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the importance of post-COVID condition phenotypes characterization to decipher the mechanisms underlying this post-viral syndrome

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World Journal of Pediatrics 2024年第6期20卷 633-634页

作者： Jon Izquierdo-Pujol Sara moron-Lopez IrsiCaixa and Institute for Health Science Research Germans trias i Pujol(IGtP) Can Ruti CampusBadalonaSpain Biomedicine doctoral programme Faculty of BiologyUniversity of BarcelonaBarcelonaSpain CIBERInFEC MadridSpain

the coronavirus disease-19(COVID-19)outbreak,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was declared a global pandemic in March *** has affected over 700 million people worldwide and resulted in almost 7 million deaths,equating to a 1%mortality *** present,the majority of COVID-19 cases are either asymptomatic or mild,typically resolving within two ***,between 1%and 10%of COVID-19 survivors do not fully recover and experience a post-viral syndrome referred to as"long COVID","post-acute COVID-19 syndrome"(PASC),or"post-COVID condition"(PCC).this post-viral syndrome affects both adult and pediatric ***,most of the studies published to date evaluate the adult population,leaving a gap in our understanding of its impact on children and adolescents.

关键词： acute mortality respiratory

胰岛素对昆虫病原线虫生长发育、生殖力及致病力的影响

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中国生物防治学报 2024年第4期 856-865页

作者：钱秀娟孙丹臧建成 edwin E.Lewis 甘肃农业大学植物保护学院/甘肃省农作物病虫害生物防治工程实验室西藏农牧学院植物科学学院美国爱达荷大学农业与生命科学学院昆虫学植物病理学及线虫学系

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经... 详细信息

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经卡森斯氏线虫Steinernemakraussei0657L和短尾异小杆线虫Heterorhabditisbrevicaudis0641tY侵染的大蜡螟Galleriamellonella注射不同浓度胰岛素，观测昆虫病原线虫的生活史及其对大蜡螟的致病力，以明确胰岛素对昆虫病原线虫生长发育、生殖力、致病力的影响。结果表明：胰岛素干预时间和干预浓度均可对卡森斯氏线虫0657L在寄主昆虫体内的生长发育产生影响，侵染当天（t）干预和高浓度（1:500）干预，会明显缩短其发育历期；侵染当天无论是高浓度还是低浓度的胰岛素干预，均会明显缩短短尾异小杆线虫0641tY的发育历期，且相比较卡森斯氏线虫0657L，胰岛素促进短尾异小杆线虫0641tY发育历期的效果更明显。在卡森斯氏线虫0657L侵染大蜡螟10 d后，注射低浓度的胰岛素，可显著提高其生殖力；在短尾异小杆线虫0641tY侵染大蜡螟1d后，注射低浓度的胰岛素，可显著提高其生殖力。胰岛素对卡森斯氏线虫0657L致病力有影响，在24 h内高浓度胰岛素可显著缩短寄主昆虫的死亡时间，但是侵染36 h后，各处理间差异不显著；而对短尾异小杆线虫0641tY致病力无影响。综上所述，胰岛素对卡森斯氏线虫0657L和短尾异小杆线虫0641tY的发育和生殖力均有影响，且对卡森斯氏线虫致病力有影响。

关键词：胰岛素昆虫病原线虫生长发育生殖力致病力

the Origin of Quarks in Quantum Gravity

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Journal of Modern Physics 2024年第8期15卷 1229-1245页

作者： edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio USA

A theory of quantum gravity has recently been developed by the author based on the concept that all forces converge to one at the moment of Creation. this primordial field can only interact with itself, as no other field exists, contrasting with the Standard Model of Particle Physics in which each elementary particle is an excitation in its own quantum field. the primordial field theory of quantum gravity has produced a model of a fermion with a mass gap, ½-integral spin, discrete charge, and magnetic moment. the mass gap is based on an existence theorem that is anchored in Yang-Mills, while Calabi-Yau anchors ½-integral spin, with charge and magnetic moment based on duality. Based on n-windings, this work is here extended to encompass fractional charge, with the result applied to quarks, yielding fermion mass and charge in agreement with experiment and novel size correlations and a unique quantum gravity-based ontological understanding of quarks.

关键词： Duality Calabi-Yau topology Fermion Charge Primordial Field Self-Interaction Equations Yang-Mills Gravity Quantum Gravity Ontology of Quarks

the Effectiveness of the Havriliak-negami Model in Predicting the Master Curves of the Asphalt Blends with SBS triblock Copolymer and Organic-Montmorillonite at Different temperatures and Frequencies

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Journal of Materials Science and Chemical Engineering 2024年第7期12卷 23-39页

作者： María Ángeles Vargas-Hernández Miguel Ángel Vargas Pedro R. García-morán Humberto Vázquez-torres Divisin de Ingeniera Qumica y Bioqumica TecNMTecnolgico de Estudios Superiores de Ecatepec Edo. de Mxico Mxico Facultad de Qumica Universidad Nacional Autonma de Mxico Cd. de Mxico Mxico Facultad de Ciencias Bsicas Ingeniera y tecnologa Universidad Autnoma de Tlaxcala Tlaxcala Mxico Departamento de Fsica Universidad Autnoma Metropolitana-Iztapalapa Cd. de Mxico Mxico

the dynamic viscoelastic properties of asphalt AC-20 and its composites with Organic-Montmorillonite clay (OMMt) and SBS were modeled using the empirical Havriliak-negami (Hn) model, based on linear viscoelastic theory (LVE). the Hn parameters, α, β, G0, G∞and τHn were determined by solving the Hn equation across various temperatures and frequencies. the Hn model successfully predicted the rheological behavior of the asphalt and its blends within the temperature range of 25˚C - 40˚C. However, deviations occurred between 40˚C - 75˚C, where the glass transition temperature tg of the asphalt components and the SBS polymer are located, rendering the Hn model ineffective for predicting the dynamic viscoelastic properties of composites containing OMMt under these conditions. Yet, the prediction error of the Hn model dropped to 2.28% - 2.81% for asphalt and its mixtures at 100˚C, a temperature exceeding the tg values of both polymer and asphalt, where the mixtures exhibited a liquid-like behavior. the exponent α and the relaxation time increased with temperature across all systems. Incorporating OMMt clay into the asphalt blends significantly enhanced the relaxation dynamics of the resulting composites.

关键词： Asphalt Blends Master Curve Linear Viscoelasticity Havriliak-negami Model

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胰岛素对昆虫病原线虫致病力及生殖力的影响

中国生物防治学报 2024年

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命都有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经... 详细信息

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命都有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经卡森斯氏线虫Steinernema kraussei 0657L和短尾异小杆线虫Heterorhabditis brevicaudis 0641tY侵染的大蜡螟Galleria mellonella注射不同浓度胰岛素，观测昆虫病原线虫的生活史及其对大蜡螟的致病力，明确胰岛素对昆虫病原线虫致病力、生殖力的影响。结果表明：胰岛素干预时间和干预浓度均可对卡森斯氏线虫0657L在寄主昆虫体内的生长发育产生影响，侵染当天（t）干预和高浓度（1:500）干预，会明显缩短其发育历期；侵染当天无论是高浓度还是低浓度的胰岛素干预，均会明显缩短短尾异小杆线虫0641tY的发育历期，且相比较卡森斯氏线虫0657L，胰岛素促进短尾异小杆线虫0641tY发育历期的效果更明显。在卡森斯氏线虫0657L侵染大蜡螟10 d后，注射低浓度的胰岛素，可显著提高其生殖力；在短尾异小杆线虫0641tY侵染大蜡螟1 d后，注射低浓度的胰岛素，可显著提高其生殖力。胰岛素对卡森斯氏线虫0657L致病力有影响，在24 h内高浓度胰岛素可显著缩短寄主昆虫的死亡时间，但是侵染36 h后，各处理间差异不显著；而对短尾异小杆线虫0641tY致病力无影响。综上所述，胰岛素对卡森斯氏线虫0657L和短尾异小杆线虫0641tY的发育和生殖力均有影响，且对卡森斯氏线虫致病力有影响。

关键词：胰岛素昆虫病原线虫个体发育生殖力致病力

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RnA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

the association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RnA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and tCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying tP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PtPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RnA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

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昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of Entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPn)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPn与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPn的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPn的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPn影响及EPn的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

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胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能研究进展

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昆虫学报 2024年 1-13页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室美国爱达荷大学农学院线虫学系

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、繁殖、胁迫抗性和寿命,且均与脊椎动物的胰岛素样肽信号通路和及胰岛素样生长因子通路高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans等的胰岛素信号通路研究,作为一根探针,在生命科学研究中为人类胰岛素相关疾病研究提供试验模型,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫作为一种重要的生防因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPn与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对昆虫病原线虫的影响,必须同时关注胰岛素对寄主昆虫的影响。为了能科学系统地展开胰岛素对昆虫病原线虫的影响并进行深入探讨,本文就胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能展开综述,以期为研究胰岛素对昆虫病原线虫的影响及昆虫病原线虫的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

Contribution of High Sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of type 2 Diabetes and Its Cardiovascular Complications

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Journal of Diabetes Mellitus 2024年第2期14卷 95-107页

作者： Maïmouna touré Léopold ngor Sène Jean Pierre Diagne Demba Diédhiou Souleymane thiam Abdou Khadir Sow mor Diaw Aïssatou Seck Salimata Diagne Houndjo Abdoulaye Ba Abdoulaye Samb Fatou Diallo-Agne Modou Oumy Kane Laboratoire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRL3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire Privé de Biologie General Kaolack S&#233n&#233gal Centre Hospitalier Universitaire (CHU) Abasse ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Biochimie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Physiologie Pharmaceutique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

Background: type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. the latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. these cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. the relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. the hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. to answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: this is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). the interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. the biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2

关键词： hsCRP Biomarker Inflammation type 2 Diabetes