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Impact of diabetes mellitus and cardiometabolic syndrome on the risk of Alzheimer’s disease among postmenopausal women

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World journal of Diabetes 2021年第1期12卷 69-83页

作者： Longjian Liu edward j Gracely Xiaoyan Yin Howard j Eisen Department of Epidemiology and Biostatistics Dornsife School of Public HealthDrexel UniversityPhiladelphiaPA 19104United States Department of Family Community and Preventive MedicineDrexel University College of MedicinePhiladelphiaPA 19129United States Institute for Diabetes Obesity and MetabolismPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104United States Heart and Vascular Institute Pennsylvania State UniversityHersheyPA 17033United States

BACKGROUND In spite of an increase in the incidence and prevalence of diabetes mellitus(DM)and Alzheimer’s disease(AD)in the aging population worldwide,limited attention has been paid to their potential *** To investigate the association of DM and cardiometabolic syndrome(CMS,a precursor to DM)with risk of incident AD among postmenopausal *** Postmenopausal women aged 50-79(n=63117)who participated in the ***’s Health Initiative Observational Study(WHIOS),recruited in 1993-1998,without baseline AD and followed up through March 1,2019,were *** was classified by participant-reported history of doctor-diagnosis of incident AD in the *** was defined by participant-report or treated because of diabetes or serum glucose concentrations≥126 mg/*** was defined as having≥3 of five CMS components:large waist circumference,high blood pressure,elevated triglycerides,elevated glucose,and low high-density lipoprotein *** associations of DM and CMS with AD were analyzed using Cox’s proportional hazards regression *** During a median follow-up of 20 years(range:3.36 to 23.36 years),of 63117 participants,8340 developed incident *** with DM had significantly higher incidence of AD[8.5,95%confidence interval(CI):8.0-9.0 per 1000 personyears(PY)]than those without DM(7.1,95%CI:6.9-7.2 per 1000 PY).Multivariate Cox’s regression analysis indicated that women with DM or CMS had a significantly higher risk of AD than those without DM or *** corresponding hazard ratios[HR(95%CI)]were 1.22(1.13-1.31,Pjects with DM,and 1.18(1.09-1.27,Pjects with *** HRs diminished with age and became non-significant in the oldest age *** During a median follow-up of 20 years,DM and CMS were significantly associated with the risk of AD among postmenopausal *** specifically,women aged 50-69 with DM or CMS vs those without these conditions had significantly higher relative risks of AD th

关键词： Epidemiology Diabetes mellitus Cardiometabolic disorders Alzheimer’s disease Aging population

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Re-evaluation of the function of the male specific lethal complex in Drosophila

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journal of Genetics and Genomics 2011年第8期38卷 327-332页

作者： james Birchler harvey Fernandez Ryan Donohue Abhijit Sanyal Division of Biological Sciences 311 Tucker HallUniversity of MissouriColumbiaMO 65211USA

A set of proteins and noncoding RNAs, referred to as the male specific lethal （MSL） complex, is present on the male X chromosome in Drosophila and has been postulated to be responsible for dosage compensation of this chromosome -- the up-regulation of its expression to be equal to that of two X chromosomes in females. This hypothesis is evaluated in view of lesser known aspects of dosage compensation such as the fact that metafemales with three X chromosomes also have equal expression to normal females, which would require a down-regulation of each gene copy Moreover, when this complex is ectopically expressed in females or specifically targeted to a reporter in males, there is no increase in expression of the genes or targets with which it is associated. These observations are not consistent with the hypothesis that the MSL complex conditions dosage compensation. A synthesis is described that can account for these observations.

关键词： Dosage compensation MSL Aneuploidy Gene balance hypothesis X chromosome

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Two Potent α3/5 Conotoxins from Piscivorous Conus achatinus

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 438-444页

作者： Geoffrey CHEW edward HAWROT Department of Molecular Pharmacology Physiology and Biotechnology Brown University Providence Rhode Island 02903 USA

Every cone snail produces a mixture of different conotoxins and secretes them to immobilize their prey and predators. α3/5 Conotoxins, isolated from fish-hunting cone snails, target muscle nicotinic acetylcholine receptors. The structure and function of α3/5 conotoxin from the piscivorous Conus achatinus have not been studied. We synthesized two pentadecamer peptides, Ac 1.1 a and Ac 1.1 b, with appropriate disulfide bonding, based on cDNA sequences of α3/5 conotoxins from C. achatinus. Ac 1.1 a and Ac 1.1 b differ by only one amino acid residue. They have similar potency on blocking recombinant mouse muscle acetylcholine receptor expressed in Xenopus laevis oocytes, with IC50values of 36 nM and 26 nM, respectively. For Ac 1.1b, deletion of the first three N-terminal amino acids did not change its activity, indicating that the Nterminus is not involved in the interaction with its receptor. Furthermore, our experiments indicate that both toxins strongly prefer the α1-δ subunit interface instead of the α1-γ binding site on the mouse muscle nicotinic acetylcholine receptor. These peptides provide additional tools for the study of the structure and function of nicotinic receptor.

关键词： cone snail α3/5 conotoxin disulfide bond nicotinic acetylcholine receptor

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Understanding Contaminant Veins in Squeeze Casting and Semi-solid Metalworking Processes

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特种铸造及有色合金 2003年第Z1期23卷 230-234,238页

作者： edward j. Vinarcik, P.E. Engineer Voctorie Co.8218 Medicine Bow Run Fort WayreIdiana 46825 U.S A

When commercializing the semi-solid metalworking processes, component producers looked to conventional die-casting to identify potential defects and control component quality. Several defects were expected including cold shuts, cold flows, flash, drags, warping, and gas entrapment, just to name a few. Efforts were taken to avoid these defects. A new defect type, contaminant veins, has surfaced unique to semi-solid metalworking. Although, semi-solid metalworking has proven to be successful, component producers have been reluctant to report defects for fear of giving this emerging processes a bad reputation. Nonetheless, this defect must be understood to avoid future problems.

关键词： Contaminant Veins Squeeze Casting Semi-solid Casting

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The calcium sensing receptor: from calcium sensing to signaling

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Science China(Life Sciences) 2015年第1期58卷 14-27页

作者： ZHANG Chen MILLER Cassandra Lynn BROWN edward M YANG jenny j. Department of Chemistry Georgia State University Center for Diagnostics and Therapeutics Georgia State University Division of Endocrinology Diabetes and HypertensionDepartment of MedicineBrigham and Women's Hospital

The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of *** in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic *** evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological *** this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated *** systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling.

关键词： the Ca2+-sensing receptor(the Ca SR) Ca2+ signaling extracellular domain(ECD) Ca2+-binding sites

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Feasibility of achieving net-zero energy performance in high-rise buildings using solar energy

Energy and Built Environment

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Energy and Built Environment 2024年第6期5卷 946-956页

作者： Mehrdad Shirinbakhsh L.D.Danny harvey University of Toronto 100St.George StreetTorontoONM5S 3G3Canada

As part of a broad strategy to reach net-zero greenhouse gas emissions and limit global warming,many countries are requiring all new buildings to have net-zero energy *** requires that on-site energy use not exceed on-site generation of renewable energy(taken here to be solar energy),or equivalently,that the building Energy Use Intensity(EUI,kWh/m^(2)a)not exceed the supply of on-site solar energy(electricity and heat)per m^(2)of floor area per *** this basis,we find that achieving net-zero energy performance in an archetype 40-story square building in 16 different cities of North America requires EUI of 17–24 kWh/m^(2)a using PV panels,and 19–28 kWh/m^(2)a using PVT *** building orientation to a non-square floor shape can improve maximum permitted EUI by up to 50%in PV and 60%in PVT ***,the best-performing residential and commercial buildings have EUIs of 50–75 kWh/m^(2)*** if building heights are limited to 5–10 floors does the available solar energy,and thus the permitted EUI,reach 50–75 kWh/m^(2)***,we recommend that policymakers not require high-rise buildings to be net-zero energy,unless they are prepared to limit building heights to 5–10 floors.

关键词： High-rise net-zero energy buildings Building geometry Building height Solar NZEB

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基于非局部损伤的环氧沥青混凝土疲劳裂缝仿真(英文)

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中国公路学报 2016年第7期29卷 30-37页

作者：罗桑钱振东陆庆 harvey j 东南大学智能运输系统研究中心江苏南京210096 加州大学伯克利分校路面研究中心加利福尼亚伯克利ca94804 南佛罗里达大学土木与环境工程系佛罗里达坦佩fl33620

基于连续介质损伤力学理论,以环氧沥青混凝土的疲劳开裂过程为研究对象,建立了梯度增强的非局部损伤模型用于表征材料的疲劳损伤,并进行有限单元数值格式化;利用FEAP有限元软件仿真分析了环氧沥青混凝土在不同温度(10℃、20℃、30℃)、... 详细信息

基于连续介质损伤力学理论,以环氧沥青混凝土的疲劳开裂过程为研究对象,建立了梯度增强的非局部损伤模型用于表征材料的疲劳损伤,并进行有限单元数值格式化;利用FEAP有限元软件仿真分析了环氧沥青混凝土在不同温度(10℃、20℃、30℃)、加载应变与饱水状态下小梁试件的四点弯曲疲劳试验。室内疲劳试验结果与仿真结果具有很好的一致性,表明所构建的梯度增强非局部损伤模型具有很好的可靠性。通过疲劳试验数据,回归拟合出不同温度与饱水状态下的环氧沥青混凝土的疲劳损伤参数,为环氧沥青混凝土材料在路面结构中的疲劳特性研究提供了基础材料参数。研究成果为沥青混凝土类材料的疲劳特性研究与性能设计提供了依据与借鉴。

关键词：道路工程环氧沥青混凝土四点弯曲疲劳试验疲劳损伤梯度增强非局部损伤

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Optimal decentralized control of large scale systems

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Control Theory and Technology 2016年第4期14卷 287-313页

作者： Xiao Qi SHI Daniel E. DAVISON Raymond KWONG edward j. DAVISON Systems Control Group Department of Electrical and Computer Engineering University of Toronto Ontario Canada MSS 3G4 Department of Electrical and Computer Engineering University of Waterloo Ontario Canada N2L 3G1

This paper presents a new optimized decentralized controller design method for solving the tracking and disturbance rejection problems for large-scale linear time-invariant systems, using only low-order decentralized controllers. To illustrate the type of results which can be obtained using the new optimized decentralized control design method, the control of a large flexible space structure is studied and compared with the standard centralized LQR-observer controller. The order of the resultant decentralized controller is much smaller than that of the standard centralized LQR-observer controller. The proposed controller also has certain fail-safe properties and, in addition, it can be five orders of magnitude more robust than the standard LQR-observer controller based on their real stability radii. The new decentralized controller design method is applied to a large flexible space structure system with 5 inputs and 5 outputs and of order 24.

关键词： Decentralized control multivariable control PID control robustness optimization large-scale systems flexiblestructures

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Behavioral primary prevention of cardiovascular diseases

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 34-37页

作者： Andrew Elagizi edward Archer Carl j.Lavie Department of Internal Medicine Leonard J Chabert Medical CenterHoumaLAUSA EnduringFX ColumbiaSCUSA Department of Cardiovascular Diseases John Ochsner Heart and Vascular InstituteOchsner Clinical School-The University of Queensland School of MedicineNew OrleansLAUSA

The 2012 grade C recommendation from the United States Preventive Service Task Force(USPSTF)is that clinicians may choose to selectively counsel adults about healthful diet and physical activity(PA)for cardiovascular ... 详细信息

关键词： prevention cardiovascular diseases

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Z-Score in Fetal Echocardiography–Is there Still Room for New Studies?

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Congenital Heart Disease 2024年第3期19卷 305-314页

作者： Marcio Fragoso Vieira Nathalie jeanne Bravo-Valenzuela edward Araujo júnior Department of Obstetrics Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetrics Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatrics Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

Congenital heart disease(CHD)is the most common type of birth defect,representing a significant cause of peri-natal morbidity and *** diagnosis of such anomalies is crucial for improving *** pro-tocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound(2DUS)and color Doppler *** cases of suspected abnormalities,quantitative assessments through cardiac structure measurements and reference curves can aid in accurate *** to centiles widely employed in obste-trics,Z-scores provide more precise quantification of various cardiac structures,particularly at the extremes of the *** the development of reference curves and Z-scores has progressed over the past two decades,a lack of standardization in measurements and statistical methodology for their determination is *** reference curves requires adherence to specific recommendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated reference values for cardiac struc-tures using 2DUS and Z-scores,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-scores reference ranges fetal echocardiography

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