derived from this dimension-ally homogeneous Jacobian is proposed for the optimal design of this type of *** an example,this paper presents a spatial RAPM involving linkages and cam *** RAPM has 4 DOFs and 6 translational *** linkage lengths and the position of the universal joints of the RAPM are optimized based on the dimensionally homogeneous Jacobian.

关键词： redundant actuation parallel manipulator linkage-cam mechanism Jacobian optimal design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of C1-symmetric primary-secondary diamines and their application in the enantioselective Henry reaction

引用

Frontiers of Chemical Science and Engineering 2013年第4期7卷 408-414页

作者： Lili ZHANG ming LIU Shijun MA Yaodong HUANG Yongmei WANG Key Laboratory of Systems Bioengineering Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China State Key Laboratory of Elemento-Organic Chemistry Department of Chemistry Nankai University Tianjin 300071 China

Two new Cl-symmetric primary-secondary diamines were synthesized via the reaction of （S,S）-1,2- diphenyl ethylene diamine with 3,5-ditert-butyl salicylal- dehyde and salicylaldehyde, respectively, followed by reduction with NaBH4. The combination of the ligand from 3,5-ditert-butyl salicylaldehyde with CuBr could effciently catalyze the Henry reaction to afford β- nitroalkanols in moderate to good yields （up to 87%） and high enantioselectivities （up to 88% ee）. A possible mechanism of the reaction was proposed.

关键词： enantioselective Henry reaction Cl-sym-metric diamines asymmetric reaction nitroalkanol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：