Synthesis of Novel Bisoxazoline Ligands for the Enantioselective Diels-Alder Reaction

作     者：Qing Hua BIAN Jun LIU Ming Ming YIN Min WANG 

作者机构：College of Science China Agricultural University Beijing 100094 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第8期

页      面：1033-1036页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Finacial support by the National Natural Science Foundation of China(No.2047211) the Science Foundation of China Agricultural University(No.2005058)is gratefully acknowledged 

主　　题：Asymmetry catalytic bisoxazoline Diels-Alder reaction ligand. 

摘      要：Four novel bisoxazoline ligands 8a-d were synthesized from （S）-amino alcohols and could be formed effective catalysts （up to 77% ee for endo isomer） with Cu（OTf）2 for enantioselective Diels-Alder addition. The facility of the reaction was dependent on the nature of the substituent R in the bisoxazoline ligand.